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Simultaneously activating metal and lattice oxygen sites to construct a compatible multi-mechanism catalysis is expected for the oxygen evolution reaction (OER) by providing highly available active sites and mediate catalytic activity/stability, but significant challenges remain. Herein, Fe and S dually modulated NiFe oxyhydroxide (R-NiFeOOH@SO 4 ) is conceived by complete reconstruction of NiMoO 4 ·xH 2 O@Fe,S during OER, and achieves compatible adsorbate evolution mechanism and lattice oxygen oxidation mechanism with simultaneously optimized metal/oxygen sites, as substantiated by in situ spectroscopy/mass spectrometry and chemical probe. Further theoretical analyses reveal that Fe promotes the OER kinetics under adsorbate evolution mechanism, while S excites the lattice oxygen activity under lattice oxygen oxidation mechanism, featuring upshifted O 2 p band centers, enlarged d-d Coulomb interaction, weakened metal-oxygen bond and optimized intermediate adsorption free energy. Benefiting from the compatible multi-mechanism, R-NiFeOOH@SO 4 only requires overpotentials of 251 ± 5/291 ± 1 mV to drive current densities of 100/500 mA cm −2 in alkaline media, with robust stability for over 300 h. This work provides insights in understanding the OER mechanism to better design high-performance OER catalysts. The oxygen evolution reaction is crucial for energy conversion but faces challenges in catalyst optimization. Here, the authors present a dual-modulated NiFe oxyhydroxide (R-NiFeOOH@SO4) that enhances OER performance through optimized metal and lattice oxygen sites, achieving a compatible multi-mechanism.

Abiotic stresses such as high temperature, salinity, and drought adversely affect the survival, growth, and reproduction of plants. Plants respond to such unfavorable changes through developmental, physiological, and biochemical ways, and these responses require expression of stress-responsive genes, which are regulated by a network of transcription factors (TFs), including heat stress transcription factors (HSFs). HSFs play a crucial role in plants response to several abiotic stresses by regulating the expression of stress-responsive genes, such as heat shock proteins (Hsps). In this review, we describe the conserved structure of plant HSFs, the identification of HSF gene families from various plant species, their expression profiling under abiotic stress conditions, regulation at different levels and function in abiotic stresses. Despite plant HSFs share highly conserved structure, their remarkable diversification across plants reflects their numerous functions as well as their integration into the complex stress signaling and response networks, which can be employed in crop improvement strategies via biotechnological intervention.

Cardiac ischaemia/reperfusion (I/R) injury causes cardiomyocyte apoptosis and mitochondrial dysfunction. Ursolic acid (UA), as a pentacyclic triterpenoid carboxylic acid, exerts several bioactivities in animal models of different diseases, but the preventive role of UA in I/R-induced myocardial dysfunction remains largely unknown. Male wild-type mice were pre-administered with UA at a dosage of 80 mg/kg i.p. and then subjected to cardiac I/R injury for 24 h. Cardiac function and pathological changes were examined by echocardiography and histological staining. The protein and mRNA levels of the genes were determined using qPCR and immunoblotting analysis. Our results revealed that UA administration in mice significantly attenuated the I/R-induced decline in cardiac function, infarct size, myocyte apoptosis, and oxidative stress. Mechanistically, UA increased three immunoproteasome catalytic subunit expressions and activities, which promoted ubiquitinated PP2A degradation and activated AMPK-PGC1α signalling, leading to improved mitochondrial biosynthesis and dynamic balance. In vitro experiments confirmed that UA treatment prevented hypoxia/reperfusion (H/R)-induced cardiomyocyte apoptosis and mitochondrial dysfunction through activation of AMPK signalling. In summary, our findings identify UA as a new activator of the immunoproteasome that exerts a protective role in I/R-induced myocardial dysfunction and suggest that UA supplementation could be beneficial for the prevention of cardiac ischaemic disease.

The rational construction of earth‐abundant and advanced electrocatalysts for oxygen evolution reaction (OER) is extremely desired and significant to seawater electrolysis. Herein, by directly etching Ni3S2 nanosheets through potassium ferricyanide, a novel self‐sacrificing template strategy is proposed to realize the in situ growth of NiFe‐based Prussian blue analogs (NiFe PBA) on Ni3S2 in an interfacial redox reaction. The well‐designed Ni3S2@NiFe PBA composite as precursor displays a unique spherical magic cube architecture composed of nanocubes, which even maintains after a phosphating treatment to obtain the derived Ni3S2/Fe‐NiPx on nickel foam. Specifically, in alkaline seawater, the Ni3S2/Fe‐NiPx as OER precatalyst marvelously realizes the ultralow overpotentials of 336 and 351 mV at large current densities of 500 and 1000 mA cm–2, respectively, with remarkable durability for over 225 h, outperforming most reported advanced OER electrocatalysts. Experimentally, a series of characterization results confirm the reconstruction behavior in the Ni3S2/Fe‐NiPx surface, leading to the in situ formation of Ni(OH)2/Ni(Fe)OOH with abundant oxygen vacancies and grain boundaries, which constructs the Ni3S2/Fe‐NiPx reconstruction system responsible for the remarkable OER catalytic activity. Theoretical calculation results further verify the enhanced OER activity for Ni3S2/Fe‐NiPx reconstruction system, and unveil that the Fe‐Ni2P/FeOOH as active origin contributes to the central OER activity. Well‐designed spherical Ni3S2/Fe‐NiPx magic cube architecture stacked by nanocubes is readily reconstructed into Ni(OH)2/Ni(Fe)OOH with abundant active sites, cocontributing to ultrahigh‐efficiency seawater oxidation.

BackgroundUterine fibroids (UFs) are the most common form of sex steroid hormone-dependent benign tumours that grow in the walls of the uterus. Several observational studies have examined the association between obesity and the risk of UFs, but findings are inconsistent. The objective of this systematic review and meta-analysis is to further examine the association of obesity with the risk/prevalence of UFs.MethodsA literature search was performed in three databases (PubMed, EMBASE and Web of Science) from 1 January 1992 to 30 May 2020. We used random-effect models to calculate the pooled ORs with corresponding 95% CIs. Additionally, we performed a dose–response meta-analysis to analyse the effect of body mass index (BMI), weight change since age 18, waist-to-hip ratio and waist circumference on the risk/prevalence of UFs.ResultsA total of 22 articles, covering 24 studies including 325 899 participants and 19 593 cases, were selected based on our inclusion criteria. We found a positive association between obesity and the risk/prevalence of UFs (OR, 1.19; 95% CI, 1.09 to 1.29). Among participants with the highest BMI, the pooled OR was 1.19 (1.09 to 1.31) when compared to participants with normal BMI. For weight change since age 18, the pooled OR (95% CI) of UFs was 1.26 (1.12 to 1.42) among the highest change group when compared with no change. Additionally, our meta-analysis indicated the relationship of BMI with risk of UFs to be an inverse J-shaped pattern.ConclusionsThe results of this meta-analysis suggest that obesity may increase the risk/prevalence of UFs, and the association is non-linear.

Transition metal high‐entropy oxides (HEOs) are an attractive class of anode materials for high‐performance lithium‐ion batteries (LIBs). However, owing to the multiple electroactive centers of HEOs, the Li+ storage mechanism is complex and debated in the literature. In this work, operando quick‐scanning X‐ray absorption spectroscopy (XAS) is used to study the lithiation/delithiation mechanism of the Cobalt‐free spinel (CrMnFeNiCu)3O4 HEO. A monochromator oscillation frequency of 2 Hz is used and 240 spectra are integrated to achieve a 2 min time resolution. High‐photon‐flux synchrotron radiation is employed to increase the XAS sensitivity. The results indicate that the Cu2+ and Ni2+ cations are reduced to their metallic states during lithiation but their oxidation reactions are less favorable compared to the other elements upon delithiation. The Mn2+/3+ and Fe2+/3+ cations undergo two‐step conversion reactions to form metallic phases, with MnO and FeO as the intermediate species, respectively. During delithiation, the oxidation of Mn occurs prior to that of Fe. The Cr3+ cations are reduced to CrO and then Cr0 during lithiation. A relatively large overpotential is required to activate the Cr reoxidation reaction. The Cr3+ cations are found after delithiation. These results can guide the material design of HEOs for improving LIB performance. The charge‐storage mechanism of Cobalt‐Free high‐entropy oxide is studied using a novel operando quick‐scanning X‐ray absorption spectroscopy (XAS) technique. High‐photon‐flux synchrotron radiation is employed to increase XAS sensitivity.XAS data are acquired in on‐the‐fly mode using a monochromator oscillation frequency of 2 Hz. Valence/coordination state variations and multiple transition steps of the constituent species upon charging/discharging are investigated in detail.

The simultaneous achievement of chiral multiple‐resonance thermally activated delayed fluorescence (MR‐TADF) emitters with narrowband and circularly polarized electroluminescence (CPEL) poses a challenge. Herein, a MR‐TADF emitter, Spiro‐BNCz, embedding spirofluorene structure was developed and chiral separated, whose emission peaks at 528 nm in toluene with Commission Internationale de L'Eclairage coordinates of (0.26, 0.69). The conjugation extension caused by embedding sulfur substituted spirofluorene on B/N framework shortens the singlet‐triplet energy gap and increases spin‐orbital coupling matrix element. Therefore, a fast reverse intersystem crossing rate constant of 2.8 × 106 s−1 and a high photoluminescence efficiency of 92% in film were achieved. The organic light‐emitting diode (OLED) exhibits a maximum external quantum efficiency of 32.3%. Particularly, the circularly polarized OLEDs based on Spiro‐BNCz enantiomers show symmetric CPEL with dissymmetry factors (|gEL|) ≈ 10−3. The integration of chiral S‐substituted spirofluorene structure and B/N skeleton has proven to be an effective approach for achieving pure‐green emission and symmetric CPL. The corresponding CP‐OLEDs demonstrate a remarkable EQE of 32.3% and symmetric CPEL with gEL factors approximately on the order of 10‐3.

IntroductionArtificial intelligence (AI) is increasingly used in tuberculosis (TB) diagnosis, but its clinical adoption depends not only on accuracy but also on physicians’ trust and understanding of AI outputs. Explainable AI (XAI) has been proposed to address this challenge, but limited evidence exists on which explanation features are most valued by physicians in TB diagnostic settings. Discrete choice experiments (DCEs) offer a structured method to elicit physicians’ preferences and quantify trade-offs among explainability attributes. This protocol describes a DCE designed to examine TB physicians’ preferences for AI explainability to inform user-centred AI development and implementation.Methods and analysisSix attributes were identified through a comprehensive literature review, one-on-one semi-structured interviews with TB physicians and expert consultations. A D-efficient experimental design was used to construct choice sets. TB physicians in Hubei Province, China, will be recruited using a stratified random sampling approach. Preference data will be analysed using multinomial logit and mixed logit models to estimate the relative importance of attributes and explore preference heterogeneity across physician subgroups.Ethics and disseminationEthical approval has been obtained from the Ethics Committee of Wuhan Pulmonary Hospital. All participants will provide written informed consent prior to participation. Study findings will be disseminated through peer-reviewed journal publications, conference presentations and academic forums, with the aim of informing the design and implementation of XAI systems for TB diagnosis.

Extubation failure is common in critically ill post-craniotomy patients. This study aimed to assess extubation outcomes and examine demographic and surgical predictors of extubation success. In this retrospective cohort study, we analyzed adult ICU patients from January 2017 to December 2020 with ≥24 hours of both ICU stay and endotracheal intubation. We collected demographic characteristics, surgical parameters, severity scores (APACHE II, SOFA, GCS), and extubation outcomes. Independent predictors of successful extubation were determined through multivariate logistic regression. Among 1,683 enrolled patients, first-attempt extubation success was achieved in 70.7% (1,190/1,683), declining to 46.6% (135/290) and 28.6% (12/42) for second and third attempts respectively. Subsequent tracheostomy was performed in 19, 3, and 1 patients following first, second, and third successful extubations. At discharge, 1,244 patients (73.9%) maintained extubation success while 348 (20.7%) required tracheostomy. Successful first extubation correlated with significantly reduced ICU stay (median 4 vs 15 days, p < 0.001) and total hospitalization duration (19 vs 30 days, p < 0.001), though mortality rates showed no significant difference (6.0% vs 8.1%, p = 0.106). Multivariable analysis demonstrated that male sex (OR 0.680, 95% CI 0.531-0.871), history of hypertension (OR 0.637, 95% CI 0.489-0.829), supratentorial lesions (OR 1.315, 95% CI 1.016-1.701), SOFA score (OR 0.844, 95% CI 0.791-0.900), and APACHE II score (OR 0.930, 95% CI 0.902-0.958) were independent factors influencing initial extubation success. Although first-attempt extubation success remains suboptimal in post-craniotomy critical care, nearly half of initial failures achieve success on subsequent attempts. Multivariable analysis identified female sex, absence of hypertension, infratentorial lesions, lower SOFA, and APACHE II score were independent predictors of initial extubation success.

The mitochondrial dynamic imbalance is an important cause of myocardial ischaemia/reperfusion (I/R) injury and dysfunction. Psmb8, as one of the immunoproteasome catalytic subunits, is a key regulator of protein homoeostasis, inflammation and some cardiac diseases. Here, we found that the expression level and activity of Psmb8 were significantly reduced in the heart of I/R mice and in subjects with myocardial infarction (MI). Cardiomyocyte-specific Psmb8 overexpression in mice markedly ameliorated I/R-mediated cardiac injury and dysfunction, which was accompanied by reduced mitochondrial division via the downregulation of dynamin-related protein-1 (Drp1). However, Psmb8 knockout (KO) mice exhibited the opposite changes. The effects of Psmb8 on mitochondrial fission and apoptosis was confirmed in primary cardiomyocytes with overexpression or knockdown of Psmb8 in vitro. Mechanistically, Psmb8 was directly associated with Drp1 and enhanced its degradation, which subsequently suppressed I/R-mediated mitochondrial fission and cardiac injury. Conversely, knockdown of Drp1 in Psmb8-KO mice restored I/R-induced cardiac dysfunction and mitochondrial dynamic imbalance. Our study identified a new cardioprotective role of Psmb8 in cardiac I/R damage through targeting Drp1, and highlight that increasing Psmb8 activity may constitute a promising therapy for ischaemic heart disease.