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Three-dimensional throughflow models represent a turbomachinery cascade via a force distribution without the need for detailed geometric modelling in the numerical solution, saving consistent computational resources. In this paper, we present the application of a body force method on an axial transonic fan implemented into an in-house tool for axisymmetric throughflow simulations. By a systematic comparison of local and integral quantities with a validated numerical solution, the capabilities and limitations of the model are discussed for different operating regimes. The implementation is first validated at the peak efficiency calibration point, providing a good duplication of blade flow variables and radial profiles. The design total pressure is matched with a 0.6% absolute difference and a slightly higher slope of the characteristic towards the stall. The isentropic efficiency curve is penalised after the choking mass flow rate calibration, presenting an absolute difference close to 2%, although with a consistent off-design trend. In general, the model provides a satisfactory representation of the flow field and the outflow spanwise distributions, with locally larger discrepancies near the endwalls. Finally, the method is applied to simulate the fan and outlet guide vanes installed into an isolated turbofan nacelle. The onset of intake stall at a high angle of attack is compared between the body force and a boundary conditions-based approaches, highlighting the importance of adopting fully coupled solution methods to study fan/airframe interaction problems.

Low pressure ratio fans of modern civil turbofans suffer from reduced stall margin in the take-off operating line and at part-speed, requiring variable geometry devices. Variable area nozzles (VAN) are one of the investigated solutions to control engine operating conditions throughout the mission. In this paper, we present a multi-fidelity modelling approach for an ultra-high bypass ratio turbofan engine with a VAN, combining a zero-dimensional thermodynamic cycle simulator using a realistic fan map with two- and three-dimensional detailed computational fluid dynamics (CFD) simulations for internal/external flow coupling. By adopting a novel algorithm to match the cycle conditions to the CFD solutions, the propulsive performance of the turbofan is analysed in a reference aircraft mission. The numerical method captures the effect on thrust generation and nacelle drag, providing a more reliable estimation of the impact of VAN on engine operation and efficiency. Low-speed mission points are confirmed to be those that benefit the most from an enlarged fan nozzle area, with a possible improvement of 3% in terms of thrust and specific fuel consumption at take-off and approach using a 10% larger area, similarly predicted by both 2D and 3D models. A preliminary acoustic evaluation based on semi-empirical noise models indicates a modest effect on noise emissions, with up to 1 dB reduction in microphone signature at the sideline for a nozzle area increased by 10%.

Background. Reported cases of vitamin D3 deficiency have been increasing in incidence worldwide. Although there is a lack of consensus relating to optimal levels of vitamin D, generally serum 25-(OH)D concentrations lower than 50 nmol/L (20 ng/mL) are at least considered to be detrimental to bone health. Aim. Aim of this systematic review is to investigate if occupations, and specifically shiftworking and indoor working, may be considered as possible contributors to the increased incidence of vitamin D3 deficiency in industrialized nations. Materials and Methods. Systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement using PubMed, Scopus, and ISI Web of Knowledge databases. Results. Overall 90 papers were found, 23 articles through PubMed, 30 through Scopus, and 37 through ISI Web of Knowledge. Successively, 46 duplicates and 34 articles that did not respect the inclusion criteria were excluded. Finally 10 articles were selected: 9 cross-sectional studies and 1 systematic review. Results of the studies included revealed that certain occupations are either suffering from, or have a predilection to suffer from, a deficiency of this vitamin. Shiftworkers and indoor workers are consistently reported as being the occupational group most likely to suffer from a deficiency of vitamin D3. It would appear prudent to investigate the potential of providing nutritional education to workers in addition to including preventative measures in the workplace.

Lactoferrin (Lf), a multifunctional cationic glycoprotein synthesized by exocrine glands and neutrophils, possesses an in vitro antiviral activity against SARS-CoV-2. Thus, we conducted an in vivo preliminary study to investigate the antiviral effect of oral and intranasal liposomal bovine Lf (bLf) in asymptomatic and mild-to-moderate COVID-19 patients. From April 2020 to June 2020, a total of 92 mild-to-moderate (67/92) and asymptomatic (25/92) COVID-19 patients were recruited and divided into three groups. Thirty-two patients (14 hospitalized and 18 in home-based isolation) received only oral and intranasal liposomal bLf; 32 hospitalized patients were treated only with standard of care (SOC) treatment; and 28, in home-based isolation, did not take any medication. Furthermore, 32 COVID-19 negative, untreated, healthy subjects were added for ancillary analysis. Liposomal bLf-treated COVID-19 patients obtained an earlier and significant (p < 0.0001) SARS-CoV-2 RNA negative conversion compared to the SOC-treated and untreated COVID-19 patients (14.25 vs. 27.13 vs. 32.61 days, respectively). Liposomal bLf-treated COVID-19 patients showed fast clinical symptoms recovery compared to the SOC-treated COVID-19 patients. In bLf-treated patients, a significant decrease in serum ferritin, IL-6, and D-dimers levels was observed. No adverse events were reported. These observations led us to speculate a potential role of bLf in the management of mild-to-moderate and asymptomatic COVID-19 patients.

Lactoferrin (Lf) is a cationic glycoprotein synthetized by exocrine glands and is present in all human secretions. It is also secreted by neutrophils in infection and inflammation sites. This glycoprotein possesses antimicrobial activity due to its capability to chelate two ferric ions per molecule, as well as to interact with bacterial and viral anionic surface components. The cationic features of Lf bind to cells, protecting the host from bacterial and viral injuries. Its anti-inflammatory activity is mediated by the ability to enter inside the nucleus of host cells, thus inhibiting the synthesis of proinflammatory cytokine genes. In particular, Lf down-regulates the synthesis of IL-6, which is involved in iron homeostasis disorders and leads to intracellular iron overload, favoring viral replication and infection. The well-known antiviral activity of Lf has been demonstrated against DNA, RNA, and enveloped and naked viruses and, therefore, Lf could be efficient in counteracting also SARS-CoV-2 infection. For this purpose, we performed in vitro assays, proving that Lf exerts an antiviral activity against SARS-COV-2 through direct attachment to both SARS-CoV-2 and cell surface components. This activity varied according to concentration (100/500 μg/ml), multiplicity of infection (0.1/0.01), and cell type (Vero E6/Caco-2 cells). Interestingly, the in silico results strongly supported the hypothesis of a direct recognition between Lf and the spike S glycoprotein, which can thus hinder viral entry into the cells. These in vitro observations led us to speculate a potential supplementary role of Lf in the management of COVID-19 patients.

Most students and researchers with limited funding are often looking for simple and low-cost devices for the acquisition of the electromyogram signal (EMG) in an educational or research setting. Thus, off-the-shelf devices are used and they have already been described in the literature, but they are used without considering their real performances, which are, in general, quite poor from the electronic and signal processing points of view. It is the purpose of this communication to present the evidence of these issues, and to describe an improved version of the “classical” duo, composed of the common ECG/EMG Olimex board and the Arduino microprocessor board. In this case, the Arduino-DUE is used. Three main points are highlighted in this paper: (a) the bandpass characteristics of the ECG/EMG Olimex board and how they can be improved to cope with EMG bandwidth requirements; (b) the increase in sampling frequency of the signal; and, finally, (c) the possibility of automatic detection of more ECG/EMG Olimex boards installed at the same time as the shields on the Arduino-DUE board. Very simple and low-cost modifications on the ECG/EMG Olimex board could deliver a much better performing multichannel EMG acquisition system, suitable for educational classroom experiments and early proof-of-concept research.

The accurate prediction of the aeroelastic behavior of turbomachinery for aircraft propulsion poses a difficult yet fundamental challenge, since modern aircraft engines tend to adopt increasingly slender blades to achieve a higher aerodynamic efficiency, incurring an increased aeroelastic interaction as a drawback. In the present work, we present a reduced order model for flutter prediction in axial compressors. The model exploits the aerodynamic influence coefficients technique with the adoption of a broadband frequency signal to compute the aerodynamic damping for multiple reduced frequencies using a single training simulation. The normalized aerodynamic work is computed for a single oscillation mode at three different vibration frequencies, comparing the outputs of aerodynamic input/output models trained with a chirp signal to those from single-frequency harmonic simulations. The results demonstrate the ability of the adopted model to accurately and efficiently reproduce the aerodynamic damping at multiple frequencies and arbitrary nodal diameters with a single simulation.

Background There is a fundamental gap of knowledge on the health effects caused by the interaction of engineered nanomaterials (ENM) with the gastro-intestinal tract (GIT). This is partly due to the incomplete knowledge of the complex physical and chemical transformations that ENM undergo in the GIT, and partly to the widespread belief that GIT health effects of ENM are much less relevant than pulmonary effects. However, recent experimental findings, considering the role of new players in gut physiology (e.g. the microbiota), shed light on several outcomes of the interaction ENM/GIT. Along with this new information, there is growing direct and indirect evidence that not only ingested ENM, but also inhaled ENM may impact on the GIT. This fact, which may have relevant implications in occupational setting, has never been taken into consideration. This review paper summarizes the opinions and findings of a multidisciplinary team of experts, focusing on two main aspects of the issue: 1) ENM interactions within the GIT and their possible consequences, and 2) relevance of gastro-intestinal effects of inhaled ENMs. Under point 1, we analyzed how luminal gut-constituents, including mucus, may influence the adherence of ENM to cell surfaces in a size-dependent manner, and how intestinal permeability may be affected by different physico-chemical characteristics of ENM. Cytotoxic, oxidative, genotoxic and inflammatory effects on different GIT cells, as well as effects on microbiota, are also discussed. Concerning point 2, recent studies highlight the relevance of gastro-intestinal handling of inhaled ENM, showing significant excretion with feces of inhaled ENM and supporting the hypothesis that GIT should be considered an important target of extrapulmonary effects of inhaled ENM. Conclusions In spite of recent insights on the relevance of the GIT as a target for toxic effects of nanoparticles, there is still a major gap in knowledge regarding the impact of the direct versus indirect oral exposure. This fact probably applies also to larger particles and dictates careful consideration in workers, who carry the highest risk of exposure to particulate matter.

The effect of a novel blade treatment on the performance characteristics of NASA Rotor 37 is investigated numerically in this study. The treatment includes making special holes in the blade and near the tip section. The impact of the treatment on the end-wall flow structure is evaluated and discussed. Furthermore, the influence of the streamwise location and the angle of the holes is investigated. The results reveal that a significant stability enhancement can be achieved by the appropriate design of the hole location and configuration, at the expense of a small degradation in the peak efficiency and pressure ratio. It is shown that the position of the holes should be downstream of the passage shock wave to maximize the operating range of the rotor. In this situation, the shock is sucked back by the hole, which reduces its angle and postpones stall inception. Maximum stability improvement (about 30%) has been obtained for a hole angle equivalent to 75 degrees and a 60% chord location.

Gas turbine fuel burn for an aircraft engine can be obtained analytically using thermodynamic cycle analysis. For large-diameter ultra-high bypass ratio turbofans, the impact of nacelle drag and propulsion system integration must be accounted for in order to obtain realistic estimates of the installed specific fuel consumption. However, simplified models cannot fully represent the complexity of installation effects. In this paper, we present a method that combines thermodynamic cycle analysis with detailed Computational Fluid Dynamics (CFD) modelling of the installation aerodynamics to obtain the fuel consumption at a given mission point. The flow field and propulsive forces arising in a transport aircraft powered by an ultra-high bypass ratio turbofan at cruise are first examined to characterise the operating conditions and measure the sensitivity to variations of the incidence at transonic flight. The proposed methodology, in which dynamic balance of the vehicle is achieved at each integration point, is then applied along a cruise segment to calculate the cumulative fuel burn and the change in the specific fuel consumption.