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ماعت : فلسفة العدالة في مصر القديمة
يتناول كتاب (ماعت : فلسفة العدالة في مصر القديمة) والذي قام بتأليفه (أنا مانسيني) في حوالي (139) صفحة من القطع المتوسط موضوع (الفلسفة المصرية القديمة) مستعرضا المحتويات التالية : الفصل الأول : العدالة المصرية من خلال علم المصريات، الفصل الثاني : الرمز كوسيلة للدخول إلى عالم ما قبل المنطق، الفصل الثالث : الاقتراب الأكثر واقعية من المشهد يتيح إمكانية استخدام العدالة (55-84)، الفصل الرابع : عدالة تضئ الحضارة المصرية (85-106).
BOOK
Mental health and psychosocial support strategies in highly contagious emerging disease outbreaks of substantial public concern: A systematic scoping review
Acute disease outbreaks such as the COVID-19 pandemic cause a high burden of psychological distress in people worldwide. Interventions to enable people to better cope with such distress should be based on the best available evidence. We therefore performed a scoping review to systematically identify and summarize the available literature of interventions that target the distress of people in the face of highly contagious disease outbreaks.
MEDLINE, Cochrane CENTRAL, Web of Science (January 2000 to May 7, 2020), and reference lists were systematically searched and screened by two independent reviewers. Quantitative and qualitative studies investigating the effects of psychological interventions before, during, and after outbreaks of highly contagious emerging infectious diseases, such as SARS, MERS, Ebola, or COVID-19 were included. Study effects were grouped (e.g. for healthcare professionals, community members, people at risk) and intervention contents at the individual and organizational level summarized. We assessed the level of evidence using a modified scheme from the Oxford Centre for Evidence-based Medicine and the Australian National Health and Medical Research Council.
Of 4030 records found, 19 studies were included (two RCTs). Most interventions were delivered during-exposure and face-to-face, focused on healthcare workers and crisis personnel, and combined psychoeducation with training of coping strategies. Based on two high-quality studies, beneficial effects were reported for resilience factors (e.g. positive cognitive appraisal) and professional attitudes of healthcare workers, with mixed findings for mental health (e.g. depression). Across all studies, there was positive qualitative feedback from participants and facilitators. We identified seven ongoing studies mostly using online- and mobile-based deliveries.
There is preliminary evidence for beneficial effects of interventions to enable people to better cope with the distress of highly contagious emerging disease outbreaks. Besides the need for more high-quality studies, the summarized evidence may inform decision makers to plan interventions during the current pandemic and to develop pandemic preparedness plans.
Journal Article
X-Ray and Ultraviolet Emission of the Young Planet-hosting Star V1298 Tau from Coordinated Observations with XMM-Newton and Hubble Space Telescope
Atmospheric mass loss plays a major role in the evolution of exoplanets. This process is driven by the stellar high-energy irradiation, especially in the first hundreds of millions of years after dissipation of the proto-planetary disk. A major source of uncertainty in modeling atmospheric photoevaporation and photochemistry is due to the lack of direct measurements of the stellar flux at extreme-UV (EUV) wavelengths. Several empirical relationships have been proposed in the past to link EUV fluxes to emission levels in X-rays, but the stellar samples employed for this aim are heterogeneous, and the available scaling laws provide significantly different predictions, especially for very active stars. We present new far-UV and X-ray observations of V1298 Tau with Hubble Space Telescope/Cosmic Origins Spectrograph and XMM-Newton, aimed to determine more accurately the high-energy emission of this solar-mass pre-main-sequence star, which hosts four exoplanets. Spectroscopic data were employed to derive the plasma emission measure distribution versus temperature, from the chromosphere to the corona, and the possible variability of this irradiation on short and year-long timescales, due to magnetic activity. As a side result, we have also measured the chemical abundances of several elements in the outer atmosphere of V1298 Tau. We employ our results as a new benchmark point for the calibration of the X-ray to EUV scaling laws, and hence to predict the time evolution of the irradiation in the EUV band, and its effect on the evaporation of exo-atmospheres.
Journal Article
Apparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis
ObjectivesTo investigate if quantitative apparent diffusion coefficient (ADC) measurements can predict genetic subtypes of non-gadolinium-enhancing gliomas, comparing whole tumour against single slice analysis.MethodsVolumetric T2-derived masks of 44 gliomas were co-registered to ADC maps with ADC mean (ADCmean) calculated. For the slice analysis, two observers placed regions of interest in the largest tumour cross-section. The ratio (ADCratio) between ADCmean in the tumour and normal appearing white matter was calculated for both methods.ResultsIsocitrate dehydrogenase (IDH) wild-type gliomas showed the lowest ADC values throughout (p < 0.001). ADCmean in the IDH-mutant 1p19q intact group was significantly higher than in the IDH-mutant 1p19q co-deleted group (p < 0.01). A volumetric ADCmean threshold of 1201 × 10−6 mm2/s identified IDH wild-type with a sensitivity of 83% and a specificity of 86%; a volumetric ADCratio cut-off value of 1.65 provided a sensitivity of 80% and a specificity of 92% (area under the curve (AUC) 0.9–0.94). A slice ADCratio threshold for observer 1 (observer 2) of 1.76 (1.83) provided a sensitivity of 80% (86%), specificity of 91% (100%) and AUC of 0.95 (0.96). The intraclass correlation coefficient was excellent (0.98).ConclusionsADC measurements can support the distinction of glioma subtypes. Volumetric and two-dimensional measurements yielded similar results in this study.Key Points• Diffusion-weighted MRI aids the identification of non-gadolinium-enhancing malignant gliomas• ADC measurements may permit non-gadolinium-enhancing glioma molecular subtyping• IDH wild-type gliomas have lower ADC values than IDH-mutant tumours• Single cross-section and volumetric ADC measurements yielded comparable results in this study
Journal Article
IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression
Interleukin (IL)-22, an immune cell-derived cytokine whose receptor expression is restricted to non-immune cells (e.g. epithelial cells), can be anti-inflammatory and pro-inflammatory. Mice infected with the tapeworm Hymenolepis diminuta are protected from dinitrobenzene sulphonic acid (DNBS)-induced colitis. Here we assessed expulsion of H. diminuta, the concomitant immune response and the outcome of DNBS-induced colitis in wild-type (WT) and IL-22 deficient mice (IL-22-/-) ± infection. Interleukin-22-/- mice had a mildly impaired ability to expel the worm and this correlated with reduced or delayed induction of TH2 immunity as measured by splenic and mesenteric lymph node production of IL-4, IL-5 and IL-13 and intestinal Muc-2 mRNA and goblet cell hyperplasia; in contrast, IL-25 increased in the small intestine of IL-22-/- mice 8 and 12 days post-infection compared to WT mice. In vitro experiments revealed that H. diminuta directly evoked epithelial production of IL-25 that was inhibited by recombinant IL-22. Also, IL-10 and markers of regulatory T cells were increased in IL-22-/- mice that displayed less DNBS (3 mg, ir. 72h)-induced colitis. Wild-type mice infected with H. diminuta were protected from colitis, as were infected IL-22-/- mice and the latter to a degree that they were almost indistinguishable from control, non-DNBS treated mice. Finally, treatment with anti-IL-25 antibodies exaggerated DNBS-induced colitis in IL-22-/- mice and blocked the anti-colitic effect of infection with H. diminuta. Thus, IL-22 is identified as an endogenous brake on helminth-elicited TH2 immunity, reducing the efficacy of expulsion of H. diminuta and limiting the effectiveness of the anti-colitic events mobilized following infection with H. diminuta in a non-permissive host.
Journal Article
Directional differences in head stabilisation in Acanthodactylus pardalis lizards
Running inevitably causes the animal trunk to undulate. The consequential head rotations have to be stabilised in space for a steady gaze and an accurate sense of self-motion for balance. The ecology and anatomy of the species determine the necessity to stabilise the head in yaw, pitch, and roll direction. Terrestrial lizards, running with a sprawled body posture, are especially prone to undulations in the horizontal (yaw) plane. Measurements on an experimental oscillation platform show that Acanthodactylus pardalis lizards stabilise their head less in pitch direction (54% stabilisation) than in yaw and roll direction (66% and 64% stabilisation, respectively). Because we performed these experiments in darkness, the lizards based their head stabilisation on vestibular information. Hence, we hypothesised that their vestibular system is less sensitive in pitch direction than in yaw and roll direction. Yet, this was not confirmed by a detailed Fluid-Structure Interaction model of the membranous labyrinth, which showed that not pitch sensitivity (88% of yaw sensitivity), but roll sensitivity (73% of yaw sensitivity) is the lowest. So why is the head stabilisation in darkness almost as good in roll direction as in yaw direction? While this may be due to neurological nonlinearities, it seems worth noticing that the moment of inertia is lowest in roll direction due to the elongated head shape. Hence, less torque is needed to stabilise a head rotation in roll direction than in the other two directions.
Journal Article
Plagioclase nucleation and growth kinetics in a hydrous basaltic melt by decompression experiments
Isothermal single-step decompression experiments (at temperature of 1075 °C and pressure between 5 and 50 MPa) were used to study the crystallization kinetics of plagioclase in hydrous high-K basaltic melts as a function of pressure, effective undercooling (Δ
T
eff
) and time. Single-step decompression causes water exsolution and a consequent increase in the plagioclase liquidus, thus imposing an effective undercooling (∆
T
eff
), accompanied by increased melt viscosity. Here, we show that the decompression process acts directly on viscosity and thermodynamic energy barriers (such as interfacial-free energy), controlling the nucleation process and favoring the formation of homogeneous nuclei also at high pressure (low effective undercoolings). In fact, this study shows that similar crystal number densities (
N
a
) can be obtained both at low and high pressure (between 5 and 50 MPa), whereas crystal growth processes are favored at low pressures (5–10 MPa). The main evidence of this study is that the crystallization of plagioclase in decompressed high-K basalts is more rapid than that in rhyolitic melts on similar timescales. The onset of the crystallization process during experiments was characterized by an initial nucleation event within the first hour of the experiment, which produced the largest amount of plagioclase. This nucleation event, at short experimental duration, can produce a dramatic change in crystal number density (
N
a
) and crystal fraction (
ϕ
), triggering a significant textural evolution in only 1 h. In natural systems, this may affect the magma rheology and eruptive dynamics on very short time scales.
Journal Article
Blood parasites in noddies and boobies from Brazilian offshore islands – differences between species and influence of nesting habitat
Seabirds are often free from blood parasites, and a recent review suggested that phylogenetic, ecological and life-history parameters can determine the prevalence of blood parasites in seabirds. However, there is a lack of data available from many seabird groups, and a larger database is needed to understand prevalence patterns of blood parasites. We used a molecular screening approach to detect parasites of the genera Plasmodium, Haemoproteus, Leucocytozoon and Babesia in five species of two genera of seabirds that breed on Atlantic Ocean islands off Brazil. The observed patterns differed between the two bird genera. Like other Laridae, brown noddy, Anous stolidus adults were infected with Haemoproteus with low prevalence. Masked boobies, Sula dactylatra and brown boobies, Sula leucogaster were infected with Babesia. Of the latter, mainly juveniles were infected. In all species, intensity of infection (i.e. number of infected erythrocytes) was so low that parasites remained undetected in blood smears. This may explain the absence of major effects on the body condition of birds, although infected juvenile masked boobies were lighter than juveniles that were not infected with Babesia. Two tree-nesting species; black noddy, Anous minutus and red-footed booby, Sula sula did not have blood parasites, suggesting that tree-nesting may reduce the exposure to arthropod vectors compared with ground nesting in these species.
Journal Article
Seabird guano reshapes intertidal reef food web in an isolated oceanic islet
Deposits of seabird guano on marine shores have drawn the attention of companies and naturalists for centuries. Among notable effects, allochthonous energy/matter inputs by seabirds are responsible for shifts in ecosystem functioning next to colonies. Here, we used stable isotopes of nitrogen-15 (ratios of
15
N:
14
N, expressed as δ
15
N) to trace guano incorporation in the intertidal reef community (fish and crab). The study areas were the Saint Peter and Saint Paul Archipelago (SPSPA), a remote and very small group of islets in the equatorial Atlantic Ocean, and two reference Atlantic islands where intertidal environments are not subject to the influence of guano. SPSPA intertidal reef fauna presented 3–7‰ higher δ
15
N values in comparison with local seabirds and with the intertidal reef fauna of reference islands. The intertidal food web of SPSPA appears supplemented by guano subsidies with carnivores, omnivores and herbivores
15
N-enriched in relation to a local seabird. While no difference in intertidal biota δ
15
N values was detected between references sites,
15
N-enrichement observed for SPSPA intertidal reef fauna is supported by guano subsidies. With emerged area < 0.02 km
2
, SPSPA is one of the world’s smallest archipelagos and only its main islet (Belmonte Island) has a few tidepools apt to be inhabited by fish. As guano readily drains into tidepools and reef crevices adjacent to the seabird colony, allochthonous nutrients become available and support habitat-restricted species in this small and isolated location.
Journal Article
Role of body size in shaping the trophic structure of tropical seabird communities
Ecological segregation among coexisting seabird species can occur due to morphological and behavioral differences. This segregation is especially important as it reduces competition during the breeding season, when birds are central-place foragers. Furthermore, seasonal variation in oceanographic processes may change prey availability and shape seabird community trophic structure and species isotopic niche. We used stable isotope analyses of seabird whole blood and prey muscle in 5 tropical seabird communities representing 12 species (Charadriiformes, Phaethontiformes, Procellariiformes and Suliformes) inhabiting 5 offshore islands off Brazil from 00°55’ N to 20° 30’ S and 65 to 1160 km from the coast. We evaluated how community trophic structure was correlated with morphology (body mass and bill length), and we verified seasonal variation in isotopic niche in 2 communities. Overall, seabird trophic position (TP) was positively correlated with body size, with frigatebirds and boobies occupying a higher TP than noddies and terns. Structuring of seabird communities according to body size probably occurred due to consumption of prey of different sizes and TP, which contributed to niche segregation by reducing interspecific competition during the breeding season. All species showed isotopic niche segregation at 2 islands, and ~60 to 70% of species segregated at the other islands, except at Atol das Rocas, where 43% of species segregated. Niche overlap occurred mainly among closely related species at Atol das Rocas, Fernando de Noronha and Trindade. The isotopic niche and TP changed across islands for all 3 boobies (red-footed Sula sula, brown S. leucogaster and masked S. dactylatra), brown noddy Anous stolidus and red-billed tropicbird Phaethon aethereus; these factors also changed seasonally in other species, such as in magnificent frigatebird Fregata magnificens, brown booby, both the red-billed P. aethereus and white-tailed P. lepturus tropicbirds and both the brown A. stolidus and black Anous minutus noddies. Such changes probably occurred due to differences in prey availability, opportunistic behavior (e.g. feeding on fishery discards) and/or local foraging and diet specialization.
Journal Article