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Green Velvet Material (PLON), which is prepared from polyester slices, has been called a green material based on its ester composition, its ability to be degraded, and the possibility of recovering the value of used material by reprocessing. PLON is expected to be used as a material for the padding layer of upholstered furniture. This paper presented a comparative study of traditional flexible polyurethane foam and Green Velvet Material as the upholstered furniture’s padding layer. The compression mechanical properties of Green Velvet Material and flexible polyurethane foam, such as indentation force deflection, support performance, compression set, and resilience property, were analyzed. The results showed that Green Velvet Material had lower surface hardness and higher comfort compared to flexible polyurethane foam. In terms of resilience, both high-density and low-density Green Velvet Material performed better than the foam control group, but Green Velvet Material had a poorer ability to regain its shape after prolonged pressure. The 30 kg/m3 density Green Velvet Material was the closest to the compression and resilience properties of flexible polyurethane foam. The conclusions provide theoretical data for the effective and reasonable application of Green Velvet Material in upholstered furniture.

The poses of robotic endoscopic capsules are indispensable for further follow-up examinations, potential targeted drug delivery, and closed-loop controlling of active locomotion. A novel tracking method using the multiple magnetic excitations with frequency division has been investigated. The multiple excitation coils can simultaneously work at different frequency to improve real-time tracking. A novel model between the magnetic flux density and the capsule’s pose has been derived, which shows a nonlinear equation group with multiple local extremum. Then, a Back-Propagation (BP) neural network algorithm combined with the mother wavelet is investigated to solve the pose. To reduce the volume and power consumption, the wireless magnetic sensing module uses digital signal processing as the core framework, which is beneficial to be miniaturized to integrate with the capsule. The functional prototype of the tracking system has been developed, which consists of a wireless magnetic sensing module mounted in the capsule, a magnetic excitation module with frequency division, a wireless receiver and data interface, an excitation coil array and a platform for pose solving. The experimental results show that the mean errors are 0.0098 m in x-component, 0.0122 m in y-component, 0.0077 m in z-component, 0.187 rad in α-component and 0.161 rad in β-component, respectively. The real-time performance of the tracking system is improved.

Background The rescue in vitro mature(Rescue IVM) technique allows the use of immature oocytes collected in conventional COH to obtain more mature oocytes for fertilization through in vitro maturation. Some studies have shown that Rescue IVM could improve clinical outcomes in patients undergoing IVF/ICSI, but the effectiveness and the indications for the clinical application of this technique remain controversial. It remains to be studied whether Rescue IVM should be universally applied in all conventional IVF/ICSI cycles. Method This is a large retrospective cohort study that included a total of 22,135 female patients undergoing their first IVF treatment cycles. The effect of the number of mature oocytes(metaphaseII[MII]) on the cumulative live birth rate was investigated in a population with routine IVF/ICSI first. The receiver operating characteristic curve(ROC) analysis was used to explore the cut-off point of the number of MII affecting CLBR. Secondly, Patients undergoing ICSI with Rescue IVM were included in the analysis with those who underwent ICSI only during the same period, grouped according to the MII cut-off values. Multi-factor binary logistic regression and inverse probability weighting (IPW) were used to investigate whether Rescue IVM influenced the final cumulative live birth rate(CLBR). Results The CLBR increased with the number of MIIoocytes (P < 0.001). The ROC analysis showed the cut-off point for the number of MIIoocytes to have a significant effect on CLBR was 9 (sensitivity 0.715, specificity 0.656). Furthermore, 912 patients who underwent ICSI with Rescue IVM were included and compared to those who underwent ICSI only during the same period, and found Rescue IVM significantly increased the number of available MIIoocytes. For patients with MII numbers < 9, Rescue IVM significantly improves their clinical pregnancy rate(55.6% vs. 46.7%, P = 0.001) and CLBR(65.4% vs. 48.1%, P < 0.001), but not for those patients with MII numbers ≥ 9. Conclusion This study further clarifies the candidates for the application of Rescue IVM technique: patients with an MII oocytes < 9 in a conventional IVF/ICSI cycle. In contrast, it is not necessary for patients who already have sufficient mature oocytes(≥ 9), to avoid over-medication.

White matter hyperintensity (WMH) represents a critical global medical concern linked to cognitive decline and dementia, yet its underlying mechanisms remain poorly understood. Here, humans are directly demonstrated that high WMH burden correlates with delayed drainage of meningeal lymphatic vessels (mLVs) and glymphatic pathway. Additionally, a longitudinal cohort study reveals that glymphatic dysfunction predicts WMH progression. Next, in a rat model of WMH, the presence of impaired lymphangiogenesis and glymphatic drainage is confirmed, followed by elevated microglial activation and white matter demyelination. Notably, enhancing meningeal lymphangiogenesis through adeno‐associated virus delivery of vascular endothelial growth factor‐C (VEGF‐C) mitigates microglial gliosis and white matter demyelination. Conversely, blocking the growth of mLVs with a VEGF‐C trap strategy exacerbates these changes. The findings highlight the role of mLVs and glymphatic pathway dysfunction in aggravating brain white matter injury, providing a potential novel strategy for WMH prevention and treatment. Patients with a high burden of white matter hyperintensities are found to have impaired drainage in the meningeal lymphatic vessels and glymphatic pathway. Enhanced meningeal lymphatic vessels and glymphatic pathway drainage via adenoviral delivery of vascular endothelial growth factor‐C ameliorate white matter damage. Improvement of meningeal lymphatic vessels and glymphatic pathway function may offer a promising strategy for delaying or even preventing the progression of white matter hyperintensities.

BackgroundWhile intravenous thrombolysis is recommended for patients who had an acute ischaemic stroke (AIS) within 4.5 hours of symptom onset, there are few randomised trials investigating the benefits of thrombolysis beyond this therapeutic window.AimTo determine whether patients who had an AIS selected with the presence of potentially salvageable tissue on CT perfusion at 4.5–24 hours after stroke onset (for stroke with unknown onset time, the midpoint of the time last known to be well and symptom recognition time; for wake-up stroke, the midpoint of the time last known to be well or sleep onset and wake up time) will benefit from intravenous thrombolysis.DesignHOPE is a prospective, multicentre, randomised, open-label blinded endpoint trial with the stage of phase III. The treatment allocation employs 1:1 randomisation. The treatment arm under investigation is alteplase with standard therapy, the control arm is standard therapy. Eligibility imaging criteria include ischaemic core volume ≤70 mL, penumbra ≥10 mL and mismatch ≥20%.Study outcomesThe primary outcome is non-disabled functional outcome (assessed as modified Rankin Scale score of 0–1 at 90 days).DiscussionHOPE is the first trial to investigate whether intravenous thrombolysis with alteplase offers benefits in patients who had an AIS presenting within 4.5–24 hours, which has the potential to extend time window and expand eligible population for thrombolysis therapy.

Background: With the guidance of multi-mode imaging, the time window for endovascular thrombectomy (EVT) has been expanded to 24 h. However, poor clinical outcomes are still not uncommon. We aimed to develop a multi-mode imaging scale for endovascular therapy in patients with acute ischemic stroke (META) to predict the neurological outcome in patients receiving endovascular thrombectomy (EVT). Methods: We included consecutive acute ischemic stroke patients with occlusion of middle cerebral artery and/or internal carotid artery who underwent EVT. Poor outcome was defined as modified Rankin Scale (mRS) score of 3–6 at 3 months. A five-point META score was constructed based on clot burden score, multi-segment clot, the Alberta Stroke Program early computed tomography score of cerebral blood volume (CBV-ASPECTS), and collateral status. We evaluated the META score performance using area under the curve (AUC) calculations. Results: A total of 259 patients were included. A higher META score was independently correlated with poor outcomes at 3 months (odds ratio, 1.690, 95% CI, 1.340 to 2.132, p < 0.001) after adjusting for age, hypertension, baseline National Institutes of Health Stroke Scale (NIHSS) score, and baseline blood glucose. Patients with a META score ≥ 2 were less likely to benefit from EVT (mRS 3–6: 60.8% vs. 29.2%, p < 0.001). The META score predicted poor outcomes with an AUC of 0.714, higher than the Pittsburgh Response to Endovascular therapy (PRE) score, the totaled health risks in vascular events (THRIVE) score (AUC: 0.566, 0.706), and the single imaging marker in the scale. Conclusions: The novel META score could refine the predictive accuracy of prognosis after EVT, which might provide a promising avenue for future automatic imaging analysis to help decision making.

The airport waiting chair frames, as an important part of the overall seating, must be designed to provide comfort, safety, and aesthetic appeal. While the airport furniture industry has made progress in terms of sustainability, more efforts are needed to improve material selection, manufacturing processes, and supply chain management to support the development of sustainable furniture. This study proposes innovative ideas for the lightweight design of the frame, based on the limitations of the existing design. Firstly, structural innovations are discussed, non-traditional mesh panels and curved rounded designs are discussed, and non-introduced mesh panels and curved designs are used to enhance the strength and stability of airport waiting chairs and enhance their overall performance. Secondly, innovations in lightweighting have focused on adjusting the thickness dimensions to enhance comfort, material utilization, and sustainability as well as to achieve a lightweight and thin appearance effect. In order to determine the optimal ranges of values for the thickness of the seat surface support strip (P5), the thickness of the backrest strip (P3), and the thickness of the seat panel (P1), nine groups of chairs with different frame sizes were tested using an orthogonal experimental method. Based on the experimental results for size and topology optimization, NX2312 software modeling will be imported into ANSYS Workbench for static analysis. Using the optimized results, the use of 2.842 kg of steel was successfully reduced by 34.8% to ensure the seat’s stability. This provides a reference and idea for the digital and standardized innovative design of airport waiting chair furniture structure in the future. Through digital design and lightweight optimization, material savings and effective use of resources can be achieved, promoting the goal of sustainable development.

Objectives It is unclear which selection strategy, plain CT vs. CT perfusion (CTP), is more powerful in predicting outcome after mechanical thrombectomy (MT). We aimed to compare the effect of plain CT and CTP in predicting outcome after MT within 6 h. Methods We conducted a prospective analysis of a retrospective cohort from our single-center study, which had occlusion of the internal carotid artery and middle cerebral artery up to the proximal M2 segment and received MT within 6 h. According to the Alberta Stroke Program Early CT Score (ASPECTS), patients were divided into a high-ASPECTS group (≥ 6) and a low ASPECTS group (< 6). Similarly, patients were divided into mismatch and no-mismatch groups according to the DEFUSE3 criteria for CTP. A good outcome was defined as a 90-day modified Rankin Scale (mRS) score of ≤ 3. Univariate and binary logistic regression analyses were used to investigate the association between different imaging modality and 90-day mRS score, and mortalities, respectively. Results The high ASPECTS group included 307 patients (89.2%). The mismatch group included 189 (54.9%) patients meeting the DEFUSE3 criterion. Compared to the low ASPECTS group, the high ASPECTS group had a good outcome (odds ratio (OR), 2.285; [95% confidence interval (CI) (1.106, 4.723)], p  = 0.026) and lower mortality (OR, 0.350; [95% CI (0.163, 0.752)], p  = 0.007). However, there were no significant differences in good outcomes and mortality between the mismatch and no-mismatch groups. Conclusions Compared with plain CT, CTP does not provide additional benefits in the selection of patients suitable for MT within 6 h. Clinical relevance statement CT perfusion is not superior to plain CT for the prediction of clinical outcomes when selecting patients for mechanical thrombectomy in the first 6 h. In that clinical setting, plain CT may be safe in the absence of perfusion data. Key Points •  The advantage of CT perfusion (CTP) over CT in pre-mechanical thrombectomy (MT) screening has not been proven for patients with a large infarct core . •  CTP is not better than plain CT in predicting good outcome following MT within 6 h . •  Plain CT is sufficient for selecting patients suitable for MT within 6 h of large artery occlusion .

Purpose The treatment for symptomatic intact discoid lateral meniscus (DLM) is controversial and the long-term clinical outcome remains unknown. The purpose of this study was to analyze the overall failure rate of nonsurgical treatment for symptomatic intact DLM and identify the risk factors for nonoperative management failure. Methods Consecutive patients who underwent nonsurgical treatment for symptomatic intact DLM at our hospital from 2014 to 2017 were retrospectively reviewed. Patients were divided into Group A (failure group) and Group B (nonfailure group) based on overall failure criteria: conversion to surgery, progression of a tear on MRI re-examination, or severely abnormal International Knee Documentation Committee (IKDC) scores. Statistical analyses between the two groups were performed for demographic and radiographic characteristics. Multivariate regression analysis was used to determine the risk factors associated with worse outcomes. Results One-hundred and four knees in 96 patients were included in this study. After a mean follow-up of 76.9 ± 11.1 months, 25 knees (24.0%) met the overall failure criteria. Multivariate regression analysis demonstrated that age and the presence of intrameniscus signals increased the risk of nonoperative management failure. The clinical criterion of age > 37.5 years combined with the imaging criterion of the presence of intrameniscal signals predicted conservative treatment failure of symptomatic intact DLM with a sensitivity of 0.87 and a specificity of 0.91. Conclusion Twenty-five (24.0%) knees that underwent nonsurgical treatment met the overall failure criteria after a mean follow-up of 76.9 months. With increased age and the presence of intrameniscal signals, the nonoperative results become worse. Level of evidence III.

To establish a reliable, reproducible and accurate release of the drug in the gastrointestinal tract, a novel release mechanism for a controllable drug-delivery system has been investigated. The release mechanism, consisting of a one-way valve for drug release, a drug chamber, two axially magnetized cylindrical permanent magnets and a multi-layer solenoid coil, is hosted in the capsule-shaped shell with diameter 11 mm and length 30 mm. To actuate the coil piston, the two static magnetic fields produced by the two magnets are aligned along the same axis, having the same magnitude, but opposite directions. Based on the principle of the electromagnetic force and the Bernoulli equation, the actuating force can be expressed as a function of the coil stroke and the excitation current, which was modeled and experimentally verified. Thus the actuating force can be controlled by adjusting the activated period and intensity of the coil, resulting in the reproducible release with different doses and mean rates. Then, a prototype of the drug-delivery system has been developed, which consists of a drug-delivery capsule, a radio frequency transmission module, an interface circuit, and an instruction setting and triggering platform. All the drug release parameters, including the release mode, times, dose and mean flow rate, can be set by the platform. The experiment verifies that the drug-delivery capsule can deliver a predetermined dose with different flow rates and dip angles of the capsule. The relative error of the releasing dose becomes larger with increasing releasing rate and decreasing releasing dose.