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"MacDonald, Eve"
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Hannibal : a Hellenistic life
\"Hannibal lived a life of incredible feats of daring and survival, massive military engagements, and ultimate defeat. A citizen of Carthage and military commander in Punic Spain, he famously marched his war elephants and huge army over the Alps into Rome's own heartland to fight the Second Punic War. Yet the Romans were the ultimate victors. They eventually captured and destroyed Carthage, and thus it was they who wrote the legend of Hannibal: a brilliant and worthy enemy whose defeat represented military glory for Rome. In this groundbreaking biography Eve MacDonald expands the memory of Hannibal beyond his military feats and tactics. She considers him in the wider context of the society and vibrant culture of Carthage which shaped him and his family, employing archaeological findings and documentary sources not only from Rome but also the wider Mediterranean world of the third century B.C. MacDonald also analyzes Hannibal's legend over the millennia, exploring how statuary, Jacobean tragedy, opera, nineteenth-century fiction, and other depictions illuminate the character of one of the most fascinating military personalities in all of history\"-- Provided by publisher.
Book
159 Lessons learned initiating a RCT using an approved drug in a new setting (SPRING Study)
BackgroundTrials of approved medications for new indications are becoming increasingly common (repurposing). SPRING – Seizure Prophylaxis IN Glioma is a trial of prophylactic Levetiracetam in adults without prior history of seizure versus no AED. Significant delays were encountered in the set up phase.IssuesLegal contracts between Sponsor and NIHR/UCB (£1.76m) were prolonged.UCB (Belgium) would only transfer drug when ethics had been granted and BREXIT loomed. Company to package levetiracetam required national procurement exercise.Conflicting IRAS advice (Ireland, Scotland, England). Inclusion criteria included patients must have capacity. As patients could lose capacity during study this required Adults with Incapacity REC (Essex), secondary review in Scotland and screening for capacity at each visit. MHRA – mandated monitoring for suicidal ideation at each visit, and detail on contraception during study. HRA – suggested changes to the Patient Information Leaflet and a Schedule of Events Cost Attribution Template – requiring multiple substantial amendments.Neurosurgical centres may feed several oncological departments - site contracts are complex. Electronic eCRF takes time to build and test.ConclusionsConsider planning for longer set up phase in grant submissions. Views expressed are those of the author(s) and not necessarily those of the NHS, NIHR or DOHSC.robin.grant@luht.scot.nhs.uk
Journal Article
A dataset of high-resolution plantar pressures for gait analysis across varying footwear and walking speeds
Gait refers to the patterns of limb movement generated during walking, which are unique to each individual due to both physical and behavioural traits. Walking patterns have been widely studied in biometrics, biomechanics, sports, and rehabilitation. While traditional methods rely on video and motion capture, advances in plantar pressure sensing technology now offer deeper insights into gait. However, underfoot pressures during walking remain underexplored due to the lack of large, publicly accessible datasets. To address this, we introduce the UNB StepUP-P150 dataset: a footStep database for gait analysis and recognition using Underfoot Pressure, including data from 150 individuals. This dataset comprises high-resolution plantar pressure data (4 sensors/cm
2
) collected using a 1.2m by 3.6m pressure-sensing walkway. It contains over 200,000 footsteps from participants walking with various speeds (preferred, slow-to-stop, fast, and slow) and footwear conditions (barefoot, standard shoes, and two personal shoes), supporting advancements in biometric gait recognition and presenting new research opportunities in biomechanics and deep learning. UNB StepUP-P150 establishes a new benchmark for plantar pressure-based gait analysis and recognition.
Journal Article
Breaking the deadlock on ivory
An iterative process that recognizes different value systems may help to protect elephants
Poaching for ivory has caused a steep decline in African elephant (
Loxodonta africana
, see the photo) populations over the past decade (
1
). This crisis has fueled a contentious global debate over which ivory policy would best protect elephants: banning all ivory trade or enabling regulated trade to incentivize and fund elephant conservation (
2
). The deep-seated deadlock on ivory policy consumes valuable resources and creates an antagonistic environment among elephant conservationists. Successful solutions must begin by recognizing the different values that influence stakeholder cognitive frameworks of how actions lead to outcomes (“mental models”) (
3
), and therefore their diverging positions on ivory trade (
4
). Based on successful conflict resolution in other areas, we propose an iterative process through which countries with wild elephant populations may be able to understand their differences and develop workable solutions in a less confrontational manner.
Journal Article
Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study
PurposeThe development of oestrogen resistance is a major challenge in managing hormone-sensitive metastatic breast cancer. Saracatinib (AZD0530), an oral Src kinase inhibitor, prevents oestrogen resistance in animal models and reduces osteoclast activity. We aimed to evaluate the efficacy of saracatinib addition to aromatase inhibitors (AI) in patients with hormone receptor-positive metastatic breast cancer.MethodsThis phase II multicentre double-blinded randomised trial allocated post-menopausal women to AI with either saracatinib or placebo (1:1 ratio). Patients were stratified into an “AI-sensitive/naïve” group who received anastrozole and “prior-AI” group who received exemestane. Primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate (ORR) and toxicity. Results140 patients were randomised from 20 UK centres to saracatinib/AI (n = 69) or placebo/AI (n = 71). Saracatinib was not associated with an improved PFS (3.7 months v. 5.6 months placebo/AI) and did not reduce likelihood of bony progression. There was no benefit in OS or ORR. Effects were consistent in “AI-sensitive/naive” and “prior-AI” sub-groups. Saracatinib was well tolerated with dose reductions in 16% and the main side effects were gastrointestinal, hypophosphatemia and rash. ConclusionSaracatinib did not improve outcomes in post-menopausal women with metastatic breast cancer. There was no observed beneficial effect on bone metastases.CRUKE/11/023, ISRCTN23804370.
Journal Article
The value of understanding feedbacks from ecosystem functions to species for managing ecosystems
Ecological systems are made up of complex and often unknown interactions and feedbacks. Uncovering these interactions and feedbacks among species, ecosystem functions, and ecosystem services is challenging, costly, and time-consuming. Here, we ask: for which ecosystem features does resolving the uncertainty about the feedbacks from ecosystem function to species improve management outcomes? We develop a dynamic value of information analysis for risk-neutral and risk-prone managers on motif ecosystems and explore the influence of five ecological features. We find that learning the feedbacks from ecosystem function to species does not improve management outcomes for maximising biodiversity, yet learning which species benefit from an ecosystem function improves management outcomes for ecosystem services by up to 25% for risk-neutral managers and 231% for risk-prone managers. Our general approach provides useful guidance for managers and researchers on when learning feedbacks from ecosystem function to species can improve management outcomes for multiple conservation objectives.
Value of information analyses are a promising approach to decision-making in conservation. Here the authors develop a dynamic approach to show that knowing which species benefit from an ecosystem function improves ecosystem service and biodiversity management, particularly for risk-prone managers.
Journal Article
Dariali
The Huns, invading through Dariali Gorge on the modern-day border between Russia and Georgia in AD 395 and 515, spread terror across the late antique world. Was this the prelude to the apocalypse? Prophecies foresaw a future Hunnic onslaught, via the same mountain pass, bringing about the end of the world. Humanity’s fate depended on a gated barrier deep in Europe’s highest and most forbidding mountain chain.Centuries before the emergence of such apocalyptic beliefs, the gorge had reached world fame. It was the target of a planned military expedition by the Emperor Nero. Chained to the dramatic sheer cliffs, framing the narrow passage, the mythical fire-thief Prometheus suffered severe punishment, his liver devoured by an eagle. It was known under multiple names, most commonly the Caspian or Alan Gates.Featuring in the works of literary giants, no other mountain pass in the ancient and medieval world matches Dariali’s fame. Yet little was known about the materiality of this mythical place. A team of archaeologists has now shed much new light on the major gorge-blocking fort and a barrier wall on a steep rocky ridge further north. The walls still standing today were built around the time of the first major Hunnic invasion in the late fourth century – when the Caucasus defenses feature increasingly prominently in negotiations between the Great Powers of Persia and Rome. In its endeavor to strongly fortify the strategic mountain pass through the Central Caucasus, the workforce erased most traces of earlier occupation. The Persian-built bastion saw heavy occupation for 600 years. Its multi-faith medieval garrison controlled Trans-Caucasian traffic. Everyday objects and human remains reveal harsh living conditions and close connections to the Muslim South, as well as the steppe world of the north. The Caspian Gates explains how a highly strategic rock has played a pivotal role in world history from Classical Antiquity into the twentieth century.
eBook