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A dream in red : Ferrari by Maggi & Maggi : a photographic journey through the finest cars ever made
A photographic celebration of Ferrari's production cars as photographed by Maggi & Maggi, across 60 years.
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Sexual dysfunction and male infertility
Infertility affects up to 12% of all men, and sexual dysfunction occurs frequently in men of reproductive age, causing infertility in some instances. In infertile men, hypoactive sexual desire and lack of sexual satisfaction are the most prevalent types of sexual dysfunction, ranging from 8.9% to 68.7%. Erectile dysfunction and/or premature ejaculation, evaluated with validated tools, have a prevalence of one in six infertile men, and orgasmic dysfunction has a prevalence of one in ten infertile men. In addition, infertile men can experience a heavy psychological burden. Infertility and its associated psychological concerns can underlie sexual dysfunction. Furthermore, general health perturbations can lead to male infertility and/or sexual dysfunction. Erectile dysfunction and male infertility are considered proxies for general health, the former underlying cardiovascular disorders and the latter cancerous and noncancerous conditions. The concept that erectile dysfunction in infertile men might be an early marker of poor general health is emerging. Finally, medications used for general health problems can cause sperm abnormalities and sexual dysfunction. The treatment of some causes of male infertility might improve semen quality and reverse infertility-related sexual dysfunction. In infertile men, an investigation of sexual, general, and psychological health status is advisable to improve reproductive problems and general health.
Journal Article
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the deadliest form of breast cancer. Unlike other types of breast cancer that can be effectively treated by targeted therapies, no such targeted therapy exists for all TNBC patients. The ADAR1 enzyme carries out A-to-I editing of RNA to prevent sensing of endogenous double-stranded RNAs. ADAR1 is highly expressed in breast cancer including TNBC. Here, we demonstrate that expression of ADAR1, specifically its p150 isoform, is required for the survival of TNBC cell lines. In TNBC cells, knockdown of ADAR1 attenuates proliferation and tumorigenesis. Moreover, ADAR1 knockdown leads to robust translational repression. ADAR1-dependent TNBC cell lines also exhibit elevated IFN stimulated gene expression. IFNAR1 reduction significantly rescued the proliferative defects of ADAR1 loss. These findings establish ADAR1 as a novel therapeutic target for TNBC tumors.
Journal Article
The role of testosterone in male sexual function
Sexual function, and testosterone (T) levels, progressively decline in aging men. Associated morbidities and metabolic disorders can accelerate the phenomenon. The specific contribution of low T to sexual function impairment in aging men has still not been completely clarified. Similarly, the role of T replacement therapy (TRT), as well as the combination of TRT with phosphodiesterase type 5 inhibitors (PDE5i) for patients with erectile dysfunction (ED), is still conflicting. Here we aim to summarize and critically discuss all available data supporting the contribution of low T to sexual impairment observed with aging as well as the possible role of TRT. Available data on men with sexual dysfunction show that reduced sexual desire is the most important correlate of male hypogonadism. Conversely, aging and associated morbidities substantially attenuate the relationship between ED and T. TRT is effective in improving sexual function in middle-aged and older subjects but its role is small and extremely variable. Lifestyle interventions can result in similar outcomes to those of TRT. In conclusion, it is our opinion that PDE5i along with lifestyle measures should be considered the first approach for treating ED even in subjects with milder T deficiency. When these interventions fail or are difficult to apply, TRT should be considered.
Journal Article
'Read ten thousand books, walk ten thousand miles': geographical mobility and capital accumulation among Chinese scholars
International movements of scientists and researchers have become more common in the increasingly interconnected global knowledge economy. Geographic mobility is often perceived as a key to academic excellence and career advancement by scholars, especially in advanced economies. In China, where international geographical mobility is a newly-gained privilege after the advent of the Open Door Policy, academics belong to one of the most mobile subsets of the population. This paper interrogates the impact of academic mobility at the individual level among Chinese scholars who have conducted research visits in Germany. Specifically, the paper operationalises the equivocal notion of personal development with the concepts of capital accumulation and conversion (after Pierre Bourdieu). Drawing upon findings from 64 in-depth interviews with Chinese scholars of postdoctoral level or above and six key informants, and a postal survey (123 Chinese scholars with mobility biography to Germany), this paper illustrates how geographical mobility can be conceptualised as a form of capital that can be accumulated and converted to cultural, social, economic and symbolic capital. While geographical mobility is predominantly considered as a capital for positive self- and professional development, examples also demonstrate the potential detrimental effect on social capital, especially among young Chinese scholars. Using an agent-centred approach, this paper argues against a mechanical translation of geographical mobility to capital accumulation, but for a grounded understanding of the highly individualised and contextualised development processes.
Journal Article
Recombination in Coronaviruses, with a Focus on SARS-CoV-2
Recombination is a common evolutionary tool for RNA viruses, and coronaviruses are no exception. We review here the evidence for recombination in SARS-CoV-2 and reconcile nomenclature for recombinants, discuss their origin and fitness, and speculate how recombinants could make a difference in the future of the COVID-19 pandemics.
Journal Article