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To construct a clean and efficient energy system, advanced solar thermal power generation technology is developed, i.e., a solar hybrid STIGT (Steam Injected Gas Turbine) system with near zero water supply. Such a system is conducive to the efficient use of solar energy and water resources, and to improvement of the performance of the overall system. Given that the strong correlation between multiple-input and multiple-output of the new system, the MDMC (Multivariable Dynamic Matrix Control) method is proposed as an alternative to a PID (Proportional-Integral-Derivative) controller to meet requirements in achieving better control characteristics for a complex power system. First, based on MATLAB/Simulink, a dynamic model of the novel system is established. Then it is validated by both experimental and literature data, yielding an error no more than 5%. Subsequently, simulation results demonstrate that the overshoot of output power on MDMC is 1.2%, lower than the 3.4% observed with the PID controller. This improvement in stability, along with a reduction in settling time and peak time by over 50%, highlights the excellent potential of the MDMC in controlling overshoot and settling time in the novel system, while providing enhanced stability, rapidity, and accuracy in the regulation and control of distribution networks.

Cutaneous-wound healing requires a coordinated reaction of multiple cells, including interstitial cells. Impaired recovery of cutaneous wounds can lead to various adverse health outcomes. Kangfuxin (KFX), an extract obtained from Periplaneta americana, is beneficial in cutaneous-wound healing. In this study, we isolated dermal cells from suckling mice and established a mouse model of cutaneous injury to evaluate the therapeutic effects of KFX. Cell biology experiments indicated that treatment with KFX improved cell proliferation and migration and also repaired cutaneous wounds in the animal model. Activation of the signal transducer and activator of transcription 3 (STAT3) signaling pathway was the core molecular mechanism of KFX. Our study provides a theoretical and practical basis for the clinical application of KFX in cutaneous-wound healing.

Background Inflammatory bowel diseases (IBDs) are characterized by sustained inflammation and/or ulcers along the lower digestive tract, and have complications such as colorectal cancer and inflammation in other organs. The current treatments for IBDs, which affect 0.3% of the global population, mainly target immune cells and inflammatory cytokines with a success rate of less than 40%. Results Here we show that berberine, a natural plant product, is more effective than the frontline drug sulfasalazine in treating DSS (dextran sulfate sodium)-induced colitis in mice, and that berberine not only suppresses macrophage and granulocyte activation but also promotes epithelial restitution by activating Lgr5 + intestinal stem cells (ISCs). Mechanistically, berberine increases the expression of Wnt genes in resident mesenchymal stromal cells, an ISC niche, and inhibiting Wnt secretion diminishes the therapeutic effects of berberine. We further show that berberine controls the expression of many circadian rhythm genes in stromal cells, which in turn regulate the expression of Wnt molecules. Conclusions Our findings suggest that berberine acts on the resident stromal cells and ISCs to promote epithelial repair in experimental colitis and that Wnt-β-Catenin signaling may be a potential target for colitis treatment.

Chronic atrophic gastritis (AG) is initiated mainly by Helicobacter pylori infection, which may progress to stomach cancer following the Correa's cascade. The current treatment regimen is H. pylori eradication, yet evidence is lacking that this treatment is effective on later stages of AG especially gastric gland atrophy. Here, using AG mouse model, patient samples, gastric organoids, and lineage tracing, this study unraveled gastric stem cell (GSC) defect as a crucial pathogenic factor in AG in mouse and human. Moreover, a natural peptide is isolated from a traditional Chinese medicine that activated GSCs to regenerate gastric epithelia in experimental AG models and revitalized the atrophic gastric organoids derived from patients. It is further shown that the peptide exerts its functions by stabilizing the EGF‐EGFR complex and specifically activating the downstream ERK and Stat1 signaling. Overall, these findings advance the understanding of AG pathogenesis and open a new avenue for AG treatment. This work identifies a natural peptide from a traditional Chinese medicine that activates gastric stem cells to regenerate gastric epithelia in experimental atrophic gastritis models and revitalizes the atrophic gastric organoids derived from patients. The peptide exerts its functions by stabilizing the EGF‐EGFR complex and specifically activating the downstream ERK and Stat1 signaling.

The coronavirus disease 2019 (COVID-19) pandemic, along with the implementation of public health and social measures (PHSMs), have markedly reshaped infectious disease transmission dynamics. We analysed the impact of PHSMs on 24 notifiable infectious diseases (NIDs) in the Chinese mainland, using time series models to forecast transmission trends without PHSMs or pandemic. Our findings revealed distinct seasonal patterns in NID incidence, with respiratory diseases showing the greatest response to PHSMs, while bloodborne and sexually transmitted diseases responded more moderately. 8 NIDs were identified as susceptible to PHSMs, including hand, foot, and mouth disease, dengue fever, rubella, scarlet fever, pertussis, mumps, malaria, and Japanese encephalitis. The termination of PHSMs did not cause NIDs resurgence immediately, except for pertussis, which experienced its highest peak in December 2023 since January 2008. Our findings highlight the varied impact of PHSMs on different NIDs and the importance of sustainable, long-term strategies, like vaccine development. Public health and social measures for COVID-19 also impacted the incidence of other infectious diseases. In this study, the authors characterise the impacts of these measures on 24 notifiable infectious diseases in China until December 2023.

Background Painless gastrointestinal endoscopy is widely used for the diagnosis and treatment of digestive diseases. At present, propofol is commonly used to perform painless gastrointestinal endoscopy, but the high dose of propofol often leads to a higher incidence of cardiovascular and respiratory complications. Studies have shown that the application of propofol combined with ketamine in painless gastrointestinal endoscopy is beneficial to reduce the dosage of propofol and the incidence of related complications. Esketamine is dextrorotatory structure of ketamine with a twice as great anesthetic effect as normal ketamine but fewer side effects. We hypothesized that esketamine may reduce the consumption of propofol and to investigate the safety of coadministration during gastrointestinal endoscopy. Methods A total of 260 patients undergoing painless gastrointestinal endoscopy (gastroscope and colonoscopy) were randomly divided into P group (propofol + saline), PK1 group (propofol + esketamine 0.05 mg/kg), PK2 group (propofol + esketamine 0.1 mg/kg), and PK3 group (propofol + esketamine 0.2 mg/kg). Anesthesia was achieved by 1.5 mg/kg propofol with different doses of esketamine. Propofol consumption per minute was recorded. Hemodynamic index, pulse oxygen saturation, operative time, induction time, awakening status, orientation recovery time, adverse events, and Mini-Mental State Examination (MMSE) were also recorded during gastrointestinal endoscopy. Results Propofol consumption per minute was 11.78, 10.56, 10.14, and 9.57 (mg/min) in groups P, PK1, PK2, and PK3, respectively; compared with group P, groups PK2 and PK3 showed a decrease of 13.92% ( P  = 0.021) and 18.76% ( P  = 0.000), respectively. In all four groups, systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), but not pulse oxygen saturation (SpO 2 ) significantly decreased ( P  = 0.000) immediately after administration of induction, but there were no significant differences between the groups. The induction time of groups P, PK1, PK2, and PK3 was 68.52 ± 18.394, 64.83 ± 13.543, 62.23 ± 15.197, and 61.35 ± 14.470 s, respectively ( P  = 0.041). Adverse events and psychotomimetic effects were observed but without significant differences between the groups. Conclusions The combination of 0.2 mg/kg esketamine and propofol was effective and safe in painless gastrointestinal endoscopy as evidenced by less propofol consumption per minute, shorter induction time, and lower incidence of cough and body movement relative to propofol alone. The lack of significant differences in hemodynamic results, anesthesia-related indices, adverse events, and MMSE results showed the safety to apply this combination for painless gastrointestinal endoscopy. Trial registration This study was registered with China Clinical Trial Registration on 07/11/2020 (registration website: chictr.org.cn; registration numbers: ChiCTR https://clinicaltrials.gov/ct2/show/2000039750 ).

Actinobacillus pleuropneumoniae is the primary etiological agent of porcine contagious pleuropneumonia, a devastating respiratory disease that causes substantial economic losses to the global swine industry. The emergence of multidrug-resistant strains with enhanced virulence poses increasing challenges to disease control and necessitates comprehensive genomic characterization to inform targeted intervention strategies. This study aimed to characterize the genomic features, antimicrobial resistance profile, and pathogenic potential of a novel A. pleuropneumoniae strain isolated from a severe outbreak in China, with particular focus on identifying unique resistance mechanisms and virulence determinants. We isolated strain APPFJLYC01 from lung and bronchial tissues of pigs during a severe pleuropneumonia outbreak in Fujian Province, China (incidence rate 30%, mortality rate 56%). Complete genome sequencing was performed using combined PacBio Sequel II and DNBSEQ platforms, followed by comprehensive bioinformatics analysis including virulence factor identification, antibiotic resistance gene profiling, phylogenetic analysis, and comparative genomics. Pathogenicity was evaluated through experimental infection of 3-week-old piglets with subsequent clinical, pathological, and histopathological examinations. The genome of APPFJLYC01 strain is 2,308,741 bp in size, encoding 2,149 genes. Notably, it contains 190 virulence factor homologs and 10 resistance genes. Phylogenetic analysis based on CorePan revealed that APPFJLYC01 shares a close evolutionary relationship with strain JL03, potentially due to their shared geographical origin in China. Pathogenicity evaluation in piglets confirms its high virulence. These findings highlight APPFJLYC01 as a multidrug-resistant and highly virulent strain, providing insights for controlling porcine pleuropneumonia.

In this work, we present a series of hammering tests on full-scale unit-plate ballastless tracks used for long-span bridges. There is no denying that it is a new attempt to pave ballastless tracks on high-speed railway long-span bridges; the related issues deserve to be studied, and especially the vibration characteristics. Hence, the vibration characteristics and transmission rules of the ballastless track with geotextile or rubber isolation layers are explored, and the vibration reduction effect of the rubber isolation layer is analyzed. The main conclusions are as follows: the isolation layers change vibration modes and transmission characteristics of ballastless tracks; the introduction of the rubber isolation layer makes the excited vibration frequency range of the ballastless track concentrated; and the vibrations of the ballastless track with the rubber isolation layers are stable. Moreover, the rubber isolation layer has an obvious attenuation effect on vibration transmission in ballastless track structures. When the vibration is transmitted from the rail to the bridge deck, the vibration level differences of the ballastless track with rubber isolation layers are 20 dB larger than that of the ballastless track with the geotextile isolation layers. The vibration attenuation rate of the rubber isolation layer is about ten times larger than that of geotextile isolation layer.

Flexible electro‐optical dual‐mode sensor fibers with capability of the perceiving and converting mechanical stimuli into digital‐visual signals show good prospects in smart human‐machine interaction interfaces. However, heavy mass, low stretchability, and lack of non‐contact sensing function seriously impede their practical application in wearable electronics. To address these challenges, a stretchable and self‐powered mechanoluminescent triboelectric nanogenerator fiber (MLTENGF) based on lightweight carbon nanotube fiber is successfully constructed. Taking advantage of their mechanoluminescent‐triboelectric synergistic effect, the well‐designed MLTENGF delivers an excellent enhancement electrical signal of 200% and an evident optical signal whether on land or underwater. More encouragingly, the MLTENGF device possesses outstanding stability with almost unchanged sensitivity after stretching for 200%. Furthermore, an extraordinary non‐contact sensing capability with a detection distance of up to 35 cm is achieved for the MLTENGF. As application demonstrations, MLTENGFs can be used for home security monitoring, intelligent zither, traffic vehicle collision avoidance, and underwater communication. Thus, this work accelerates the development of wearable electro‐optical textile electronics for smart human‐machine interaction interfaces. Stretchable and self‐powered mechanoluminescent triboelectric nanogenerator fiber (MLTENGF) is successfully assembled for smart human‐machine interaction applications. Benefiting from their mechanoluminescent‐triboelectric synergistic effect, the resulting MLTENGF demonstrates prominent electro‐optical signals in response to mechanical stimulus in amphibious environments. Furthermore, such MLTENGF possesses remarkable non‐contact capability with a detection distance of as high as 35 cm.

Integrating immune repertoire sequencing data with single cell sequencing data offers profound insights into the diversity of immune cells and their dynamic changes across various disease states. Here, we propose a novel KDDC framework that integrates kmers, dataset selection, dimensionality reduction and classification algorithms to facilitate the heterogeneous classification of immune cells. By comparing various kmer length combinations across seven different classification algorithms, we found that B cell receptor-based cellsubset classification outperforms T cell receptor-based classification, achievingan average AUC of over 96%. This finding offers a new perspective on the classification of immune cells. We also observed that 11 distinct cell subpopulations exhibited differences in cell proportions, inflammatory factorexpression, cell communication, and metabolic pathways, with notable activity in metabolic pathways. These variations may reflect the adaptive changes of cellsubpopulations in response to different disease states. This study aims to uncoverthe potential biological significance of immune prediction, target antigens, andeffective evaluation by analyzing the immune characteristics of specific cellsubsets at the cellular level. These findings will not only enhance ourunderstanding of immune system functions but also offer new directions for the development and optimization of immunotherapy.