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"Malinowski, M"
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Cascaded multilevel converters in recent research and applications
Multilevel converters have been intensively investigated and developed since 1960s and have found successful industrial applications. The aim of this paper is to present state of the art as well as recent research and applications of cascaded multilevel converters, which are a very interesting solution for power distribution systems and renewable energy sources. Cascaded multilevel converters can easily operate at medium and high voltage based on the series connection of power modules (cells), which use standard low-voltage component configurations. Series connections of modules (cells) allow for high quality output voltages and input currents, reduction of passive components and availability of component redundancy. Due to these features the cascaded multilevel converters have been recognized as attractive solutions for high-voltage direct-current (HVDC) transmission, solid state transformers (SST) and photovoltaic (PV) systems.
Journal Article
Transcurrent nature of the Teisseyre–Tornquist Zone in Central Europe: results of the POLCRUST-01 deep reflection seismic profile
Teisseyre–Tornquist Zone (TTZ) corresponds to a crustal boundary between the Precambrian East European Platform (EEP) and the Palaeozoic West European Platform. Although the zone has been controlling Phanerozoic evolution of large parts of Central Europe, its course, geometry and origin are still poorly constrained. Deep reflection seismic profile POLCRUST-01, recently acquired in SE Poland, for the first time allowed a precise comparison of the Ediacaran and later tectonic patterns to the deep crustal features of the TTZ and adjacent areas. The TTZ corresponds to the subvertical Tomaszów Fault separating the Radom–Kraśnik Elevation, composed of the typical EEP crust, from the Biłgoraj–Narol Block (BNB) in the SW, with a thinned crystalline basement showing affinities to the EEP crust. The BNB is a part of the larger Caledonian Łysogóry Terrane as evidenced by its Lower Palaeozoic stratigraphy and gravity data. Thus, for the first time, the proximal Baltican affinity of this unit has been documented unambiguously. The Łysogóry Terrane is delimited from the SW by the subvertical Cieszanów Fault Zone, corresponding to the Holy Cross Suture. The adjacent Małopolska Terrane is characterized by a distinct Early Palaeozoic stratigraphy, and lower-middle crust exhibiting SW-dipping reflective packages interpreted as NE-verging thrust and shear zones of a Neoproterozoic orogen. The observations from the POLCRUST-01 profile and regional comparisons indicate that the TTZ is a major Caledonian transcurrent zone between Poland and East Romania. In central Poland, the TTZ likely forms a narrow subvertical contact between the EEP and a proximal Kuiavia Terrane, as constrained by the deep refraction seismic data. To the NW, the zone extends towards the Pomeranian part of the Caledonide fold-and-thrust belt related to the Avalonia–Baltica collision zone (Thor Suture). South-east of Poland the TTZ corresponds to the Rava Ruska Fault Zone established as a Caledonian suture separating adjacent terrane, probably of a Baltican affinity. The East Romanian part of the TTZ conforms with the Sfântu Gheorghe Fault separating reworked EEP crust of the Pre-Dobrogean Depression from the North Dobrogea unit bearing a strong Variscan and Cimmerian overprint.
Journal Article
Nickelodeon pandemonium! 3, Receiving you loud and clear
\"Calling all Nickelodeon fans! Calling all Nickelodeon fans! All-new comics featuring Nickelodeon's craziest characters are here! Join the Breadwinners, Sanjay and Craig, Harvey Beaks, Pig, Goat, Banana, Cricket, and the residents of The Loud House as they cause all sorts of Pandemonium in true Nickelodeon style!\"-- Amazon.com.
Book
Automating long-term glacier dynamics monitoring using single-station seismological observations and fuzzy logic classification: a case study from Spitsbergen
Retreating glaciers are a consequence of a warming climate. Thus, numerous monitoring campaigns are being carried out to increase understanding of this on-going process. One phenomenon related to dynamic glacial changes is glacier-induced seismicity; however, weak seismic events are difficult to record due to the sparse seismological network in arctic areas. We have developed an automatic procedure capable of detecting glacier-induced seismic events using records from a single permanent seismological station. To distinguish between glacial and non-glacial signals, we developed a fuzzy logic algorithm based on the signal frequency and energy flow analysis. We studied the long-term changes in glacier-induced seismicity in Hornsund (southern Spitsbergen) and in Kongsfjorden (western Spitsbergen). We found that the number of detected glacial-origin events in the Hornsund dataset over the years 2013-14 has doubled. In the Kongsfjorden dataset, we observed a steady increase in the number of glacier-induced events with each year. We also observed that the seasonal event distribution correlates best with 1 month lagged temperatures, and that extreme rain events can intensify seismic emissions. Our study demonstrates the possibility of using long-term seismological observations from a single permanent station to automatically monitor the dynamic activity of nearby glaciers and retrieve its characteristic features.
Journal Article
The Integration of Veterinary Medicine and Behavioral Management in the Care of Captive Pigtail Macaques (Macaca nemestrina)
The Washington National Primate Research Center (WaNPRC) maintains the largest domestic breeding colony of pigtail macaques (Macaca nemestrina) in the United States, with animals housed in small to medium-sized social groups. As part of the animal care plan, a programmatic framework is utilized, which integrates clinical care with socialization considerations for nonhuman primates (NHPs). This framework encompasses the following areas: (1) socialization in the clinical setting; (2) positive reinforcement training (PRT); (3) measures to ensure proper identification and medication distribution; and (4) in-group treatments. The success of this framework is demonstrated by the high socialization rate for hospitalized animals (99.5% social pairing success), with the majority of clinical cases (95%) being treated in social groups. Ultimately, this framework seeks to buffer stressors when animals require clinical care or husbandry manipulations. Taken together, the above components foster an environment that provides a comprehensive approach to NHP medical and behavioral management.
Journal Article
Real-Time insight into in vivo redox status utilizing hyperpolarized 1-13C N-acetyl cysteine
Drastic sensitivity enhancement of dynamic nuclear polarization is becoming an increasingly critical methodology to monitor
real-time
metabolic and physiological information in chemistry, biochemistry, and biomedicine. However, the limited number of available hyperpolarized
13
C probes, which can effectively interrogate crucial metabolic activities, remains one of the major bottlenecks in this growing field. Here, we demonstrate [1-
13
C]
N
-acetyl cysteine (NAC) as a novel probe for hyperpolarized
13
C MRI to monitor glutathione redox chemistry, which plays a central part of metabolic chemistry and strongly influences various therapies. NAC forms a disulfide bond in the presence of reduced glutathione, which generates a spectroscopically detectable product that is separated from the main peak by a 1.5 ppm shift. In vivo hyperpolarized MRI in mice revealed that NAC was broadly distributed throughout the body including the brain. Its biochemical transformation in two human pancreatic tumor cells in vitro and as xenografts differed depending on the individual cellular biochemical profile and microenvironment in vivo. Hyperpolarized NAC can be a promising non-invasive biomarker to monitor in vivo redox status and can be potentially translatable to clinical diagnosis.
Journal Article
Tricuspid valve leaflet strains in the beating ovine heart
The tricuspid leaflets coapt during systole to facilitate proper valve function and, thus, ensure efficient transport of deoxygenated blood to the lungs. Between their open state and closed state, the leaflets undergo large deformations. Quantification of these deformations is important for our basic scientific understanding of tricuspid valve function and for diagnostic or prognostic purposes. To date, tricuspid valve leaflet strains have never been directly quantified in vivo. To fill this gap in our knowledge, we implanted four sonomicrometry crystals per tricuspid leaflet and six crystals along the tricuspid annulus in a total of five sheep. In the beating ovine hearts, we recorded crystal coordinates alongside hemodynamic data. Once recorded, we used a finite strain kinematic framework to compute the temporal evolutions of area strain, radial strain, and circumferential strain for each leaflet. We found that leaflet strains were larger in the anterior leaflet than the posterior and septal leaflets. Additionally, we found that radial strains were larger than circumferential strains. Area strains were as large as 97% in the anterior leaflet, 31% in the posterior leaflet, and 31% in the septal leaflet. These data suggest that tricuspid valve leaflet strains are significantly larger than those in the mitral valve. Should our findings be confirmed they could suggest either that the mechanobiological equilibrium of tricuspid valve resident cells is different than that of mitral valve resident cells or that the mechanotransductive apparatus between the two varies. Either phenomenon may have important implications for the development of tricuspid valve-specific surgical techniques and medical devices.
Journal Article
Deep amoA amplicon sequencing reveals community partitioning within ammonia-oxidizing bacteria in the environmentally dynamic estuary of the River Elbe
The community composition of betaproteobacterial ammonia-oxidizing bacteria (ß-AOB) in the River Elbe Estuary was investigated by high throughput sequencing of ammonia monooxygenase subunit A gene (
amoA
) amplicons. In the course of the seasons surface sediment samples from seven sites along the longitudinal profile of the upper Estuary of the Elbe were investigated. We observed striking shifts of the ß-AOB community composition according to space and time. Members of the
Nitrosomonas oligotropha
-lineage and the genus
Nitrosospira
were found to be the dominant ß-AOB within the river transect, investigated. However, continuous shifts of balance between members of both lineages along the longitudinal profile were determined. A noticeable feature was a substantial increase of proportion of
Nitrosospira
-like sequences in autumn and of sequences affiliated with the
Nitrosomonas marina
-lineage at downstream sites in spring and summer. Slightly raised relative abundances of sequences affiliated with the
Nitrosomonas europaea/Nitrosomonas mobilis
-lineage and the
Nitrosomonas communis
-lineage were found at sampling sites located in the port of Hamburg. Comparisons between environmental parameters and AOB-lineage (ecotype) composition revealed promising clues that processes happening in the fluvial to marine transition zone of the Elbe estuary are reflected by shifts in the relative proportion of ammonia monooxygenase sequence abundance, and hence, we propose ß-AOB as appropriate indicators for environmental dynamics and the ecological condition of the Elbe Estuary.
Journal Article