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Background and Objective AtopyReg ® is a multicenter, prospective, observational, non-profit cohort study on moderate-to-severe atopic dermatitis in adults promoted in 2018 by the Italian Society of Dermatology and Venereology (SIDeMaST). We aimed to describe baseline demographics, disease characteristics, comorbidities, and therapeutic data of adult patients affected by moderate-to-severe atopic dermatitis. Methods Patients were selected based on the following inclusion criteria: age ≥ 18 years; Eczema Area and Severity Index score ≥ 16 or localization in visible or sensitive areas (face, neck, hands, or genitalia), or a Numeric Rating Scale itch score ≥ 7 or a Numeric Rating Scale sleep loss score ≥ 7, or a Dermatology Life Quality Index score ≥ 10. Demographic and clinical data at baseline were recorded and analyzed. Results A total of 1170 patients (male 51.1%; mean age: 44.7 years; range 18–90 years) were enrolled by 12 Italian Dermatology Units between January 2019 and November 2022. Skin lesions were eczematous in 83.2% of patients, the most involved site were the flexures (53.9%), face (50.9%), and neck (48.0%). Mean Eczema Area and Severity Index score was 22.3, mean Dermatology Life Quality Index value was 17.6, mean Patient Oriented Eczema Measure score was 13.1, and mean Numeric Rating Scale itch and sleep loss scores were 7.6 and 5.9, respectively. Previous systemic therapies were corticosteroids in 77.7% of patients, antihistamines in 50.3% of patients, and cyclosporine A in 42.6% of patients. Conclusions This baseline data analysis deriving from AtopyReg ® provides real-life evidence on patients with moderate-to-severe atopic dermatitis in Italy confirming the high burden of atopic dermatitis with a significant impact on patients’ quality of life.

The subject of this book is the thought of the American pragmatist and founder of semiotics, Charles Sanders Peirce. The book collects the papers presented to the International Conference Semiotics and Philosophy in C.S. Peirce (Milan, April 2005), together with some additional new contributions by well-known Peirce scholars, bearing witness to the vigour of Peircean scholarship in Italy and also hosting some of the most significant international voices on this topic. The book is introduced b.

The subject of this book is the thought of the American pragmatist and founder of semiotics, Charles Sanders Peirce. The book collects the papers presented to the International Conference Semiotics and Philosophy in C.S. Peirce (Milan, April 2005), together with some additional new contributions by well-known Peirce scholars, bearing witness to the vigour of Peircean scholarship in Italy and also hosting some of the most significant international voices on this topic. The book is introduced by the two editors and is divided into three sections, corresponding to the three main areas of the most interesting contemporary reflection on Peirce. Namely, Semiotics and the Logic of Inquiry (part I); Abduction and Philosophy of Mathematics (part II); Peirce and the Western Tradition. (part III). The analysis is carried out from a semiotic perspective, in which semiotics should not be understood as a specific doctrine but rather as the philosophical core of Peirce's system. As we read in the introduction: \"it is semiotics and philosophy or, rather, semiotics as philosophy and philosophy as semiotics, which emerge from a reading of these papers\".