Explore the vast range of titles available.

Abelmoschus manihot , an annual herbal flowering plant, is widely distributed throughout eastern Europe and in temperate and subtropical regions of Asia. Its flowers have been traditionally used for the treatment of chronic kidney disease in China. Currently, more than 128 phytochemical ingredients have been obtained and identified from the flowers, seeds, stems, and leaves of A. manihot . The primary components are flavonoids, amino acids, nucleosides, polysaccharides, organic acids, steroids, and volatile oils. A. manihot and its bioactive constituents possess a plethora of biological properties, including antidiabetic nephropathy, antioxidant, antiadipogenic, anti-inflammatory, analgesic, anticonvulsant, antidepressant, antiviral, antitumor, cardioprotective, antiplatelet, neuroprotective, immunomodulatory, and hepatoprotective activities, and have effects on cerebral infarction, bone loss, etc. However, insufficient utilization and excessive waste have already led to a rapid reduction of resources, meaning that a study on the sustainable use of A. manihot is urgent and necessary. Moreover, the major biologically active constituents and the mechanisms of action of the flowers have yet to be elucidated. The present paper provides an early and comprehensive review of the traditional uses, chemical constituents, pharmacological activities, and pharmaceutical, quality control, toxicological, and clinical settings to emphasize the benefits of this plant and lays a solid foundation for further development of A. manihot .

Juglans mandshurica Maxim., also known as “Manchurian walnut” (Chinese) and “Onigurumi” (Japanese), is a medicinal plant widely distributed in Western and Central Asia, especially in China. It has been traditionally used to treat cancer, gastric ulcers, diarrhea, dysentery, dermatosis, uterine prolapse, and leukopenia. To date, more than 400 constituents including quinones (e.g. naphthoquinones, anthraquinones, naphthalenones, tetralones), phenolics, flavonoids, triterpenoids, coumarins, lignans, phenylpropanoids, diarylheptanoids, and steroids, were isolated and structurally identified from different plant parts of J. mandshurica . Among them, quinones, phenolics, triterpenoids, and diarylheptanoids, as the major bioactive substances, have been extensively studied and displayed significant bioactivity. Previous studies have demonstrated that J. mandshurica and a few of its active components exhibit a wide range of pharmacologically important properties, such as antitumor, immunomodulatory, anti-inflammatory, neuroprotective, anti-diabetic, antiviral, antimicrobial, and anti-melanogenesis activities. However, many investigations on biological activities were mainly based on crude extracts of this plant, and the major bioactive ingredients responsible for these bioactivities have not been well identified. Further in vitro and in vivo studies on the mechanisms of action of the pure bioactive compounds, and more elaborate toxicity studies as well as clinical studies are needed to ensure safety and effectiveness of the plant for human use. Taken together, the present review will provide some specific useful suggestions guide to further investigations and applications of this plant in the preparation of medicines and functional foods.

Through the work of steam turbine technical supervision, the paper focuses on the construction of technical supervision system, daily management, equipment management, operation indicators, countermeasures management, hidden danger investigation, network-related safety and personnel training and other aspects, and finds out the existing common problems and analyzes them.

There are many problems in the start-up stage of thermal power unit, which seriously affect the safe and economic operation of the unit. Therefore, it is of great significance to study the energy-saving technology of thermal power unit in the start-up stage. The adjacent heating technology is put forward to solve these problems in the boiler start-up stage. Thermal power unit USES the adjacent machine heating technology, improve the conditions of the boiler ignition and steady combustion conditions, improve the safety of the boiler start-up, saves the costs of fuel oil, coal, electricity, strengthened the flushing efficiency, shorten the flush time, improve the economic benefit of the adjacent machine, and prevent the scale caused by dramatic change wall temperature fall off, It can also ensure the safe operation of desulfurization, denitration and dust removal devices, and reduce the emission of pollutants, so it has a broad application prospect.

In order to further improve the operation level of thermal power units directly regulated by the power grid, the regulation capacity of a power plant unit is comprehensively analyzed and evaluated from the aspects of heating capacity, minimum startup mode of the whole plant, heating state and load capacity, etc., to provide support for the accurate dispatching of the unit.

A 1000MW ultra supercritical unit heat consumption rate was higher than design value 324.81 kJ/kW h, in this paper, by comparing the conventional test and assessment test, the result of the analysis of conventional test data at the same time, found out the factors that affect the unit heat consumption, low efficiency of unit mainly include cylinder and putting-in-service proactively reheat steam consumption reduction of warm water, small machine increase, feed water by-pass leakage, system other internal leakage, etc., application of equivalent enthalpy drop method, calculated the influence of the influence factors on the heat consumption of value.

After the formulation of the \"3060\" double carbon target, the installed capacity of new energy has increased rapidly and the proportion of power generation has become higher and higher. In the heating season, under the operation mode of \"determining electricity by heat\" of cogeneration units, in order to meet the consumption of renewable energy and the heating guarantee of people's livelihood, the contradiction with power grid peak shaving is increasing. This paper mainly introduces the load capacity of a 300MW cogeneration unit in the heating season. Through the test method, find out the load capacity of the unit under different heating capacity, which can be used as a reference for power generation enterprises and power grid dispatching.

Background. Reproductive system cancer is an important cause of morbidity and mortality worldwide which threatens women’s health and lives. Breast, cervical, and ovarian cancer have the higher incidence and mortality among a series of gynecology malignant tumor. We aimed to compare and assess the temporal trends of common female malignances on breast, cervical, and ovarian cancer mortality in developed regions of Asia including Japan, Republic of Korea, and Singapore and analyze the detached effects of chronological age, time period, and birth cohort by age-period-cohort (APC) analysis. Methods. The mortality data for these three cancers were collected from the WHO Mortality Database in Japan, Republic of Korea, and Singapore from 1954 to 2013, from 1989 to 2013, and from 1964 to 2013, respectively. We fitted an age-period-cohort model and intrinsic estimator method to estimate the independent effect of each age, time period, and birth cohort on cancer mortality and describe the secular changes in three Asian countries. Results. For the overall trends of breast cancer, the ASMRs of breast cancer showed a general increasing trend among three countries during the study periods while the change pattern in Singapore was different from the rest of the two countries for cervical and ovarian cancer. By APC analysis, the three cancer mortality risks generally increased with age and decreased with birth cohort. For period effects of breast and ovarian cancer, increasing effects with time were observed; however, for period effects of cervical cancer, converse change pattern was presented among three countries. Conclusions. Our study shows that the ASMRs of breast, cervical, and ovarian cancer remain high in Singapore compared to Japan and Korea. Generally speaking, the mortality risk of three cancers increased with age, and period and cohort effects may collectively affect the common female malignances mortality for East Asian women.

Long non-coding RNAs (lncRNAs) exert their pharmacological functions by serving as sponges for related microRNAs (miRNAs), thereby modulating gene expression. Nevertheless, the regulatory roles of the lncRNA-mediated competing endogenous RNA (ceRNA) mechanism in the interplay between burns and keloids remain largely elusive. To construct the ceRNA regulatory network of burns, leveraging network pharmacology and bioinformatics analyses. 3576 DELs (Differentially Expressed lncRNAs), 1427 DEMis (Differentially Expressed miRNAs), and 2555 DEMs (Differentially Expressed mRNAs) were identified as differentially expressed genes. A ceRNA network composed of DELs-DEMis-DEMs in burns and keloids was constructed, with a prominent sub-network consisting of 23 DELs, 330 DEMs, and 8 DEMis. Subsequently, the clusterProfiler package in the R programming language was utilized to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. The sub-network within the ceRNA network was extracted, in which three lncRNAs, namely lnc-WRB, lnc-SCNN1G, and LINC00271, and three miRNAs, namely hsa-miR-21, hsa-miR-34a, and hsa-miR-155, were identified as key genes. All nodes within the sub-ceRNA network exert either a direct or an indirect influence on the pathological processes of burns and post-burn keloids. The current study successfully constructed the ceRNA network in burns and keloids and provided a potentially novel perspective on the DELs-DEMis-DEMs ceRNA network, contributing to the elucidation of the ceRNA regulatory mechanisms in the pathogenesis of burns and keloids. Nevertheless, systematic and rigorous experimental validations are indispensable to confirm our findings.

Thermal power units account for a large proportion of the total installed capacity of Shandong power grid, so the output adjustment of thermal power units has a great impact on Shandong power grid. This paper analyzes all the output adjustment of thermal power units in Shandong power grid in November 2019, and puts forward a classification method of output adjustment for units with different capacity levels, gives the verification method of output adjustment, and puts forward the suggestions for output adjustment.