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The definitive guide to Squarespace : learn to deliver custom, professional web experiences for yourself and your clients
\"Utilize the power of Squarespace to create custom professional websites. Learn the principles and tools used by Squarespace's most successful web professionals to take your skills to the next level. Beginning with an overview of the Squarespace interface and template selection guidelines, this book shows you how the key web languages work together within Squarespace. You'll also see how to use the Custom CSS Editor, Code Injections, and Code Blocks to customize Squarespace templates and how the Style Editor selections affect the template's structure. Learn the accommodations that must be made in JavaScript for the customizations to work correctly in AJAX-based templates. Finally, discover what Developer Mode is, how to use it, and when to use it. The Definitive Guide to Squarespace is the only book you need to get up and running with Squarespace web development.\"--Publisher's description.
Book
Cerebrospinal fluid neurofilament light chain in multiple sclerosis and its subtypes: a meta-analysis of case–control studies
ObjectiveNeurofilament is a biomarker of axonal injury proposed as a useful adjunct in the monitoring of patients with multiple sclerosis (MS). We conducted a systematic review and meta-analysis of case–control studies that have measured neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF) of people with MS (pwMS), in order to determine whether, and to what degree, CSF NfL levels differentiate MS from controls, or the subtypes or stages of MS from each other.MethodsGuidelines on Preferred Reporting Items for Systematic Reviews and Meta-Analyses were followed. Electronic databases were searched for published and ‘grey’ literature, with 151 hits. Of 51 full articles screened, 20 were included in qualitative analysis, and 14 in meta-analysis.ResultsCSF NfL was higher in 746 pwMS than 435 (healthy and disease) controls, with a moderate effect size of 0.61 (p < 0.00001). Mean CSF NfL levels were significantly higher in 176 pwMS with relapsing disease than 92 with progressive disease (2124.8 ng/L, SD 3348.9 vs 1121.4 ng/L, SD 947.7, p = 0.0108). CSF NfL in 138 pwMS in relapse (irrespective of MS subtype) was double that seen in 268 pwMS in remission (3080.6 ng/L, SD 4715.9 vs 1541.7 ng/L, SD 2406.5, p < 0.0001).ConclusionsCSF NfL correlates with MS activity throughout the course of MS, reflecting the axonal damage in pwMS. Relapse is more strongly associated with elevated CSF NfL levels than the development of progression, and NfL may be most useful as a marker of disease ‘activity’ rather than as a marker of disability or disease stage.
Journal Article
The SENCO handbook : leading provision and practice
This handbook will give aspiring and practising SENCOs, teachers and headteachers an in-depth knowledge and understanding of effective policy, provision and practice to meet the diverse needs of children with special educational needs and disabilities.
Book
The effect of Apolipoprotein E4 on cognitive function in Parkinson’s disease: A structural MRI study in the PPMI cohort
Cognitive impairment is a common non-motor symptom of Parkinson's disease (PD), yet its underlying mechanisms remain poorly understood. Apolipoprotein E4 (APOE4), a genetic risk factor of Alzheimer's Disease, has been associated with PD-related cognitive impairment. However, findings are inconsistent, highlighting the need for further investigation. Neuroimaging studies have found gray matter abnormalities, mainly reductions in gray matter volume (GMV) and cortical thickness (CTh), in both cognitively impaired PD patients and APOE4 carriers. Yet, APOE4's role in these structural changes and their cognitive impact in PD is underexplored.
This study aimed to determine whether APOE4 influences early structural brain differences in terms of GMV and CTh in PD prior to the emergence of cognitive dysfunction.
A total of 51 PD APOE4 carriers and 120 non-carriers who were cognitively unimpaired from the Parkinson's Progression Markers Initiative (PPMI) database were included. T1-weighted MRI scans were used to calculate GMV and CTh in regions previously associated with PD-related cognitive impairment, including hippocampal subregions. Cognitive scores assessing global cognition and specific cognitive domains were used to examine associations between regions showing significant GMV or CTh group differences and cognitive performance.
PD APOE4 carriers showed increased GMV in the left angular gyrus (AnG) and decreased GMV in the left nucleus accumbens (NAcc) compared to non-carriers, though neither survived multiple comparison correction. Left AnG GMV correlated with visuospatial function in both groups but did not remain significant after co-variate adjustment. Left NAcc GMV correlated with visuospatial function and working memory, but only in non-carriers even after co-variate adjustment. No group differences were observed in CTh measures and hippocampal subregion GMVs.
This study suggests that APOE4 may not influence cognitive function in PD by affecting GMV and CTh. However, longitudinal analyses must confirm these observations.
Journal Article
Coaching for performance : realising the Olympic dream
This book celebrates two important aspects of the London 2012 Olympic and Paralympic Games. For those involved in any aspect of Olympism, and particularly coaches and athletes, London 2012 was about realising dreams, achieving success and participating in competitive sport at the highest level. This book sets out some of these dreams and the part coaches play in this. The book also looks at the notion of 'coaching-for-performance' and does this from an international and multi-sport perspective. From interviews with Olympic coaches, the experiences of those working in the field of high performance and from applied sport researchers, the book uses the metaphor of the 'coach-as-alchemist' in order to capture the dynamics of coach-athlete relationships and performance. Sports such as diving, swimming, gymnastics, skiing are included as well as individual and team sports.
BOOK
Using machine learning for detection of Parkinson’s disease and mild cognitive impairment
Parkinson's disease is a movement disorder featuring motor symptoms and cognitive decline, which can manifest as mild cognitive impairment. The incidence of mild cognitive impairment increases with disease progression, and Parkinson's disease can cause significant disability, therefore, identification of Parkinson's disease and mild cognitive impairment in Parkinson's disease is imperative. Neuroimaging and biofluid biomarkers have been studied separately, however, research suggests that combining biomarkers may improve detection.
We aimed to investigate using machine learning whether a combination of neuroimaging and biofluid biomarkers would result in more effective identification of Parkinson's disease and mild cognitive impairment.
Utilizing the Parkinson's Progression Markers Initiative dataset, we applied two different machine learning approaches, support vector machine and random forest, to explore combinations of neuroimaging and cerebrospinal fluid biomarkers for detection.
Overall, both machine learning techniques had an equivalent performance. In general, in those models for detecting Parkinson's disease, DaT-SPECT performed better than biofluid biomarkers. In models for detecting Parkinson's disease patients with mild cognitive impairment, combining DaT-SPECT with phosphorylated-tau-181 resulted in higher accuracy, outperforming DaT-SPECT alone.
Classification for Parkinson's disease and mild cognitive impairment may be improved by combining neuroimaging with biofluid biomarkers through machine learning models.
Journal Article
Materialities of care : encountering health and illness through artefacts and architecture
\"Materialities of Care addresses the role of material culture within health and social care encounters, including everyday objects, dress, furniture and architecture. Makes visible the mundane and often unnoticed aspects of material culture and attends to interrelations between materials and care in practice. Examines material practice across a range of clinical and non-clinical spaces including hospitals, hospices, care homes, museums, domestic spaces and community spaces such as shops and tenement stairwells. Addresses fleeting moments of care, as well as choreographed routines that order bodies and materials. Focuses on practice and relations between materials and care as ongoing, emergent and processual International contributions from leading scholars draw attention to methodological approaches for capturing the material and sensory aspects of health and social care encounters\"--Provided by publisher.
Book
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases, including cancer and neurological disorders. While BER is well studied on naked DNA, it remains unclear how BER efficiently operates on chromatin. Here, we show that AAG binds to chromatin and forms complex with RNA polymerase (pol) II. This occurs through direct interaction with Elongator and results in transcriptional co-regulation. Importantly, at co-regulated genes, aberrantly methylated bases accumulate towards the 3′end in regions enriched for BER enzymes AAG and APE1, Elongator and active RNA pol II. Active transcription and functional Elongator are further crucial to ensure efficient BER, by promoting AAG and APE1 chromatin recruitment. Our findings provide insights into genome stability maintenance in actively transcribing chromatin and reveal roles of aberrantly methylated bases in regulation of gene expression.
How genome stability is maintained at regions of active transcription is currently not entirely clear. Here, the authors reveal an association between base excision repair factors and transcription elongation to modulate DNA repair.
Journal Article
The simple home : the luxury of enough
Presents the stories of young city families, single people, and retirees across the country who have opted for simple homes and lifestyles, and includes photographs and descriptions of their houses and interior designs.
Book
The acceptability of photovoice as a method for incorporating resilience-enhancing factors into pediatric pain research
Recurrent or chronic pain affects 11–38% of children and adolescents. Pediatric pain research typically focuses on risk factors, such as anxiety and parent functional disability, but resilience-building, protective factors also play an important role in the pain experience. New methods to incorporate resilience-enhancing factors into pain research are needed. Photovoice is a highly participatory research method, where participants take photos to address a common question, caption their photos, and discuss the meaning of the photos in a group. The main objective of this study was to determine whether photovoice is an acceptable method to young people living with chronic pain for identifying and sharing sources of joy. Another objective was to explore sources of joy. Sixteen adolescents and young adults participated, which involved meeting in a group to discuss the goal of the study, taking photographs of self-identified sources of joy over a two-week period, and meeting as a group again to discuss the photographs and participate in a focus group about the experience. Results suggest that photovoice is an acceptable method, as all participants took photographs and attended both meetings, and three themes from the focus group data suggested the participants considered photovoice to be appropriate: 1.) Relief associated with meeting peers, 2.) Potential to benefit young people living with pain, and 3.) Potential to raise awareness. Three themes emerged from the discussion of the photographs to describe sources of joy: 1.) Gratitude for everyday pleasures and accomplishments, 2.) Support from pets, and 3.) Journey of acceptance. Results add to the strengths-based literature on pediatric pain by identifying an acceptable method that could be further explored for use as an intervention to enhance protective factors such as positive affect, gratitude, and social support and to compare the experiences of different populations of youth living with pain.
Journal Article