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Background: Child abuse and neglect pose significant public health challenges, contributing to compromised development and adverse health outcomes. Neglect is the most frequent type of child abuse, presenting substantial challenges for paediatricians. Aims: To identify types of neglect associated with poisoned children, analyse potential risk factors and develop a novel severity scoring system to assess child neglect in Alexandria, Egypt. Methods: Using a simple random sampling technique, with an observational checklist we collected data on children aged 2 months to 17 years admitted for poisoning at the poison centre of Alexandria Main University Hospital from October to December 2022. We analysed the data using SPSS version 20.0 and tested the associations between neglect score and child data, current condition and carer data using the χ2 test, the Monte Carlo simulation and Fisher’s exact P. Results: The study enrolled 147 children, male-to-female ratio 1:1.17. Pesticides were the most common cause of poisoning. Lack of supervision was noted in 83% of cases and the neglect severity score showed that 27.9% of the children experienced severe neglect. There was significant association between severity of neglect and caregiver’s education level and between severity of neglect and child’s residence; severe neglect cases were significantly higher among children whose caregivers had no formal education (70.7%) and among those from rural areas (61%). Conclusion: These findings highlight the critical need to address educational disparities among caregivers and improve supervision for children, especially in rural areas.

In October 2019, ninety-four patients were admitted into Alexandria Poison Center (APC) with a history of ingestion of Feseekh (salted fish). In an attempt to allocate the resources, not all patients were given HBAT (botulism antitoxin heptavalent (A, B, C, D, E, F, G) equine immediately. The current study aimed to portray the clinical characteristics of the cases, explore the possible relation between these characteristics and necessity of HBAT administration, explore the reliability of mouse lethal test, and establish a clinical guide for management including preservation of resources. The current prospective study included 94 patients who were admitted to Alexandria Poison Center (APC) in the period from the 29 th of September to the 27 th of October 2019. The patients’ data were recorded using a checklist that includes: personal data, past medical history, clinical assessment, investigations, treatment, and the outcome. The checklist was carried out to assess and follow up each patient. Hospitalized patients were categorized according to symptoms consistent with botulism. The equine HBAT, made by Emergent BioSolutions Canada Inc. (formerly Cangene Corporation), was used in the treatment. HBAT was given to thirty-four patients (36.2%) only out of the total admission. However, eighty-two (87.2%) of patients were completely cured, whereas ten patients (10.6%) were discharged with mild neurological sequels and death occurred only in two cases (2.2%). Sixty cases (63.8%) with suspected foodborne botulism could be managed by supportive treatment only with no need for HBAT, while patients with evident neurological signs received HBAT immediately.

Determination of sex and ethnicity is one of the main tasks in building the biological profile of individuals. Keen examination of footprints that may be found at the crime scene can give valuable clues in forensic identification. The current work aimed to study the footprint morphological features and their relation to sex and population difference. The study was conducted on 200 adult volunteers. They were divided into two equal racial groups: Malaysians and Egyptians. The collected footprints were classified into four types based on relative morphological toes lengths. Toes inter-distance, phalangeal marks position and number, humps count and Chippaux-Smirak index (CSI) were examined. The frequency of these characteristics was analyzed statistically using regression analysis. Among the studied morphological features, it was found that t3-t4 inter-distance, phalangeal marks number, humps count and CSI differed significantly between males and females. As regards ethnicity, all footprints characteristics differed significantly between Egyptians and Malaysians except CSI. The study showed that foot has unique morphological characteristics that differ by sex and population difference and would help in establishing the personal identity.

Background: Child abuse and neglect pose significant public health challenges, contributing to compromised development and adverse health outcomes. Neglect is the most frequent type of child abuse, presenting substantial challenges for paediatricians. Aims: To identify types of neglect associated with poisoned children, analyse potential risk factors and develop a novel severity scoring system to assess child neglect in Alexandria, Egypt. Methods: Using a simple random sampling technique, with an observational checklist we collected data on children aged 2 months to 17 years admitted for poisoning at the poison centre of Alexandria Main University Hospital from October to December 2022. We analysed the data using SPSS version 20.0 and tested the associations between neglect score and child data, current condition and carer data using the χ2 test, the Monte Carlo simulation and Fisher's exact P. Results: The study enrolled 147 children, male-to-female ratio 1:1.17. Pesticides were the most common cause of poisoning. Lack of supervision was noted in 83% of cases and the neglect severity score showed that 27.9% of the children experienced severe neglect. There was significant association between severity of neglect and caregiver's education level and between severity of neglect and child's residence; severe neglect cases were significantly higher among children whose caregivers had no formal education (70.7%) and among those from rural areas (61%). Conclusion: These findings highlight the critical need to address educational disparities among caregivers and improve supervision for children, especially in rural areas.

One of the commoly used chemotherapeutic agents is 5-Fluorouracil (5-FU). Unfortunately, the clinical administration of 5-FU is complicated with serious cardiotoxic effects and the safe use becomes an urgent task in cardio-oncology. Till now, there are no studies discussed the role of empagliflozin (EMP) against 5-FU cardiotoxicity. Thus, we investigated this effect and the involved mechanisms in 5-FU induced heart injury. Forty male rats of Wistar albino species were used and divided randomly into four groups. Group I is the control group, group II is EMP given group, group III is 5-FU cardiotoxic group and group IV is 5-FU plus EMP group. 5-FU (150 mg/kg) was administered as a single intraperitoneal (i.p.) dose on 1st day to induce cardiotoxicity with or without EMP (30 mg/kg/d) orally for 5 days. The dose of 5-FU is relevant to the human toxic dose. Our data showed that 5-FU given group caused cardiotoxicity with significant increase of serum cardiac enzymes, toll like receptors, enhancement of nuclear factor kappa B (NF-κB), interleukin1β (IL1β), IL6, myeloid-differentiation-factor 88 (MYD88), heart weight, malondialdehyde (MDA), tumor-necrosis-factor-alpha (TNFα), sodium glucose co-transporter 2 (SGLT2), P53 and caspase3 expression with clear histopathological features of cardiotoxicity. Moreover, there is a significant decrease in reduced glutathione (GSH) and total antioxidant capacity (TAC). Interestingly, co-administration of EMP could ameliorate 5-FU induced biochemical and histopathological changes. This effect may be due to modulation of SGLT2, decreasing inflammation, oxidative stress and apoptosis with downregulation of an essential inflammatory cascade that mediates 5-FU cardiotoxicity; TNFα/TLR/NF-κB.