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In the field of beam physics, two frontier topics have taken center stage due to their potential to enable new approaches to discovery in a wide swath of science. These areas are: advanced, high gradient acceleration techniques, and x-ray free electron lasers (XFELs). Further, there is intense interest in the marriage of these two fields, with the goal of producing a very compact XFEL. In this context, recent advances in high gradient radio-frequency cryogenic copper structure research have opened the door to the use of surface electric fields between 250 and 500 MV m−1. Such an approach is foreseen to enable a new generation of photoinjectors with six-dimensional beam brightness beyond the current state-of-the-art by well over an order of magnitude. This advance is an essential ingredient enabling an ultra-compact XFEL (UC-XFEL). In addition, one may accelerate these bright beams to GeV scale in less than 10 m. Such an injector, when combined with inverse free electron laser-based bunching techniques can produce multi-kA beams with unprecedented beam quality, quantified by 50 nm-rad normalized emittances. The emittance, we note, is the effective area in transverse phase space (x, p x /m e c) or (y, p y /m e c) occupied by the beam distribution, and it is relevant to achievable beam sizes as well as setting a limit on FEL wavelength. These beams, when injected into innovative, short-period (1-10 mm) undulators uniquely enable UC-XFELs having footprints consistent with university-scale laboratories. We describe the architecture and predicted performance of this novel light source, which promises photon production per pulse of a few percent of existing XFEL sources. We review implementation issues including collective beam effects, compact x-ray optics systems, and other relevant technical challenges. To illustrate the potential of such a light source to fundamentally change the current paradigm of XFELs with their limited access, we examine possible applications in biology, chemistry, materials, atomic physics, industry, and medicine-including the imaging of virus particles-which may profit from this new model of performing XFEL science.

Metagenome-assembled genomes, or MAGs, can be constructed without pure cultures of microbes. Large-scale efforts to build MAGs have yielded more complete pangenomes (i.e., sets of all genes found in one species). Pangenomes allow us to measure strain variation in gene content, which can strongly affect phenotype. However, because MAGs come from mixed communities, they can contaminate pangenomes with unrelated DNA; how much this impacts downstream analyses has not been studied. Using a metagenomic study of gut microbes in cirrhosis as our test case, we investigate how contamination affects analyses of microbial gene content. Surprisingly, even small, typical amounts of MAG contamination (<5%) result in disproportionately high levels of false positive associations (38%). Fortunately, we show that most contaminants can be automatically flagged and provide a simple method for doing so. Furthermore, applying this method reveals a new association between cirrhosis and gut microbial motility.

The use of a periodic electron beam bunch train to resonantly excite plasma wakefields in the quasinonlinear (QNL) regime has distinct advantages over employing a single, higher charge bunch. Resonant QNL excitation can produce plasma electron blowout using a small charge per pulse if the beam emittance beams are very low. The local density perturbation in such a case is extremely nonlinear, achieving total rarefaction, yet the resonant response of the plasma electrons at the plasma frequency is preserved. The needed electron beam pulse train with interbunch spacing equal to the plasma period can be produced via inverse free-electron laser bunching. As such, in achieving resonance with a laser wavelength of a few microns, a high plasma density is employed, with the attendant possibility of obtaining extremely large wakefield amplitudes, near1TV/mfor FACET-II parameters. In this article, we use particle-in-cell (PIC) simulations to study the plasma response, the beam evolution including density modulation, and the instabilities encountered when using a bunched-beam scheme to resonantly excite waves in a dense plasma.

Undulators and wigglers based on Halbach arrays have been in widespread use since their description in the 1980s, due to the high fields they generate from permanent magnets. The most common implementation of a pure permanent magnet Halbach undulator consists of four magnetic segment widths per undulator period. In typical undulators with periods of order∼cmit is straightforward to use sufficiently small magnetic segments to achieve the desired undulator period. However, in the context of new microundulators with periods of order∼mmor shorter, there is a lower bound on the feature sizes achievable by existing fabrication techniques. This motivates the use of modified Halbach arrays comprised of right triangle magnet segments with only two magnet segment widths per undulator period. These configurations are demonstrated to have superior field strengths to up-down arrays with no increase to the undulator period. Additional considerations arising from the broken symmetries in such configurations, such as the presence of previously forbidden harmonic components, are also considered. Such right triangle Halbach arrays may be fabricated using MEMS techniques for use in the next generation of compact light sources.

The production of high spectral brilliance radiation from electron beam sources depends critically on the electron beam qualities. One must obtain very high electron beam brightness, implying simultaneous high peak current and low emittance. These attributes are enabled through the use of very high field acceleration in a radio-frequency (rf) photoinjector source. Despite the high fields currently utilized, there is a limit on the achievable peak current in high brightness operation, in the range of tens of Ampere. This limitation can be overcome by the use of a hybrid standing wave/traveling wave structure; the standing wave portion provides acceleration at a high field from the photocathode, while the traveling wave part yields strong velocity bunching. This approach is explored here in a C-band scenario, at field strengths (>100MV/m) at the current state-of-the-art. It is found that one may arrive at an electron beam with many hundreds of Amperes with well-sub-micron normalized emittance. This extremely compact injector system also possesses attractive simplification of the rf distribution system by eliminating the need for an rf circulator. We explore the use of this device in a compact 400 MeV-class source, driving both inverse Compton scattering and free-electron laser radiation sources with unique, attractive properties.

We report the development of a multileaf collimator (MLC) for charged particle beams, based on independently actuated tungsten strips that can selectively scatter unwanted particles. The MLC is used in conjunction with an emittance exchange beamline to rapidly generate highly variable longitudinal bunch profiles. The developed MLC consists of 40 independent leaves that are 2 mm wide and can move up to 10 mm and operates in an ultrahigh vacuum environment, enabled by novel features such as magnetically coupled actuation. An experiment at the Argonne Wakefield Accelerator, which previously used inflexible, laser-cut masks for beam shaping before an emittance exchange beamline, was conducted to test functionality. The experiment demonstrated myriad transverse mask silhouettes, as measured on a scintillator downstream of the MLC, and the corresponding longitudinal profiles after emittance exchange, as measured using a transverse-deflecting cavity. Rapidly changing between mask shapes enables expeditious execution of various experiments without the downtime associated with traditional methods. The many degrees of freedom of the MLC can enable the optimization of experimental figures of merit using feed-forward control and advanced machine learning methods.

The luminosity requirements of TeV-class linear colliders demand use of intense charged beams at high repetition rates. Such features imply multi-bunch operation with long current trains accelerated over the km length scale. Consequently, particle beams are exposed to the mutual parasitic interaction due to the long-range wakefields excited by the leading bunches in the accelerating structures. Such perturbations to the motion induce transverse oscillations of the bunches, potentially leading to instabilities such as transverse beam break-up. Here we present a dedicated tracking code that studies the effects of long-range transverse wakefield interaction among different bunches in linear accelerators. Being described by means of an efficient matrix formalism, such effects can be included while preserving short computational times. As a reference case, we use our code to investigate the performance of a state-of-the-art linear collider currently under design and, in addition, we discuss possible mitigation techniques based on frequency detuning and damping.

Inverse Compton scattering (ICS) is a unique mechanism for producing fast pulses—picosecond and below—of bright photons, ranging from x to γ rays. These nominally narrow spectral bandwidth electromagnetic radiation pulses are efficiently produced in the interaction between intense, well-focused electron and laser beams. The spectral characteristics of such sources are affected by many experimental parameters, with intense laser effects often dominant. A laser field capable of inducing relativistic oscillatory motion may give rise to harmonic generation and, importantly for the present work, nonlinear redshifting, both of which dilute the spectral brightness of the radiation. As the applications enabled by this source often depend sensitively on its spectra, it is critical to resolve the details of the wavelength and angular distribution obtained from ICS collisions. With this motivation, we present an experimental study that greatly improves on previous spectral measurement methods based on x-ray K -edge filters, by implementing a multilayer bent-crystal x-ray spectrometer. In tandem with a collimating slit, this method reveals a projection of the double differential angular-wavelength spectrum of the ICS radiation in a single shot. The measurements enabled by this diagnostic illustrate the combined off-axis and nonlinear-field-induced redshifting in the ICS emission process. The spectra obtained illustrate in detail the strength of the normalized laser vector potential, and provide a nondestructive measure of the temporal and spatial electron-laser beam overlap.

A study of the optimization of iron dominated dipole magnets with pole face widths comparable or less than the gap size, i.e., low aspect ratio (AR), is conducted using both theoretical and computational approaches. This regime of magnet design is particularly relevant in the context of laser plasma accelerators (LPA) due to unique beam parameters and geometric constraints, namely large energy spreads and the requirement for large apertures to accommodate drive laser passage. The breakdown of commonly employed approximations and rules of thumb in typicalAR≫1magnet design is examined. A library of generalized, optimized pole face geometries is provided to expedite optimization of future magnets. Finally, this methodology is used to design an electromagnetic chicane which has been fabricated, validated, and is currently in use in an x-ray free electron laser driven LPA experiment at LBNL.

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