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Silver nanoparticles are one of the most important materials in the nanotechnology industry. Additionally, the protein corona is emerging as a key entity at the nanobiointerface; thus, a comprehensive understanding of the interactions between proteins and silver nanoparticles is imperative. Therefore, literature reporting studies involving both single molecule protein coronas (i.e., bovine and human serum albumin, tubulin, ubiquitin and hyaluronic-binding protein) and complex protein coronas (i.e., fetal bovine serum and yeast extract proteins) were selected to demonstrate the effects of protein coronas on silver nanoparticle cytotoxicity and antimicrobial activity. There is evidence that distinct and differential protein components may yield a “protein corona signature” that is related to the size and/or surface curvature of the silver nanoparticles. Therefore, the formation of silver nanoparticle protein coronas together with the biological response to these coronas (i.e., oxidative stress, inflammation and cytotoxicity) as well as other cellular biophysicochemical mechanisms (i.e., endocytosis, biotransformation and biodistribution) will be important for nanomedicine and nanotoxicology. Researchers may benefit from the information contained herein to improve biotechnological applications of silver nanoparticles and to address related safety concerns. In summary, the main aim of this mini-review is to highlight the relationship between the formation of silver nanoparticle protein coronas and toxicity.

Science-fiction movies portray volumetric systems that provide not only visual but also tactile and audible three-dimensional (3D) content. Displays based on swept-volume surfaces 1 , 2 , holography 3 , optophoretics 4 , plasmonics 5 or lenticular lenslets 6 can create 3D visual content without the need for glasses or additional instrumentation. However, they are slow, have limited persistence-of-vision capabilities and, most importantly, rely on operating principles that cannot produce tactile and auditive content as well. Here we present the multimodal acoustic trap display (MATD): a levitating volumetric display that can simultaneously deliver visual, auditory and tactile content, using acoustophoresis as the single operating principle. Our system traps a particle acoustically and illuminates it with red, green and blue light to control its colour as it quickly scans the display volume. Using time multiplexing with a secondary trap, amplitude modulation and phase minimization, the MATD delivers simultaneous auditive and tactile content. The system demonstrates particle speeds of up to 8.75 metres per second and 3.75 metres per second in the vertical and horizontal directions, respectively, offering particle manipulation capabilities superior to those of other optical or acoustic approaches demonstrated until now. In addition, our technique offers opportunities for non-contact, high-speed manipulation of matter, with applications in computational fabrication 7 and biomedicine 8 . A volumetric display that can simultaneously deliver visual, tactile and auditory content is demonstrated.

The chytrid fungus Batrachochytrium dendrobatidis has caused the most prominent loss of vertebrate diversity ever recorded, which peaked in the 1980s. Recent incursion by its sister species B. salamandrivorans in Europe raised the alarm for a new wave of declines and extinctions in western Palearctic urodeles. The European Commission has responded by restricting amphibian trade. However, private amphibian collections, the main end consumers, were exempted from the European legislation. Here, we report how invasion by a released, exotic newt coincided with B. salamandrivorans invasion at over 1000 km from the nearest natural outbreak site, causing mass mortality in indigenous marbled newts (Triturus marmoratus), and posing an acute threat to the survival of nearby populations of the most critically endangered European newt species (Montseny brook newt, Calotriton arnoldi). Disease management was initiated shortly after detection in a close collaboration between policy and science and included drastic on site measures and intensive disease surveillance. Despite these efforts, the disease is considered temporarily contained but not eradicated and continued efforts will be necessary to minimize the probability of further pathogen dispersal. This precedent demonstrates the importance of tackling wildlife diseases at an early stage using an integrated approach, involving all stakeholders and closing loopholes in existing regulations.

Sugarcane bagasse is an abundant agroindustrial bioresource from production of ethanol and sugar, which could be used as raw material to obtain advanced biofuels, electric energy, among other high added-value green products in biorefineries. This work shed light on necessary integration of state-of-art characterization of critical physico-chemical properties with techno-economic aspects of activated carbons from sugarcane bagasse. Activated carbons were produced by thermochemical activation using various ratios of NaOH and pyrolyzed bagasse. Impacts of tuning these materials critical properties such as process yield, apparent density, surface oxidation states and textural characteristics by the activation conditions are discussed addressing their applicability as adsorbents for water and air decontamination treatment. Moreover, this study was concisely bound to techno-economic assessment of full-scale plants which pointed to pyrolyzed bagasse being an economically-competitive alternative raw material to produce activated carbons at broad range of activation conditions that would enable this sustainable technology. Graphic Abstract

Background Most data on mortality and prognostic factors of universal healthcare waiting lists come from North America, Australasia, and Europe, with little information from South America. We aimed to determine the relationship between medical center-specific waiting time and waiting list mortality in Chile. Method Using data from all new patients listed in medical specialist waitlists for non-prioritized health problems from 2008 to 2015 in three geographically distant regions of Chile, we constructed hierarchical multivariate survival models to predict mortality risk at two years after registration for each medical center. Kendall rank correlation analysis was used to measure the association between medical center-specific mortality hazard ratio and waiting times. Result There were 987,497 patients waiting for care at 77 medical centers, including 33,546 (3.40%) who died within two years after registration. Male gender (hazard ratio [HR] = 1.17, 95% confidence interval [CI] 1.1–1.24), older age (HR = 2.88, 95% CI 2.72–3.05), urban residence (HR = 1.19, 95% CI 1.09–1.31), tertiary care (HR = 2.2, 95% CI 2.14–2.26), oncology (HR = 3.57, 95% CI 3.4–3.76), and hematology (HR = 1.6, 95% CI 1.49–1.73) were associated with higher risk of mortality at each medical center with large region-to-region variations. There was a statistically significant association between waiting time variability and death (Z = 2.16, P  = 0.0308). Conclusion Patient wait time for non-prioritized health conditions was associated with increased mortality in Chilean hospitals.

Understanding the susceptibility and infectiousness of children and adolescents in comparison to adults is important to appreciate their role in the COVID-19 pandemic. To determine SARS-CoV-2 susceptibility and infectiousness of children and adolescents with adults as comparator for three variants (wild-type, alpha, delta) in the household setting. We aimed to identify the effects independent of vaccination or prior infection. We searched EMBASE, PubMed and medRxiv up to January 2022. Two reviewers independently identified studies providing secondary household attack rates (SAR) for SARS-CoV-2 infection in children (0-9 years), adolescents (10-19 years) or both compared with adults (20 years and older). Two reviewers independently extracted data, assessed risk of bias and performed a random-effects meta-analysis model. Odds ratio (OR) for SARS-CoV-2 infection comparing children and adolescents with adults stratified by wild-type (ancestral type), alpha, and delta variant, respectively. Susceptibility was defined as the secondary attack rate (SAR) among susceptible household contacts irrespective of the age of the index case. Infectiousness was defined as the SAR irrespective of the age of household contacts when children/adolescents/adults were the index case. Susceptibility analysis: We included 27 studies (308,681 contacts), for delta only one (large) study was available. Compared to adults, children and adolescents were less susceptible to the wild-type and delta, but equally susceptible to alpha. Infectiousness analysis: We included 21 studies (201,199 index cases). Compared to adults, children and adolescents were less infectious when infected with the wild-type and delta. Alpha -related infectiousness remained unclear, 0-9 year old children were at least as infectious as adults. Overall SAR among household contacts varied between the variants. When considering the potential role of children and adolescents, variant-specific susceptibility, infectiousness, age group and overall transmissibility need to be assessed.

In this work, we obtain an expression for the total observational frequency shift of photons emitted by massive geodesic particles circularly orbiting a black hole in a general spherically symmetric background. Our general relations are presented in terms of the metric components and their derivatives that characterize the black hole parameters. As a concrete example of this general relativistic approach, a special case is studied by applying the formalism to a nonsingular black hole conformally related to the Schwarzchild solution that possesses a length scale parameter l and an integer parameter N in addition to the black hole mass. Besides, we express the nonsingular black hole mass in terms of the observational redshift/blueshift. Finally, we investigate the effects of the free parameters of the conformal gravity theory on the observational frequency shift and compare results with those of the standard Schwarzschild black hole.

We provide a construction of Roe ( C^* -)algebras of general coarse spaces in terms of coarse geometric modules. This extends the classical theory of Roe algebras of metric spaces and gives a unified framework to deal with either uniform or non-uniform Roe algebras, algebras of operators of controlled propagation and algebras of quasi-local operators, both in the metric and general coarse geometric settings. The key new definitions are those of coarse geometric module and coarse support of operators between coarse geometric modules. These let us construct natural bridges between coarse geometry and operator algebras. We then study the general structure of Roe-like algebras and investigate several structural properties, such as admitting (non-commutative) Cartan subalgebras or computing their intersection with the compact operators. Lastly, we prove that assigning to a coarse space the K -theory groups of its Roe algebra(s) is a natural functorial operation.

Background This study examines the relationship between universal health coverage (UHC) and the burden of emergency diseases at a global level. Methods Data on Disability-Adjusted Life Years (DALYs) from emergency conditions were extracted from the Institute for Health Metrics and Evaluation (IHME) database for the years 2015 and 2019. Data on UHC, measured using two variables 1) coverage of essential health services and 2) proportion of the population spending more than 10% of household income on out-of-pocket health care expenditure, were extracted from the World Bank Database for years preceding our outcome of interest. A linear regression was used to analyze the association between UHC variables and DALYs for emergency diseases, controlling for other variables. Results A total of 132 countries were included. The median national coverage of essential health services index was 67.5/100, while the median national prevalence of catastrophic spending in the sample was 6.74% of households. There was a strong significant relationship between health service coverage and the burden of emergency diseases, with an 11.5-point reduction in DALYs of emergency medical diseases (95% CI -9.5, -14.8) for every point increase in the coverage of essential health services index. There was no statistically significant relationship between catastrophic expenditures and the burden of emergency diseases, which may be indicative of inelastic demand in seeking services for health emergencies. Conclusion Increasing the coverage of essential health services, as measured by the essential health services index, is strongly correlated with a reduction in the burden of emergency conditions. In addition, data affirms that financial protection remains inadequate in many parts of the globe, with large numbers of households experiencing significant economic duress related to seeking healthcare. This evidence supports a strategy of strengthening UHC as a means of combating death and disability from health emergencies, as well as extending protection against impoverishment related to healthcare expenses.