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We report photometric observations of Comet 103P/Hartley 2 during its 2023 apparition. Our campaign, conducted from August through December 2023, combined data from a global network of citizen astronomers coordinated by Unistellar and the Association Française d'Astronomie. Photometry was derived using an automated pipeline for eVscope observations in partnership with the SETI Institute and aperture photometry via AstroLab Stellar. We find that the comet's peak reduced brightness, measured at \\(G_{\\rm min} = 10.24 \\pm 0.47\\), continues a long-term fading trend since 1991. The decline in activity follows a per-apparition minimum magnitude increase of \\(\\Delta G_{\\rm min} = 0.59 \\pm 0.11\\) mag, corresponding to an approximately \\(42\\%\\) reduction in brightness each return. This trend implies that the comet's active fraction has declined by about an order of magnitude since 1991 and may indicate that Hartley 2 is no longer hyperactive by definition. The fading is consistent with progressive volatile depletion rather than orbital effects. These results offer insight into the evolutionary processes shaping Jupiter-family comets.

The eco-design of materials can provide solutions to improve the sorting and traceability of these materials. Codes added into the material can be detected and help identify the various types of polymers. Tracer/polymer systems were finalized from laboratory tests, and a spectrometric detection system was designed to detect the signals of these systems.

The recycling of polymer materials from end-of-life products is essential to protect our nonrenewable resources, as well as to decrease our impacts on climate change and the effects on human health and ecosystems. Several barriers exist to the recycling of materials, including technical and social barriers linked to the acceptability of recycled materials.

(1) Background: The current diagnostic algorithm for acute pulmonary embolism (PE) is associated with the overuse of CT pulmonary angiography (CTPA). An additional highly specific blood test could potentially lower the proportion of patients with suspected PE that require CTPA. The aim was to summarize the literature on the diagnostic performance of biomarkers of patients admitted to an emergency department with suspected acute PE. (2) Methods: Medline and Embase databases were searched from 1995 to the present. The study selection process, data extraction, and risk of bias assessment were conducted by two reviewers. Eligibility criteria accepted all blood biomarkers except D-dimer, and CTPA was used as the reference standard. Qualitative data synthesis was performed. (3) Results: Of the 8448 identified records, only 6 were included. Eight blood biomarkers were identified, of which, three were investigated in two separate studies. Red distribution width and mean platelet volume were reported to have a specificity of ≥ 90% in one study, although these findings were not confirmed by other studies. The majority of the studies contained a high risk of selection bias. (4) Conclusions: The modest findings and the uncertain validity of the included studies suggest that none of the biomarkers identified in this systematic review have the potential to improve the current diagnostic algorithm for acute PE by reducing the overuse of CTPA.

ABSTRACT Objectives: to understand the work process dimensions related to innovative actions developed by nurses in Primary Health Care. Methods: qualitative, descriptive study, developed in Primary Health Care in a city in the Southern Region of Brazil. Seventy-six nurses, who worked in management and assistance, participated in this study through semi-structured interviews. After data processing by IRAMUTEQ software, the textual analysis occurred by descending hierarchical classification. Results: forty-two innovative actions, considered by the participants as new ways of working, were identified. There was a predominance of innovative actions related to the Management and Assist dimensions; we noticed the fragility of the actions to contemplate all the nurse’s work process dimensions. Final Considerations: the predominance of innovative actions was related to users’ assistance and better conditions in the teamwork process, besides highlighting the role of nurses in the perspective of a new way of working in health services. RESUMO Objetivos: apreender as dimensões do processo de trabalho relacionadas às ações inovadoras desenvolvidas por enfermeiras na Atenção Primária à Saúde. Métodos: estudo qualitativo, descritivo, desenvolvido na Atenção Primária à Saúde de um município do Sul do Brasil. Participaram 76 enfermeiras que atuavam na gestão e assistência, por meio de entrevista semiestruturada. A análise textual ocorreu após o processamento dos dados pelo software IRAMUTEQ, pela classificação hierárquica descendente. Resultados: identificaram-se 42 ações inovadoras, consideradas pelos participantes como novas formas de trabalho. Predominaram ações inovadoras relacionadas às dimensões Administrar e Assistir; notou-se fragilidade das ações para contemplarem todas as dimensões do processo de trabalho da enfermeira. Considerações Finais: o predomínio das ações inovadoras relacionou-se à assistência prestada aos usuários e às melhores condições no processo de trabalho em equipe, além de destacar o papel das enfermeiras na perspectiva de um novo modo de se trabalhar nos serviços de saúde. RESUMEN Objetivos: aprender dimensiones del proceso laboral relacionadas a acciones innovadoras desarrolladas por enfermeras en la Atención Primaria de Salud. Métodos: estudio cualitativo, descriptivo, desarrollado en la Atención Primaria de Salud de un municipio del Sur brasileño. Participaron 76 enfermeras que actuaban en la gestión y asistencia, por medio de entrevista semiestructurada. El análisis textual ocurrió tras el procesamiento de datos por software IRAMUTEQ, por clasificación jerárquica descendente. Resultados: identificaron 42 acciones innovadoras, consideradas por participantes como nuevas maneras laborales. Predominaron acciones innovadoras relacionadas a las dimensiones Administrar y Asistir; ha visto debilidad de acciones para contemplaren todas dimensiones del proceso laboral de la enfermera. Consideraciones Finales: el predominio de las acciones innovadoras se relacionó a asistencia prestada a usuarios y a mejores condiciones en el proceso laboral en equipo, además destacar el papel de las enfermeras en la perspectiva de un nuevo modo de trabajarse en los servicios de salud.

Background To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC). Methods The SAC (3 pediatric rheumatologists and 2 pediatric infectious disease specialists) elaborated and approved by consensus a provisional list of OI for use in JIA. Through a 5 step-procedure, all the severe and serious infections, classified as per MedDRA dictionary and retrieved in the Pharmachild registry, were evaluated by the SAC by answering six questions and adjudicated with the agreement of 3/5 specialists. A final evidence-based list of OI resulted by matching the adjudicated infections with the provisional list of OI. Results A total of 772 infectious events in 572 eligible patients, of which 335 serious/severe/very severe non-OI and 437 OI (any intensity/severity), according to the provisional list, were retrieved. Six hundred eighty-two of 772 (88.3%) were adjudicated as infections, of them 603/682 (88.4%) as common and 119/682 (17.4%) as OI by the SAC. Matching these 119 opportunistic events with the provisional list, 106 were confirmed by the SAC as OI, and among them infections by herpes viruses were the most frequent (68%), followed by tuberculosis (27.4%). The remaining events were divided in the groups of non-OI and possible/patient and/or pathogen-related OI. Conclusions We found a significant number of OI in JIA patients on immunosuppressive therapy. The proposed list of OI, created by consensus and validated in the Pharmachild cohort, could facilitate comparison among future pharmacovigilance studies. Trial registration Clinicaltrials.gov NCT 01399281; ENCePP seal: awarded on 25 November 2011.