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"Ma, Sheng"
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The anti-inflammatory activity of licorice, a widely used Chinese herb
Context: Increasing incidence and impact of inflammatory diseases have encouraged the search of new pharmacological strategies to face them. Licorice has been used to treat inflammatory diseases since ancient times in China.Objective: To summarize the current knowledge on anti-inflammatory properties and mechanisms of compounds isolated from licorice, to introduce the traditional use, modern clinical trials and officially approved drugs, to evaluate the safety and to obtain new insights for further research of licorice.Methods: PubMed, Web of Science, Science Direct and ResearchGate were information sources for the search terms ‘licorice’, ‘licorice metabolites’, ‘anti-inflammatory’, ‘triterpenoids’, ‘flavonoids’ and their combinations, mainly from year 2010 to 2016 without language restriction. Studies were selected from Science Citation Index journals, in vitro studies with Jadad score less than 2 points and in vivo and clinical studies with experimental flaws were excluded.Results: Two hundred and ninety-five papers were searched and 93 papers were reviewed. Licorice extract, 3 triterpenes and 13 flavonoids exhibit evident anti-inflammatory properties mainly by decreasing TNF, MMPs, PGE2 and free radicals, which also explained its traditional applications in stimulating digestive system functions, eliminating phlegm, relieving coughing, nourishing qi and alleviating pain in TCM. Five hundred and fifty-four drugs containing licorice have been approved by CFDA. The side effect may due to the cortical hormone like action.Conclusion: Licorice and its natural compounds have demonstrated anti-inflammatory activities. More pharmacokinetic studies using different models with different dosages should be carried out, and the maximum tolerated dose is also critical for clinical use of licorice extract and purified compounds.
Journal Article
Off-white : yellowface and Chinglish by Anglo-American culture
\"How do English-speaking novelists and filmmakers tell stories of China from a Chinese perspective? How do they keep up appearances of pseudo-Sino immanence while ventriloquizing solely in the English language? Anglo writers and their readers join in this century-old game of impersonating and dubbing Chinese. Throughout this wish fulfillment, writers lean on grammatical and conceptual frameworks of their mother tongue to represent an alien land and its yellowface aliens. Off-white or yellow-ish characters and their foreign-sounding speech are thus performed in Anglo-American fiction and visual culture; both yellowface and Chinglish are of, for, by the (white) people. Off-White interrogates seminal Anglo-American fiction and film on off-white bodies and voices. It commences with one Nobel laureate, Pearl Buck, and ends with another, Kazuo Ishiguro, almost a century later. The trajectory in between illustrates that the detective and mystery genres continue unabated their stock yellowface characters, who exude a magnetic field so powerful as to pull in Japanese anime. This universal drive to fashion a foil is ingrained in any will to power, so much so that even millennial China creates an \"off-yellow,\" darker-hued Orient in Huallywood films to silhouette its global ascent\"-- Provided by publisher.
Book
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury
Background
Necroptosis of macrophages is a necessary element in reinforcing intrapulmonary inflammation during acute lung injury (ALI). However, the molecular mechanism that sparks macrophage necroptosis is still unclear. Triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor expressed broadly on monocytes/macrophages. The influence of TREM-1 on the destiny of macrophages in ALI requires further investigation.
Methods
TREM-1 decoy receptor LR12 was used to evaluate whether the TREM-1 activation induced necroptosis of macrophages in lipopolysaccharide (LPS)-induced ALI in mice. Then we used an agonist anti-TREM-1 Ab (Mab1187) to activate TREM-1 in vitro. Macrophages were treated with GSK872 (a RIPK3 inhibitor), Mdivi-1 (a DRP1 inhibitor), or Rapamycin (an mTOR inhibitor) to investigate whether TREM-1 could induce necroptosis in macrophages, and the mechanism of this process.
Results
We first observed that the blockade of TREM-1 attenuated alveolar macrophage (AlvMs) necroptosis in mice with LPS-induced ALI. In vitro, TREM-1 activation induced necroptosis of macrophages. mTOR has been previously linked to macrophage polarization and migration. We discovered that mTOR had a previously unrecognized function in modulating TREM-1-mediated mitochondrial fission, mitophagy, and necroptosis. Moreover, TREM-1 activation promoted DRP1
Ser616
phosphorylation through mTOR signaling, which in turn caused surplus mitochondrial fission-mediated necroptosis of macrophages, consequently exacerbating ALI.
Conclusion
In this study, we reported that TREM-1 acted as a necroptotic stimulus of AlvMs, fueling inflammation and aggravating ALI. We also provided compelling evidence suggesting that mTOR-dependent mitochondrial fission is the underpinning of TREM-1-triggered necroptosis and inflammation. Therefore, regulation of necroptosis by targeting TREM-1 may provide a new therapeutic target for ALI in the future.
Journal Article
Biotemplated synthesis of three-dimensional porous MnO/C-N nanocomposites from renewable rapeseed pollen： An anode material for lithium-ion batteries
Lithium-ion batteries （LIBs） are currently recognized as one of the most popular power sources available. To construct advanced LIBs exhibiting long-term endurance, great attention has been paid to enhancing their poor cycle stabilities. As the performance of LIBs is dependent on the electrode materials employed, the most promising approach to improve their life span is the design of novel electrode materials. We herein describe the rational design of a three-dimensional （3D） porous MnO/C-N nanoarchitecture as an anode material for long cycle life LIBs based on their preparation from inexpensive, renewable, and abundant rapeseed pollen （R-pollen） via a facile immersion-annealing route. Remarkably, the as-prepared MnO/C-N with its optimized 3D nanostructure exhibited a high specific capacity （756.5 mAh·g^-1 at a rate of 100 mA·g^-1）, long life span （specific discharge capacity of 513.0 mAh·g^-1, -95.16% of the initial reversible capacity, after 400 cycles at 300 mA·g^-1）, and good rate capability. This material therefore represents a promising alternative candidate for the high-performance anode of next-generation LIBs.
Journal Article
China pop! : pop culture, propaganda, Pacific pop-ups
\"Takes an autotheoretical approach to critiquing the propaganda embedded in millennial Chinese pop culture, particularly TV dramas, films, and web novels, from both within and outside China\"-- Provided by publisher.
BOOK
A Bio-Inspired Vibration Energy Harvesting System with Internal Resonance and Slapping Mechanism for Enhanced Low-Frequency Power Generation
This study presents the development and validation of a bio-inspired vibration energy harvesting system, termed the Bio-Inspired Epiphytic-Plant Slapping Vibration Energy Harvesting System (BIS-VEHS). Inspired by the swaying and slapping behavior of epiphytic plants, the system integrates a circular plate, an elastic beam, a surface-bonded piezoelectric patch (PZT), and a lever-type slapping mechanism to enhance energy conversion. A nonlinear beam model is established and analyzed using the method of multiple scales, through which a 1:3 internal resonance between the first and third bending modes is identified as a key mechanism for promoting energy transfer from higher to lower modes. Time responses are obtained via numerical simulation using the Runge–Kutta method, and the model is validated experimentally. The results confirm that both internal resonance and the slapping mechanism significantly increase the harvested voltage compared with non-resonant and non-slapping configurations. Comparative tests under different excitation modes and plate configurations show good agreement between theory and experiment, with most discrepancies within 10%. These findings demonstrate that the BIS-VEHS is a promising candidate for sustainable low-frequency vibration energy harvesting, particularly for autonomous low-power sensor applications.
Journal Article
Bug mapping and fitness testing of chemically synthesized chromosome X
Debugging a genome sequence is imperative for successfully building a synthetic genome. As part of the effort to build a designer eukaryotic genome, yeast synthetic chromosome X (synX), designed as 707,459 base pairs, was synthesized chemically. SynX exhibited good fitness under a wide variety of conditions. A highly efficient mapping strategy called pooled PCRTag mapping (PoPM), which can be generalized to any watermarked synthetic chromosome, was developed to identify genetic alterations that affect cell fitness (“bugs”). A series of bugs were corrected that included a large region bearing complex amplifications, a growth defect mapping to a recoded sequence in FIP1 , and a loxPsym site affecting promoter function of ATP2 . PoPM is a powerful tool for synthetic yeast genome debugging and an efficient strategy for phenotype-genotype mapping.
Journal Article