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"Marsch, Patrick"
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Coordinated multi-point in mobile communications : from theory to practice
\"A self-contained guide to coordinated multi-point (CoMP), this comprehensive book covers everything from theoretical basics to practical implementation. Addressing a wide range of topics, it highlights the potential gains of CoMP, the fundamental degrees of freedom involved and the key challenges of using CoMP in practice. The editors and contributors bring unique real-world experience from running the world's first and largest test beds for LTE-Advanced, and recent field trial results from these tests are presented. With detailed insight into the realistic potential of CoMP as a key technology for LTE-Advanced and beyond, this is a must-read resource for professionals and students who want the big picture on CoMP or require in-depth knowledge of how to build cellular communication systems for the future\"--Provided by publisher.
Book
5G System Design
A timely overview by industry experts of ongoing developments in the run up to 5G rollout. This book provides a comprehensive overview of the latest research and standardization progress towards the 5th generation (5G) of mobile communications technology and beyond. It covers a wide range of topics from 5G use cases and their requirements, to spectrum, 5G end-to-end (E2E) system architecture including core network (CN), transport network (TN) and radio access network (RAN) architecture, network slicing, security and network management.
eBook
5G system design : architectural and functional considerations and long term research
\"This book provides a comprehensive overview of the latest research and standardization progress towards the 5th generation (5G) of mobile communications technology and beyond. It covers a wide range of topics from 5G use cases and their requirements, to spectrum, 5G end-to-end (E2E) system architecture including core network (CN), transport network (TN) and radio access network (RAN) architecture, network slicing, security and network management. It further dives into the detailed functional design and the evaluation of different 5G concepts, and provides details on planned trials and pre-commercial deployments across the globe\"--Page 4 of cover.
Book
Predicting Tight Junction Formation via Claudin Chimeras
Tight junctions are vital to epithelial and endothelial barrier functions aiding in ion transport and preventing toxins from crossing into paracellular space. Claudins, made of four transmembrane helices and two extracellular loops, are a major part of the assembly of tight junctions along with other transmembrane proteins. The dimer interactions of two members of the 27-known members of the claudin family—claudin-2 and claudin-4—were analyzed. We created claudin chimera by switching claudin 2’s extracellular loops with claudin 4’s. The chimeras were analyzed using molecular dynamic simulations by comparing them to the natural claudins. This analysis provided new insight into the assembly of tight junction strands that ultimately will aid in paracellular drug delivery through barriers in the human body.
Dissertation
The Role of ZO-2 in Modulating JAM-A and γ-Actin Junctional Recruitment, Apical Membrane and Tight Junction Tension, and Cell Response to Substrate Stiffness and Topography
This work analyzes the role of the tight junction (TJ) protein ZO-2 on mechanosensation. We found that the lack of ZO-2 reduced apical membrane rigidity measured with atomic force microscopy, inhibited the association of γ-actin and JAM-A to the cell border, and instead facilitated p114RhoGEF and afadin accumulation at the junction, leading to an enhanced mechanical tension at the TJ measured by FRET, with a ZO-1 tension probe, and increased tricellular TJ tension. Simultaneously, adherens junction tension measured with an E-cadherin probe was unaltered. The stability of JAM-A and ZO-2 binding was assessed by a collaborative in silico study. The absence of ZO-2 also impacted the cell response to the substrate, as monolayers plated in 20 kPa hydrogels developed holes not seen in parental cultures and displayed a retarded elongation and formation of cell aggregates. The absence of ZO-2 was sufficient to induce YAP and Snail nuclear accumulation in cells cultured over glass, but when ZO-2 KD cells were plated in nanostructured ridge arrays, they displayed an increased abundance of nuclear Snail and conspicuous internalization of claudin-4. These results indicate that the absence of ZO-2 also impairs the response of cells to substrate stiffness and exacerbates transformation triggered by substrate topography.
Journal Article
LTE Advanced
From the editors of the highly successful LTE for UMTS: Evolution to LTE-Advanced, this new book examines the main technical enhancements brought by LTE-Advanced, thoroughly covering 3GPP Release 10 specifications and the main items in Release 11. Using illustrations, graphs and real-life scenarios, the authors systematically lead readers through this cutting-edge topic to provide an outlook on existing technologies as well as possible future developments. The book is structured to follow the main technical areas that will be enhanced by the LTE-Advanced specifications. The main topics covered include: Carrier Aggregation; Multiantenna MIMO Transmission, Heterogeneous Networks; Coordinated Multipoint Transmission (CoMP); Relay nodes; 3GPP milestones and IMT-Advanced process in ITU-R; and LTE-Advanced Performance Evaluation. Key features: Leading author and editor team bring their expertise to the next generation of LTE technology Includes tables, figures and plots illustrating the concepts or simulation results, to aid understanding of the topic, and enabling readers to be ahead of the technological advances
eBook
Uplink CoMP under a Constrained Backhaul and Imperfect Channel Knowledge
Coordinated Multi-Point (CoMP) is known to be a key technology for next generation mobile communications systems, as it allows to overcome the burden of inter-cell interference. Especially in the uplink, it is likely that interference exploitation schemes will be used in the near future, as they can be used with legacy terminals and require no or little changes in standardization. Major drawbacks, however, are the extent of additional backhaul infrastructure needed, and the sensitivity to imperfect channel knowledge. This paper jointly addresses both issues in a new framework incorporating a multitude of proposed theoretical uplink CoMP concepts, which are then put into perspective with practical CoMP algorithms. This comprehensive analysis provides new insight into the potential usage of uplink CoMP in next generation wireless communications systems.
Paper
Modulation and Demodulation
This chapter provides an overview of analog modulation and frequency modulation (FM). Information is encoded through a variation of the phase of the carrier wave in phase modulation (PM). An alternative approach is to not map a zero data bit to a carrier signal which is turned off, but rather to a carrier signal with a negative amplitude, which is referred as amplitude shift keying (ASK). A way to modulate digital data onto an analog carrier is to apply data‐dependent phase shifts to the carrier signal, referred to as phase shift keying (PSK). Information bits are represented in a change of frequency of the carrier in binary frequency shift keying (BFSK). Pulse shaping enables successful demodulation at the receiver side. Orthogonal frequency division multiplex (OFDM) and orthogonal frequency division multiple access (OFDMA) are multiplexing and multiple access schemes, respectively, including a particular choice of pulse shape and modulation concept.
Book Chapter
Application Driven Joint Uplink-Downlink Optimization in Wireless Communications
This paper introduces a new mathematical framework, which is used to derive joint uplink/downlink achievable rate regions for multi-user spatial multiplexing between one base station and multiple terminals. The framework consists of two models: the first one is a simple transmission model for uplink and downlink, which is capable to give a lower bound on the capacity for the case that the transmission is subject to imperfect CSI. A detailed model for concrete channel estimation and feedback schemes provides parameter input to the former model and covers the most important aspects such as pilot design optimization, linear channel estimation, feedback delay, and feedback quantization. We apply this framework to determine optimal pilot densities and CSI feedback quantity, given that a weighted sum of uplink and downlink throughput is to be maximized for a certain user velocity. We show that for low speed, and if downlink throughput is of particular importance, a significant portion of the uplink should be invested into CSI feedback. At higher velocity, however, downlink performance becomes mainly affected by CSI feedback delay, and hence CSI feedback brings little gain considering the inherent sacrifice of uplink capacity. We further show that for high velocities, it becomes beneficial to use no CSI feedback at all, but apply random beamforming in the downlink and operate in time-division duplex.
Paper