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This paper focuses on the sufficient condition of block sparse recovery with the l 2 / l 1 -minimization. We show that if the measurement matrix satisfies the block restricted isometry property with δ 2 s | I < 0.6246 , then every block s -sparse signal can be exactly recovered via the l 2 / l 1 -minimization approach in the noiseless case and is stably recovered in the noisy measurement case. The result improves the bound on the block restricted isometry constant δ 2 s | I of Lin and Li (Acta Math. Sin. Engl. Ser. 29(7):1401-1412, 2013 ).

The objective of this multicenter, single‐arm trial (ChiCTR1900022293) was to explore the efficacy and safety of neoadjuvant therapy with epirubicin, cyclophosphamide, and pyrotinib followed by docetaxel, trastuzumab, and pyrotinib (ECPy‐THPy) in the treatment of patients with stage II–III HER2‐positive breast cancer. The present study enrolled patients with stage II–III HER2‐positive breast cancer. Epirubicin and cyclophosphamide were administrated for four 21‐day cycles, followed by four cycles of docetaxel and trastuzumab. Pyrotinib was taken orally once per day throughout the treatment period. The primary endpoint was total pathological complete response (tpCR, ypT0/is ypN0) rate in the modified intention‐to‐treat (mITT) population. In total, 175 patients were included. The tpCR rate was 68.6% (95% CI, 60.7–75.8%), while the objective response rate was 89.1%. In the post‐hoc subgroup analysis, no association between clinical characteristics and the tpCR rate was observed. The most common grade ≥3 adverse events were diarrhea (54.3%), followed by white blood cell count decreased (5.1%), and neutrophil count decreased (4.6%). In conclusion, the neoadjuvant regimen with ECPy‐THPy showed promising pathological response and clinical benefits with an acceptable safety profile in patients with stage II–III HER2‐positive breast cancer. In this multicenter, single‐arm trial, we investigated the efficacy and safety of the ECPy‐THPy regimen (epirubicin, cyclophosphamide, and pyrotinib followed by docetaxel, trastuzumab, and pyrotinib) as neoadjuvant therapy for patients with stage II–III HER2‐positive breast cancer. Our results revealed that tpCR was achieved in 107 (68.6%) out of 156 patients, which was in line with our previous pilot study and numerically higher than the tpCR rate in previous phase III KRISTINE trial and the phase III POENY trial.

Introduction As ceRNA network of long non-coding RNA (lncRNA)–microRNA (miR)–messenger RNAs (mRNA) can be predicted on the basis of bioinformatics tools, we are now one step closer to deeper understanding carcinogenic mechanisms. In this study, we clarified the mechanistic understanding of JHDM1D-AS1-miR-940-ARTN ceRNA network in the development of breast cancer (BC). Materials and Methods The lncRNA–miRNA–mRNA interaction of interest was predicted by in silico analysis and identified by conducting RNA immunoprecipitation, RNA pull-down and luciferase assays. The expression patterns of JHDM1D-AS1, miR-940 and ARTN in BC cells were altered by lentivirus infection and plasmid transfection for functional assays on the biological properties of BC cells. Finally, the tumorigenic and metastatic abilities of BC cells were assessed in vivo. Results JHDM1D-AS1 was highly expressed, while miR-940 was poorly expressed in BC tissues and cells. JHDM1D-AS1 could competitively bind to miR-940, whereby promoting the malignant behaviors of BC cells. Furthermore, ARTN was identified as a target gene of miR-940. Through targeting ARTN, miR-940 exerted a tumor-suppressive role. In vivo experiments further confirmed that JHDM1D-AS1 enhanced the tumorigenesis and metastasis through up-regulation of ARTN. Conclusions Taken together, our study demonstrated the involvement of ceRNA network JHDM1D-AS1-miR-940-ARTN in the progression of BC, which highlighted promising therapeutic targets for BC treatment.

Recent studies revealed that long non-coding RNAs (lncRNA) play crucial roles in cancer initiation and progression. However, the function and underlying mechanism of lncRNAs in triple-negative breast cancer (TNBC) are little investigated. qRT-PCR was used to investigate LINC00096 expression in TNBC tissues and cells. Function assays were used to test the effects of LINC00096 on TNBC cells progression. In addition, luciferase reporter and qRT-PCR assays were used to determine the underlying mechanism of LINC00096 on TNBC progression. In our present study, we identify LINC00096 as one of the most upregulated lncRNA in TNBC progression by using microarray screening. High LINC00096 expression was obviously related to advanced tumor stage, metastasis, poor prognosis of patients. Loss-of-function assays showed that LINC00096 suppression reduced TNBC cells proliferation and invasive abilities in vitro. Mechanistically, we demonstrated that LINC00096 directly interacted with miR-383-5p, subsequently acted as a miRNA sponge to increase RBM3 expression. In the present study, we indicated that LINC00096 might promote the proliferation and invasion through regulating the miR-383-5p/RBM3 pathway in TNBC, which providing a novel therapeutic target for cancer treatment.

Lightweight structures with multi-functions such as electromagnetic wave absorption and excellent mechanical properties are required in spacecraft. A three-dimensional metamaterial absorber consisting of honeycomb and resistive films was proposed and fabricated through 3D printing and silk-screen printing technology. According to simulation and experiment results, the present three-dimensional metamaterial absorber can realize an absorptivity of more than 90% in a wide band of 3.53–24.00 GHz, and improve absorbing efficiency for transverse magnetic (TM) waves of oblique incidence angle from 0° to 70°. The compression test results reveal that compressive strength of the 3D printed honeycomb can reach 10.7 MPa with density of only 254.91 kg/m 3 , and the energy absorption per volume W v and per unit mass W m are 4.37 × 10 3  KJ/m 3 and 17.14 KJ/Kg, respectively. The peak compressive strength and energy absorption per mass are at least 2.2 and 3 times comparing to metallic lattice cores with the same density. Outstanding electromagnetic wave absorption and mechanical performance make the present three-dimensional metamaterial absorber more competitive in engineering applications.

Due to the fault vibration signal of the rolling bearing is greatly interfered by the background noise, the fault features are easily submerged and result in a low fault diagnosis accuracy. A novel fault diagnosis method of rolling bearing is proposed based on improved VMD-adaptive wavelet threshold combined with noise reduction in this paper. Firstly, the modal components are obtained based on VMD decomposition; Secondly, the dual determination criteria of sample entropy and correlation coefficient are constructed to filter the components; Subsequently, an adaptive wavelet thresholding function is proposed, and quadratic noise reduction is applied to mixed IMFs, which in turn reconstructs each component to achieve joint noise reduction. Finally, based on traditional machine learning and deep learning diagnosis methods, the features of noise reduction signals are extracted to realize fault diagnosis. By verifying and analyzing the simulated signal with the measured signal, noise components, the expression of fault characteristics, and the accuracy of fault diagnosis are eliminated, enhanced, and improved.

The unloading creep deformation and failure of the frozen surrounding rock and soil stratum are common problems in artificial freezing construction. This research aims to experimentally and theoretically study the unloading creep behaviors of frozen soil. A wide range of test conditions, including different pressure history, shear stress paths, and creep stress levels, were employed to examine the sensitivity of triaxial shear and creep behaviors to the selected experimental variables. The testing results manifest that both the axial deformation and the volumetric deformation behaviors are dependent on the pressure history and shear stress path at the shear stage and creep stage. The three-stage damage evolution feature during the entire creep process was experimentally observed, and the damage evolution model based on the disturbance state concept was presented to characterize this damage accumulation process. A new fractal creep model, considering the effect of pressure history and shear stress path on the rheologic behaviors, was proposed. The capability of the fractal creep model was examined by predicting the triaxial creep responses of frozen soil under different stress paths. The comparison results exhibit very good agreement between the experimental curves and the simulation responses determined from the proposed creep model.HighlightsA series of triaxial unloading creep tests were conducted on frozen soil, and the effects of stress path on creep properties were investigated. The unloading creep behaviors of frozen soil are dependent on the stress history and stress path. The dilatancy characteristics in the volumetric creep process were found, and the dilatancy characteristics are sensitive to the unloading path.The damage development of frozen soil in the creep process was evaluated by using typical damage evolution equations of other geomaterials. A new damage-evolution equation was presented for frozen soil. The simulation ability of this model was examined by the testing results.A new fractal creep model was proposed to characterize the unloading creep behaviors of frozen soil, and the predictive ability of this model was verified by the testing results under different stress paths.

A series of radial splitting tests were conducted on frozen subgrade soil to systematically study the effects of sample size, temperatures, ice contents, loading rates, and prefabricated cracks on the tensile deformation and failure behaviors. Based on extensive experimental results including testing data and photos during the whole loading process, a typical splitting load-splitting displacement model for frozen soil was established which can be employed to visually analyze the influencing mechanism for tensile deformation and failure behaviors under various loading conditions. Testing results indicate that the tensile deformation and failure behaviors of frozen samples are strongly affected by ice content, loading rate, and prefabricated cracks. The evaluations of load–displacement curve and crack propagation show diverse property features under different conditions of ice contents and loading rates. The influencing mechanism of the temperatures on the tensile strength behavior of frozen soil is analyzed in detail and the temperature effect on tensile strength is not influenced by loading rates. The crack initiation and propagation in the frozen sample are directly influenced by the prefabricated cracks and show different failure features at various inclination angles and coupling angles. Frozen subgrade soil exhibits obvious rate-dependent failure and deformation behaviors. Furthermore, an empirical formula was proposed to predict the long-term tensile strength of frozen subgrade soil and this formula is capable of giving a good description of the attenuation characteristics of tensile strength as the development of time. This research can provide useful insights into the strength mechanism for frozen subgrade soils.

Absorption of electromagnetic waves in a medium is generally manipulated by controlling the frequency dispersion of constitutive parameters. However, it is still challenging to gain the desired constitutive parameters for customized absorption over a broad frequency range. Here, by virtue of spoof surface plasmonic polaritons (SPPs), we demonstrate capabilities of the spatial k -dispersion engineering for producing the customized broadband absorption. Incident waves can be efficiently converted to the spoof SPPs by plasmonic arrays and their propagation and/or absorption can be controlled by engineering the spatial dispersion of k -vector. Based on this feature, we show how such concept is employed to achieve broadband as well as frequency-selective broadband absorptions as examples. It is expected that the proposed concept can be extended to other manipulations of propagating electromagnetic waves over a broad frequency range.

This study investigates the vibration control issue of active suspension systems. Unlike previous results that neglect the actuator dynamics or consider the impractical symmetrical hydraulic cylinder model, this paper incorporates more reasonable asymmetric electrohydraulic actuator into active suspension system and derives its dynamic model. However, whether active suspension or electrohydraulic actuator suffers from nonlinearities (e.g. nonlinear spring, nonlinear damper and nonlinear actuator dynamics) and parameters uncertainties (e.g. the variations of sprung mass and hydraulic fluid’s bulk modulus as well as hydraulic cylinder original control volumes) , which were rarely synthetically considered in the existing researches.To address these issues, we develop a novel dual adaptive robust controller (ARC). An ARC is firstly designed for main-loop system for stabilizing the car body and improving ride comfort in the presence of nonlinearities and parameter uncertainties as well as road disturbances. In order to meet the constraints requirements of suspension system, the tunable parameters in main-loop control law are optimized by solving linear matrix inequality with kidney-inspired algorithm. Another ARC is further synthesized for sub-loop system to deal with the nonlinear and uncertain dynamics in electrohydraulic actuator for ensuring the force tracking performance. Meanwhile, the uncertain parameters are estimated online to compensate the model deviation. The terminal control law is able to guarantee the asymptotic stability of close-loop system within Lyapunov framework. Finally, the effectiveness and robustness of the proposed controller are demonstrated via excessive simulation experiments over different road conditions.