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"Martinovich, V"
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Redox Buffer Capacity of the Cell: Theoretical and Experimental Approach
Reactive oxygen species (ROS) are involved in a variety of biological phenomena, such as mutation, carcinogenesis, inflammation, aging, development, and signal transduction. Intracellular generation of ROS might lead to the activation of redox signaling or oxidative stress. Nonetheless, it is difficult to estimate whether ROS-induced intracellular events are beneficial or deleterious to the cell. The quantitative basis of changes in the intracellular redox state of cells is not well-defined, thus leading to the dilemma that redox changes induced by oxidants in distinct cell types cannot be predicted. To overcome this limitation this study undertakes to analyze on a theoretical as well as on an experimental basis the intracellular redox state changes occurring inside cells upon addition of oxidants or reductants. 2,7-Dichlorodihydrofluorescein (H
2
DCF) was used to characterize the redox buffer capacity in erythrocytes. It was shown that the redox buffer capacity of erythrocytes in the relation to peroxynitrite (ONOO
−
) is 2.1 times lower than the redox buffer capacity of erythrocytes in the relation to hydrogen peroxide (H
2
O
2
). The feasibility of redox buffer capacity assessment as an innovative tool for investigation and description of redox signaling events in cells is discussed.
Journal Article
Zhivago's children : the last Russian intelligentsia
This is an in-depth history of the cultural and intellectual evolution of the intelligentsia in Russia from Stalin's death in 1953 to the collapse of the Soviet Union in 1991.
BOOK
Optimization of management of scientific departments in departmental organizations
In the paper current types of the organizational management structures have analyzed as well as typical problems of scientific departments are considered and organizational structure is proposed allowing optimization of management for the research center in the frames of organization in a law enforcement agency.
Journal Article
Methods for prediction of the avalanche danger
The work considers methods for the prediction of the avalanche danger. It shown that for the local forecasts the most efficient way is to simulate snow mass by the particles dynamics technique. Basin on this model it is possible to predict the critical parameters for the avalanche sliding, the character of motion of snow mass, the force and energy of its impact on the movable and immovable obstacles with different shape and, hence, a destructive avalanche ability.
Journal Article
Redox Regulation of Calcium Signaling in Cancer Cells by Ascorbic Acid Involving the Mitochondrial Electron Transport Chain
Previously, we have reported that ascorbic acid regulates calcium signaling in human larynx carcinoma HEp-2 cells. To evaluate the precise mechanism of Ca2+ release by ascorbic acid, the effects of specific inhibitors of the electron transport chain components on mitochondrial reactive oxygen species (ROS) production and Ca2+ mobilization in HEp-2 cells were investigated. It was revealed that the mitochondrial complex III inhibitor (antimycin A) amplifies ascorbate-induced Ca2+ release from intracellular stores. The mitochondrial complex I inhibitor (rotenone) decreases Ca2+ release from intracellular stores in HEp-2 cells caused by ascorbic acid and antimycin A. In the presence of rotenone, antimycin A stimulates ROS production by mitochondria. Ascorbate-induced Ca2+ release in HEp-2 cells is shown to be unaffected by catalase. The results obtained suggest that Ca2+ release in HEp-2 cells caused by ascorbic acid is associated with induced mitochondrial ROS production. The data obtained are in line with the concept of redox signaling that explains oxidant action by compartmentalization of ROS production and oxidant targets.
Journal Article
Algorithm design for management decision-making support in the educational institutions of higher education basing of the application of risk-oriented approach
Current state of the education area requires adoption of such approaches to the management from the educational institutions that enable to respond to the permanent changes in the higher education system in \"the real-time mode\" while maintaining a high level of the educational services and satisfying all of the interested parties by the quality of training for the specialists in the near future. Authors of the work propose implementation of risk-oriented approach as an innovation which acquired good advantages at the enterprises both in Russia and abroad.
Journal Article