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result(s) for
"Madaffari, D."
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Measurement of the $ZZ$ production cross section in $pp$ collisions at $\\sqrt{s}$ = 8 TeV using the $ZZ\\to\\ell^{-}\\ell^{+}\\ell^{\\prime -}\\ell^{\\prime +}$ and $ZZ\\to\\ell^{-}\\ell^{+}\\nu\\bar{\\nu}$ channels with the ATLAS detector
2017
A measurement of the $ZZ$ production in the $\\ell^{-}\\ell^{+}\\ell^{\\prime -}\\ell^{\\prime +}$ and $\\ell^{-}\\ell^{+}\\nu\\bar{\\nu}$ channels $(\\ell = e, \\mu)$ in proton--proton collisions at $\\sqrt{s} = 8$ TeV at the Large Hadron Collider at CERN, using data corresponding to an integrated luminosity of 20.3 fb$^{-1}$ collected by the ATLAS experiment in 2012 is presented. The fiducial cross sections for $ZZ\\to\\ell^{-}\\ell^{+}\\ell^{\\prime -}\\ell^{\\prime +}$ and $ZZ\\to \\ell^{-}\\ell^{+}\\nu\\bar{\\nu}$ are measured in selected phase-space regions. The total cross section for $ZZ$ events produced with both $Z$ bosons in the mass range 66 to 116 GeV is measured from the combination of the two channels to be $7.3\\pm0.4\\textrm{(stat)}\\pm0.3\\textrm{(syst)}\\pm0.2\\textrm{(lumi)}$ pb, which is consistent with the Standard Model prediction of $6.6^{+0.7}_{-0.6}$ pb. The differential cross sections in bins of various kinematic variables are presented. The differential event yield as a function of the transverse momentum of the leading $Z$ boson is used to set limits on anomalous neutral triple gauge boson couplings in $ZZ$ production.
Journal Article
Search for new phenomena in events containing a same-flavour opposite-sign dilepton pair, jets, and large missing transverse momentum in $\\sqrt{s}=13$ TeV pp collisions with the ATLAS detector
2017
Two searches for new phenomena in final states containing a same-flavour opposite-lepton (electron or muon) pair, jets, and large missing transverse momentum are presented. These searches make use of proton--proton collision data, collected during 2015 and 2016 at a centre-of-mass energy $\\sqrt{s}=13$ TeV by the ATLAS detector at the Large Hadron Collider, which correspond to an integrated luminosity of 14.7 fb$^{-1}$. Both searches target the pair production of supersymmetric particles, squarks or gluinos, which decay to final states containing a same-flavour opposite-sign lepton pair via one of two mechanisms: a leptonically decaying Z boson in the final state, leading to a peak in the dilepton invariant-mass distribution around the Z boson mass; and decays of neutralinos (e.g. $\\tilde{\\chi}_2^0 \\rightarrow \\ell^+\\ell^- \\tilde{\\chi}_1^0$), yielding a kinematic endpoint in the dilepton invariant-mass spectrum. The data are found to be consistent with the Standard Model expectation. Results are interpreted in simplified models of gluino-pair (squark-pair) production, and provide sensitivity to gluinos (squarks) with masses as large as 1.70 TeV (980 GeV).
Journal Article
Study of the rare decays of B0s and B0 into muon pairs from data collected during the LHC Run 1 with the ATLAS detector
2016
A study of the decays B0→μ+μ− and B0s→μ+μ− has been performed using data corresponding to an integrated luminosity of 25 fb−1 of 7 TeV and 8 TeV proton--proton collisions collected with the ATLAS detector during the LHC Run 1. For B0, an upper limit on the branching fraction is set at B(B0→μ+μ−)<4.2×10−10 at 95% confidence level. For B0s, the branching fraction B(B0s→μ+μ−)=(0.9+1.1−0.8)×10−9 is measured. The results are consistent with the Standard Model expectation with a p-value of 4.8%, corresponding to 2.0 standard deviations.
Journal Article
A search for an excited muon decaying to a muon and two jets in $pp$ collisions at $\\sqrt{s}$ = 8 TeV with the ATLAS detector
2016
A search is performed for an excited muon in the channel pp→μμ∗→μμ jet jet, assuming both the production and decay occur via a contact interaction. The analysis is based on 20.3 fb−1 of pp collision data at a centre-of-mass energy of s√ = 8 TeV taken with the ATLAS detector at the Large Hadron Collider. No evidence of excited muons is found, and limits are set at the 95% confidence level on the cross section times branching ratio as a function of the excited-muon mass mμ∗. For mμ∗ between 1.3 TeV and 3.0 TeV, the upper limit on σB(μ∗→μqq¯) is between 0.6 and 1 fb. Limits on σB are converted to lower bounds on the compositeness scale Λ. In the limiting case Λ=mμ∗, excited muons with a mass below 2.8 TeV are excluded. With the same model assumptions, these limits at larger μ∗ masses improve upon previous limits from searches based on the decay μ∗→μγ.
Journal Article
Measurement of the inclusive jet cross-section in proton-proton collisions at $\\sqrt{s}=7$ TeV using 4.5 fb$^{-1}$ of data with the ATLAS detector
2015
The inclusive jet cross-section is measured in proton-proton collisions at a centre-of-mass energy of 7 TeV using a data set corresponding to an integrated luminosity of 4.5 fb$^{-1}$ collected with the ATLAS detector at the Large Hadron Collider in 2011. Jets are identified using the anti-$k_t$ algorithm with radius parameter values of 0.4 and 0.6. The double-differential cross-sections are presented as a function of the jet transverse momentum and the jet rapidity, covering jet transverse momenta from 100 GeV to 2 TeV. Next-to-leading-order QCD calculations corrected for non-perturbative effects and electroweak effects, as well as Monte Carlo simulations with next-to-leading-order matrix elements interfaced to parton showering, are compared to the measured cross-sections. A quantitative comparison of the measured cross-sections to the QCD calculations using several sets of parton distribution functions is performed.
Journal Article
Search for production of $WW/WZ$ resonances decaying to a lepton, neutrino and jets in $pp$ collisions at $\\sqrt{s}$ = 8 TeV with the ATLAS detector
2015
A search is presented for a narrow diboson resonances decaying to $WW$ or $WZ$ in the final state where one $W$ boson decays leptonically (to an electron or a muon plus a neutrino) and the other $W/Z$ boson decays hadronically. The analysis is performed using an integrated luminosity of 20.3 fb$^{-1}$ of $pp$ collisions at $\\sqrt{s}$ = 8 TeV collected by the ATLAS detector at the LHC. No evidence for resonant diboson production is observed, and resonance masses below 700 GeV and 1490 GeV are excluded at 95% confidence level for the spin-2 Randall-Sundrum bulk graviton $G^*$ with coupling constant of 1.0 and the extended gauge model $W'$ boson respectively.
Journal Article
Measurement of the $t\\bar{t}$ production cross-section using $e\\mu$ events with $b$-tagged jets in $pp$ collisions at $\\sqrt{s}=7$ and 8 TeV with the ATLAS detector
2014
The inclusive top quark pair production cross-section has been measured in proton-proton collisions at sqrt(s)=7 TeV and sqrt(s)=8 TeV with the ATLAS experiment at the LHC, using ttbar events with an opposite-charge e-mu pair in the final state. The measurement was performed with the 2011 7 TeV dataset corresponding to an integrated luminosity of 4.6 fb-1 and the 2012 8 TeV dataset of 20.3 fb-1. The numbers of events with exactly one and exactly two b-tagged jets were counted and used to simultaneously determine sigma(ttbar) and the efficiency to reconstruct and b-tag a b-jet from a top quark decay, thereby minimising the associated systematic uncertainties. The cross-section was measured to be: sigma(ttbar)=$182.9\\pm3.1\\pm4.2\\pm3.6\\pm3.3$ pb (7 TeV) and sigma(ttbar)=$242.4\\pm1.7\\pm5.5\\pm7.5\\pm4.2$ pb (8 TeV), where the four uncertainties arise from data statistics, experimental and theoretical systematic effects, the knowledge of the integrated luminosity and of the LHC beam energy. The results are consistent with recent theoretical QCD calculations at NNLO. Fiducial measurements corresponding to the experimental acceptance of the leptons are also reported, together with the ratio of cross-sections measured at the two centre-of-mass energies. The inclusive cross-section results were used to determine the top quark pole mass via the dependence of the theoretically-predicted cross-section on $m_t^{pole}$, giving a result of $m_t^{pole}=172.9^{+2.5}_{-2.6}$ GeV. By looking for an excess of ttbar production with respect to the QCD prediction, the results were also used to place limits on the pair-production of supersymmetric top squarks with masses close to the top quark mass decaying to predominantly right-handed top quarks and a light neutralino, the lightest supersymmetric particle. Top squarks with masses between the top quark mass and 177 GeV are excluded at the 95% confidence level.
Journal Article
Lymph Node Metastasis in Extraperitoneal Rectal Cancer After Neoadjuvant Therapy: An Unsolved Problem?
by
DE GIACOMO, FLAVIA
,
MASSIMI, FANNY
,
BALDUCCI, GENOVEFFA
in
Chemoradiotherapy
,
Humans
,
Lymph Nodes - pathology
2023
Thanks to the promising benefits obtained in terms of quality of life, there has been growing interest in organ-sparing approaches after neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer, mainly represented by transanal local excision and watch-and-wait. The main mandatory criterion is complete lymph nodal response (pN0). However, considering the reduced specificity of current radiological means in identifying one-to-one correspondence between clinical and pathological staging, the problem of underestimating lymph nodal involvement remains unsolved. The aim of this study was to identify the true percentage of patients eligible for conservative surgery and possible predictive factors.
Data for 59 patients with rectal cancer treated with nCRT followed by total mesorectal excision were analyzed. Patients with metastatic tumors and tumors treated with up-front surgery were excluded. Our primary endpoint was the pathological lymph nodal response rate after neoadjuvant chemoradiotherapy. The secondary endpoint was to identify predictive factors for lymph nodal response.
The percentage of patients with pN0 was 62.71%, while in 37.28%, an organ-sparing approach would have not been oncologically correct. Parameters associated with pN0 were lower tumor size (T0-T2) (p=0.013) and lower grading (
Journal Article
Impact of advance care planning consults on advance directives completion
2021
Am J Manag Care. 2021;27(10):e361-e364. https://doi.org/10.37765/ajmc.2021.88767 _____ Takeaway Points Patients who are offered advance care planning consults have significantly higher advance directive documentation rates than those without consults in both primary and specialty care practices. * Advance directives were completed by 82% of primary care and 71% of hematology/oncology patients completing advance care planning consults. * Consult acceptance rates appear to be influenced by mode of invitation, as well as patient age and underlying condition. * In addition to making end-of-life care more likely to match patient wishes, advance directives have been shown to lower end-of-life costs. _____ The Patient Self-Determination Act was established in 1990 to ensure that US patients are informed of their right to make medical care decisions.1 Medical ethicist Bud Hammes, PhD, led a community effort in La Crosse, Wisconsin, in 1993 to develop an advance care planning (ACP) and decision-making model known as Respecting Choices.2 ACP entails 4 primary actions: (1) thinking through one's relevant values and preferences, (2) talking about one's values and preferences, (3) documenting one's stated values and preferences, and (4) reviewing and updating documentation specific to one's stated values and preferences. When performed in a comprehensive manner, these actions serve to (1) minimize decision-making burden on family members; (2) reduce the likelihood of conflicts among a patient's spokesperson, family members, and health care providers; (3) minimize the likelihood of over- or undertreatment; and (4) maximize the likelihood that medical care is consistent with patient wishes.3 Within 2 years of implementing ACP in La Crosse, completion of advance directives (ADs) in the region rose from 2% to 45%.4 This improvement was attributed to widespread standardization, documentation, and utilization of ACP processes. In 2015, Dartmouth Atlas identified the La Crosse region as ranking among the areas with the lowest hospital utilization and total health care cost for end-of-life care.6 The national rate for hospitalizations in the last 6 months of life was 125 hospitalizations per 100 older decedents, whereas inpatient spending for that time frame was $15,366 per decedent. ACP consults are performed using the Honoring Choices model.7 An AD describes 2 types of legal documents, a Living Will and a Healthcare Power of Attorney/Designation of Healthcare Surrogate, that enable patients to plan for and communicate end-of-life wishes and designate health care decision makers to act on their behalf if necessary.
Journal Article
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