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"Martin, Robin"
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Southern Asia, Australia, and the search for human origins
\"This is the first book to focus on the role of Southern Asia and Australia in our understanding of modern human origins and the expansion of Homo sapiens between East Africa and Australia before 30,000 years ago. With contributions from leading experts that take into account the latest archaeological evidence from India and Southeast Asia, this volume critically reviews current models of the timing and character of the spread of modern humans out of Africa. It also demonstrates that the evidence from Australasia should receive much wider and more serious consideration in its own right if we want to understand how our species achieved its global distribution. Critically examining the 'Out of Africa' model, this book emphasizes the context and variability of the global evidence in the search for human origins\"-- Provided by publisher.
Book
Leader–member exchange (LMX) differentiation and work outcomes
According to leader–member exchange (LMX) theory, leaders develop different quality relationships with followers in their team (termed LMX differentiation). An important theoretical question concerns how different LMX relationships within a team affect followers' work outcomes. This paper provides a critical review of the concept of LMX differentiation. We propose that the LMX differentiation process leads to patterns of LMX relationships that can be captured by 3 properties (central tendency, variation, and relative position). We describe a taxonomy illustrating the different ways these properties have been conceptualized and measured. We identify 2 approaches to LMX differentiation as being a “perspective of the team” (that are shared perceptions amongst team members) or a “perspective of the follower” (subjective perceptions unique to each follower). These perspectives lead to different types of measures that predict different outcomes at the individual and team levels. We describe theoretical models employed to explain the effects of LMX differentiation (justice, social comparison, and social identity theories). Generally, the lower the within-team variation in LMX or the more a team member's LMX is higher than the mean team LMX, the better are the work outcomes, but many moderators condition these effects. Finally, we identify some key areas for future research.
Journal Article
Operational Tree Species Mapping in a Diverse Tropical Forest with Airborne Imaging Spectroscopy
Remote identification and mapping of canopy tree species can contribute valuable information towards our understanding of ecosystem biodiversity and function over large spatial scales. However, the extreme challenges posed by highly diverse, closed-canopy tropical forests have prevented automated remote species mapping of non-flowering tree crowns in these ecosystems. We set out to identify individuals of three focal canopy tree species amongst a diverse background of tree and liana species on Barro Colorado Island, Panama, using airborne imaging spectroscopy data. First, we compared two leading single-class classification methods--binary support vector machine (SVM) and biased SVM--for their performance in identifying pixels of a single focal species. From this comparison we determined that biased SVM was more precise and created a multi-species classification model by combining the three biased SVM models. This model was applied to the imagery to identify pixels belonging to the three focal species and the prediction results were then processed to create a map of focal species crown objects. Crown-level cross-validation of the training data indicated that the multi-species classification model had pixel-level producer's accuracies of 94-97% for the three focal species, and field validation of the predicted crown objects indicated that these had user's accuracies of 94-100%. Our results demonstrate the ability of high spatial and spectral resolution remote sensing to accurately detect non-flowering crowns of focal species within a diverse tropical forest. We attribute the success of our model to recent classification and mapping techniques adapted to species detection in diverse closed-canopy forests, which can pave the way for remote species mapping in a wider variety of ecosystems.
Journal Article
Marvel Knights Punisher : the complete collection. Vol. 1
\"Welcome back, Frank! The Punisher returns, more brutal than ever, courtesy of writer Garth Ennis - and his perfect artistic partner, Steve Dillon! The critically acclaimed creators that brought you Preacher restore one of Marvel's most popular characters to ultraviolent glory - as a one-man army locked, loaded and ready to take out anyone in his way. And Frank starts with Ma Gnucci and her entire crime family! Spacker Dave, Joan the Mouse and Mr. Bumpo all await in one of the most celebrated Punisher stories ever told! And Frank's war on crime continues as he targets disgraced General Kreigkopf, and has a very unique team-up with Spider-Man! Plus, in Ennis' very first Punisher story, watch as Frank Castle unleashes his fury on the entire Marvel Universe!\"--Provided by publisher.
Book
Barth syndrome
First described in 1983, Barth syndrome (BTHS) is widely regarded as a rare X-linked genetic disease characterised by cardiomyopathy (CM), skeletal myopathy, growth delay, neutropenia and increased urinary excretion of 3-methylglutaconic acid (3-MGCA). Fewer than 200 living males are known worldwide, but evidence is accumulating that the disorder is substantially under-diagnosed. Clinical features include variable combinations of the following wide spectrum: dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), endocardial fibroelastosis (EFE), left ventricular non-compaction (LVNC), ventricular arrhythmia, sudden cardiac death, prolonged QTc interval, delayed motor milestones, proximal myopathy, lethargy and fatigue, neutropenia (absent to severe; persistent, intermittent or perfectly cyclical), compensatory monocytosis, recurrent bacterial infection, hypoglycaemia, lactic acidosis, growth and pubertal delay, feeding problems, failure to thrive, episodic diarrhoea, characteristic facies, and X-linked family history. Historically regarded as a cardiac disease, BTHS is now considered a multi-system disorder which may be first seen by many different specialists or generalists. Phenotypic breadth and variability present a major challenge to the diagnostician: some children with BTHS have never been neutropenic, whereas others lack increased 3-MGCA and a minority has occult or absent CM. Furthermore, BTHS was first described in 2010 as an unrecognised cause of fetal death. Disabling mutations or deletions of the
tafazzin
(
TAZ
) gene, located at Xq28, cause the disorder by reducing remodeling of cardiolipin, a principal phospholipid of the inner mitochondrial membrane. A definitive biochemical test, based on detecting abnormal ratios of different cardiolipin species, was first described in 2008. Key areas of differential diagnosis include metabolic and viral cardiomyopathies, mitochondrial diseases, and many causes of neutropenia and recurrent male miscarriage and stillbirth. Cardiolipin testing and
TAZ
sequencing now provide relatively rapid diagnostic testing, both prospectively and retrospectively, from a range of fresh or stored tissues, blood or neonatal bloodspots.
TAZ
sequencing also allows female carrier detection and antenatal screening. Management of BTHS includes medical therapy of CM, cardiac transplantation (in 14% of patients), antibiotic prophylaxis and granulocyte colony-stimulating factor (G-CSF) therapy. Multidisciplinary teams/clinics are essential for minimising hospital attendances and allowing many more individuals with BTHS to live into adulthood.
Journal Article
CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
CD47, a \"don't eat me\" signal for phagocytic cells, is expressed on the surface of all human solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue revealed that CD47 is overexpressed on cancer cells. CD47 mRNA expression levels correlated with a decreased probability of survival for multiple types of cancer. CD47 is a ligand for SIRPα, a protein expressed on macrophages and dendritic cells. In vitro, blockade of CD47 signaling using targeted monoclonal antibodies enabled macrophage phagocytosis of tumor cells that were otherwise protected. Administration of anti-CD47 antibodies inhibited tumor growth in orthotopic immunodeficient mouse xenotransplantation models established with patient tumor cells and increased the survival of the mice over time. Anti-CD47 antibody therapy initiated on larger tumors inhibited tumor growth and prevented or treated metastasis, but initiation of the therapy on smaller tumors was potentially curative. The safety and efficacy of targeting CD47 was further tested and validated in immune competent hosts using an orthotopic mouse breast cancer model. These results suggest all human solid tumor cells require CD47 expression to suppress phagocytic innate immune surveillance and elimination. These data, taken together with similar findings with other human neoplasms, show that CD47 is a commonly expressed molecule on all cancers, its function to block phagocytosis is known, and blockade of its function leads to tumor cell phagocytosis and elimination. CD47 is therefore a validated target for cancer therapies.
Journal Article
Automatic Body Segment and Side Recognition of an Inertial Measurement Unit Sensor during Gait
Inertial measurement unit (IMU) sensors are widely used for motion analysis in sports and rehabilitation. The attachment of IMU sensors to predefined body segments and sides (left/right) is complex, time-consuming, and error-prone. Methods for solving the IMU-2-segment (I2S) pairing work properly only for a limited range of gait speeds or require a similar sensor configuration. Our goal was to propose an algorithm that works over a wide range of gait speeds with different sensor configurations while being robust to footwear type and generalizable to pathologic gait patterns. Eight IMU sensors were attached to both feet, shanks, thighs, sacrum, and trunk, and 12 healthy subjects (training dataset) and 22 patients (test dataset) with medial compartment knee osteoarthritis walked at different speeds with/without insole. First, the mean stride time was estimated and IMU signals were scaled. Using a decision tree, the body segment was recognized, followed by the side of the lower limb sensor. The accuracy and precision of the whole algorithm were 99.7% and 99.0%, respectively, for gait speeds ranging from 0.5 to 2.2 m/s. In conclusion, the proposed algorithm was robust to gait speed and footwear type and can be widely used for different sensor configurations.
Journal Article