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Atomic gravimeter has been more frequently applied under complex and dynamic environments, but its measurement accuracy is seriously hampered by vibration-induced noise. In this case, vibration compensation provides a way to enhance the accuracy of gravity measurements by correcting the phase noise that resulted from the vibration of a Raman reflector, and improving the fitting of an interference fringe. An accurate estimation of the transfer function of vibration between the Raman reflector and the sensor plays a significant role in optimizing the effect of vibration compensation. For this reason, a vibration compensation approach was explored based on EO (equilibrium optimizer) for estimating the transfer function simplified model of a Raman reflector, and it was used to correct the interference fringe of an atomic gravimeter. The test results revealed that this approach greatly restored the actual vibration of the Raman reflector in a complex vibration environment. With a vibration compensation algorithm, it achieved the correction and fitting of the original interference fringe. In general, it dramatically reduced the RMSE (root mean square error) at the time of fitting and significantly improved the residual error in the gravity measurement. Compared with other conventional algorithms, such as GA (genetic algorithm) and PSO (particle swarm optimization), this approach realized a faster convergence and better optimization, so as to ensure more accurate gravity measurements. The study of this vibration compensation approach could provide a reference for the application of an atomic gravimeter in a wider and more complex environment.

In this paper, we present a robust and reliable framework based on L0 gradient minimization (LGM) and the fuzzy c-means (FCM) method to detect various fabric defects with diverse textures. In our framework, the L0 gradient minimization is applied to process the fabric images to eliminate the influence of background texture and preserve sharpened significant edges on fabric defects. Then, the processed fabric images are clustered by using the fuzzy c-means. Through continuous iterative calculation, the clustering centers of fabric defects and non-defects are updated to realize the defect regions segmentation. We evaluate the proposed method on various samples, which include plain fabric, twill fabric, star-patterned fabric, dot-patterned fabric, box-patterned fabric, striped fabric and statistical-texture fabric with different defect types and shapes. Experimental results demonstrate that the proposed method has a good detection performance compared with other state-of-the-art methods in terms of both subjective and objective tests. In addition, the proposed method is applicable to industrial machine vision detection with limited computational resources.

MnWO 4 nanorods with different contents of F-doping were synthesized by a facile approach. The morphological studies further confirmed formation of MnWO 4 nanorod structure with dimensional size and length of 50 and 100 nm, respectively. The differences of Li-storage performance that caused by F-doping contents in MnWO 4 nanomaterials were systematically investigated. The results show by tuning the F-doping contents in the MnWO 4 nanorods, both the reversible capacity and the cycling stability of nano-MnWO 4 electrode attain remarkable improvement. Furthermore when the content of F-doping is 0.05 mol%, the reversible capacity for lithium storage in nano-MnWO 4 is at its maximum. What makes that all the more remarkable is that the 0.05 mol% F-doped nano-MnWO 4 shows a long cycle life. Even cycled under a low current density (200 mA h g −1 ), the capacity retention still can keep more than 85% after 150 cycles, which are much superior to the report ones. These results provide insight into the effective method which can easily be applied to improve the electrochemical performances of the advanced electrode materials for Li ion batteries.

Controllable BaF2 microcrystals with super-hydrophobic property have been successfully synthesized via a facile hydrothermal process. XRD, SEM and CA were used to study the structure, morphology and the hydrophobic properties of the BaF2 materials. The effects of reaction time, surfactants and pH were investigated in order to get a series of accurate reaction conditions for the preparation of BaF2 material. The results showed that uniform BaF2 cubic phase structure was fabricated when the reaction temperature was controlled at 160 °C for 24 h. In addition, the BaF2 materials showed excellent super-hydrophobic properties. The results of the influence of time and substrates exhibited that the sample could maintain the stable super-hydrophobic property for over 10 days. As a promising superhydrophobic material, the studies of BaF2 reported in this paper have potential application prospect and have a certain guiding meaning for the future study about superhydrophobic materials.

The biological functions of the circadian clock on growth and development have been well elucidated in model plants, while its regulatory roles in crop species, especially the roles on yield-related traits, are poorly understood. In this study, we characterized the core clock gene CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1) homoeologs in wheat and studied their biological functions in seedling growth and spike development. TaCCA1 homoeologs exhibit typical diurnal expression patterns, which are positively regulated by rhythmic histone modifications including histone H3 lysine 4 trimethylation (H3K4me3), histone H3 lysine 9 acetylation (H3K9Ac), and histone H3 lysine 36 trimethylation (H3K36me3). TaCCA1s are preferentially located in the nucleus and tend to form both homo- and heterodimers. TaCCA1 overexpression ( TaCCA1- OE) transgenic wheat plants show disrupted circadian rhythmicity coupling with reduced chlorophyll and starch content, as well as biomass at seedling stage, also decreased spike length, grain number per spike, and grain size at the ripening stage. Further studies using DNA affinity purification followed by deep sequencing [DNA affinity purification and sequencing (DAP-seq)] indicated that TaCCA1 preferentially binds to sequences similarly to “evening elements” (EE) motif in the wheat genome, particularly genes associated with photosynthesis, carbon utilization, and auxin homeostasis, and decreased transcriptional levels of these target genes are observed in TaCCA1- OE transgenic wheat plants. Collectively, our study provides novel insights into a circadian-mediated mechanism of gene regulation to coordinate photosynthetic and metabolic activities in wheat, which is important for optimal plant growth and crop yield formation.

The marine atomic interferometric gravimeter is a vital precision instrument for measuring marine geophysical information, which is widely used in mineral resources exploration, military applications, and missile launches. In practical measurements, vibration disturbance is an important factor that affects measurement accuracy. This paper proposes the combination of improved complete ensemble empirical mode decomposition with adaptive noise and locally weighted regression for vibration characterization of gravimeter vibration data. Firstly, the original signal is added into a pair of white noise for adaptive noise-complete ensemble empirical mode decomposition to obtain multiple intrinsic mode functions. The efficient IMF components and noise components are filtered out under the dual indicators of correlation coefficient and variance contribution ratio, and then the LOESS filtering method is used for noise reduction to obtain useful signal detail information; finally, the noise-containing components are reconstructed with the effective components after the noise-reduction process. The experimental results of both simulated and measured vibration signals show that the proposed method can effectively decompose the different high- and low-frequency bands contained in the vibration signal and remove the noise of the original signal.

Key Clinical Message Large malignant breast phyllodes tumors are uncommon in clinical settings. Here, we report such a case to provide a reference for clinical work. A 48‐year‐old woman identified a lump in her right breast, which eventually grew up to 25 cm × 10 cm and began to rapidly bleed and ulcerate within 3 months. The patient had visible signs of anemia and significant emaciation as a result of the tumor's wasting effect and the protracted course of the disease. The patient underwent a modified radical mastectomy on the right breast. The pathology results obtained after surgery revealed a malignant phyllodes tumor. No adjuvant therapy, such as chemotherapy or radiation, was administered. The patient had no symptoms of tumor recurrence and complications from the surgery after a follow‐up of 9 months.

Lung cancer represents one of the most frequent solid tumors. Adenocarcinoma is a common type of tumor and a significant threat to individual health globally. MicroRNAs (miRNAs) are recognized as critical governors of gene expression during carcinogenesis, while their effects on lung cancer occurrence and development are required for further investigation. Herein, the functional role of miR-210-3p and its regulation mechanism were characterized in lung cancer. A total of 50 pairs of tumor and tumor-free lung tissues were surgically resected from lung cancer patients. Dual-luciferase reporter assay and RNA immunoprecipitation assay were performed to examine USF1 binding with miR-210-3p and PCGF3. Cultured human lung cancer cells A549 were assayed for viability, apoptosis, migration, and invasion in vitro by CCK-8 test, flow cytometry, transwell chamber assays, tumorigenesis, and lymph node metastasis in vivo by mouse xenograft experiments. miR-210-3p was upregulated in lung cancer tissues. The inhibition of miR-210-3p by specific inhibitor tempered lung cancer development and metastasis in vitro and in vivo. miR-210-3p targeted USF1 and inhibited its expression. USF1 was bound with PCGF3, which increased its transcription. PCGF3-specific knockdown mimicked the effect of miR-210-3p on lung cancer development and metastasis in vitro and in vivo. The current study demonstrated that miR-210-3p facilitates lung cancer development and metastasis by impairing USF1-mediated promotion of PCGF3, which provides a better understanding of the mechanism of lung cancer development and metastasis.

Background: Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed. The real role of corticosteroid use in COVID-19 has long been of interest and is disputable. Methods: We aimed to quantitatively reevaluate the efficacy of corticosteroids on COVID-19. Databases were searched for eligible meta-analyses/systematic reviews with available outcome data. For each association, we estimated the summary effect size with fixed- and random-effects models, 95% confidence intervals, and 95% prediction intervals. Heterogeneity, Egger’s test, evidence of small-study effects and excess significance bias, and subgroup analyses were rigorously evaluated. Results: Intended outcomes of 12 eligible studies were mortality, clinical improvement, hospitalization, mechanical ventilation (MV), adverse events (AEs), intensive care unit (ICU) stay, hospital stay, virus clearance time (VCT), and negative conversion. Corticosteroid administration was associated with a 27% risk reduction in MV [hazard ratio (HR): 0.73 (0.64–0.83)] and a 20% reduction in mortality of critically ill/severe COVID-19 patients [HR: 0.80 (0.65–0.98)]. Interestingly, shorter ICU stays and, conversely, potentially longer hospital stays, a longer VCT, and a longer time to negative conversion were associated with corticosteroid use. There was no significant impact of different corticosteroid doses on mortality. Only one study showed slightly excess significant bias. Caution should be applied given the weak nature of the evidence, and it has been confirmed by sensitivity analyses too. Conclusion: This umbrella study found benefits from corticosteroids on MV and especially the mortality of critically ill/severe patients with shorter ICU stays but prolonged hospital stays and VCT. The benefits and harms should be reevaluated and balanced before corticosteroids are cautiously prescribed in clinical practice.

This study compared the role of neoadjuvant chemotherapy (NAC) followed by surgery vs. upfront surgery for avoiding axillary lymph node dissection (ALND) in patients with cT1-2N0M0 breast cancer and clinically negative axillary lymph nodes (LNs) at diagnosis. Medical records of a sample of 1,695 patients with a primary diagnosis of axillary LN-negative early-stage breast cancer who underwent surgical treatment for breast cancer at the First Bethune Hospital of Jilin University between June 2019 and December 2022 were retrospectively reviewed. The positive rate of sentinel lymph nodes (PR ) and the positive rate of total axillary lymph nodes (PR ) were compared between patients who received 4-8 cycles of NAC followed by surgery (  = 135) and patients who underwent upfront surgery (  = 1,560). 15 patients who received NAC followed by surgery and 79 patients who underwent upfront surgery had positive SLNs. Four patients who received NAC followed by surgery and 1 patient who underwent upfront surgery had other positive LNs. Overall, NAC followed by surgery significantly lowered PR and PR compared to upfront surgery in patients with cT1-2N0M0 breast cancer. In subgroup analyses, PR and PR were significantly lower for NAC followed by surgery compared to upfront surgery in patients aged 40-60 years, with cT2 stage disease, and HER2+ breast cancer. At a median follow-up of 23.15 months, invasive disease-free survival was similar for all patients. NAC may reduce the rate of axillary LN positivity and the likelihood of ALND in patients aged 40-60 years with cT2N0M0 HER2+ breast cancer and clinically negative axillary LNs at diagnosis.