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AbstractObjectiveTo study the clinical characteristics of patients in Zhejiang province, China, infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease 2019 (covid-2019).DesignRetrospective case series.SettingSeven hospitals in Zhejiang province, China.Participants62 patients admitted to hospital with laboratory confirmed SARS-Cov-2 infection. Data were collected from 10 January 2020 to 26 January 2020.Main outcome measuresClinical data, collected using a standardised case report form, such as temperature, history of exposure, incubation period. If information was not clear, the working group in Hangzhou contacted the doctor responsible for treating the patient for clarification.ResultsOf the 62 patients studied (median age 41 years), only one was admitted to an intensive care unit, and no patients died during the study. According to research, none of the infected patients in Zhejiang province were ever exposed to the Huanan seafood market, the original source of the virus; all studied cases were infected by human to human transmission. The most common symptoms at onset of illness were fever in 48 (77%) patients, cough in 50 (81%), expectoration in 35 (56%), headache in 21 (34%), myalgia or fatigue in 32 (52%), diarrhoea in 3 (8%), and haemoptysis in 2 (3%). Only two patients (3%) developed shortness of breath on admission. The median time from exposure to onset of illness was 4 days (interquartile range 3-5 days), and from onset of symptoms to first hospital admission was 2 (1-4) days.ConclusionAs of early February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in Zhejiang province are relatively mild.

Parkinson’s disease (PD) is a prevalent type of neurodegenerative disease. There is mounting evidence that the gut microbiota is involved in the pathogenesis of PD. Sodium butyrate (NaB) can regulate gut microbiota and improve brain functioning in neurological disorders. Hence, we examined whether the neuroprotective function of NaB on PD was mediated by the modulation of gut microbial dysbiosis and revealed its possible mechanisms. Mice were administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 7 consecutive days to construct the PD model. NaB gavage was given 2 h after the daily MPTP injections for 21 days. NaB improved the motor functioning of PD mice, increased striatal neurotransmitter levels, and reduced the death of dopaminergic neurons. The 16S rRNA sequencing analysis revealed that NaB restored the gut microbial dysbiosis. NaB also attenuated the intestinal barrier’s disruption and reduced serum, colon, and striatal pro-inflammatory cytokines, along with inhibiting the overactivation of glial cells, suggesting an inhibitory effect on inflammation from NaB throughout the gut–brain axis of the PD mice. Mechanistic studies revealed that NaB treatment suppressed the TLR4/MyD88/NF-kB pathway in the colon and striatum. In summary, NaB had a neuroprotective impact on the PD mice, likely linked to its regulation of gut microbiota to inhibit gut–brain axis inflammation.

With the increased incidence of wine fraud, a fast and reliable method for wine certification has become a necessary prerequisite for the vigorous development of the global wine industry. In this study, a classification strategy based on three-dimensional fluorescence spectroscopy combined with chemometrics was proposed for oak-barrel and stainless steel tanks with oak chips aged wines. Principal component analysis (PCA), partial least squares analysis (PLS-DA), and Fisher discriminant analysis (FDA) were used to distinguish and evaluate the data matrix of the three-dimensional fluorescence spectra of wines. The results showed that FDA was superior to PCA and PLS-DA in classifying oak-barrel and stainless steel tanks with oak chips aged wines. As a general conclusion, three-dimensional fluorescence spectroscopy can provide valuable fingerprint information for the identification of oak-barrel and stainless steel tanks with oak chips aged wines, while the study will provide some theoretical references and standards for the quality control and quality assessment of oak-barrel aged wines.

Functionally graded (FG) graphene origami (GOri)-enabled auxetic metamaterials (FG-GOEAM) have received much attention due to their excellent mechanical properties. In this study, the buckling and free vibration behaviours of FG-GOEAM beams supported by elastic foundations in a thermal environment are investigated. Three temperature distributions were considered: uniform temperature profile (UTP), linear temperature profile (LTP), and sinusoidal temperature profile (STP). By assuming that the temperature at the geometrical neutral planes of any layer in an FG-GOEAM beam represents the temperature of the entire layer, this study determines the correction function for the material parameters associated with FG-GOEAM beams under LTP and STP. Mechanical response analysis of FG-GOEAM beams under LTP and STP was not reported. The effect of the thermal environment is described in the form of thermal strain energy. The control equations were derived based on refined beam theory (RBT) and Lagrange equations. Numerical results were obtained using the Chebyshev-Ritz method. The accuracy of the study in this paper was verified by comparing the results with the existing literature. It should be noted that bifurcation buckling does not occur for FG-GOEAM beams that exhibit asymmetric material distribution and temperature profiles in the thickness direction. Therefore, these asymmetric distributions are not considered in the buckling analysis. Emphasis was placed on the effects of temperature profiles, weight fraction, and degree of folding of Gori on the buckling and vibrational behaviour of FG-GOEAM beams under various boundary conditions. These numerical results provide important insights for the further design and development of FG-GOEAM beams.

Objectives The recommended treatment for limited‐stage small‐cell lung cancer (LS‐SCLC) is a combination of thoracic radiotherapy (TRT) and etoposide plus cisplatin (EP) chemotherapy, typically administered over 4–6 cycles. Nonetheless, the optimal duration of chemotherapy is still not determined. This study aimed to compare the outcomes of patients with LS‐SCLC who received either 6 cycles or 4–5 cycles of EP chemotherapy combined with TRT. Materials and Methods In this retrospective analysis, we utilized data from our prior prospective trial to analyze the outcomes of 265 LS‐SCLC patients who received 4–6 courses of EP combined with concurrent accelerated hyperfractionated TRT between 2002 and 2017. Patients were categorized into two groups depending on their number of chemotherapy cycles: 6 or 4–5 cycles. To assess overall survival (OS) and progression‐free survival (PFS), we employed the Kaplan–Meier method after conducting propensity score matching (PSM). Results Among the 265 LS‐SCLC patients, 60 (22.6%) received 6 cycles of EP chemotherapy, while 205 (77.4%) underwent 4–5 cycles. Following PSM (53 patients for each group), the patients in the 6 cycles group exhibited a significant improvement in OS and PFS in comparison to those in the 4–5 cycles group [median OS: 29.8 months (95% confidence interval [CI], 23.6–53.1 months) vs. 22.7 months (95% CI, 20.8–29.1 months), respectively, p = 0.019; median PFS: 17.9 months (95% CI, 13.7–30.5 months) vs. 12.0 months (95% CI, 9.8–14.2 months), respectively, p = 0.006]. The two‐year and five‐year OS rates were 60.38% and 29.87% in the 6 cycles group, whereas 47.17% and 15.72% in the 4–5 cycles group, respectively. Conclusion Patients diagnosed with LS‐SCLC who were treated with EP regimen chemotherapy combined with TRT exhibited notably enhanced survival when administered 6 cycles of chemotherapy, as compared to those who underwent only 4–5 cycles.

Aiming to investigate the effects of the near-surface delamination on buckling response behavior of carbon fiber reinforced laminated composites under different bending modes, acoustic emission (AE) data analysis and X-ray micro-computed tomography (micro-CT) imaging method were promoted to characterize the mechanical properties, acoustic responses and damage visualization. Due to the existence of the artificial embedded delamination, when subjected to local compression induced by bending loads, the laminated composites showed a strong tendency to buckling behavior. The mechanical properties indicated that under different bending modes, the size of delamination had little influence on the relative change ratio of ultimate bearing capacity, but the thickness of specimen had a significant influence on the relative change ratio of ultimate load. AE monitoring results showing the characteristics of energy release for composites were related to the mutation rate of load curve. Moreover, cluster results indicate that matrix failure, interfacial failure and fiber failure are the main damage mechanisms. Micro-CT results illustrated that as the thickness of composites increases, there is a reduction in crack density. AE monitoring can reflect the initiation and evolution process of damage, and damage mechanism identification can be realized by clustering analysis. Besides, the internal damage morphologies acquired by micro-CT can directly verify the damage mechanisms. The cross-validation of AE and micro-CT can provide a basis for structural health monitoring of composites.

Background Human adenoviruses (HAdVs) cause a wide range of diseases. However, the genotype diversity and epidemiological information relating to HAdVs among hospitalized children with respiratory tract infections (RTIs) is limited. Here, we describe the epidemiology and genotype distribution of HAdVs associated with RTIs in Beijing, China. Methods Nasopharyngeal aspirates (NPA) were collected from hospitalized children with RTIs from April 2017 to March 2018. HAdVs were detected by a TaqMan-based quantitative real-time polymerase chain reaction (qPCR) assay, and the hexon gene was used for phylogenetic analysis. Epidemiological data were analyzed using statistical product and service solutions (SPSS) 21.0 software. Results HAdV was detected in 72 (5.64%) of the 1276 NPA specimens, with most (86.11%, 62/72) HAdV-positives cases detected among children < 6 years of age. HAdV-B3 (56.06%, 37/66) and HAdV-C2 (19.70%, 13/66) were the most frequent. Of the 72 HAdV-infected cases, 27 (37.50%) were co-infected with other respiratory viruses, most commonly parainfluenza virus (12.50%, 9/72) and rhinovirus (9.72%, 7/72). The log number of viral load ranged from 3.30 to 9.14 copies per mL of NPA, with no significant difference between the HAdV mono- and co-infection groups. The main clinical symptoms in the HAdV-infected patients were fever and cough, and 62 (86.11%, 62/72) were diagnosed with pneumonia. Additionally, HAdVs were detected throughout the year with a higher prevalence in summer. Conclusions HAdV prevalence is related to age and season. HAdV-B and HAdV-C circulated simultaneously among the hospitalized children with RTIs in Beijing, and HAdV-B type 3 and HAdV-C type 2 were the most frequent.

An experimental investigation was conducted to explore the flow boiling heat transfer characteristics of refrigerants R134A and R410A inside a smooth tube, as well as inside two newly developed surface-enhanced tubes. The internal surface structures of the two enhanced tubes are comprised of protrusions/dimples and petal-shaped bumps/cavities. The equivalent inner diameter of all tested tubes is 11.5 mm, and the tube length is 2 m. The experimental test conditions included saturation temperatures of 6 °C and 10 °C; mass velocities ranging from 70 to 200 kg/(m2s); and heat fluxes ranging from 10 to 35 kW/m2, with inlet and outlet vapor quality of 0.2 and 0.8. It was observed that the enhanced tubes exhibit excellent flow boiling heat transfer performance. This can be attributed to the complex surface patterns of dimples and petal arrays that increase the active heat transfer area; in addition, more nucleation sites are produced, and there is also an increased interfacial turbulence. Results showed that the boiling heat transfer coefficient of the enhanced surface tubes was 1.15–1.66 times that of the smooth tubing. Also, effects of the flow pattern and saturated temperature are discussed. Finally, a comparison of several existing flow boiling heat transfer models using the data from the current study is presented.

In this paper, the simple refined plate theory (S-RPT) is extended for the analysis of the bending and buckling behaviours of functionally graded graphene platelets reinforced composite (FG-GPLRC) plates supported by local elastic foundations under different boundaries. For the first time, an analytical method for determining the location of the local elastic foundation distribution by simple integration is extended to the analysis of the bending and buckling behaviour of plates. The method avoids complex calculations compared to previous methods for determining the position of the elastic foundation. Compared with other simplified plate theories, the displacement pattern of S-RPT is able to reflect the interrelationship between the gradient material properties and the displacement distribution along plate’s thickness. The material properties of FG-GPLRC plates are affected by temperature. Using the static equilibrium method, the plate equilibrium equations are derived by directly integrating the three-dimensional elastic equations along the plate cross section. Galerkin’s method is used to solve the governing equations. The accuracy of S-RPT under different boundary conditions and the accuracy of the analytical method for determining the location of the elastic foundation are verified by comparing the numerical results with the existing literature. Finally, the effects of different distribution patterns, weight fractions of GPLs, thickness ratios, aspect ratios, boundary conditions, temperature, elastic foundation distribution patterns, and elastic foundation parameters were investigated in detail.

Endoplasmic reticulum (ER) stress is implicated in the pathogenesis of many diseases, including myocardial ischemia/reperfusion injury. We hypothesized that human umbilical cord mesenchymal stromal cells derived extracellular vesicles (HuMSC-EVs) could protect cardiac cells against hyperactive ER stress induced by hypoxia/reoxygenation (H/R) injury. The H/R model was generated using the H9c2 cultured cardiac cell line. HuMSC-EVs were extracted using a commercially available exosome isolation reagent. Levels of apoptosis-related signaling molecules and the degree of ER stress were assessed by western blot. The role of the PI3K/Akt pathway was investigated using signaling inhibitors. Lactate dehydrogenase leakage and 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) analysis were used for evaluating the therapeutic effects of HuMSC-EVs in vitro. The results showed that ER stress and the rate of apoptosis were increased in the context of H/R injury. Treatment with HuMSC-EVs inhibited ER stress and increased survival in H9c2 cells exposed to H/R. Mechanistically, the PI3K/Akt pathway was activated by treatment with HuMSC-EVs after H/R. Inhibition of the PI3K/Akt pathway by a specific inhibitor, LY294002, partially reduced the protective effect of HuMSC-EVs. Our findings suggest that HuMSC-EVs could alleviate ER stress–induced apoptosis during H/R via activation of the PI3K/Akt pathway.