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"Marsch, Patrick"
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Coordinated multi-point in mobile communications : from theory to practice
\"A self-contained guide to coordinated multi-point (CoMP), this comprehensive book covers everything from theoretical basics to practical implementation. Addressing a wide range of topics, it highlights the potential gains of CoMP, the fundamental degrees of freedom involved and the key challenges of using CoMP in practice. The editors and contributors bring unique real-world experience from running the world's first and largest test beds for LTE-Advanced, and recent field trial results from these tests are presented. With detailed insight into the realistic potential of CoMP as a key technology for LTE-Advanced and beyond, this is a must-read resource for professionals and students who want the big picture on CoMP or require in-depth knowledge of how to build cellular communication systems for the future\"--Provided by publisher.
Book
5G System Design
A timely overview by industry experts of ongoing developments in the run up to 5G rollout. This book provides a comprehensive overview of the latest research and standardization progress towards the 5th generation (5G) of mobile communications technology and beyond. It covers a wide range of topics from 5G use cases and their requirements, to spectrum, 5G end-to-end (E2E) system architecture including core network (CN), transport network (TN) and radio access network (RAN) architecture, network slicing, security and network management.
eBook
5G system design : architectural and functional considerations and long term research
\"This book provides a comprehensive overview of the latest research and standardization progress towards the 5th generation (5G) of mobile communications technology and beyond. It covers a wide range of topics from 5G use cases and their requirements, to spectrum, 5G end-to-end (E2E) system architecture including core network (CN), transport network (TN) and radio access network (RAN) architecture, network slicing, security and network management. It further dives into the detailed functional design and the evaluation of different 5G concepts, and provides details on planned trials and pre-commercial deployments across the globe\"--Page 4 of cover.
Book
On multicell cooperative transmission in backhaul-constrained cellular systems
Recent work has shown that multicell cooperative signal processing in cellular networks can significantly increase system capacity and fairness. For example, multicell joint transmission and joint detection can be performed to combat intercell interference, often mentioned in the context of distributed antenna systems. Most publications in this field assume that an infinite amount of information can be exchanged between the cooperating base stations, neglecting the main downside of such systems, namely, the need for an additional network backhaul. In recent publications, we have thus proposed an optimization framework and algorithm that applies multicell signal processing to only a carefully selected subset of users for cellular systems with a strongly constrained backhaul. In this paper, we consider the cellular downlink and provide a comprehensive summary and extension of our previous and current work. We compare the performance obtained through centralized or decentralized optimization approaches, or through optimal or suboptimal calculation of precoding matrices, and identify reasonable performance–complexity trade-offs. It is shown that even low-complexity optimization approaches for cellular systems with a strongly constrained backhaul can yield major performance improvements over conventional systems.
Journal Article
Predicting Tight Junction Formation via Claudin Chimeras
Tight junctions are vital to epithelial and endothelial barrier functions aiding in ion transport and preventing toxins from crossing into paracellular space. Claudins, made of four transmembrane helices and two extracellular loops, are a major part of the assembly of tight junctions along with other transmembrane proteins. The dimer interactions of two members of the 27-known members of the claudin family—claudin-2 and claudin-4—were analyzed. We created claudin chimera by switching claudin 2’s extracellular loops with claudin 4’s. The chimeras were analyzed using molecular dynamic simulations by comparing them to the natural claudins. This analysis provided new insight into the assembly of tight junction strands that ultimately will aid in paracellular drug delivery through barriers in the human body.
Dissertation
Homomeric Tight Junction Strand Assembly of Claudin Proteins
Tight junctions, a form of cell junction, are utilized throughout the animal kingdom in one way or another. Tasked with facilitating a critical blockade between toxins and vital tissues while also allowing small crucial molecules to pass, the tight junction provides an important line of defense against disease. To build this barrier, various proteins with self-assemble within a cell membrane to then zipper with another cell membrane. The strand-like architecture and size & charge selective pore channels created within the barrier are chiefly governed by the claudin family of proteins. Without claudins present, the tight junction cannot form, and toxic molecules can flood into important barriers like the blood-brain barrier, the gastrointestinal tract, kidney nephrons, and others. To better understand the role claudins play in the tight junction, and complement experimental imaging data of claudin strands, this work describes three in silico approaches to better understand the components of the tight junction. Chapter 1 details the past three decades of experiments understanding claudin proteins, from the initial discovery and experimental understanding of claudin function to the solution of the first crystal structure and subsequent in silico studies. Chapter 2 details the prediction of a claudin-like protein’s structure and assembly in Hydra vulgaris, a freshwater invertebrate known for its regenerative ability. This work presented a novel claudin-like structure with a unique pore assembly not seen in human studies. Chapter 3 investigated the interaction between two tight junction proteins, JAM-A and ZO-2. This work provided further context to the importance of the C-terminal tail of tight junction proteins and the affinity ZO proteins possess to bind to membrane-embedded proteins like JAM-A. Chapter 4 describes an approach to predicting tight junction strand assembly using top claudin dimer conformations. This work provides a reproducible, yet stochastic process to quickly generate millions of claudin monomers, creating strands of over ten microns in length.
Dissertation
The Role of ZO-2 in Modulating JAM-A and γ-Actin Junctional Recruitment, Apical Membrane and Tight Junction Tension, and Cell Response to Substrate Stiffness and Topography
This work analyzes the role of the tight junction (TJ) protein ZO-2 on mechanosensation. We found that the lack of ZO-2 reduced apical membrane rigidity measured with atomic force microscopy, inhibited the association of γ-actin and JAM-A to the cell border, and instead facilitated p114RhoGEF and afadin accumulation at the junction, leading to an enhanced mechanical tension at the TJ measured by FRET, with a ZO-1 tension probe, and increased tricellular TJ tension. Simultaneously, adherens junction tension measured with an E-cadherin probe was unaltered. The stability of JAM-A and ZO-2 binding was assessed by a collaborative in silico study. The absence of ZO-2 also impacted the cell response to the substrate, as monolayers plated in 20 kPa hydrogels developed holes not seen in parental cultures and displayed a retarded elongation and formation of cell aggregates. The absence of ZO-2 was sufficient to induce YAP and Snail nuclear accumulation in cells cultured over glass, but when ZO-2 KD cells were plated in nanostructured ridge arrays, they displayed an increased abundance of nuclear Snail and conspicuous internalization of claudin-4. These results indicate that the absence of ZO-2 also impairs the response of cells to substrate stiffness and exacerbates transformation triggered by substrate topography.
Journal Article
LTE Advanced
From the editors of the highly successful LTE for UMTS: Evolution to LTE-Advanced, this new book examines the main technical enhancements brought by LTE-Advanced, thoroughly covering 3GPP Release 10 specifications and the main items in Release 11. Using illustrations, graphs and real-life scenarios, the authors systematically lead readers through this cutting-edge topic to provide an outlook on existing technologies as well as possible future developments. The book is structured to follow the main technical areas that will be enhanced by the LTE-Advanced specifications. The main topics covered include: Carrier Aggregation; Multiantenna MIMO Transmission, Heterogeneous Networks; Coordinated Multipoint Transmission (CoMP); Relay nodes; 3GPP milestones and IMT-Advanced process in ITU-R; and LTE-Advanced Performance Evaluation. Key features: Leading author and editor team bring their expertise to the next generation of LTE technology Includes tables, figures and plots illustrating the concepts or simulation results, to aid understanding of the topic, and enabling readers to be ahead of the technological advances
eBook
Uplink CoMP under a Constrained Backhaul and Imperfect Channel Knowledge
Coordinated Multi-Point (CoMP) is known to be a key technology for next generation mobile communications systems, as it allows to overcome the burden of inter-cell interference. Especially in the uplink, it is likely that interference exploitation schemes will be used in the near future, as they can be used with legacy terminals and require no or little changes in standardization. Major drawbacks, however, are the extent of additional backhaul infrastructure needed, and the sensitivity to imperfect channel knowledge. This paper jointly addresses both issues in a new framework incorporating a multitude of proposed theoretical uplink CoMP concepts, which are then put into perspective with practical CoMP algorithms. This comprehensive analysis provides new insight into the potential usage of uplink CoMP in next generation wireless communications systems.
Paper