Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
19
result(s) for
"Marsh, Carole"
Sort by:
The rip-roaring mystery on the African safari : South Africa
Grant and Christina get involved with a mystery while on an African safari with their father and grandmother.
Book
THE CASE OF THE PEEPING TOM
The face at the window may give you a nasty shock but the men who get a kick out of looking are seldom looking for action
Magazine Article
VIOLIN IN THE NURSERY
If your child can learn to speak he can also learn to make music -and he needs your help with both. Carole Marsh describes the Suzuki method of teaching
Magazine Article
The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
Current vaccine strategies against the asexual blood stage of
Plasmodium falciparum
are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have yet to induce robust protection in any clinical trial. Here we compare human-compatible viral-vectored vaccines targeting ten different blood-stage antigens. We show that the full-length
P. falciparum
reticulocyte-binding protein homologue 5 (PfRH5) is highly susceptible to cross-strain neutralizing vaccine-induced antibodies, out-performing all other antigens delivered by the same vaccine platform. We find that, despite being susceptible to antibody, PfRH5 is unlikely to be under substantial immune selection pressure; there is minimal acquisition of anti-PfRH5 IgG antibodies in malaria-exposed Kenyans. These data challenge the widespread beliefs that any merozoite antigen that is highly susceptible to immune attack would be subject to significant levels of antigenic polymorphism, and that erythrocyte invasion by
P. falciparum
is a degenerate process involving a series of parallel redundant pathways.
At present there are no highly effective vaccines for
Plasmodium falciparum
. In this study, a vaccine raised against the
P. falciparum
reticulocyte-binding protein homologue 5 is shown to induce an IgG response in rabbits that could block the proliferation of multiple parasite strains
in vitro
.
Journal Article
International recommendations for a vascular access minimum dataset: a Delphi consensus-building study
BackgroundData regarding vascular access device use and outcomes are limited. In part, this gap reflects the absence of guidance on what variables should be collected to assess patient outcomes. We sought to derive international consensus on a vascular access minimum dataset.MethodsA modified Delphi study with three rounds (two electronic surveys and a face-to-face consensus panel) was conducted involving international vascular access specialists. In Rounds 1 and 2, electronic surveys were distributed to healthcare professionals specialising in vascular access. Survey respondents were asked to rate the importance of variables, feasibility of data collection and acceptability of items, definitions and response options. In Round 3, a purposive expert panel met to review Round 1 and 2 ratings and reach consensus (defined as ≥70% agreement) on the final items to be included in a minimum dataset for vascular access devices.ResultsA total of 64 of 225 interdisciplinary healthcare professionals from 11 countries responded to Round 1 and 2 surveys (response rate of 34% and 29%, respectively). From the original 52 items, 50 items across five domains emerged from the Delphi procedure.Items related to demographic and clinical characteristics (n=5; eg, age), device characteristics (n=5; eg, device type), insertion (n=16; eg, indication), management (n=9; eg, dressing and securement), and complication and removal (n=15, eg, occlusion) were identified as requirements for a minimum dataset to track and evaluate vascular access device use and outcomes.ConclusionWe developed and internally validated a minimum dataset for vascular access device research. This study generated new knowledge to enable healthcare systems to collect relevant, useful and meaningful vascular access data. Use of this standardised approach can help benchmark clinical practice and target improvements worldwide.
Journal Article
Sex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysis
Female and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and predictors of mortality. In total, 7555 patients were included in this analysis, 3973 (53%) male and 3582 (47%) female patients. The primary endpoint was 30-day-mortality. Baseline characteristics, data on management and geriatric scores including frailty assessed by Clinical Frailty Scale (CFS) were documented. Two propensity scores (for being male) were obtained for consecutive matching, score 1 for baseline characteristics and score 2 for baseline characteristics and ICU management. Male VIPs were younger (83 ± 5 vs. 84 ± 5;
p
< 0.001), less often frail (CFS > 4; 38% versus 49%;
p
< 0.001) but evidenced higher SOFA (7 ± 6 versus 6 ± 6 points;
p
< 0.001) scores. After propensity score matching, no differences in baseline characteristics could be observed. In the paired analysis, the mortality in male VIPs was higher (mean difference 3.34% 95%CI 0.92–5.76%;
p
= 0.007) compared to females. In both multivariable logistic regression models correcting for propensity score 1 (aOR 1.15 95%CI 1.03–1.27;
p
= 0.007) and propensity score 2 (aOR 1.15 95%CI 1.04–1.27;
p
= 0.007) male sex was independently associated with higher odds for 30-day-mortality. Of note, male gender was not associated with ICU mortality (OR 1.08 95%CI 0.98–1.19;
p
= 0.14). Outcomes of elderly intensive care patients evidenced independent sex differences. Male sex was associated with adverse 30-day-mortality but not ICU-mortality. Further research to identify potential sex-specific risk factors after ICU discharge is warranted.
Trial registration
: NCT03134807 and NCT03370692; Registered on May 1, 2017
https://clinicaltrials.gov/ct2/show/NCT03370692
.
Journal Article
Correction: Corrigendum: The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
Nature Communications 2: Article number: 601 (2011); Published: 20 December 2011; Updated: 19 September 2013. In the Methods section of this Article, the species of the tissue plasminogen activator secretory signal used in adenovirus vector construction was stated incorrectly and should have been given as human.
Journal Article