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The astonishing account of the decades-long cocaine use of Sigmund Freud and William Halsted. The author discusses the physical and emotional damage caused by the constant use of the then-heralded wonder drug, and of how each man ultimately changed the world in spite of it--or because of it.

With great apprehension, the world is now watching the birth of a novel pandemic already causing tremendous suffering, death, and disruption of normal life. Uncertainty and dread are exacerbated by the belief that what we are experiencing is new and mysterious. However, deadly pandemics and disease emergences are not new phenomena: they have been challenging human existence throughout recorded history. Some have killed sizeable percentages of humanity, but humans have always searched for, and often found, ways of mitigating their deadly effects. With great apprehension, the world is now watching the birth of a novel pandemic already causing tremendous suffering, death, and disruption of normal life. Uncertainty and dread are exacerbated by the belief that what we are experiencing is new and mysterious. However, deadly pandemics and disease emergences are not new phenomena: they have been challenging human existence throughout recorded history. Some have killed sizeable percentages of humanity, but humans have always searched for, and often found, ways of mitigating their deadly effects. We here review the ancient and modern histories of such diseases, discuss factors associated with their emergences, and attempt to identify lessons that will help us meet the current challenge.

\"John Harvey Kellogg was one of America's most beloved physicians; a best-selling author, lecturer, and health-magazine publisher; founder of the Battle Creek Sanitarium; and patron saint of the pursuit of wellness. His youngest brother, Will, was the founder of the Battle Creek Toasted Corn Flake Company, which revolutionized the mass production of food and what we eat for breakfast. In The Kelloggs, Howard Markel tells the sweeping saga of these two extraordinary men, whose lifelong competition and enmity toward one another changed America's notion of health and wellness from the mid-nineteenth to the mid-twentieth centuries, and who helped change the course of American medicine, nutrition, wellness, and diet. The Kelloggs were of Puritan stock, a family that came to the shores of New England in the mid-seventeenth century, went west to the wooded Michigan frontier to start a farm that became one of the biggest in the county, and then renounced it all for the religious calling of Ellen Harmon White, a self-proclaimed prophetess, and James White, whose new Seventh-day Adventist theology was based on Christian principles and sound body, mind, and hygiene rules--Ellen called it \"health reform.\" The Whites groomed the young John Kellogg for a central role in the Seventh-day Adventist Church and sent him to America's finest medical school, Bellevue Hospital Medical College. Kellogg's main medical focus--and America's number one malady: indigestion. Markel gives us the life and times of the Kellogg brothers of Battle Creek: Dr. John Harvey Kellogg and his world-famous Battle Creek Sanitarium medical center, spa, and grand hotel attracted thousands actively pursuing health and well-being. Among the guests: Mary Todd Lincoln, Amelia Earhart, Booker T. Washington, Johnny Weissmuller, Dale Carnegie, Sojourner Truth, Henry Ford, John D. Rockefeller, Jr., and George Bernard Shaw. And the presidents he advised: Taft, Harding, Hoover, and Roosevelt, with first lady Eleanor. The brothers Kellogg experimented on malt, wheat, and corn meal, and, tinkering with special ovens and toasting devices, came up with a ready-to-eat, easily digested cereal they called Corn Flakes. As Markel chronicles the Kelloggs' fascinating, Magnificent Ambersons-like ascent into the pantheon of American industrialists, we see the vast changes in American social mores that took shape in diet, health, medicine, philanthropy, and food manufacturing during seven decades--changing the lives of millions and helping to shape our industrial age.\"--Jacket.

\"By early morning of June 30, 1860, a large crowd began to congregate in front of Oxford University's brand-new Museum of Natural History. The occasion was the annual meeting of the British Association for the Advancement of Science, and the subject of discussion was Charles Darwin's new treatise: fact or fiction? Darwin, a simultaneously reclusive and intellectually audacious squire from Kent, claimed to have solved 'that mystery of mysteries,' introducing a logical explanation of the origin of species--how they adapted, even transmogrified, through natural selection. At stake, on that summer's day of spirited debate, was the very foundation of modern biology, not to mention the future of the church. Without fear of exaggeration, Darwin's thesis would forever change our understanding of the life sciences and the natural world. And yet the author himself was nowhere to be found in the debate hall--instead, he was miles away, seeking respite from a spate of illnesses that had plagued him for much of his adult life. In Origin Story, medical historian Howard Markel recounts the two-year period (1858 to 1860) of Darwin's writing of On the Origin of Species through its spectacular success and controversy. Simultaneously, Markel delves into the mysterious health symptoms Darwin developed, combing the literature to emerge with a cogent diagnosis of a case that has long fascinated medical historians. The result is a colorful portrait of the main, his friends and enemies, and his seminal work, which resonates to this day\"-- Provided by publisher.

Human beings have benefited from vaccines for more than two centuries. Yet the pathway to effective vaccines has been neither neat nor direct. This paper explores the history of vaccines and immunization, beginning with Edward Jenner's creation of the world's first vaccine for smallpox in the 1790s. We then demonstrate that many of the issues salient in Jenner's era - such as the need for secure funding mechanisms, stream-lined manufacturing and safety concerns, and deep-seated public fears of inoculating agents - have frequently reappeared and have often dominated vaccine policies. We suggest that historical awareness can help inform viable long-term solutions to contemporary problems with vaccine research, production, and supply. [PUBLICATION ABSTRACT]

The Bayh–Dole Act of 1980 permitted scientists, universities, and businesses to patent and profit from discoveries made through federally funded research. A review of the law's history supports the idea that such policies merit frequent reappraisal and reform. In June, the U.S. Supreme Court issued a unanimous opinion in Association for Molecular Pathology v. Myriad Genetics that invalidated the claim of ownership of the BRCA1 and BRCA2 genes. On one level, the legal contretemps leading up to this decision grew out of the University and Small Business Patent Procedures Act of 1980, commonly known as the Bayh–Dole Act. 1 Sponsored by Senators Birch Bayh (D-IN) and Robert Dole (R-KS), the law reversed decades of government policy by allowing scientists, universities, and small businesses to patent and profit from discoveries they made through federally funded research — like Myriad's research . . .

In a landmark article published 50 years ago, Avedis Donabedian proposed using the triad of structure, process, and outcome to evaluate the quality of health care. That triad, along with his eventual seven pillars of quality, continues to inform efforts to improve care. Though historians are often hesitant to declare any event a “first,” one might safely claim that the contemporary health care quality movement had its “founding moment” in October 1965. Less than 3 months after the Medicare and Medicaid programs were enacted, the newly created Health Services Research Section of the U.S. Public Health Service convened a meeting in Chicago of leaders from many health-related fields. These leaders considered the influence of social and economic research on public health, the organization of community health agencies, and the quality of health services. One of these experts, Avedis Donabedian, a professor of medical . . .

Vaccine adverse events (VAEs) are adverse bodily changes occurring after vaccination. Understanding the adverse event (AE) profiles is a crucial step to identify serious AEs. Two different types of seasonal influenza vaccines have been used on the market: trivalent (killed) inactivated influenza vaccine (TIV) and trivalent live attenuated influenza vaccine (LAIV). Different adverse event profiles induced by these two groups of seasonal influenza vaccines were studied based on the data drawn from the CDC Vaccine Adverse Event Report System (VAERS). Extracted from VAERS were 37,621 AE reports for four TIVs (Afluria, Fluarix, Fluvirin, and Fluzone) and 3,707 AE reports for the only LAIV (FluMist). The AE report data were analyzed by a novel combinatorial, ontology-based detection of AE method (CODAE). CODAE detects AEs using Proportional Reporting Ratio (PRR), Chi-square significance test, and base level filtration, and groups identified AEs by ontology-based hierarchical classification. In total, 48 TIV-enriched and 68 LAIV-enriched AEs were identified (PRR>2, Chi-square score >4, and the number of cases >0.2% of total reports). These AE terms were classified using the Ontology of Adverse Events (OAE), MedDRA, and SNOMED-CT. The OAE method provided better classification results than the two other methods. Thirteen out of 48 TIV-enriched AEs were related to neurological and muscular processing such as paralysis, movement disorders, and muscular weakness. In contrast, 15 out of 68 LAIV-enriched AEs were associated with inflammatory response and respiratory system disorders. There were evidences of two severe adverse events (Guillain-Barre Syndrome and paralysis) present in TIV. Although these severe adverse events were at low incidence rate, they were found to be more significantly enriched in TIV-vaccinated patients than LAIV-vaccinated patients. Therefore, our novel combinatorial bioinformatics analysis discovered that LAIV had lower chance of inducing these two severe adverse events than TIV. In addition, our meta-analysis found that all previously reported positive correlation between GBS and influenza vaccine immunization were based on trivalent influenza vaccines instead of monovalent influenza vaccines.

The influenza pandemic of 1918–1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.