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"Martin, Justin"
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Rebel Souls : Walt Whitman and America's First Bohemians
\"In the shadow of the Civil War, a circle of radicals in a rowdy saloon changed American society and helped set Walt Whitman on the path to poetic immortality. Rebel Souls is the first book ever written about the colorful group of artists-- regulars at Pfaff's Saloon in Manhattan-- rightly considered America's original Bohemians. Besides a young Whitman, the circle included actor Edwin Booth; trailblazing stand-up comic Artemus Ward; psychedelic drug pioneer and author Fitz Hugh Ludlow; and brazen performer Adah Menken, famous for her Naked Lady routine. Central to their times, the artists managed to forge connections with Ralph Waldo Emerson, Mark Twain, and even Abraham Lincoln. Justin Martin shows how this first bohemian culture--imported from Paris to a dingy Broadway saloon--seeded and nurtured an American tradition of rebel art that thrives to this day. \"-- Provided by publisher.
BOOK
To Punish or to Leave: Distinct Cognitive Processes Underlie Partner Control and Partner Choice Behaviors
When a cooperative partner defects, at least two types of response are available: Punishment, aimed at modifying behavior, and ostracism, aimed at avoiding further social interaction with the partner. These options, termed partner control and partner choice, have been distinguished at behavioral and evolutionary levels. However, little work has compared their cognitive bases. Do these disparate behaviors depend on common processes of moral evaluation? Specifically, we assess whether they show identical patterns of dependence on two key dimensions of moral evaluation: A person's intentions, and the outcomes that they cause. We address this issue in a \"trembling hand\" economic game. In this game, an allocator divides a monetary stake between themselves and a responder based on a stochastic mechanism. This allows for dissociations between the allocator's intent and the actual outcome. Responders were either given the opportunity to punish or reward the allocator (partner control) or to switch to a different partner for a subsequent round of play (partner choice). Our results suggest that partner control and partner choice behaviors are supported by distinct underlying cognitive processes: Partner control exhibits greater sensitivity to the outcomes a partner causes, while partner choice is influenced almost exclusively by a partner's intentions. This cognitive dissociation can be understood in light of the unique adaptive functions of partner control and partner choice.
Journal Article
Building a Sensor Benchmark for E-Nose Based Lung Cancer Detection: Methodological Considerations
Lung cancer is one of the deadliest form of cancer in Europe, characterized by a lack of obvious symptoms until the terminal stages of the illness. Electronic noses are a rising screening technology to detect early-stage lung cancer directly in the homes of people at risk. Electronic noses need to be tested using samples from patients. However, obtaining numerous samples from cancer patient turns out to be a difficult task in practice. Therefore, the development of a sensor benchmark able to evaluate the performance of sensors without direct breath sampling is of high interest. This paper focuses on the methodology for developing such a benchmark, in the case of a breath sampling electronic nose. The setup used is introduced and general recommendations based on literature and undergoing experiments is detailed. The benchmark can be used for a variety of sensors and a variety of target illnesses. It is also possible to apply it to other types of medical gaseous samples or environmental VOC monitoring. The benchmark is currently still undergoing tests, and results will be published in a following article.
Journal Article
Splendour! : art in living craftsmanship
This exhibition celebrates 80 years of conservation work by the Georgian Group. It aims to transport the visitor into a world of craftsmanship, beauty and design. Gathering together an eclectic selection of traditional 'Georgian' crafts practised in the 21st century, objects range from silk wallpaper and chandeliers to carved stone sculpture and ceiling designs. The works on display demonstrate that the Georgian tradition is a living tradition, and is one that should be supported and preserved. Founded in 1937, the Georgian Group is a conservation organisation created to campaign for the preservation of historic buildings and planned landscapes of the 18th and early 19th centuries. Exhibition: The Georgian Group, London, UK (02.02 - 25.02.2017).
Book
The Attentional Blink Reveals the Probabilistic Nature of Discrete Conscious Perception
Attention and awareness are two tightly coupled processes that have been the subject of the same enduring debate: Are they allocated in a discrete or in a graded fashion? Using the attentional blink paradigm and mixture-modeling analysis, we show that awareness arises at central stages of information processing in an all-or-none manner. Manipulating the temporal delay between two targets affected subjects' likelihood of consciously perceiving the second target, but did not affect the precision of its representation. Furthermore, these results held across stimulus categories and paradigms, and they were dependent on attention having been allocated to the first target. The findings distinguish the fundamental contributions of attention and awareness at central stages of visual cognition: Conscious perception emerges in a quantal manner, with attention serving to modulate the probability that representations reach awareness.
Journal Article
The impact of group membership on punishment versus partner rejection
People often display ingroup bias in punishment, punishing outgroup members more harshly than ingroup members. However, the impact of group membership may be less pronounced when people are choosing whether to stop interacting with someone (i.e., partner rejection). In two studies (N = 1667), we investigate the impact of group membership on both response types. Participants were assigned to groups based on a “minimal” groups paradigm (Study 1) or their self-reported political positions (Study 2) and played an incentivized economic game with other players. In this game, participants (Responders) responded to other players (Deciders). In the Punishment condition, participants could decrease the Decider’s bonus pay. In the Partner Rejection condition, participants could reject future interactions with the Decider. Participants played once with an ingroup member and once with an outgroup member. To control for the effects of intent and outcome, scenarios also differed based on the Decider’s Intent (selfish versus fair) and the Outcome (equal versus unequal distribution of resources). Participants punished outgroup members more than ingroup members, however group membership did not influence decisions to reject partners. These results highlight partner rejection as a boundary condition for the impact of group on responses to transgressions.
Journal Article
Unified attentional bottleneck in the human brain
Human information processing is characterized by bottlenecks that constrain throughput. These bottlenecks limit both what we can perceive and what we can act on in multitask settings. Although perceptual and response limitations are often attributed to independent information processing bottlenecks, it has recently been suggested that a common attentional limitation may be responsible for both. To date, however, evidence supporting the existence of such a \"unified\" bottleneck has been mixed. Here, we tested the unified bottleneck hypothesis using time-resolved fMRI. Experiment 1 isolated brain regions involved in the response selection bottleneck that limits speeded dual-task performance. These same brain regions were not only engaged by a perceptual encoding task in Experiment 2, their activity also tracked delays to a speeded decision-making task caused by concurrent perceptual encoding (Experiment 3). We conclude that a unified attentional bottleneck, including the inferior frontal junction, superior medial frontal cortex, and bilateral insula, temporally limits operations as diverse as perceptual encoding and decision-making.
Journal Article
Increased drought severity tracks warming in the United States’ largest river basin
Across the Upper Missouri River Basin, the recent drought of 2000 to 2010, known as the “turn-of-the-century drought,” was likely more severe than any in the instrumental record including the Dust Bowl drought. However, until now, adequate proxy records needed to better understand this event with regard to long-term variability have been lacking. Here we examine 1,200 y of streamflow from a network of 17 new tree-ring–based reconstructions for gages across the upper Missouri basin and an independent reconstruction of warm-season regional temperature in order to place the recent drought in a long-term climate context. We find that temperature has increasingly influenced the severity of drought events by decreasing runoff efficiency in the basin since the late 20th century (1980s) onward. The occurrence of extreme heat, higher evapotranspiration, and associated low-flow conditions across the basin has increased substantially over the 20th and 21st centuries, and recent warming aligns with increasing drought severities that rival or exceed any estimated over the last 12 centuries. Future warming is anticipated to cause increasingly severe droughts by enhancing water deficits that could prove challenging for water management.
Journal Article
Machine learning using genotype and gene-expression data identifies alterations of genes involved in infection susceptibility, antigen presentation and cytokine signalling as key contributors to JIA risk prediction
BackgroundPrevious genome-wide association studies (GWAS) have identified numerous genetic loci associated with juvenile idiopathic arthritis (JIA). However, the functional impact of these variants—particularly on tissue-specific gene expression—and which regulatory interactions make the greatest relative contribution to JIA risk remain unclear. Identifying these key single-nucleotide polymorphism (SNP)–gene–tissue combinations can help prioritise targets for future functional studies and therapeutic interventions.MethodWe performed two-sample Mendelian randomisation (2SMR) using spatial expression quantitative trait loci (eQTLs) from nine tissue-specific gene-regulatory networks as instrumental variables (IVs). We also identified JIA-associated SNPs from previous GWAS and mapped their spatial eQTL effects across 49 human tissues. These SNP sets were then used as features in a Lasso-regularised logistic regression model to predict JIA disease status. The model weight magnitudes served as proxies for each SNP’s contribution to JIA risk. We evaluated the robustness of our model’s feature ranking across 50 cross-validation runs.ResultsThe top-ranked SNPs included rs7775055, which tags the human leukocyte antigen (HLA) class II haplotype DRB1*0801-DQA1*0401-DQB1*0402, and rs6679677, a non-coding variant that is in 100% linkage with with a coding variant in PTPN22. IVs for genes implicated in infection-related immune processes (eg, MSH5, MICA and LINC01149) also made significant contributions to JIA risk. We additionally identified a spatial eQTL (rs10849448) that upregulated the cytokine signalling gene LTBR across all 49 tissues. Overall, our model highlighted the roles of genes involved in antigen presentation, infection susceptibility and cytokine signalling.ConclusionBy applying a machine learning approach to rank SNP–gene–tissue contributions to JIA risk, our findings offer insights into the genetic mechanisms underlying JIA pathogenesis. Future experimental validation could facilitate new therapeutic targets for the treatment or prevention of JIA.
Journal Article