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IVF is a widely-used assisted reproductive technology with a consistent success rate of around 30%, and improving this rate is crucial due to emotional, financial, and health-related implications for infertile couples. This study aimed to develop a model for predicting IVF outcome by comparing five machine-learning techniques. The research approached five prominent machine learning algorithms, including Random Forest, Artificial Neural Network (ANN), Support Vector Machine (SVM), Recursive Partitioning and Regression Trees (RPART), and AdaBoost, in the context of IVF success prediction. The study also incorporated GA as a feature selection method to enhance the predictive models' robustness. Findings demonstrate that AdaBoost, particularly when combined with GA feature selection, achieved the highest accuracy rate of 89.8%. Using GA, Random Forest also demonstrated strong performance, achieving an accuracy rate of 87.4%. Genetic Algorithm significantly improved the performance of all classifiers, emphasizing the importance of feature selection. Ten crucial features, including female age, AMH, endometrial thickness, sperm count, and various indicators of oocyte and embryo quality, were identified as key determinants of IVF success. These findings underscore the potential of machine learning and feature selection techniques to assist IVF clinicians in providing more accurate predictions, enabling tailored treatment plans for each patient. Future research and validation can further enhance the practicality and reliability of these predictive models in clinical IVF practice.

Nowadays, retinal optical coherence tomography (OCT) plays an important role in ophthalmology and automatic analysis of the OCT is of real importance: image denoising facilitates a better diagnosis and image segmentation and classification are undeniably critical in treatment evaluation. Synthetic OCT was recently considered to provide a benchmark for quantitative comparison of automatic algorithms and to be utilized in the training stage of novel solutions based on deep learning. Due to complicated data structure in retinal OCTs, a limited number of delineated OCT datasets are already available in presence of abnormalities; furthermore, the intrinsic three-dimensional (3D) structure of OCT is ignored in many public 2D datasets. We propose a new synthetic method, applicable to 3D data and feasible in presence of abnormalities like diabetic macular edema (DME). In this method, a limited number of OCT data is used during the training step and the Active Shape Model is used to produce synthetic OCTs plus delineation of retinal boundaries and location of abnormalities. Statistical comparison of thickness maps showed that synthetic dataset can be used as a statistically acceptable representative of the original dataset ( p  > 0.05). Visual inspection of the synthesized vessels was also promising. Regarding the texture features of the synthesized datasets, Q-Q plots were used, and even in cases that the points have slightly digressed from the straight line, the p -values of the Kolmogorov–Smirnov test rejected the null hypothesis and showed the same distribution in texture features of the real and the synthetic data. The proposed algorithm provides a unique benchmark for comparison of OCT enhancement methods and a tailored augmentation method to overcome the limited number of OCTs in deep learning algorithms. Graphical abstract

Schizophrenia, a complex psychotic condition, is challenging to diagnose due to its reliance on clinical assessments and behavioral evaluations. Neuroimaging studies, particularly structural MRI, have revealed reductions in grey matter volume in brain regions such as the temporal lobe and insula. This study combines deep learning and neuroimaging for precise automatic detection of schizophrenia. Using T1-weighted coronal MRI data from three publicly accessible datasets (MCICShare, COBRE, UCLA), a DeepLabv3+ model with ResNet50-based segmentation was employed to isolate the temporal lobe and insula, achieving segmentation accuracies of 96% and 97%, respectively. Enhanced visualization of isolated regions through color-to-grayscale conversion distinguished schizophrenia patients from controls, achieving an AUC of 0.99. Our study specifically focuses on the regions critically linked to both cognitive and emotional dysfunctions in schizophrenia. These results advance the literature by demonstrating improved diagnostic performance and reliability compared to traditional clinical assessments and earlier imaging-based methods.

Background Emotion recognition is an increasingly important field of research in brain computer interactions. Introduction With the advance of technology, automatic emotion recognition systems no longer seem far-fetched. Be that as it may, detecting neural correlates of emotion has remained a substantial bottleneck. Settling this issue will be a breakthrough of significance in the literature. Methods The current study aims to identify the correlations between different emotions and brain regions with the help of suitable electrodes. Initially, independent component analysis algorithm is employed to remove artifacts and extract the independent components. The informative channels are then selected based on the thresholded average activity value for obtained components. Afterwards, effective features are extracted from selected channels common between all emotion classes. Features are reduced using the local subset feature selection method and then fed to a new classification model using modified Dempster-Shafer theory of evidence. Results The presented method is employed to DEAP dataset and the results are compared to those of previous studies, which highlights the significant ability of this method to recognize emotions through electroencephalography, by the accuracy of about 91%. Finally, the obtained results are discussed and new aspects are introduced. Conclusions The present study addresses the long-standing challenge of finding neural correlates between human emotions and the activated brain regions. Also, we managed to solve uncertainty problem in emotion classification which is one of the most challenging issues in this field. The proposed method could be employed in other practical applications in future.

Brain computer interface (BCI) systems have been regarded as a new way of communication for humans. In this research, common methods such as wavelet transform are applied in order to extract features. However, genetic algorithm (GA), as an evolutionary method, is used to select features. Finally, classification was done using the two approaches support vector machine (SVM) and Bayesian method. Five features were selected and the accuracy of Bayesian classification was measured to be 80% with dimension reduction. Ultimately, the classification accuracy reached 90.4% using SVM classifier. The results of the study indicate a better feature selection and the effective dimension reduction of these features, as well as a higher percentage of classification accuracy in comparison with other studies.

PurposeThe length of stay (LOS) in hospitals is a widely used indicator for goals such as health care management, quality control, utilizing hospital services and resources, and determining the degree of efficiency. Various methods have been used to identify the factors influencing the LOS. This study adopts a comparative approach of data mining techniques for investigating effective factors and predict the length of stay in Shahid-Mohammadi Hospital, Bandar Abbas, Iran.MethodsUsing a dataset consists of 526 patient records of the Shahid-Mohammadi Hospital from March 2016 to March 2017, factors affecting the LOS were ranked using information gain and correlation indices. In addition, classification models for LOS prediction were created based on nine data mining classifiers applied with and without feature selection technique. Finally, the models were compared.ResultsThe most important factors affecting LOS are the number of para-clinical services, counseling frequency, clinical ward, the specialty and the degree of the doctor, and the cause of hospitalization. In addition, regarding to the classifiers created based on the dataset, the best accuracy (83.91%) and sensitivity (80.36%) belongs to the Logistic Regression and Naïve Bayes respectively. In addition, the best AUC (0.896) belongs to the Random Forest and Generalized Linear classifiers.ConclusionThe results showed that most of the proposed models are suitable for classification of the length of stay, although the Logistic Regression might have a slightly better performance than others in term of accuracy, and this model can be used to determine the patients’ Length of Stay. In general, continuous monitoring of the factors influencing each of the performance indicators based on proper and accurate models in hospitals is important for helping management decisions.

PurposeMammography plays a key role in the diagnosis of breast cancer; however, decision-making based on mammography reports is still challenging. This paper aims to addresses the challenges regarding decision-making based on mammography reports and propose a Clinical Decision Support System (CDSS) using data mining methods to help clinicians to interpret mammography reports.MethodsFor this purpose, 2441 mammography reports were collected from Imam Khomeini Hospital from March 21, 2018, to March 20, 2019. In the first step, these mammography reports are analyzed and program code is developed to transform the reports into a dataset. Then, the weight of every feature of the dataset is calculated. Random Forest, Naïve Bayes, K-nearest neighbor (K-NN), Deep Learning classifiers are applied to the dataset to build a model capable of predicting the need for referral to biopsy. Afterward, the models are evaluated using cross-validation with measuring Area Under Curve (AUC), accuracy, sensitivity, specificity indices.ResultsThe mammography type (diagnostic or screening), mass and calcification features mentioned in the reports are the most important features for decision-making. Results reveal that the K-NN model is the most accurate and specific classifier with the accuracy and specificity values of 84.06% and 84.72% respectively. The Random Forest classifier has the best sensitivity and AUC with the sensitivity and AUC values of 87.74% and 0.905 respectively.ConclusionsAccordingly, data mining approaches are proved to be a helpful tool to make the final decision as to whether patients should be referred to biopsy or not based on mammography reports. The developed CDSS may also be helpful especially for less experienced radiologists.

Among neurological patients, stroke is the most common cause of mortality. It is a health problem that is very costly all over the world. Therefore, the mortality due to the disease can be reduced by identifying and modifying the risk factors. Controllable factors which are contributing to stroke including hypertension, diabetes, heart disease, hyperlipidemia, smoking, and obesity. Therefore, by identifying and controlling the risk factors, stroke can be prevented and the effects of this disease could be reduced to a minimum. Therefore, for the quick and timely diagnosis of the disease, we need an intelligent system to predict the stroke risk. In this paper, a method has been proposed for predicting the risk rate of stroke which is based on fuzzy cognitive maps and nonlinear Hebbian learning algorithm. The accuracy of the proposed NHL-FCM model is tested using 15-fold cross-validation, for 90 actual cases, and compared with those of support vector machine and k-nearest neighbours. The proposed method shows superior performance with a total accuracy of (95.4 ± 7.5)%.

Convolutional Neural Networks (CNN) have recently made considerable advances in the field of biomedical signal processing. These methodologies can assist in emotion recognition for affective brain computer interface. In this paper, a novel emotion recognition system based on the effective connectivity and the fine-tuned CNNs from multichannel Electroencephalogram (EEG) signal is presented. After preprocessing EEG signals, the relationships among 32 channels of EEG in the form of effective brain connectivity analysis which represents information flow between regions are computed by direct Directed Transfer Function (dDTF) method which yields a 32*32 image. Then, these constructed images from EEG signals for each subject were fed as input to four versions of pre-trained CNN models, AlexNet, ResNet-50, Inception-v3 and VGG-19 and the parameters of these models are fine-tuned, independently. The proposed deep learning architectures automatically learn patterns in the constructed image of the EEG signals in frequency bands. The efficiency of the proposed approach is evaluated on MAHNOB-HCI and DEAP databases. The experiments for classifying five emotional states show that the ResNet-50 applied on dDTF images in alpha band achieves best results due to specific architecture which captures the brain connectivity, efficiently. The accuracy and F1-score values for MAHNOB-HCI were obtained 99.41, 99.42 and for DEAP databases, 98.17, and 98.23. Newly proposed model is capable of effectively analyzing the brain function using information flow from multichannel EEG signals using effective connectivity measure of dDTF and ResNet-50.