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يتخذ هذا الكتاب مسلمي هونغ كونغ كخط أساسيا، حيث يصف مساجدهم ومنازلهم وأعيادهم وحياتهم اليومية وأسلوب معيشتهم، كما يناقش أيضا بعض الاختلافات بين مسلمي هونغ كونغ وسكان البر الرئيس للصين، ويلقي الضوء على عدد من مشاكلهم التي تسببها الاختلافات الثقافية والعرقية، وذلك عن طريق بعض الخواطر النثرية لهذا الكاتب الذي قضى بضع سنوات من حياته في هونغ كونغ.

Agricultural biodiversity includes many species that have biological variants (natives, ecotypes, races, morphotypes). Their use is restricted to local areas because they do not fulfill the commercial requirements; however, it is well documented that these species are a source of metabolites, proteins, enzymes, and genes. Rescuing and harnessing them through traditional genetic breeding is time-consuming and expensive. Inducing mutagenesis may be a short-time option for its genetic improvement. A review of outstanding research was carried out, in order to become familiar with gene breeding using gamma radiation and its relevance to obtain outstanding agronomic characteristics for underutilized species. An approach was made to the global panorama of the application of gamma radiation in different conventional crop species and in vitro cultivated species, in order to obtain secondary metabolites, as well as molecular tools used for mutation screening. The varied effects of gamma radiation are essentially the result of the individual responses and phenotypic plasticity of each organism. However, even implicit chance can be reduced with specific genetic breeding, environmental adaptation, or conservation objectives.

أنجبت نيمو ولدا (ترى هل وصل الخبر إلى دونيو، هل عرف أنه صار أبا ؟ ربما، فهو لم يكتب لها أية خطابات حتى الآن)، كم انتظرت منه أن يكتب لها شيئا، أى شيء، بل اقتنعت بأنه لابد سيرسل لها خطابا ذات يوم ترى هل نسيها ؟ أيا ما كان، فهو لم يكتب لها، ولا لأجل طفله رجع ظلت نيمو تقاسى شتائم أبيها ولعناته، وما أفظعها، فقد كان الرجل بوذيا خالص الإيمان والتقوى، متعبدا فى محرابه منذ أن أدرك وجوده على ظهر الدنيا، منذ صباه الباكر، لكنه فقد امرأته فى شبابه الأول ووجد نفسه مسئولا عن طفلة يتيمة. وهنت فيه إشراقة الإقبال على الحياة وانعزل منحرف المزاج منفردا بكئوس خمر يخمد بها سطوة شعور ممض بالأسى، حتى لم يعد يفيق إلا بعض وقت، بصدر حرج وذهن مكدود لحظات الوعى الضئيلة هى لحظات سخطه المحموم على الناس والحياة.

Arylamine N -acetyltransferase 2 has been related to drug side effects and cancer susceptibility; its protein structure and acetylation capacity results from the polymorphism’s arrays on the NAT 2 gene. Absorption, distribution, metabolism, and excretion, cornerstones of the pharmacological effects, have shown diversity patterns across populations, ethnic groups, and even interethnic variation. Although the 1000 Genomes Project database has portrayed the global diversity of the NAT 2 polymorphisms, several populations and ethnicities remain underrepresented, limiting the comprehensive picture of its variation. The NAT 2 clinical entails require a detailed landscape of its striking diversity. This systematic review spans the genetic and acetylation patterns from 164 articles from October 1992 to October 2020. Descriptive studies and controls from observational studies expanded the NAT 2 diversity landscape. Our study included 243 different populations and 101 ethnic minorities, and, for the first time, we presented the global patterns in the Middle Eastern populations. Europeans, including its derived populations, and East Asians have been the most studied genetic backgrounds. Contrary to the popular perception, Africans, Latinos and Native Americans have been significantly represented in recent years. NAT 2*4, *5B, and *6A were the most frequent haplotypes globally. Nonetheless, the distribution of *5B and *7B were less and more frequent in Asians, respectively. Regarding the acetylator status, East Asians and Native Americans harboured the highest frequencies of the fast phenotype, followed by South Europeans. Central Asia, the Middle East, and West European populations were the major carriers of the slow acetylator status. The detailed panorama presented herein, expands the knowledge about the diversity patterns to genetic and acetylation levels. These data could help clarify the controversial findings between acetylator states and the susceptibility to diseases and reinforce the utility of NAT 2 in precision medicine.

خواطر نثرية للأديب الصيني ما يوي تشن، يسرد فيها مجموعة من المقتطفات النثرية التي تعكس تكوينه الذاتي ومشاعره تجاه قوميته، يتحدث فيها عن مشاهداته وانطباعاته ويومياته في نثر أدبي شديد العذوبة. ومنها أن تكون وحيدا، عين الروح، الطفو على سطح البحر، نهر الأمس، الانسياب مع أحداث الماضي، الأمور الحياتية كالدخان ... وموضوعات أخرى.‪‪‪

The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review.

مجموعة مترادفات قصصية للأديب الصيني «ما تشونغ جينغ» ضمن سلسلة إبداعات أدب الأقليات الصينية، وتضم قصصا قصيرة لعادات الأقليات الصينية، وسلوكيات العائلات في المناسبات الدينية والاحتفالات الأخرى المختلفة، وتتباين فيها الشخصيات والزمان والمكان، لتضع القارئ أمام رسم أدبي يشرح حياة الأقليات الصينية المليئة بالتناص.‪‪‪

Cell death occurs in various tissues and organs in the body. It is a physiological or pathological process that has different effects. It is of great significance in maintaining the morphological function of cells and clearing abnormal cells. Pyroptosis, apoptosis, and necrosis are all modes of cell death that have been studied extensively by many experts and scholars, including studies on their effects on the liver, kidney, the heart, other organs, and even the whole body. The heart, as the most important organ of the body, should be a particular focus. This review summarizes the mechanisms underlying the various cell death modes and the relationship between the various mechanisms and heart diseases. The current research status for heart therapy is discussed from the perspective of pathogenesis.

تمت كتابته لتجنب الملل بينما كان صاحب البلاغ يقضي عقوبة بالسجن لمدة 42 يوما في غرفته لمشاركته في مبارزة غير قانونية. الكتاب مكتوب بأسلوب رواية الرحلات ويناقش محتويات وأثاث غرفته بالإضافة إلى مواقف وحوارات خيالية. يتمثل موضوع العمل في أنه يمكن العثور على المتعة في محيط الفرد اليومي.

A previous phase 2 trial showed promising outcomes for patients with HER2-positive early-stage breast cancer using neoadjuvant de-escalation chemotherapy with paclitaxel, trastuzumab, and pertuzumab. We aimed to evaluate the efficacy of weekly nab-paclitaxel compared with the standard regimen of docetaxel plus carboplatin, both with trastuzumab and pertuzumab, as neoadjuvant therapies for patients with HER2-positive breast cancer. HELEN-006 was a multicentre, randomised, phase 3 trial done at six hospitals in China. We enrolled patients aged 18–70 years with untreated, histologically confirmed stage II–III invasive HER2-positive breast cancer and an Eastern Cooperative Oncology Group performance status of 0 or 1. Using an interactive response system, patients were randomly assigned (1:1) under a permuted block randomisation scheme (block size of four), stratified by tumour stage, nodal status, and hormone receptor status. Patients received either intravenous nab-paclitaxel (125 mg/m2 on days 1, 8, and 15) for six 3-week cycles, or intravenous docetaxel (75 mg/m2 on day 1) plus intravenous carboplatin (area under the concentration-time curve 6 mg/mL per min on day 1) for six 3-week cycles. Both groups also received concurrent intravenous trastuzumab, with an initial loading dose of 8 mg/kg and a maintenance dose of 6 mg/kg on day 1, as well as intravenous pertuzumab with a loading dose of 840 mg and a maintenance dose of 420 mg on day 1. This report is the final analysis of the primary endpoint, pathological complete response (ypT0/is ypN0), analysed in all patients who started treatment (modified intention to treat). The trial is registered with ClinicalTrials.gov, NCT04547907, and follow-up of the adjuvant phase is ongoing. Between Sept 20, 2020, and March 1, 2023, 789 patients were screened for eligibility, 689 of whom were randomly assigned (343 to the nab-paclitaxel group and 346 to the docetaxel plus carboplatin group). All 689 patients were Asian women. 669 patients received at least one dose of the study treatment and were included in the full analysis set (332 in the nab-paclitaxel group and 337 in the docetaxel plus carboplatin group). Median age of the patients was 50 years (IQR 43–55). Median follow-up time was 26 months (IQR 19–32). 220 (66·3% [95% CI 61·2–71·4]) patients in the nab-paclitaxel group had a pathological complete response, compared with 194 (57·6% [52·3–62·9]) in the docetaxel plus carboplatin group (combined odds ratio 1·54 [95% CI 1·10–2·14]; stratified p=0·011). 100 (30%) patients in the nab-paclitaxel group and 128 (38%) in the docetaxel plus carboplatin group had grade 3–4 adverse events. The most common grade 3–4 adverse events were nausea (22 [7%] in the nab-paclitaxel group vs 76 [23%] in the docetaxel plus carboplatin group), diarrhoea (25 [8%] vs 55 [16%]), and neuropathy (43 [13%] vs eight [2%]). Serious drug-related adverse events were reported in three (1%) patients in the nab-paclitaxel group and five (2%) in the docetaxel plus carboplatin group. No treatment-related deaths were reported in either group. These findings might suggest a potential advantage of nab-paclitaxel combined with trastuzumab and pertuzumab compared with the standard regimen in neoadjuvant therapy for patients with HER2-positive early breast cancer, suggesting that this new combination might establish a new standard for neoadjuvant treatment in this patient population. National Natural Science Foundation of China, and Science and Technology Research Projects of Henan Province, China. For the Chinese translation of the abstract see Supplementary Materials section.