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In order to improve the lubrication performance and reduce tooth surface wear (TSW) of double involute gears (DIGs), this study comprehensively considers the mutual influence relationship between tooth surface wear, gear pair meshing characteristics, and lubrication characteristics. A calculation model for tooth surface wear of double involute gears under mixed elastohydrodynamic lubrication (EHL) is established, and a calculation method for the lubrication characteristics of DIGs considering the effect of tooth surface wear is proposed. Based on this, the distribution of tooth surface wear in DIGs is investigated, along with the impact of TSW on the lubrication characteristics between meshing tooth surfaces under varying operating conditions, tooth waist order parameters, and tooth surface roughness parameters. Research findings indicate that the influence of TSW on DIGs’ lubrication characteristics is closely associated with accumulated wear depth. Tooth surface wear can deteriorate the lubrication state, and has a significant impact on the lubrication characteristics near meshing in and out positions. Under low velocity, high torque, and large roughness conditions, TSW exerts a greater effect on the lubrication characteristics. However, when there are changes in tooth waist order parameters, its impact on overall lubrication performance becomes relatively small.

In humans, the uterus undergoes a dramatic transformation to form an endometrial stroma-derived secretory tissue, termed decidua, during early pregnancy. The decidua secretes various factors that act in an autocrine/paracrine manner to promote stromal differentiation, facilitate maternal angiogenesis, and influence trophoblast differentiation and development, which are critical for the formation of a functional placenta. Here, we investigated the mechanisms by which decidual cells communicate with each other and with other cell types within the uterine milieu. We discovered that primary human endometrial stromal cells (HESCs) secrete extracellular vesicles (EVs) during decidualization and that this process is controlled by a conserved HIF2α-RAB27B pathway. Mass spectrometry revealed that the decidual EVs harbor a variety of protein cargo, including cell signaling molecules, growth modulators, metabolic regulators, and factors controlling endothelial cell expansion and remodeling. We tested the hypothesis that EVs secreted by the decidual cells mediate functional communications between various cell types within the uterus. We demonstrated that the internalization of EVs, specifically those carrying the glucose transporter 1 (GLUT1), promotes glucose uptake in recipient HESCs, supporting and advancing the decidualization program. Additionally, delivery of HESC-derived EVs into human endothelial cells stimulated their proliferation and led to enhanced vascular network formation. Strikingly, stromal EVs also promoted the differentiation of trophoblast stem cells into the extravillous trophoblast lineage. Collectively, these findings provide a deeper understanding of the pleiotropic roles played by EVs secreted by the decidual cells to ensure coordination of endometrial differentiation and angiogenesis with trophoblast function during the progressive phases of decidualization and placentation.

Objective: To investigate the effects of Mingmu Xiaoyao granules (MMXY) on the morphology and function of the retina and the mechanism of PI3K/Akt/mTOR pathway-related proteins in rats with anxiety and depression induced by chronic unpredictable mild stress (CUMS). Methods: Fifty-two male Sprague Dawley rats were randomly allocated to either a control (n = 14) or a simulated CUMS group (n = 38). The CUMS model was established successfully at 4 weeks. Six rats in each group were randomly selected to be sacrificed and their retinas isolated for histological examination. At 5 weeks, rats in the CUMS group were randomly allocated to the following groups: Model (CUMS + pure water), MMXY-H (CUMS + MMXY 7.2 g/kg/d), MMXY-L (CUMS + MMXY 3.6 g/kg/d), and CBZ (CUMS + Carbamazepine 20 mg/kg/d), with eight rats in each group. All rats were given the relevant intervention once a day. At 12 weeks, sucrose preference and open field tests were performed to evaluate the anxiety and depression status of rats. In live rats, optical coherence tomography angiography was used to measure retinal thickness and blood flow, while electroretinograms (ERGs) and visual evoked potentials (VEPs) were used to evaluate retinal function. The next day, the specimens were sacrificed for serological, histological, immunofluorescence, Western blot and transmission electron microscopy examinations to explore the mechanism of MMXY in CUMS rats. Results: MMXY improved the anxiety and depression-like behavior of rats. Results of optical coherence tomography angiography showed that MMXY improved retinal inner thickness and blood flow in CUMS rats. MMXY improved the amplitude of a- and b-waves in the scotopic and photopic ERG, as well as N2 and P2 peak time and amplitude in the flash-VEP in CUMS rats. Retinal histological staining and transmission electron microscopy showed that MMXY reversed retinal morphology and ultrastructure in CUMS rats. MMXY reduced the expression of Beclin1 and LC3I/II proteins, regulated the PI3K/Akt/mTOR pathway, inhibited autophagy, and had a protective effect on the retina in CUMS rats. Conclusion: MMXY may effectively improve retinal morphology and function as well as anxiety and depression-like behaviors in CUMS rats by regulating the PI3K/Akt/mTOR signaling pathway.

Implantation is initiated when an embryo attaches to the uterine luminal epithelium and subsequently penetrates into the underlying stroma to firmly embed in the endometrium. These events are followed by the formation of an extensive vascular network in the stroma that supports embryonic growth and ensures successful implantation. Interestingly, in many mammalian species, these processes of early pregnancy occur in a hypoxic environment. However, the mechanisms underlying maternal adaptation to hypoxia during early pregnancy remain unclear. In this study, using a knockout mouse model, we show that the transcription factor hypoxia-inducible factor 2 alpha (Hif2α), which is induced in subluminal stromal cells at the time of implantation, plays a crucial role during early pregnancy. Indeed, when preimplantation endometrial stromal cells are exposed to hypoxic conditions in vitro, we observed a striking enhancement in HIF2α expression. Further studies revealed that HIF2α regulates the expression of several metabolic and protein trafficking factors, including RAB27B, at the onset of implantation. RAB27B is a member of the Rab family of GTPases that allows controlled release of secretory granules. These granules are involved in trafficking MMP-9 from the stroma to the epithelium to promote luminal epithelial remodeling during embryo invasion. As pregnancy progresses, the HIF2α-RAB27B pathway additionally mediates crosstalk between stromal and endothelial cells via VEGF granules, developing the vascular network critical for establishing pregnancy. Collectively, our study provides insights into the intercellular communication mechanisms that operate during adaptation to hypoxia, which is essential for embryo implantation and establishment of pregnancy.

There are several critical events that occur in the uterus during early pregnancy which are necessary for the establishment and maintenance of pregnancy. These events include blastocyst implantation, uterine decidualization, uterine neoangiogenesis, differentiation of trophoblast stem cells into different trophoblast cell lineages, and formation of a placenta. These processes involve several different cell types within the pregnant uterus. Communication between these cell types must be intricately coordinated for successful embryo implantation and the formation of a functional maternal–fetal interface in the placenta. Understanding how this intricate coordination transpires has been a focus of researchers in the field for many years. It has long been understood that maternal endometrial tissue plays a key role in intercellular signaling during early pregnancy, sending signals to nearby tissues in a paracrine manner. Recently, insights have been obtained into the mechanisms by which these signaling events occur. Notably, the endometrium has been shown to secrete extracellular vesicles (EVs) that contain crucial cargo (proteins, lipids, RNA, miRNA) that are taken up by recipient cells to initiate a response leading to the occurrence of critical events during implantation and placentation. In this review, we aim to summarize the role that endometrium-derived EVs play in mediating cell-to-cell communications within the pregnant uterus to orchestrate the events that must occur to establish and maintain pregnancy. We will also discuss how aberrant endometrial EV signaling may lead to pathophysiological conditions, such as endometriosis and infertility.

Vortex pump has characteristics of low efficiency and serious surface erosion of blade, which seriously affects service life. Therefore, it is particularly important to improve the efficiency of vortex pump and reduce erosion of blade surface. In this investigation, the design of experiment was used to determine the test plan and the number of samples tested. The relationship between geometric factors of vortex pump and efficiency and erosion rate of blade was established using the kriging approximation model. The genetic algorithm solved the multiobjective optimization and obtained the Pareto front solution using NSGA-II. The results showed that the width of nonblade cavity of the vortex pump is reduced by 18.93%, the number of blades of the impeller is increased by one, and the outlet width of the blade is increased by 19.81%. The performance after optimization is significantly improved compared with the original prototype. At design flow rate, the efficiency of the vortex pump increases by 3.24%, while the efficiency increases by 2.59% and 6.24% at 0.8Qd and 1.2Qd, respectively. The maximum erosion rate of blade surface 8.52 × 10−4 kg/(m2·s) is reduced to 7.18 × 10−4 kg/(m2·s) at 1.0Qd by optimization, which is reduced by 15.73%. The blade erosion after optimization is significantly controlled, and the angle of particle hitting blade surface is reduced.

Implementation of guideline recommendations for cardiovascular disease (CVD) prevention in people with diabetes in low- and middle-income countries (LMICs) is unclear. We assessed the achievement of CVD prevention targets among patients with diabetes in LMICs. We pooled nationally representative cross-sectional surveys from 38 LMICs. We evaluated three targets according to the World Health Organization's (WHO) recommendations: treatment (glucose-lowering drugs, statins, antihypertensive drugs, and aspirin); metabolism (blood glucose, body mass index, blood pressure, and cholesterol); and lifestyle (non-smoking, non-drinking, physical activity, and diet). We used multivariable Poisson regression models to assess sociodemographic factors influencing adherence to guideline recommendations. The study included 110 083 participants, of whom 6789 (6.0%) had self-reported diabetes. The prevalence of achieving the treatment, metabolic and lifestyle targets for all components were 9.9%, 8.1%, and 7.2%, respectively. The components with the lowest prevalence of the three targets were 11.1% for statin use, 27.3% for body mass index control, and 19.5% for sufficient consumption of fruit and vegetables, respectively. Upper-middle-income countries were better at achieving the treatment, non-drinking, and dietary targets than lower-middle-income countries. Women, middle-aged and older patients, and highly educated patients had a lower prevalence of metabolic adherence. In LMICs, the prevalence of patients with diabetes meeting WHO-recommended treatment, metabolic and lifestyle targets for CVD prevention was low. Our findings highlighted the need to strengthen the prevention of CVD in patients with diabetes in LMICs.

旋流泵无叶腔宽度、叶片数和叶片宽度是影响旋流泵性能中最重要的几何参数。【目的】建立旋流泵性能优化方法，为今后的工程提供参考。【方法】采用中心复合的方法对无叶腔宽度L、叶片数Z和叶片出口宽度b2进行了试验设计，使用CFD数值计算获得了样本的性能特性，而后采用Kriging模型建立了几何参数与旋流泵效率和叶片表面剪切应力的关系，最后利用非支配排序遗传算法对几何参数进行多目标寻优并进行了性能预测和对比分析。【结果】研究确定旋流泵最优几何参数L为25 mm、Z为8枚、b2为26.45 mm；优化后旋流泵无叶腔的宽度降低了16.67%，叶轮的叶片数增加了1枚，叶片的出口宽度增加了25.95%。优化后旋流泵的效率显著提高，同时叶片的表面剪切应力降低；在设计工况点，旋流泵的效率提高了1.06%，叶片平均剪切应力从优化前的274.37 Pa减少至204.57 Pa，降低了25.44%；优化后消除了在叶片的前缘处较大的剪切应力；叶片的表面的剪切应力在靠近叶片的出口处得到显著抑制。【结论】通过数值模拟验证了中心复合的方法是可行，提高了旋流泵性能。

Different types of crowdfunding backers adopt various social and economic roles, beyond just financial support. Yet the most appropriate message strategy for attracting these different types of backers remains unclear. To fill this gap, using insights into advertising appeals and the elaboration likelihood model (ELM), we propose a conceptual framework reflecting how the emphasis of the appeals in a crowdfunding message might influence support decisions by two types of backers: consumers and investors. Objective data from a crowdfunding website reveal that appeals that emphasize information (emotion) exert more positive persuasive effects on consumer (investment) backers than on investment (consumer) backers. When devising the appeal emphasis, entrepreneurs thus must make a trade-off while also considering contingent factors such as decision control, social orientation, and reward tangibility. The practical implications of these findings suggest that entrepreneurs should activate backers’ information processing routes differentially, using distinct appeal emphases, rather than relying on an undifferentiated message strategy.

Diabetic kidney disease (DKD) is a common complication of diabetes and has become the leading cause of end-stage kidney disease. The pathogenesis of DKD is complicated, and oxidative stress is considered as a core of DKD onset. High glucose can lead to increased production of reactive oxygen species (ROS) via the polyol, PKC, AGE/RAGE and hexosamine pathways, resulting in enhanced oxidative stress response. In this way, pathways such as PI3K/Akt, TGF-β1/p38-MAPK and NF-κB are activated, inducing endothelial cell apoptosis, inflammation, autophagy and fibrosis that cause histologic and functional abnormalities of the kidney and finally result in kidney injury. Presently, the treatment for DKD remains an unresolved issue. Traditional Chinese medicine (TCM) has unique advantages for DKD prevention and treatment attributed to its multi-target, multi-component, and multi-pathway characteristics. Numerous studies have proved that Chinese herbs (e.g., Golden Thread, Kudzuvine Root, Tripterygium glycosides, and Ginseng) and patent medicines (e.g., Shenshuaining Tablet, Compound Rhizoma Coptidis Capsule, and Zishen Tongluo Granule) are effective for DKD treatment. The present review described the role of oxidative stress in DKD pathogenesis and the effect of TCM intervention for DKD prevention and treatment, in an attempt to provide evidence for clinical practice.