Explore the vast range of titles available.

Three dead bodies found inside the home of a Massachusetts man who had 68 offenses overall; Police chief placed on leave amid probe into Rachael DelTondo's murder. A Memphis, Tennessee, woman was charged with child endangerment after video of her confining her grandkids to pet kennels on the back of her car. The mother of Ethan Couch, the infamous \"Affluenza\" teen who was jailed for a fatal drunk driving accident, was arrested again for violating the terms of her probation. Actor Vince Vaughn was arrested and charged early Sunday morning on driving under the influence. A woman who kidnapped a newborn from a Florida hospital two decades ago and raised the child as her own in South Carolina was sentenced Friday to 18 years for kidnapping. GUESTS: Stephanie Barry, Fanon Rucker, Randy Kessler, John Paul, Justin Freiman, Ray Caputo; Joseph Scott Morgan

Mom accused of trying to hire hitman on Craigslist to poison ex; Sweetheart deal for mom once accused in murder-for-hire case; Mom wanted to hire hitman to poison ex's coffee with ricin; Man kept woman prisoner in small wooden box in his basement; Abductor used homemade stun gun to tase her, force her into box. Victim now says she is scared to have a relationship with anybody; Cops: Seven-year-old tortured during home invasion; Mom poisoned to death on Valentine's Day. Killer sent coded messages to new girlfriend to ensure his alibi. Outrage as killer on hunger strike gets around the clock care; Chris Cuomo unravels the twisted tale of what happened to Debra when her promising love story went horribly wrong and somebody ended up dead; Donut squirrel steals treat from anchorage PD. Tristan Bodette was found dead inside a tent in a camping site with his two daughters. No suspect had identified yet. 20-year-old woman was stun gun, duct taping her wrists, her knees, and her ankles, sexually assaulting her and then locking her inside a wooden box. Allen Jamrose, 56 years old has been sentenced for 13 years imprisonment. GUESTS: Joseph Scott Morgan, Heather Hanson, Daniel Bober, Jane Harper, Mario Lorello, Rocky Holcomb, Heather Hansen, Dan O`Donnell

Excessive alcohol consumption is one of the leading causes of preventable death in the United States. Approximately 14% of those who use alcohol meet criteria during their lifetime for alcohol dependence, which is characterized by tolerance, withdrawal, inability to stop drinking, and continued drinking despite serious psychological or physiological problems. We explored genetic influences on alcohol dependence among 1,897 European-American and African-American subjects with alcohol dependence compared with 1,932 unrelated, alcohol-exposed, nondependent controls. Constitutional DNA of each subject was genotyped using the Illumina 1M beadchip. Fifteen SNPs yielded P < 10⁻⁵, but in two independent replication series, no SNP passed a replication threshold of P < 0.05. Candidate gene GABRA2, which encodes the GABA receptor α2 subunit, was evaluated independently. Five SNPs at GABRA2 yielded nominal (uncorrected) P < 0.05, with odds ratios between 1.11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence.

Outbreak response efforts for the 2014–15 Ebola virus disease epidemic in west Africa brought widespread transmission to an end. However, subsequent clusters of infection have occurred in the region. An Ebola virus disease cluster in Liberia in November, 2015, that was identified after a 15-year-old boy tested positive for Ebola virus infection in Monrovia, raised the possibility of transmission from a persistently infected individual. Case investigations were done to ascertain previous contact with cases of Ebola virus disease or infection with Ebola virus. Molecular investigations on blood samples explored a potential linkage between Ebola virus isolated from cases in this November, 2015, cluster and epidemiologically linked cases from the 2014–15 west African outbreak, according to the national case database. The cluster investigated was the family of the index case (mother, father, three siblings). Ebola virus genomes assembled from two cases in the November, 2015, cluster, and an epidemiologically linked Ebola virus disease case in July, 2014, were phylogenetically related within the LB5 sublineage that circulated in Liberia starting around August, 2014. Partial genomes from two additional individuals, one from each cluster, were also consistent with placement in the LB5 sublineage. Sequencing data indicate infection with a lineage of the virus from a former transmission chain in the country. Based on serology and epidemiological and genomic data, the most plausible scenario is that a female case in the November, 2015, cluster survived Ebola virus disease in 2014, had viral persistence or recurrent disease, and transmitted the virus to three family members a year later. Investigation of the source of infection for the November, 2015, cluster provides evidence of Ebola virus persistence and highlights the risk for outbreaks after interruption of active transmission. These findings underscore the need for focused prevention efforts among survivors and sustained capacity to rapidly detect and respond to new Ebola virus disease cases to prevent recurrence of a widespread outbreak. US Centers for Disease Control and Prevention, Defense Threat Reduction Agency, and WHO.

As far as one's individual identity, I would argue that it is impossible to extricate the influence of one social marker from others. Race, class, gender, sexual orientation, and any other demographic variable associated with social status are all intertwined. They work in concert to shape identity, life circumstances, and others' responses to us. It becomes difficult to argue that class is eclipsed by other social markers when it is impossible to separate classism from other forms of oppression. However, individuals may view other social markers, such as race or sexual orientation as far more central to their identity than social class. One could also attempt to conceal one's social class or pass as a member of another social class. For example, it is an interesting phenomenon that many Americans, whether they be working class or upper middle class, label themselves middle class. Yet the middle class is one of the levels of social class occupied by the fewest people. What motivates such a heterogenous group of people to identify with this label? Furthermore, social class is somewhat fluid. Unlike ethnicity and gender, social class is subject to change. People strive to improve their socioeconomic status and all of us are vulnerable to a downward shift. People also have a tendency to attribute others' social class to internal variables such as motivation and effort. This fluidity, vulnerability, and sense of personal responsibility may contribute to the tendency to consider class less central to identity, particularly for those at lower levels of social status. Consider first the young people we don't teach. Millions of low-income children -- disproportionately racial and ethnic minorities -- suffer stunting deprivations in nutrition, housing, and healthcare that cause them to drop out of school; or they attend destitute schools that don't prepare them for college; or they aspire to college but cannot surmount the financial obstacles. According to a report prepared by the staff of the U.S. Commission on Civil Rights (See \"Beyond Percentage Plans: The Challenge of Equal Opportunity in Higher Education,\" November 2002), federal programs serve only a fraction of the low- and middle-income students they were designed to assist (on the government's unrealistic definition, their families have, respectively, annual incomes under $25,000 and $25,000-$74,999). The TRIO programs, which help students prepare for and complete college, are so underfunded that they serve only 7 percent of the 9.6 million eligible students (94, 96). The Pell Grants Program is so chronically underfunded that its purchasing power has declined precipitously. In 1975 the maximum grant covered 84 percent of the total cost of attending a 4-year public college; in 2001 it covered 39 percent of tuition only (102, 106). Instead of pumping up this grants program, conservative administrations expanded student loan programs. To complete four years at a public college, a low-income student's average debt soared to $12,888 in 1999 and the family's average contribution gobbled up 25 percent of its annual income in 2001 (106). How many can afford to pay that price? What about progressive scholarship? I would argue that most of it doesn't influence policymakers and citizens for several reasons. First, it isn't designed for deployment in nonacademic arenas, a point made by Donna E. Shalala when she was Secretary of Health and Human Services. Academic research on welfare, she wrote, was not useful to the Clinton administration's effort to reformulate welfare policy because it didn't address the issues that concerned policymakers, produced contradictory findings, and was too slow in coming out (\"Welfare Reform: We Must All Assume Responsibility,\" Chronicle of Higher Education, 4 October 1996, B5-B6). Second, social problems must be constru(ct)ed in ways that rouse citizens and compel policymakers to respond (see Barbara Nelson's Making an Issue of Child Abuse). To be politically effective, we have to weld academic knowledge to social activism that targets the laws, policies, and customs which in turn order the nation's processes and resource flows.

Fragile X syndrome (FXS) is an incurable neurodevelopmental disorder with no effective treatment. FXS is caused by epigenetic silencing of FMR1 and loss of FMRP expression. To investigate the consequences of FMRP deficiency in the context of human physiology, we established isogenic FMR1 knockout (FMR1KO) human embryonic stem cells (hESCs). Integrative analysis of the transcriptomic and proteomic profiles of hESC-derived FMRPdeficient neurons revealed several dysregulated pathways important for brain development including processes related to axon development, neurotransmission, and the cell cycle. We functionally validate alterations in a number of these pathways, showing abnormal neural rosette formation and increased neural progenitor cell proliferation in FMR1KO cells. We further demonstrate neurite outgrowth and branching deficits along with impaired electrophysiological network activity in FMRP-deficient neurons. Using isogenic FMR1KO hESC-derived neurons, we reveal key molecular signatures and neurodevelopmental abnormalities arising from loss of FMRP. We anticipate that the FMR1KO hESCs and the neuronal transcriptome and proteome datasets will provide a platform to delineate the pathophysiology of FXS in human neural cells.