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Improving soil water holding capacity (WHC) through conservation agriculture (CA)-practices, i.e., minimum mechanical soil disturbance, crop diversification, and soil mulch cover/crop residue retention, could buffer soil resilience against climate change. CA-practices could increase soil organic carbon (SOC) and alter pore size distribution (PSD); thus, they could improve soil WHC. This paper aims to review to what extent CA-practices can influence soil WHC and water-availability through SOC build-up and the change of the PSD. In general, the sequestered SOC due to the adoption of CA does not translate into a significant increase in soil WHC, because the increase in SOC is limited to the top 5–10 cm, which limits the capacity of SOC to increase the WHC of the whole soil profile. The effect of CA-practices on PSD had a slight effect on soil WHC, because long-term adoption of CA-practices increases macro- and bio-porosity at the expense of the water-holding pores. However, a positive effect of CA-practices on water-saving and availability has been widely reported. Researchers attributed this positive effect to the increase in water infiltration and reduction in evaporation from the soil surface (due to mulching crop residue). In conclusion, the benefits of CA in the SOC and soil WHC requires considering the whole soil profile, not only the top soil layer. The positive effect of CA on water-saving is attributed to increasing water infiltration and reducing evaporation from the soil surface. CA-practices’ effects are more evident in arid and semi-arid regions; therefore, arable-lands in Sub-Sahara Africa, Australia, and South-Asia are expected to benefit more. This review enhances our understanding of the role of SOC and its quantitative effect in increasing water availability and soil resilience to climate change.

Onion peels are often discarded, representing an unlimited amount of food by-products; however, they are a valuable source of bioactive phenolics. Thus, we utilized UPLC-MS/MS to analyze the metabolomic profiles of red (RO) and yellow (YO) onion peel extracts. The cytotoxic (SRB assay), anti-inflammatory (Griess assay), and antimicrobial (sensitivity test, MIC, antibiofilm, and SP-SDS tests) properties were assessed in vitro. Additionally, histological analysis, immunohistochemistry, and ELISA tests were conducted to investigate the healing potential in excisional skin wound injury and Candida albicans infection in vivo. RO extract demonstrated antibacterial activity, limited skin infection with C. albicans, and improved the skin’s appearance due to the abundance of quercetin and anthocyanin derivatives. Both extracts reduced lipopolysaccharide-induced nitric oxide release in vitro and showed a negligible cytotoxic effect on MCF-7 and HT29 cells. When extracts were tested in vivo for their ability to promote tissue regeneration, it was found that YO peel extract had the greatest impact. Further biochemical analysis revealed that YO extract suppressed NLRP3/caspase-1 signaling and decreased inflammatory cytokines. Furthermore, YO extract decreased Notch-1 levels and boosted VEGF-mediated angiogenesis. Our findings imply that onion peel extract can effectively treat wounds by reducing microbial infection, reducing inflammation, and promoting tissue regeneration.

Climate-smart agriculture (CSA)-based management practices are getting popular across South-Asia as an alternative to the conventional system for particular weed suppression, resources conservation and environmental quality. An 8-year study (2012–2013 to 2019–2020) was conducted to understand the shift in weed density and diversity under different CSA-based management practices called scenarios (Sc). These Sc involved: Sc1, conventional tillage (CT)-based rice–wheat system with flood irrigation (farmers’ practice); Sc2, CT-rice, zero tillage (ZT)-wheat–mungbean with flood irrigation (partial CA-based); Sc3, ZT rice–wheat–mungbean with flood irrigation (partial CSA-based rice); Sc4, ZT maize–wheat–mungbean with flood irrigation (partial CSA-based maize); Sc5, ZT rice–wheat–mungbean with subsurface drip irrigation (full CSA-based rice); and Sc6, ZT maize–wheat–mungbean with subsurface drip irrigation (full CSA-based maize). The most abundant weed species were P. minor  >  A. arvensis  >  M. indicus  >  C. album and were favored by farmers’ practice. However, CSA-based management practices suppressed these species and favored S. nigrum and R. dentatus and the effect of CSAPs was more evident in the long-term. Maximum total weed density was observed for Sc1, while minimum value was recorded under full CSA-based maize systems, where seven weed-species vanished, and P. minor density declined to 0.33 instead of 25.93 plant m −2 after 8-years of continuous cultivation. Full CSA-based maize–wheat system could be a promising alternative for the conveniently managed rice–wheat system in weed suppression in north-west India.

The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical properties by complexation with pure phosphatidylcholine or phosphatidylinositol enriched soybean lecithin to form MSP-phospholipid complex (MSP-PLCP). Changes in physicochemical properties were assessed and the optimum MSP-PLCP formula was then used for formulation into a flushing resistant platform using two mucoadhesive polymers; sodium alginates and sodium carboxymethylcellulose at different concentrations. Design of experiment approach was used to characterize and optimize the formulated flushing resistant platform. The optimized formulation was then used in a comparative pharmacokinetics study with the market formulation in human volunteers. Results showed a marked change in MSP physicochemical properties of MSP-PLCP compared to MSP. Addition of mucoadhesive polymers to flushing resistant platform at an optimum concentration balanced between desired mucoadhesive properties and a reasonable drug release rate. The optimized formulation showed significantly a superior bioavailability in humans when compared to the market sublingual product. Finally, the novel developed sublingual flushing resistant platform offers a very promising and efficient tool to extend the use of sublingual route and widen its applications.

Barley (Hordeum vulgare L.) thrives in the arid and semi-arid regions of the world; nevertheless, it suffers large grain yield losses due to drought stress. A panel of 426 lines of barley was evaluated in Egypt under deficit (DI) and full irrigation (FI) during the 2019 and 2020 growing seasons. Observations were recorded on the number of days to flowering (NDF), total chlorophyll content (CH), canopy temperature (CAN), grain filling duration (GFD), plant height (PH), and grain yield (Yield) under DI and FI. The lines were genotyped using the 9K Infinium iSelect single nucleotide polymorphisms (SNP) genotyping platform, which resulted in 6913 high-quality SNPs. In conjunction with the SNP markers, the phenotypic data were subjected to a genome-wide association scan (GWAS) using Bayesian-information and Linkage-disequilibrium Iteratively Nested Keyway (BLINK). The GWAS results indicated that 36 SNPs were significantly associated with the studied traits under DI and FI. Furthermore, eight markers were significant and common across DI and FI water regimes, while 14 markers were uniquely associated with the studied traits under DI. Under DI and FI, three (11_10326, 11_20042, and 11_20170) and five (11_20099, 11_10326, 11_20840, 12_30298, and 11_20605) markers, respectively, had pleiotropic effect on at least two traits. Among the significant markers, 24 were annotated to known barley genes. Most of these genes were involved in plant responses to environmental stimuli such as drought. Overall, nine of the significant markers were previously reported, and 27 markers might be considered novel. Several markers identified in this study could enable the prediction of barley accessions with optimal agronomic performance under DI and FI.

Background and Aims The viral agent of the novel coronavirus disease 2019 (COVID‐19) continues to spread worldwide, leading to a global pandemic. this may negatively affect students' mental health who have to maintain their learning efforts. Therefore, we aimed to assess students' perceptions of the online learning programs designed for university students in Arab countries during the COVID‐19 pandemic. Methods This cross‐sectional study was conducted on university students using a self‐administered online questionnaire in 15 Arab countries, including 6779 participants. The actual sample size was calculated using the EpiInfo program calculator. The validated, piloted questionnaire assessed the effectiveness of internet‐based distance learning applications used in these countries during the pandemic. The SPSS version 22 was used. Results Among the 6779 participants, 26.2% believed that their teachers diversify learning methods, 22.0% thought that their teachers were able to treat the weakness the students have, and 30.7% agreed that their teachers efficiently communicate with them through COVID‐19 internet‐based learning process. Around 33% of students participated in lectures effectively, 47.4% submitted their homework within accepted deadlines, and 28.6% thought that their colleagues did not cheat during exams and homework. Around 31.3% of students believed that online‐based learning had a role in directing them towards research, and 29.9% and 28.9%, respectively, believed that online learning had a role in developing analytical thinking and synthesis skills. Participants reported many suggestions to enhance the process of internet‐based distance learning in the future. Conclusion Our study suggests that online‐based distance learning in Arab countries still needs more improvement as students still are more inclined toward face‐to‐face teaching. However, exploring the factors that influence students' perceptions of e‐learning is vital for improving the quality of online‐based distance learning. We recommend exploring the perceptions of educators regarding their experience towards online‐based distance learning during COVID‐19 lockdown.

Earthworms (EWs) could be a viable indicator of soil biology and agri-food system management. The influence of climate-smart agriculture (CSA)-based sustainable intensification practices (zero tillage, crop rotations, crop residue retention, and precision water and nutrients application) on earthworms’ (EWs) populations and soil physico-biochemical properties of rice-wheat cropping system in the Indo-Gangetic plains of South Asia was investigated. This study investigates the effect of 10-years adoption of various CSA practices on the abundance of earthworms and physical and biochemical properties of the soil and EWs’ casts (EWC). Five scenarios (Sc) were included: conventionally managed rice-wheat system (farmers’ practices, Sc1), CSA-based rice-wheat-mungbean system with flood irrigation (FI) (Sc2) and subsurface drip irrigation (SDI) (Sc3), CSA-based maize-wheat-mungbean system with FI (Sc4), and SDI (Sc5). Results revealed that EWs were absent under Sc1, while the 10-year adoption of CSA-based scenarios (mean of Sc2–5) increased EWs’ density and biomass to be 257.7 no. m−2 and 36.05 g m−2, respectively. CSA-based maize scenarios (Sc4 and Sc5) attained higher EWs’ density and biomass over rice-based CSA scenarios (Sc2 and Sc4). Also, SDI-based scenarios (Sc3 and Sc5) recorded higher EWs’ density and biomass over FI (Sc2 and Sc4). Maize-based CSA with SDI recorded the highest EWs’ density and EWs’ biomass. The higher total organic carbon in EWC (1.91%) than in the bulk soil of CSA-based scenarios (0.98%) and farmers’ practices (0.65%) suggests the shift of crop residue to a stable SOC (in EWC). EWC contained significant amounts of C and available NPK under CSA practices, which were nil under Sc1. All CSA-based scenarios attained higher enzymes activities over Sc1. CSA-based scenarios, in particular, maize-based scenarios using SDI, improved EWs’ proliferation, SOC, and nutrients storage (in soil and EWC) and showed a better choice for the IGP farmers with respect to C sequestration, soil quality, and nutrient availability.

Sustainable agricultural practices that enhance soil fertility and increase its capacity for carbon sequestration are increasingly needed. This study evaluates two types of sheep wool residues (SWRs)—carbonized (black wool, BW) and non-carbonized (white wool, WW) to enhance soil fertility and act as a N-source. The two SWRs were tested on two plant species, in two pot experiments: ornamental sunflower on soil mixtures with each of SWR types at different concentrations (0, 0.5, 1, and 2% w / w ), and maize on BW- or WW-soil mixture (1% w / w ) and supplementary N fertilization (0, 50, and 100% of recommended N rates). In sunflower, with the exception of WW at 2%, all SWRs-soil mixtures increased plant growth and biomass production. Lower SWRs concentrations enhanced the growth rate at an initial stage, and in general, BW provided optimal biomass, and flower yield. In maize, the SWRs (1%), especially BW, even without N-fertilization, were beneficial for plant physiological behavior and biomass production. High mineral N-fertilization (100% N with BW1%- or WW1%-soil mixture) resulted in lower biomass than the other BW-treatments. The results highlighted the efficacy of BW on biomass production for both species growing in a sandy-loam soil, and for maize, no need for further mineral N-fertilization.

By integrating various irrigation and agriculture management techniques, it is possible to considerably improve water productivity. In order to examine the impact of irrigation scheduling (1.0 and 1.2 pan evaporation coefficient), planting method (ridge and raised bed), and potassium silicate foliar application (0 ppm and 100 ppm) on maize ( Zea mays L) growth, yield, and water-related factors, a two-season field experiment was conducted in a hot-dry climate region of southern Egypt during 2017 and 2018. The results showed that the seasonal irrigation requirement and consumptive use were higher at 1.2 than the 1.0 pan evaporation coefficient, irrespective of the planting methods. Raised bed planting method saved about 19% of applied water (two seasons average) compared to the ridge planting method. Plants treated with potassium silicates attained higher yields compared to the control, irrespective of the irrigation level and planting method. Moreover, irrigation at 1.2 pan evaporation resulted in the lowest daily ETc values, i.e., 3.15, 6.0, 6.7, and 2.8 mm for plant growth stages, i.e., ini, dev, mid and late. This resulted in the lowest Kc values (0.47, 0.91, 1.16, and 0.61) at different plant growth stages (ini, dev, mid and late). Based on the study findings, it is recommended to use a deficit irrigation of 0.15% based on accumulated pan evaporation values of 1.2, coupled with raised bed planting method and the application of 100 ppm potassium silicates, for optimal maize water productivity and net return.

Background Previous investigations indicate that methotrexate, an old anticancer drug, could be used at low doses to treat malaria. A phase I evaluation was conducted to assess the safety and pharmacokinetic profile of this drug in healthy adult male Kenyan volunteers. Methods Twenty five healthy adult volunteers were recruited and admitted to receive a 5 mg dose of methotrexate/day/5 days. Pharmacokinetics blood sampling was carried out at 2, 4, 6, 12 and 24 hours following each dose. Nausea, vomiting, oral ulcers and other adverse events were solicited during follow up of 42 days. Results The mean age of participants was 23.9 ± 3.3 years. Adherence to protocol was 100%. No grade 3 solicited adverse events were observed. However, one case of transiently elevated liver enzymes, and one serious adverse event (not related to the product) were reported. The maximum concentration (C max ) was 160-200 nM and after 6 hours, the effective concentration (C eff ) was <150 nM. Conclusion Low-dose methotraxate had an acceptable safety profile. However, methotrexate blood levels did not reach the desirable C eff of 250-400-nM required to clear malaria infection in vivo . Further dose finding and safety studies are necessary to confirm suitability of this drug as an anti-malarial agent.