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An Al/Mg/Al composite with a trilaminate structure was fabricated by hot rolling and its mechanical properties at quasi-static rates of strain were investigated. The bonding strength of the trilaminated composite is about 40 MPa, mainly attributing to the mechanical bond at the interfaces. The first layer failure strength of the laminated composite increases from 305 to 372 MPa when the relative thickness of aluminium alloy layer increases from 0.235 to 0.265. The tensile and bending properties of the laminates were calculated based on the Classical Laminate Theory (CLT). The calculations of first layer failure strength based on CLT agree with the experimental data in the error of 2.9–18%. Thus, the first layer failure strength of the Al/Mg/Al trilaminated composite fabricated by hot rolling can be calculated by CLT with the maximum stress criteria. The calculations also show that the tensile modulus, the tensile rigidity, the specific tensile rigidity and the first layer failure strength of the laminated composite increase almost linearly with the relative thickness of the aluminium alloy component. The bending rigidity of the laminated composite increases with the relative thickness of aluminium alloy, and approximates to a fixed value after the relative thickness over 0.3. The specific bending rigidity increases with the relative thickness of aluminium alloy and reaches a maximum value when the relative thickness is 0.25.

Afatinib, a second-generation covalent EGFR TKI, has been approved for the treatment of the three \"uncommon\" mutations (G719X, S768I, and L861Q) based on one pooled retrospective analysis of three prospective trials (LUX-Lung 2, 3 and 6). The confirmed overall response rate, as assessed by independent radiology review, was 66% (95% confidence interval: 47-81). Among the 21 responders, the proportion of patients with response duration of ≥12 months was 52% and the proportion with response durations of ≥18 months was 33%. Of note, all patients received afatinib at 40 or 50 mg once daily which is higher than the approved dose of 40 mg once daily and the usual 30 mg once daily starting dose by most thoracic oncologists. Given the approval of afatinib for \"uncommon\" mutations was based on the limited number of patients analyzed, the retrospective nature of the analysis, lack of randomized phase 2 or 3 trial, there remains uncertainty as to whether afatinib, chemotherapy or other next-generation EGFR TKIs is the optimal treatment. This uncertainty also hinders the development of future treatment of these \"uncommon\" mutations because of the uncertainty that afatinib is the optimal treatment and hence should be the standard of care control arm in future randomized trials. Finally, the ACHILLES/TORG1834 provided us with the first randomized trial result that afatinib achieved superior progression-free survival over platinum-based chemotherapy (10.6 months vs 5.7 months, HR = 0.42; 95% CI: 0.256-0.694; P = 0.0007). However, ACHILLES should mostly be considered as phase 2 trial given the limited number (N = 109) of patients enrolled. Furthermore, the PFS benefit seemed to be with the 40 mg daily dose (HR = 0.128; 95% CI: 0.050-0.327) and not with the 30 mg daily dose (HR = 0.704; 95% CI: 0.352-1.406). Further investigation of the 30 once daily dosing for the treatment of uncommon mutations is needed.

The current standard of care for unresectable stage III non-small cell lung cancer (NSCLC) involves a concurrent platinum-based doublet chemotherapy and chest radiotherapy, followed by consolidative therapy with durvalumab, an anti-programmed death ligand 1 (PD-L1) antibody, based on the PACIFIC trial (NCT02125461). However, the utility of durvalumab in -mutated lung cancer patients is questionable based on post-hoc analysis and multi-institutional retrospective analysis. Osimertinib is a third-generation -tyrosine kinase inhibitor (TKI) with proven clinical efficacy in NSCLC. Given that durvalumab showed no benefit in unresectable Stage III -mutated NSCLC, it is exciting that most recently, the LAURA trial has demonstrated promising outcomes with adjuvant osimertinib in unresectable, stage III -mutated NSCLC after definitive chemoradiotherapy with significant improvement in PFS compared to placebo. Furthermore, the LAURA trial demonstrates that osimertinib has a protective effect against distant metastases and CNS progression in this patient population. Here, we explore the results of the LAURA trial and how it transforms the standard-of-care treatment for patients with unresectable, stage III -mutated NSCLC moving forward.

In the paper, frequency selective surfaces (FSS) composed of quad-layer FSS with staggered tuning are designed, to allow signals to pass through at the frequency range of the global positioning system (GPS) cum DCS1800 mobile communications operation, while rejecting signals at the higher frequencies. The FSS is analysed by visualising the transformation of the admittance locus on the Smith chart, on subsequent additions of material layers to the multilayer stack-up. In addition, a single-layer FSS with convoluted loop elements (with interelement spacing of 6.08 cm) is designed to yield a similar band-pass response at 1.575 GHz (wavelength λ = 19.05 cm). This relatively close spacing is achieved by convoluting the conventional 1λ square-loop element at its four comers. The convoluted segment provides a short-circuit response when the segment length is λ/4 long. This provides a reflection to the electromagnetic energy at the selected band-stop frequency range. The performance of the quad-layer and single-layer FSS are compared.

The objective of this investigation is to study the effects of annealing treatment on the ratcheting behavior of extruded AZ31B magnesium alloy. First, the microstructures and monotonic tensile properties of the extruded and annealed alloys were assessed. The results showed that the grain size increased slightly with increasing annealing time until an annealing time of 6 h after which abnormal grain growth happened. Accordingly, the ultimate tensile strength of the Mg alloy decreased with increasing annealing time, while the tensile yield strength and elongation percentage of the Mg alloy increased with annealing time until the annealing time reached 2 h. The cyclic softening/hardening behavior of the annealed AZ31B Mg alloy was similar to that of the extruded alloy: first an apparent cyclic softening was observed, then a cyclic hardening occurred, and finally a stable state was reached. The annealing treatment delayed the occurrence of the cyclic hardening. It was also shown that the effects of the annealing time on the ratcheting strain of the Mg alloy depended of the loading path.

As the world's leading aquaculture, aquatic production and trading country, China's development of aquatic products trade with ASEAN is facing a historic opportunity in the favourable circumstances of construction of the 21st century Maritime Silk Road. In order to make guidance of the product selection and transformation for corresponding export enterprises, this article makes a quantitative analysis the Revealed Comparative Advantage of aquatic products trade from China and ASEAN respectively based on the HS classification and thoroughly compares the RCA indices. The comparison results show that the international competitiveness of aquatic products structures of China and ASEAN are quite different with few overlaps of strong competitive products, and there is a great gap between the two areas in many kinds of products.

The super τ-charm facility (STCF) is an electron−positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5 × 10 35 cm −2·s −1 or higher. The STCF will produce a data sample about a factor of 100 larger than that of the present τ-charm factory - the BEPCII, providing a unique platform for exploring the asymmetry of matter-antimatter (charge-parity violation), in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions, as well as searching for exotic hadrons and physics beyond the Standard Model. The STCF project in China is under development with an extensive R&D program. This document presents the physics opportunities at the STCF, describes conceptual designs of the STCF detector system, and discusses future plans for detector R&D and physics case studies.

The paper describes a novel attempt to integrate a quad-layer frequency selective surface (FSS) with a circularly polarised Maltese-cross antenna for the global positioning system and DCS 1800 mobile communications. The effect of integrating the FSS with the antenna is presented for both in-band (1.5-1.9 GHz) and out-of-band (8.5-9.7 GHz) operation. For out-of-band operation, a reduction of antenna scattering is observed with the integration of the FSS. A comparison of the total scattering of the antenna with that calculated for the finite ground plate is included. The seemingly contradictory two-fold impact of the FSS performance on the link budget equation is illustrated.