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16,340 result(s) for "Martin, Lawrence"
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Material Passports in Construction Waste Management: A Systematic Review of Contexts, Stakeholders, Requirements, and Challenges
The growth in the adoption of circular economy principles in the construction industry has given rise to material passports as a critical implementation tool. Given the existing problems of high resource use and high waste generation in the construction industry, there is a pressing need to adopt novel strategies and tools to mitigate the adverse impacts of the built environment. However, research on the application of material passports in the context of construction waste management remains limited. The aim of this paper is to identify the contextual uses, stakeholders, requirements, and challenges in the application of material passports for managing waste generated from building construction and demolition processes through a systematic review approach. Comprehensive searches in Scopus and the Web of Science databases are used to identify relevant papers and reduce the risk of selection bias. Thirty-five (35) papers are identified and included in the review. The identified key contexts of use included buildings and cities as material banks, waste management and trading, and integrated digital technologies. Asset owners, waste management operators, construction and deconstruction teams, technology providers, and regulatory and sustainability teams are identified as key stakeholders. Data requirements related to material, components, building stock data, lifecycle, environmental impact data, and deconstruction and handling data are critical. Moreover, the key infrastructure requirements include modeling and analytical tools, collaborative information exchange systems, sensory tracking tools, and digital and physical storage hubs. However, challenges with data management, costs, process standardization, technology, stakeholder collaboration, market demand, and supply chain logistics still limit the implementation. Therefore, it is recommended that future research be directed towards certification and standardization protocols, automation, artificial intelligence tools, economic viability, market trading, and innovative end-use products.
Pershing's tankers : personal accounts of the AEF Tank Corps in World War I
\"In Pershing's Tankers, Lawrence M. Kaplan compiles 47 official personal experience reports, 27 unofficial accounts, and six letters written by George Patton to his family to provide insight into the human dimension of US tank operations in World War I. These narratives vary in size, scope and depth, and cover a range of topics, including the organizing, training, combat operations, and equipping of the Tank Corps. Kaplan offers accounts from a broad cross-section of men from senior leaders down to the platoon level\"-- Provided by publisher.
In the Trenches
Tatiana L. Dubinskaya's autobiographical novel of life in the Russian army marked the first major work published by a female World War I soldier in the Soviet Union. Often compared toAll Quiet on the Western Front, Dubinskaya's stark and unsparing story presents a rare look at women in combat and one of the few works of fiction set on the eastern front. Zinaida, a Russian schoolgirl, runs away from home to join the army. Sent to the front, she endures the horrors of trench warfare and the hardships of military life. Undercurrents of revolutionary thinking filter into the ranks as morale begins to crumble. Zinaida must come to grips with the havoc unleashed by the czar's overthrow and the new socialist government's attempts to impose revolutionary reforms on the army. Destabilization and desertion follow, and her regiment joins the chaotic mass retreat of the Russian army in the summer of 1917. In addition to Dubinskaya's original novel, this edition includes selections from her 1936 autobiographical work,Machine Gunner, which she rewrote to satisfy Stalinist censors.
Cyclic Tetra-Adenylate (cA4) Recognition by Csa3; Implications for an Integrated Class 1 CRISPR-Cas Immune Response in Saccharolobus solfataricus
Csa3 family transcription factors are ancillary CRISPR-associated proteins composed of N-terminal CARF domains and C-terminal winged helix-turn-helix domains. The activity of Csa3 transcription factors is thought to be controlled by cyclic oligoadenyate (cOA) second messengers produced by type III CRISPR-Cas surveillance complexes. Here we show that Saccharolobus solfataricus Csa3a recognizes cyclic tetra-adenylate (cA4) and that Csa3a lacks self-regulating “ring nuclease” activity present in some other CARF domain proteins. The crystal structure of the Csa3a/cA4 complex was also determined and the structural and thermodynamic basis for cA4 recognition are described, as are conformational changes in Csa3a associated with cA4 binding. We also characterized the effect of cA4 on recognition of putative DNA binding sites. Csa3a binds to putative promoter sequences in a nonspecific, cooperative and cA4-independent manner, suggesting a more complex mode of transcriptional regulation. We conclude the Csa3a/cA4 interaction represents a nexus between the type I and type III CRISPR-Cas systems present in S. solfataricus, and discuss the role of the Csa3/cA4 interaction in coordinating different arms of this integrated class 1 immune system to mount a synergistic, highly orchestrated immune response.
Structure of an Archaeal Virus Capsid Protein Reveals a Common Ancestry to Eukaryotic and Bacterial Viruses
Archaea and their viruses are poorly understood when compared with the Eukarya and Bacteria domains of life. We report here the crystal structure of the major capsid protein (MCP) of the Sulfolobus turreted icosahedral virus, an archaeal virus isolated from an acidic hot spring (pH 2-4, 72-92°C) in Yellowstone National Park. The structure is nearly identical to the MCP structures of the eukaryotic Paramecium bursaria Chlorella virus, and the bacteriophage PRD1, and shows a common fold with the mammalian adenovirus. Structural analysis of the capsid architecture, determined by fitting the subunit into the electron cryomicroscopy reconstruction of the virus, identified a number of key interactions that are akin to those observed in adenovirus and PRD1. The similar capsid proteins and capsid architectures strongly suggest that these viral capsids originated and evolved from a common ancestor. Hence, this work provides a previously undescribed example of a viral relationship spanning the three domains of life (Eukarya, Bacteria, and Archaea). The MCP structure also provides insights into the stabilizing forces required for extracellular hyperthermophilic proteins to tolerate high-temperature hot springs.
Structural studies of Acidianus tailed spindle virus reveal a structural paradigm used in the assembly of spindle-shaped viruses
The spindle-shaped virion morphology is common among archaeal viruses, where it is a defining characteristic of many viral families. However, structural heterogeneity intrinsic to spindle-shaped viruses has seriously hindered efforts to elucidate the molecular architecture of these lemon-shaped capsids. We have utilized a combination of cryo-electron microscopy and X-ray crystallography to study Acidianus tailed spindle virus (ATSV). These studies reveal the architectural principles that underlie assembly of a spindle-shaped virus. Cryo-electron tomography shows a smooth transition from the spindle-shaped capsid into the tubular-shaped tail and allows low-resolution structural modeling of individual virions. Remarkably, higher-dose 2D micrographs reveal a helical surface lattice in the spindle-shaped capsid. Consistent with this, crystallographic studies of the major capsid protein reveal a decorated four-helix bundle that packs within the crystal to form a four-start helical assembly with structural similarity to the tube-shaped tail structure of ATSV and other tailed, spindle-shaped viruses. Combined, this suggests that the spindle-shaped morphology of the ATSV capsid is formed by a multistart helical assembly with a smoothly varying radius and allows construction of a pseudoatomic model for the lemon-shaped capsid that extends into a tubular tail. The potential advantages that this novel architecture conveys to the life cycle of spindle-shaped viruses, including a role in DNA ejection, are discussed.