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Steep slopes covered by loose unsaturated pyroclastic deposits widely dispersed in Campania, Southern Italy, are often subjected to shallow landslides that turn into fast debris flows causing a large amount of damage and many casualties, triggered by heavy and persistent precipitation. The slope of Cervinara, located around 40 km northeast of Naples, was involved in a destructive flowslide between 15 and 16 December 1999, triggered by a rain event of 325 mm in 48 h. Hydrometeorological monitoring activities have been carried out near the landslide scarp of 1999 since 2017 to assess the water balance and to identify major hydrological processes involving the cover and the shallow groundwater system developing in the upper part of the underlying limestone fractured bedrock. Since 1 December 2022, a remotely accessible low-cost network has been installed to expand the field hydrological monitoring. The use of a network of low-cost capacitive sensors, communicating within the domain of Internet of Things (IoT) technology, aiming at dispersed monitoring of soil moisture, has been tested. Specifically, the tested prototype network allows measurements of the soil water content at two different points, communicating through a Wi-Fi-based IoT system using ESP32 boards. The ThingSpeakTM IoT platform has been used for remote field data visualization. Based on the obtained results, the prototype of this IoT-based low-cost network shows the potential to expand the amount of hydrological data, suitable for setting up early warning systems in landslide-prone areas.

Survey tra Fiumi, Pianure e Colline analyses the territory of Santa Croce di Magliano in the province of Campobasso, Molise, Italy and studies all its archaeological aspects in order to understand patterns of occupation of the human groups that have inhabited it and how they, through the evolution of social interactions, have received extraterritorial influences. It maintains a focus on this small area of the lower Molise in the wider regional context of the Frentano state. This study has been able to contribute further evidence to support attempts to explain the interactions between the Samnite cultures located north of the Fortore river and those located south of the same river, characterised by a Daunian culture (at least until the sixth century BC). It also highlights the evolution of settlement types over the centuries. Furthermore it has been also possible to highlight how the types of settlement have evolved over the centuries, up to the current urban form of the village considered in this study.

Nutrition has a significant effect and a crucial role in disease prevention. Low consumption of fruit and vegetables and a sedentary lifestyle are closely related with the onset and development of many types of cancer. Recently, nutraceuticals have gained much attention in cancer research due to their pleiotropic effects and relatively non-toxic behavior. In fact, although in the past there have been conflicting results on the role of some antioxidant compounds as allies against cancer, numerous recent clinical studies highlight the efficacy of dietary phytochemicals in the prevention and treatment of cancer. However, further investigation is necessary to gain a deeper understanding of the potential anticancer capacities of dietary phytochemicals as well as the mechanisms of their action. Therefore, this review examined the current literature on the key properties of the bioactive components present in the diet, such as carotenoids, polyphenols, and antioxidant compounds, as well as their use in cancer therapy. The review focused on potential chemopreventive properties, evaluating their synergistic effects with anticancer drugs and, consequently, the side effects associated with current cancer treatments.

L'archeologia del paesaggio abbina lo studio dei materiali archeologici con lo studio del paesaggio per comprendere le fasi di sviluppo, mutazione e, nel caso, abbandono di un determinato territorio. Essa può essere considerata un grande contenitore in cui far confluire ogni aspetto dell'archeologia per ricostruire tutte le fasi umane relative ad un determinato territorio. La ricostruzione dei commerci, delle vie di comunicazione, del comportamento di gruppi localizzati in un determinato territorio e come essi possano essere stati influenzati dal territorio stesso.In questo volume è stato preso in analisi il territorio di Santa Croce di Magliano, in provincia di Campobasso, Molise, Italia ed è stato analizzato in tutti i suoi aspetti archeologici per tentare di capire le modalità di spostamento dei gruppi umani che lo hanno abitato e come essi, con l'evolversi delle interazioni sociali, abbiano avuto influenze extraterritoriali, cercando di inquadrare questo fazzoletto di terra del basso Molise in quello che è un contesto di macro area come lo stato Frentano. Con questo è stato possibile inserire un altro tassello che tenta di spiegare le interazioni tra culture poste a nord del fiume Fortore, di derivazione sannitica, con quelle culture poste a sud dello stesso fiume, di cultura daunia, almeno fino al VI sec. a.C.. Inoltre è stato possibile mettere in evidenza come si siano evolute le tipologie di insediamento nel corso dei secoli, fino ad arrivare all'attuale forma cittadina del paese di riferimento in questo studio.

In recent years, peptides have gained more success as therapeutic compounds. Nowadays, the preferred method to obtain peptides is solid-phase peptide synthesis (SPPS), which does not respect the principles of green chemistry due to the large number of toxic reagents and solvents used. The aim of this work was to research and study an environmentally sustainable solvent able to replace dimethylformamide (DMF) in fluorenyl methoxycarbonyl (Fmoc) solid-phase peptide synthesis. Herein, we report the use of dipropyleneglycol dimethylether (DMM), a well-known green solvent with low human toxicity following oral, inhalant, and dermal exposure and that is easily biodegradable. Some tests were needed to evaluate its applicability to all the steps of SPPS, such as amino acid solubility, resin swelling, deprotection kinetics, and coupling tests. Once the best green protocol was established, it was applied to the synthesis of different length peptides to study some of the fundamental parameters of green chemistry, such as PMI (process mass intensity) and the recycling of solvent. It was revealed that DMM is a valuable alternative to DMF in all steps of solid-phase peptide synthesis.

Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an important source of bioactive compounds such as polysaccharides, carotenoids, phenolics, and various other non-nutritive compounds. These constituents give it a multitude of health benefits, including antioxidant, anti-inflammatory, and anticancer properties. However, the precise biochemical mechanisms responsible for its anticancer effects remain unclear, and the comprehensive composition of goji berry extracts is often insufficiently explored. This study aimed to investigate the biochemical pathways modulated in breast cancer cells by an ethanolic extract of Lycium barbarum fruit (LBE). Following metabolomic profiling using UHPLC-HRMS/MS, we assessed the antitumoral properties of LBE on different breast cancer cell lines. This investigation revealed that LBE exhibited cytotoxic effects, inducing a pro-oxidant effect that triggered pyroptosis activation through endoplasmic reticulum (ER) stress and subsequent activation of the P-IRE1α/XBP1/NLRP3 axis in MCF-7 cells. In addition, LBE did not display cytotoxicity toward healthy human cells but demonstrated antioxidant properties by neutralizing ROS generated by doxorubicin. These findings underscore the potential of LBE as a highly promising natural extract in cancer therapy.

Sulla coronaria is indigenous to the Mediterranean region. It is grown as fodder in southern Italy because it contains various secondary metabolites with beneficial activities on animals. Recently, its potential use in cosmeceutical treatments for skin problems was reported. In this scenario, to contribute to a possible cosmeceutical application, we characterized the phytochemical profile of Sulla coronaria flowers’ hydroalcoholic extract by HPLC-DAD, Folin-Ciocalteu, Aluminum Chloride methods, DPPH assay, and, for the first time, we evaluated the antioxidant and anti-inflammatory activities on dermal fibroblasts. The phytochemical analysis confirmed the significant content of phenolic compounds (TPC 69.8 ± 0.6 mg GAE/g extract, TFC 15.07 mg CE/g extract) and the remarkable presence of rutin, quercetin, and isorhamnetin derivatives that give to the phytocomplex a good antioxidant activity as highlighted by the DPPH assay (IC50 of 8.04 ± 0.5 µg/mL). Through the reduction in NO• and ROS levels in human dermal fibroblasts, the biological tests demonstrated both the safety of the extract and its ability to counteract the inflammatory state generated by Interleukin-1β exposure. Our findings indicate that the antioxidant activities of the phytocomplex are strictly related to the anti-inflammatory action of the Sulla coronaria flowers extract, confirming that this plant could be a valuable source of bioactive molecules for cosmeceutical and nutraceutical applications.

A physically based mathematical model of the slope of Cervinara (southern Italy), which is characterized by a shallow pyroclastic soil cover laying upon a limestone fractured bedrock, has been developed. Previous and current ongoing monitoring suggested that leakage through the soil–bedrock interface occurred, with leaking water temporarily stored in a perched aquifer located in the upper part of the fractured limestone (epikarst). This aquifer supplied several springs, and recharge to the deeper groundwater circulation occurred. Hence, in the proposed model, the unsaturated water flow taking place within the soil cover is coupled with the saturated water flow in the perched aquifer. The application of the model to the simulation of the slope hydrologic behavior over a period of 11 years, between 2006–2017, provides realistic results in terms of soil storage, epikarst storage, spring discharge, and groundwater recharge. The different response times of soil and epikarst aquifer to precipitation input allow distinguishing the hydrological predisposing causes of potential landsliding (i.e., a few months of persistent rainfall that is capable of filling the epikarst aquifer) from the triggers, which are represented by single intense rainfall events. The application of the model offers a key of interpretation of the hydrological processes leading to the landslide that occurred on 16 December 1999.

Mediterranean countries represent a dynamic hub of cultural exchange, where wild plants play a significant role in culinary traditions. A substantial number of these plants belong to the Asteraceae family. The climate similarities across the region contribute to the common distribution ranges of the plants. While many species are widely distributed, others are confined to specific subregions, such as the western Mediterranean, eastern Mediterranean, or North Africa. Only six taxa of the traditionally consumed wild Asteraceae plants are endemic to just one country. This review focuses on wild plants from the Asteraceae family traditionally used as food across 13 study sites, comprising 11 countries in the Mediterranean and adjacent territories, including both mainland areas and three islands. The objective is to identify and analyze patterns of native distribution in relation to actual consumption. As a result, 167 edible wild plants from the Asteraceae family were identified. Their patterns of distribution and consumption are described and analyzed. The highest number of these edible wild plants from the Asteraceae family is consumed in Spain (n = 65), followed by southern Italy (n = 44) and Morocco (n = 32). A similar pattern of consumption is seen in Turkey (n = 24), Sicily (n = 23), Jordan and Palestine (n = 21), and Bulgaria (n = 21). It is notable that 106 plants are used as food in one particular country only, although most of them are distributed in several other countries. Many of the species consumed in certain countries are not used by neighboring populations, highlighting a limited cross-border transmission of ethnobotanical knowledge. The findings from a Jaccard index statistical analysis are discussed.

Microbial colonization plays a relevant role in the biodegradation and biodeterioration of cultural and natural heritage, representing a revealing problem in conservation strategy. In this study, the essential oil (EO) and hydro-alcoholic extract (HAE) of Origanum vulgare L. (Lamiaceae), an aromatic perennial plant, representative of the Mediterranean basin, growing spontaneously and cultivated all over the world, were analysed. Natural products, such as essential oil and hydro-alcoholic extract, have strong antiseptic and antimicrobial properties and are ad hoc applied for the sustainable conservation of Erithryna caffra (Fabaceae). The main taxa revealed in the damaging of these arboreal heritage, are Bacillus sp., Streptomyces sp. and Terribacillus sp. (as bacteria), Alternaria sp., Aspergillus sp. and Chaetomium sp. (as fungi). GS-MS analysis identified carvacrol, thymol and their biosynthetic precursors γ-terpinene and p-cymene, as main components, and the antimicrobial efficiency assayed by in vitro methods (Agar Dish Diffusion, Well Plate Diffusion). In this study, by combining the application/exposure of both HAE and EO, the bacterial and fungal colonies development has been in vitro countered. The results confirm the possible use of plant products as a valid alternative to the traditional synthetic chemical biocides, with full respect to the environment.