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A century after the prediction of gravitational waves, detectors have reached the sensitivity needed to proof their existence. One of them, the Virgo interferometer in Pisa, is presently being upgraded to Advanced Virgo (AdV) and will come into operation in 2016. The power stored in the interferometer arms raises from 20 to 700 kW. This increase is expected to introduce higher order modes in the beam, which could reduce the circulating power in the interferometer, limiting the sensitivity of the instrument. To suppress these higher-order modes, the core optics of Advanced Virgo is equipped with a thermal compensation system. Phase cameras, monitoring the real-time status of the beam constitute a critical component of this compensation system. These cameras measure the phases and amplitudes of the laser-light fields at the frequencies selected to control the interferometer. The measurement combines heterodyne detection with a scan of the wave front over a photodetector with pin-hole aperture. Three cameras observe the phase front of these laser sidebands. Two of them monitor the in-and output of the interferometer arms and the third one is used in the control of the aberrations introduced by the power recycling cavity. In this paper the working principle of the phase cameras is explained and some characteristic parameters are described.

The Timepix detector can be operated in Time-over-Threshold mode to allow for charge integration measurements as required by short (< 50 fs) x-ray pulses of the Linac Coherent Light Source (LCLS). Initial commissioning activities have started at the X-ray Correlation Spectroscopy (XCS) instrument at LCLS, where speckle patterns have been measured.

We plan to develop an advanced Transition Radiation Detector (TRD) for hadron identification in the TeV momentum range, based on the simultaneous measurement of the energies and of the emission angles of the Transition Radiation (TR) X-rays with respect to the radiating particles. To study the feasibility of this project, we have carried out a beam test campaign at the CERN SPS facility with 20 GeV/c electrons and muons up to 300 GeV/c. To detect the TR X-rays and the radiating particles, we used a 300 μm thick double-sided silicon strip detector, with a strip readout pitch of 50 μm. A 2 m long helium pipe was placed between the radiators and the detector, in order to ensure adequate separation between the TR X-rays and the radiating particle on the detector plane and to limit the X-ray absorption before the detector. We measured the double-differential (in energy and angle) spectra of the TR emitted by several radiators. The results are in good agreement with the predictions obtained from the TR theory.

First measurements are presented from a newly commissioned two-photon absorption (TPA) setup at Nikhef. The characterisation of the various components of the system is discussed. Two planar silicon sensors, one being electron collecting and one hole collecting, are characterised with detailed measurements of the charge collection and time resolution. The TPA spot is determined to have a radius of 0.975(11) \\(\\mu\\text{m}\\) and length of 23.8 \\(\\mu\\text{m}\\) in silicon. The trigger time resolution of the system is shown to be maximally 30.4 ps. For both sensors, uniform charge collection is observed over the pixels, and the pixel side metallisation is imaged directly using the TPA technique. The best time resolution for a single pixel is found to be 600 ps and 560 ps for the electron and hole collecting sensors respectively, and is dominated by ASIC contributions. Further scans at different depths in the sensor and positions within the pixels have been performed and show a uniform response. It is concluded that the TPA setup is a powerful tool to investigate the charge collection and temporal properties of silicon sensors.

A characterisation of the Timepix4 pixel front-end with a strong focus on timing performance is presented. Externally generated test pulses were used to probe the per-pixel time-to-digital converter (TDC) and measure the time-bin sizes by precisely controlling the test-pulse arrival time in steps of 10 ps. The results indicate that the TDC can achieve a time resolution of 60 ps, provided that a calibration is performed to compensate for frequency variation in the voltage controlled oscillators of the pixel TDCs. The internal clock distribution system of Timepix4 was used to control the arrival time of internally generated analog test pulses in steps of about 20 ps. The analog test pulse mechanism injects a controlled amount of charge directly into the analog front-end (AFE) of the pixel, and was used to measure the time resolution as a function of signal charge, independently of the TDC. It was shown that for the default configuration, the AFE time resolution in the hole-collecting mode is limited to 105 ps. However, this can be improved up to about 60 ps by increasing the preamplifier bias-current at the cost of increased power dissipation. For the electron-collecting mode, an AFE time resolution of 47 ps was measured for a bare Timepix4 device at a signal charge of 21 ke. It was observed that additional input capacitance from a bonded sensor reduces this figure to 62 ps.

The detection of a gravitational wave signal in September 2015 by LIGO interferometers, announced jointly by LIGO collaboration and Virgo collaboration in February 2016, opened a new era in Astrophysics and brought to the whole community a new way to look at - or \"listen\" to - the Universe. In this regard, the next big step was the joint observation with at least three detectors at the same time. This configuration provides a twofold benefit: it increases the signal-to-noise ratio of the events by means of triple coincidence and allows a narrower pinpointing of GW sources, and, in turn, the search for Electromagnetic counterparts to GW signals. Advanced Virgo (AdV) is the second generation of the gravitational-wave detector run by the Virgo collaboration. After a shut-down lasted 5 years for the upgrade, AdV has being commissioned to get back online and join the two advance LIGO (aLIGO) interferometers to realize the aforementioned scenario. We will describe the challenges and the status of the commissioning of AdV, and its current performances and perspectives. A few lines wil be also devoted to describe the latest achievements, occurred after the TAUP 2017 conference.

The Advanced Virgo interferometer is the upgraded version of the Virgo detector having the goal to extend by a factor 10 the observation horizon in the universe and consequently increase the detection rate by three orders of magnitude. Its installation is in progress and is expected to be completed in late 2015. In this proceeding we will present the scheme and the main challenging technical features of the detector and we will give an outline of the installation status and the foreseen time schedule which will bring Advanced Virgo to its full operation.

Kinematic correlations for pairs of beauty hadrons, produced in high energy proton-proton collisions, are studied. The data sample used was collected with the LHCb experiment at centre-of-mass energies of 7 and 8 TeV and corresponds to an integrated luminosity of 3 fb−1. The measurement is performed using inclusive b → J/ψX decays in the rapidity range 2 < yJ/ψ < 4.5. The observed correlations are in good agreement with theoretical predictions.

OBJECTIVES. The goal of the study was to determine survival time after diagnosis of acquired immunodeficiency syndrome (AIDS) and to identify predictors of survival. METHODS. We conducted a population-based prospective survival analysis of all Massachusetts-resident adult AIDS patients diagnosed from January 1, 1979, through December 31, 1988. RESULTS. Median survival was 406 days, with a 5-year survival rate of 3%. Age older than 40 years (P = .001), a diagnosis other than Kaposi's sarcoma (P = .001), and a history of intravenous drug use (P < or = .01) were associated with shorter survival after confounding was controlled. Survival increased as year of diagnosis became more recent (P < .0001). This temporal effect was strongest for patients with Pneumocystis carinii pneumonia. Individuals with Kaposi's sarcoma, Hispanics, homosexual men who were concurrent intravenous drug users, and residents of the greater Boston standard metropolitan statistical area, excluding the city of Boston, did not experience increases in survival over time. CONCLUSIONS. With the exception of cases initially defined by Kaposi's sarcoma, recently diagnosed AIDS case subjects survive longer than those diagnosed earlier in the epidemic. Further work is needed to determine whether this effect is due to lead-time bias or better treatment after diagnosis.

A comprehensive study of the spatial resolution and detection efficiency of sensor prototypes developed for the LHCb VELO upgrade is presented. Data samples were collected at the CERN SPS H8 beam line using a hadron mixture of protons and pions with momenta of approximately 180 GeV/c. The sensor performance was characterised using both irradiated and non-irradiated sensors. Irradiated samples were subjected to a maximum fluence of \\(\\mathrm{8\\times10^{15}~1~MeV~n_{eq}~cm^{-2}}\\), of both protons and neutrons. The spatial resolution is measured comparing the detected hits to the position as predicted by tracks reconstructed by the Timepix3 telescope. The resolution is presented for different applied bias voltages and track angles, sensor thickness and implant size.