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People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. A cross-sectional, case-control study was conducted in sequential recruitment phases (July 2024-July 2025) at Ignace Deen Hospital, Conakry. Adult (≥ 18 years) PWE enrolled consecutively, excluding those with a seizure within the past 24 h. Controls were healthy adults accompanying PWE at the hospital. Cognitive status was assessed with the Montreal Cognitive Assessment (MoCA) in French or translated into the patient's preferred language (Pular, Susu, Maninka, Kissi) as needed. We enrolled 100 PWE (mean age 30.4 years, range 18-71, SD = 12.0) and 100 controls (mean age 39.4 years, range 19-70, SD = 12.3). Although 93% of PWE had previously used anti-seizure medications (ASMs), only 85% were currently receiving treatment and 50% reported interrupted access to ASMs, primarily due to cost barriers. The mean MoCA score of controls (21.8, SD = 4.9) was higher than that of PWE (17.9, SD = 6.1; mean difference -4.2, 95% CI [-5.6, -2.8], SE = 0.69, p < 0.001), adjusted for education level, sex, age, and language. Participants who attended lower secondary, upper secondary, or university education scored 4.9, 5.3, and 8.3 points higher, respectively, than those with no school or primary education (all p < 0.001). Speaking an indigenous language was on average associated with a 2.5-point decline in MoCA scores (95% CI [-3.8, -1.2], SE = 0.65, p < 0.001). PWE in Guinea demonstrated significantly lower cognitive performance on the MoCA compared to healthy controls, even after adjusting for covariates.

Coastal marine environments, such as lagoons, fjords or estuaries, experience pronounced environmental variability, with fluctuations in salinity, temperature and nutrient levels shaping microbial community structure and function. These gradients result in diverse habitats, which may harbour taxonomic and genetic novelty with biogeochemical and biotechnological relevance. To explore microbial diversity and functional potential across these dynamic ecosystems, we sampled 26 sites along the coasts of France and Chile, including lagoons, estuaries, fjords, harbours, as well as coastal and offshore marine sites. Surface waters were collected from all sites, with deeper layers included at three sites. Monthly sampling at six sites in France enabled the assessment of seasonal dynamics. In total, 116 samples were processed for both metabarcoding and metagenomic sequencing yielding over 53,000 amplicon sequence variants (ASVs) and 1,372 metagenome-assembled genomes (MAGs). This dataset further includes a comprehensive gene catalogue and environmental variables such as salinity, temperature, nutrient concentrations, productivity, as well as oxygen consumption metrics collected across the different ecosystems.

The democratization process which bolstered a culture of periodic elections has also fostered election-related violent conflicts. As democratic transitions gained currency in the new millennium, orderly transitions through the ballot boxes began replacing military coups but deaths and destructions came in the wake of elections in many countries. Inspired by decades-long pro-democracy movements across Africa that culminated in the Arab Spring of 2010-2011, and motivated by the desire to find long-term solutions to election-related violent conflicts in the continent, this book explores the terrain of democratization, elections, and conflict management. It raises and answers many questions, such as: What are the root causes of election-related conflicts? How free, fair, and credible are elections in many African countries? What institutional mechanisms are available for ballot and voter security and for mandate protection? What has been the role of civil society organizations in conflict prevention and management? What are the responsibilities of the international community, especially regional organizations like the Economic Community of West African States (ECOWAS) and the African Union (AU), in conflict resolution? What indigenous mechanisms for conflict management have been identified that may be proactively engaged?