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Background Abiotic stresses, like drought, are the major cause of shrinking plant, growth crop yields and quality. Nanotechnology has provided a significant improvement in increasing plant growth and yield of crops under stress conditions. This work assessed the potential of silicon for mitigating the negative effects of drought against wheat. In completely randomized design with three replicates, wheat seedlings grown under three watering levels (100, 60 and 40% of water holding capacity) were treated by silicon dioxide (SiO 2 ) as a normal or bulk form (Si) and SiO 2 nanoparticles (SiNPs) with concentrations of 100 and 200 mg L −1 . SiNPs was extracted from rice husk. Results Si and SiNPs treatments are shown to improve the growth of plants and increase the shoots and root weight, relative water content, photosynthetic pigments, and proline in wheat. SiO 2 either normal or nanoparticles at 100 mg L −1 decreased lipid peroxidation as malondialdehyde was reduced. Also, nano-silicon increased free amino acids, antioxidant enzymes while decreased soluble sugars. Cytotoxicity assay proved the safety of nano-silicon usage. Conclusions In conclusion, the present study documented the significance of rice husk-extracted nano-silicon at rate of 100 mg L −1 for improving growth and increasing tolerance to drought in wheat grown under water deficit.

Railway infrastructure plays a critical role in transportation networks, and ensuring its integrity and resilience is of utmost importance. Culverts are vital components of railway tracks, providing drainage and water management to prevent structural damage and disruptions. Identifying suitable locations for culverts requires careful evaluation and consideration of various factors. A study using GIS techniques was conducted on an existing commercial railway track in the Eastern Desert of Upper Egypt to assess the effectiveness of existing culverts in preventing flash floods. The culvert suitability index map revealed that areas with high slopes and large drainage areas were more susceptible to water accumulation, indicating the need for culverts. The study also highlighted areas where culverts could be installed without significantly impacting existing infrastructure. It was recommended to install culverts in 27 locations along the track where they intersect with watercourses. Existing culverts covered just 93 watercourses, while 5 specialized culverts needed to be relocated. The findings have significant implications for railway engineering, as using GIS techniques streamlines the process of culvert location evaluation, saving time and resources. The systematic approach ensures culverts are installed in the most appropriate locations, minimizing flooding risks and ensuring the safety and efficiency of railway operations.

The microstructure of grainstone, grain-supported limestone, samples representing different geographic and stratigraphic intervals in Egypt were examined before and after calcination at 950°C for 0.25, 0.5, 1 and 2 h. The examination utilized are X-ray diffraction (XRD), X-ray fluorescence (XRF), transmitted light microscopy (TLM), scanning electron microscopy (SEM) and X-ray micro tomography (μ-CT). Both the free lime content and reactivity of the produced quicklime were measured. The quicklime produced at 950°C for 0.25 and 0.5 h is un-reactive (R DIN < 10) due to its low content of free lime. However, quicklime produced at 1 and 2 h conditions is highly reactive (R DIN > 30) with variable reactivity due to the differences in the lime microfabric. The grainstones enriched in nummulites resulted in quicklime of higher reactivity than those dominated by foraminifera, peloids and miliolids. This is mainly attributed to the preservation of the intraparticle pores of the original limestone and the development of pinhole and fracture micropores. The shape of pores and not their amount is the main controlling variable in the quicklime reactivity. The grainstones enriched in fracture pores showed more reactive lime, whereas those with compact structures are less reactive post calcination.

ETOPOSIDE and teniposide, two semisynthetic derivatives of podophyllotoxin, have a broad range of antineoplastic activity and have been used widely in the treatment of children and adults with malignant diseases. 1 , 2 Reports appearing over the past four years have implicated these agents in the development of acute myeloid leukemia (AML) in patients treated for solid tumors or acute leukemia of lymphoid origin (ALL). 3 4 5 6 7 8 9 10 In contrast to the myeloid leukemias induced by alkylating agents, 11 cases of leukemia linked to epipodophyllotoxin therapy tend to appear early after diagnosis of the primary tumor (i.e., within six years), to lack a myelodysplastic phase, and to . . .

Pepper originated from the Capsicum genus, which is recognized as one of the most predominant and globally distributed genera of the Solanaceae family. It is a diverse genus, consisting of more than 31 different species including five domesticated species, Capsicum baccatum, C. annuum, C. pubescen, C. frutescens, and C. chinense. Pepper is the most widely used spice in the world and is highly valued due to its pungency and unique flavor. Pepper is a good source of provitamin A; vitamins E and C; carotenoids; and phenolic compounds such as capsaicinoids, luteolin, and quercetin. All of these compounds are associated with their antioxidant as well as other biological activities. Interestingly, Capsicum fruits have been used as food additives in the treatment of toothache, parasitic infections, coughs, wound healing, sore throat, and rheumatism. Moreover, it possesses antimicrobial, antiseptic, anticancer, counterirritant, appetite stimulator, antioxidant, and immunomodulator activities. Capsaicin and Capsicum creams are accessible in numerous ways and have been utilized in HIV-linked neuropathy and intractable pain.

In this study, a set of novel benzoxazole derivatives were designed, synthesised, and biologically evaluated as potential VEGFR-2 inhibitors. Five compounds (12d, 12f, 12i, 12l, and 13a) displayed high growth inhibitory activities against HepG2 and MCF-7 cell lines and were further investigated for their VEGFR-2 inhibitory activities. The most potent anti-proliferative member 12 l (IC 50 = 10.50 μM and 15.21 μM against HepG2 and MCF-7, respectively) had the most promising VEGFR-2 inhibitory activity (IC 50 = 97.38 nM). A further biological evaluation revealed that compound 12l could arrest the HepG2 cell growth mainly at the Pre-G1 and G1 phases. Furthermore, compound 12l could induce apoptosis in HepG2 cells by 35.13%. likely, compound 12l exhibited a significant elevation in caspase-3 level (2.98-fold) and BAX (3.40-fold), and a significant reduction in Bcl-2 level (2.12-fold). Finally, docking studies indicated that 12l exhibited interactions with the key amino acids in a similar way to sorafenib.

Currently, the humanity is in a fierce battle against various health-related challenges especially those associated with human malignancies. This created the urge to develop potent and selective inhibitors for tumor cells through targeting specific oncogenic proteins possessing crucial roles in cancer progression and survive. In this respect, new series of pyrazole-thiazol-4-one hybrids ( 9a–p ) were synthesized as potential anticancer agents. All the synthesized molecules exhibited potent antiproliferative actions against breast cancer (BC) T-47D and MDA-MB-231 cell lines with IC 50 ranges 3.14–4.92 and 0.62–58.01, respectively. Moreover, the most potent anti-proliferative counterparts 9g and 9k were assessed against EGFR. They displayed nanomolar inhibitory activity, IC 50 267 ± 12 and 395 ± 17 nM, respectively. Worth noting, both compounds 9g and 9k induced apoptosis in MDA-MB-231 cells, and resulted in a cell cycle arrest at G2/M phase. Furthermore, an in silico analysis including docking and molecular dynamic simulations was performed.

Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications that usually include colonization by pathogenic bacteria, leading to fever and sepsis, which further impairs and complicates the healing process. So, there is an urgent need to develop a novel pharmaceutical material that promotes the healing of infected wounds. The present work aimed to prepare and evaluate the efficacy of novel azithromycin-loaded zinc oxide nanoparticles (AZM-ZnONPs) in the treatment of infected wounds. The Box–Behnken design and response surface methodology were used to evaluate loading efficiency and release characteristics of the prepared NPs. The minimum inhibitory concentration (MIC) of the formulations was determined against Staphylococcus aureus and Escherichia coli. Moreover, the anti-bacterial and wound-healing activities of the AZM-loaded ZnONPs impregnated into hydroxyl propyl methylcellulose (HPMC) gel were evaluated in an excisional wound model in rats. The prepared ZnONPs were loaded with AZM by adsorption. The prepared ZnONPs were fully characterized by XRD, EDAX, SEM, TEM, and FT-IR analysis. Particle size distribution for the prepared ZnO and AZM-ZnONPs were determined and found to be 34 and 39 nm, respectively. The mechanism by which AZM adsorbed on the surface of ZnONPs was the best fit by the Freundlich model with a maximum load capacity of 160.4 mg/g. Anti-microbial studies showed that AZM-ZnONPs were more effective than other controls. Using an experimental infection model in rats, AZM-ZnONPs impregnated into HPMC gel enhanced bacterial clearance and epidermal regeneration, and stimulated tissue formation. In conclusion, AZM -loaded ZnONPs are a promising platform for effective and rapid healing of infected wounds.