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"Marchetti"
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Women Filmmakers and the Visual Politics of Transnational China in the #MeToo Era
Manoeuvring around mainland China's censors and pushing back against threats of lawsuits, online harassment, and physical violence, #MeToo activists shed a particularly harsh light on the treatment of women in the cinema and entertainment industries. Focusing on films from the People's Republic of China, Hong Kong, Taiwan, and the Chinese diaspora, this book considers how female directors shape Chinese visual politics through the depiction of the look, the stare, the leer, the glare, the glimpse, the glance, the queer and the oppositional gaze in fiction and documentary filmmaking. In the years leading up to and following in the wake of #MeToo, these cosmopolitan women filmmakers offer innovative angles on body image, reproduction, romance, family relations, gender identity, generational differences, female sexuality, sexual violence, sex work, labor migration, career options, minority experiences, media access, feminist activism and political rights within the rapidly changing Chinese cultural orbit.
eBook
COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure
COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high reported morbidity has been related to hypoxia and inflammation leading to endothelial dysfunction and aberrant coagulation in small and large vessels. This review addresses some of the pathways leading to endothelial derangement, such as complement, HIF-1α, and ABL tyrosine kinases. This review also highlights potential targets for prevention and therapy of COVID-19-related organ damage and discusses the role of marketed drugs, such as eculizumab and imatinib, as suitable candidates for clinical trials.
Journal Article
Hopelessness: A Network Analysis
Hopelessness is a complex phenomenon with important clinical consequences, such as depression and suicidality. Despite its major impact on mental health, little is known about the structure of hopelessness. In this study, hopelessness was investigated in a large community sample (n = 1985), recruited to be highly representative of general population in Germany. In the context of network analysis, state-of-the-art techniques were adopted (i) to investigate which thoughts and beliefs (nodes) are the most central ones and (ii) to shed light on the specific associations (edges) among them. Stability and accuracy were also checked to ensure trustworthiness of the findings. The analyses revealed that expecting more negative than positive future events and having important goals blocked along with feelings of giving-up were the most central elements of hopelessness. Moreover, being unable to imagine the future and perceiving it as vague and uncertain were both coupled with anticipating a dark future. Theoretical and clinical consequences of this study were discussed.
Journal Article
Global democracy : normative and empirical perspectives
\"Democracy is increasingly seen as the only legitimate form of government, but few people would regard international relations as governed according to democratic principles. Can this lack of global democracy be justified? Which models of global politics should contemporary democrats endorse and which should they reject? What are the most promising pathways to global democratic change? To what extent does the extension of democracy from the national to the international level require a radical rethinking of what democratic institutions should be? This book answers these questions by providing a sustained dialogue between scholars of political theory, international law, and empirical social science. By presenting a broad range of views by prominent scholars, it offers an in-depth analysis of one of the key challenges of our century: globalizing democracy and democratizing globalization\"-- Provided by publisher.
Book
Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson’s Disease
Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) signaling is one of the most critical pathways in developing and adult tissues. In the brain, Wnt signaling contributes to different neurodevelopmental aspects ranging from differentiation to axonal extension, synapse formation, neurogenesis, and neuroprotection. Canonical Wnt signaling is mediated mainly by the multifunctional β-catenin protein which is a potent co-activator of transcription factors such as lymphoid enhancer factor (LEF) and T-cell factor (TCF). Accumulating evidence points to dysregulation of Wnt/β-catenin signaling in major neurodegenerative disorders. This review highlights a Wnt/β-catenin/glial connection in Parkinson’s disease (PD), the most common movement disorder characterized by the selective death of midbrain dopaminergic (mDAergic) neuronal cell bodies in the subtantia nigra pars compacta (SNpc) and gliosis. Major findings of the last decade document that Wnt/β-catenin signaling in partnership with glial cells is critically involved in each step and at every level in the regulation of nigrostriatal DAergic neuronal health, protection, and regeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD, focusing on Wnt/β-catenin signaling to boost a full neurorestorative program in PD.
Journal Article
Nonreciprocity as a generic route to traveling states
We examine a nonreciprocally coupled dynamical model of a mixture of two diffusing species. We demonstrate that nonreciprocity, which is encoded in the model via antagonistic cross-diffusivities, provides a generic mechanism for the emergence of traveling patterns in purely diffusive systems with conservative dynamics. In the absence of nonreciprocity, the binary fluid mixture undergoes a phase transition from a homogeneous mixed state to a demixed state with spatially separated regions rich in one of the two components. Above a critical value of the parameter tuning nonreciprocity, the static demixed pattern acquires a finite velocity, resulting in a state that breaks both spatial and time-reversal symmetry, as well as the reflection parity of the static pattern. We elucidate the generic nature of the transition to traveling patterns using a minimal model that can be studied analytically. Our work has direct relevance to nonequilibrium assembly in mixtures of chemically interacting colloids that are known to exhibit nonreciprocal effective interactions, as well as to mixtures of active and passive agents where traveling states of the type predicted here have been observed in simulations. It also provides insight on transitions to traveling and oscillatory states seen in a broad range of nonreciprocal systems with nonconservative dynamics, from reaction–diffusion and prey–predators models to multispecies mixtures of microorganisms with antagonistic interactions.
Journal Article