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"Madison, Stephen"
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Don't be afraid of the dark
Sally Hurst is going to Rhode Island to live with her father Alex and his new girlfriend Kim in the nineteenth-century mansion they are restoring. While exploring the estate, Sally finds a hidden basement and accidentally lets loose a race of ancient, dark-dwelling creatures who conspire to drag her down into the mysterious house's bottomless depths. Before the evil lurking in the dark consumes them all, Sally must convince Alex and Kim that it's not a fantasy.
DVD
Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation
Inter-organellar communication is emerging as one of the most crucial regulators of cellular physiology. One of the key regulators of inter-organellar communication is Mitofusin-2 (MFN2). MFN2 is also involved in mediating mitochondrial fusion–fission dynamics. Further, it facilitates mitochondrial crosstalk with the endoplasmic reticulum, lysosomes and melanosomes, which are lysosome-related organelles specialized in melanin synthesis within melanocytes. However, the role of MFN2 in regulating melanocyte-specific cellular function, i.e., melanogenesis, remains poorly understood. Here, using a B16 mouse melanoma cell line and primary human melanocytes, we report that MFN2 negatively regulates melanogenesis. Both the transient and stable knockdown of MFN2 leads to enhanced melanogenesis, which is associated with an increase in the number of mature (stage III and IV) melanosomes and the augmented expression of key melanogenic enzymes. Further, the ectopic expression of MFN2 in MFN2-silenced cells leads to the complete rescue of the phenotype at the cellular and molecular levels. Mechanistically, MFN2-silencing elevates mitochondrial reactive-oxygen-species (ROS) levels which in turn increases melanogenesis. ROS quenching with the antioxidant N-acetyl cysteine (NAC) reverses the MFN2-knockdown-mediated increase in melanogenesis. Moreover, MFN2 expression is significantly lower in the darkly pigmented primary human melanocytes in comparison to lightly pigmented melanocytes, highlighting a potential contribution of lower MFN2 levels to higher physiological pigmentation. Taken together, our work establishes MFN2 as a novel negative regulator of melanogenesis.
Journal Article
Does hope matter? The influence of dispositional hope on persistence in a developmental writing course
The purpose of this study was to determine hope’s unique role, if any, in predicting persistence in a developmental writing course. Perceived academic self-efficacy was also included as a variable of interest for comparison because self-efficacy has been more widely studied than hope in terms of its non-cognitive role in predicting academic outcomes. A significant body of research indicates that self-efficacy influences academic motivation to persist and academic performance. Hope, however, is an emerging psychological construct in the study of non-cognitive factors that influence college outcomes and warrants further exploration in higher education. This study examined the predictive value of hope and self-efficacy on persistence in a developmental writing course. The research sample was obtained from a community college in the southeastern United States. Participants were 238 students enrolled in developmental writing courses during their first year of college. Participants were given a questionnaire that included measures for perceived academic self-efficacy and hope. The self-efficacy scale asked participants to self-report on their beliefs about how they cope with different academic tasks in order to be successful. The hope scale asked students to self-report on their beliefs about their capability to initiate action towards a goal (“agency”) and create a plan to attain these goals (“pathways”). This study utilized a correlational research design. A statistical association was estimated between hope and self-efficacy as well as the unique variance contributed by each on course persistence. Correlational analysis confirmed a significant relationship between hope and perceived academic self-efficacy, and a Fisher’s z-transformation confirmed a stronger relationship between the agency component of hope and perceived academic self-efficacy than for the pathways component. A series of multinomial logistic regression analyses were conducted to assess if (a) perceived self-efficacy and hope predict course persistence, (b) hope independent of self-efficacy predicts course persistence, and (c) if including the interaction of perceived self-efficacy and hope predicts course persistence. It was found that hope was only significant independent of self-efficacy. Some implications for future research are drawn for those who lead and coordinate academic support initiatives in student and academic affairs.
Dissertation
MILLER FAIR, HONEST AND DESERVES VOTE
DEAR EDITOR: ERIC PETERSON, REPUBLICAN CANDIDATE FOR THE 16TH SENATE DISTRICT, IS NOT ONLY GROSSLY MISREPRESENTING THE VOTING RECORD AND CONDUCT OF ASSEMBLY REP. MARK MILLER, D-MONONA, BUT IS OUTRIGHT CONCOCTING LIES ABOUT HIM. I KNOW THIS BECAUSE I SERVED WITH MARK ON THE DANE COUNTY BOARD AND COULD PERHAPS GO SO FAR AS TO SAY THAT I MENTORED HIM A BIT.
Newspaper Article
REDUCE OVERALL FERTILIZER USE
To eliminate phosphorus from fertilizers is analogous to removing the vitamins from vitamin pills. However, just like it is not necessary and often harmful to consume vitamins in excess of the recommended minimum daily needs, it is also unnecessary and undesirable to fertilize in excess.
Newspaper Article
Obama hits back Romney `owes the American people the truth
Romney celebrated his debate coup with a surprise visit to a conservative conference in the Colorado city of Denver, and warned Obama's economic policies would take America down a slippery slope to the fate of debt-laden Europe.
Newspaper Article