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"Martinuzzi, A."
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ملخص كتاب القائد كإنسان
في العديد من المجتمعات اليهودية، لم تعد الكلمة الألمانية « Mensch تعني ببساطة «الإنسان» أو «الكائن الحي». إنه يشير إلى مجموعة من السمات الإيجابية والسمات الرائعة. Mensch هو رجل أو امرأة يتمتعان بالنزاهة والشرف وهو إنسان قوي. السمات التي تشكل Mensch أو أي قائد عظيم حقا لها هيكل يشبه الأشجار. تماما كما أن الشجرة لها جذور وجذع وأغصان وأوراق، فإن لدى Mensch سمات تضرب جذورها بقوة داخل الأرض، والبعض الآخر يبقيها شامخة والبعض الآخر يوفر ظلا مريحا لمن تقودهم. عندما يتم الجمع بين كل هذه السمات، تحصل على قائد يلهم الآخرين ويمكنه خلق جو إبداعي يقوم فيه الأشخاص بأفضل أعمالهم. لكن ما هي هذه السمات بالضبط ؟ في هذه الصفحات، ستتعلم أيضًا : لماذا لا يتفاخر لاعب اتحاد كرة القدم الأميركي السابق Anthony بإنجازاته ؟ Kevin Dungy.
Book
\PEI-ICF PETRA\: a smart web platform to foster cooperation in drafting the individualized Education Plan (IEP) for students with disability
The implementation of the framework offered by the international classification of functioning disability and health (ICF) is recognized as a necessary step in the process of school inclusion for pupils with disabilities. This step may be greatly eased by informatics tools that guide users without requiring extensive familiarity with the ICF. Here we describe the development and testing of PETRA, a specific digital tool that supports the personalization of the educational path for students with certified disabilities in Italy. The tool foresees the active participation of the family and the student himself in his own training path and guides the user through sequential steps: observation, planning, realization, validation, The usability and efficiency of the tool was tested in a representative set of schools in the Trento province. Using this tool, each student is considered in his uniqueness and the educational and didactic interventions are calibrated to its specificities (including the oftenunrecognized potentialities,) and the context in which it lives. The tool was well received, showed its efficiency in each of the steps promising to offer substantial support in improving school inclusion and empowerment of students with disabilities.
Journal Article
Psychological Profile in Children and Adolescents with Severe Course Juvenile Idiopathic Arthritis
Objective. Juvenile Idiopathic Arthritis (JIA) is the most common chronic pediatric rheumatic disease. It is recognized that only reliance on clinical signs of disease outcome is inadequate for understanding the impact of illness and its treatment on child’s life and functioning. There is a need for a multidisciplinary and holistic approach to children with arthritis which considers both physical and emotional functioning. This study investigated the psychosocial functioning of children and adolescent with JIA and the disease-related changes in their family. Methods. The sample consisted of 33 hospitalized patients, aged 6–16 years. Both parents and the children were given a number of questionnaire to fill out. Clinical information was extracted from the interviews. Results. Self-reported psychological functioning (depression, anxiety, and behavior) was not different from the normal population; however significant psychological suffering was detected by the clinical interview. Conclusions. Children and adolescents with JIA do not show overt psychopathology by structured assessment; nevertheless a more clinically oriented holistic approach confirms JIA as a disrupting event causing relevant changes in the quality of life of the affected families.
Journal Article
Caspase-independent death of Leber’s hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G
Leber's hereditary optic neuropathy (LHON) is associated with mitochondrial DNA point mutations affecting different subunits of complex I. By replacing glucose with galactose in the medium, cybrids harboring each of the three LHON pathogenic mutations (11778/ND4, 3460/ND1, 14484/ND6) suffered a profound ATP depletion over a few hours and underwent apoptotic cell death, which was caspase-independent. Control cybrids were unaffected. In addition to cytochrome c, apoptosis inducing factor (AIF) and endonuclease G (EndoG) were also released from the mitochondria into the cytosol in LHON cybrids, but not in control cells. Exposure of isolated nuclei to cytosolic fractions from LHON cybrids maintained in galactose medium caused nuclear fragmentation, which was strongly reduced by immuno-depletion with anti-AIF and anti-EndoG antibodies. In conclusion, the caspase-independent death of LHON cybrids incubated in galactose medium is triggered by rapid ATP depletion and mediated by AIF and EndoG.
Journal Article
Children in Vegetative State and Minimally Conscious State : Patients’ Condition and Caregivers’ Burden
Caring for children in vegetative state (VS) or minimally conscious state (MCS) challenges parents and impacts on their well-being. This study aims to evaluate caregivers’ health condition, coping, anxiety and depression levels, and how these issues relate to children’s disability. 35 children with VS and MCS were administered the disability rating scale (DRS) and 35 caregivers completed the Coping Orientations to Problem Experiences, Short Form-12, Beck Depression Inventory, and the Spielberger State-Trait Anxiety Inventory-Y. Children were mainly males (68.6%), hosted at domicile (77.1%), and diagnosed with VS (60%), with anoxic aetiology (45.7%). Caregivers were mainly mothers (85.7%), married (82.9%), and housewives (51.4%); 60% declared financial difficulties, and 82.9% provided full-time assistance. 57.2% reported depressive symptoms, poor mental health, and high level of state and trait anxiety. “Problem-oriented” (P<0.001) and “emotional-oriented” (P<0.001), were more adopted than “potentially dysfunctional” ones. DRS scores (mean = 22.0; SD = 1.9) did not significantly correlate to any psychological measure. Rehabilitative programs for children with SV and SMC should also provide interventions on surrounding systems: improving the network of psychological support and social assistance may decrease the burden of caregivers and, in turn, improve caring abilities and children quality of life.
Journal Article
20 Years of ICF—International Classification of Functioning, Disability and Health: Uses and Applications around the World
The International Classification of Functioning Disability and Health (ICF) was approved in 2001 and, since then, several studies reported the increased interest about its use in different sectors. A recent overview that summarizes its applications is lacking. This study aims to provide an updated overview about 20 years of ICF application through an international online questionnaire, developed by the byline authors, and sent to each World Health Organization Collaborating Centers of the Family of International Classifications (WHO-FIC CCs). Data was collected during October 2020 and December 2021 and descriptive content analyses were used to report main results. Results show how, in most of the respondent countries represented by WHO-FIC CCs, ICF was mainly used in clinical practice, policy development and social policy, and in education areas. Despite its applications in different sectors, ICF use is not mandatory in most countries but, where used, it provides a biopsychosocial framework for policy development in health, functioning and disability. The study provides information about the needs related to ICF applications, that can be useful to organize targeted intervention plans. Furthermore, this survey methodology can be re-proposed periodically to monitor the use of the ICF in the future.
Journal Article
Point mutations and a large intragenic deletion in SPG11 in complicated spastic paraplegia without thin corpus callosum
Background:Hereditary spastic paraplegia (HSP) with thin corpus callosum (HSP-TCC) is a frequent subtype of complicated HSP clinically characterised by slowly progressive spastic paraparesis with cognitive impairment and thin corpus callosum (TCC). SPG11, the gene associated with the major locus involved, encodes spatacsin, a protein of unknown function.Methods:Different types of mutations were identified in patients with the complex form of HSP (cHSP) including TCC. We screened a series of 45 index patients with different types of cHSP with (n = 10) and without (n = 35) TCC.Results:Ten mutations, of which five are novel, were detected in seven patients. Of importance, three out of seven mutated patients present with cHSP without TCC. Among the novel mutations identified, we characterised a large intragenic rearrangement deleting 2.6 kb of the SPG11 gene. The rearrangement is due to non-allelic homologous recombination between Alu sequences flanking the breakpoints.Conclusions:These findings expand the mutation spectrum of SPG11 and suggest that SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC. This helps to define further clinical and molecular criteria for a correct diagnosis of the SPG11 related form of cHSP. In addition, the intragenic deletion detected here, and the mechanism involved, both provide clues to address the issue of SPG11 missing mutant alleles previously reported.
Journal Article
Corporations, Stakeholders and Sustainable Development I: A Theoretical Exploration of Business-Society Relations
Sustainable development (SD) - that is, \"Development that meets the needs of current generations without compromising the ability of future generations to meet their needs and aspirations\" - can be pursued in many dierent ways. Stakeholder relations management (SRM) is one such way, through which corporations are confronted with economic, social, and environmental stakeholder claims. This paper lays the groundwork for an empirical analysis of the question of how far SD can be achieved through SRM. It describes the so-called SD-SRM perspective as a distinctive research approach and shows how it relates to the wider body of stakeholder theory. Next, the concept of SD is operationalized for the microeconomic level with reference to important documents. Based on the ensuing SD framework, it is shown how SD and SRM relate to each other, and how the two concepts relate to other popular concepts such as Corporate Sustainability and Corporate Social Responsibility. The paper concludes that the significance of societal guiding models such as SD and of management approaches like CSR is strongly dependent on their footing in society.
Journal Article
MELAS Mutation in mtDNA Binding Site for Transcription Termination Factor Causes Defects in Protein Synthesis and in Respiration but no Change in Levels of Upstream and Downstream Mature Transcripts
The pathogenetic mechanism of the mitochondrial tRNALeu
UURgene mutation responsible for the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome was investigated in transformants obtained by transfer of mitochondria from three genetically unrelated MELAS patients into human mitochondrial DNA (mtDNA)-less (ρ⚬) cells. Marked defects in mitochondrial protein synthesis and respiratory activity were observed in transformants containing virtually pure mutant mtDNA, as compared to the parent of the ρ⚬cells (the 143B cell line) or to transformants containing exclusively wild-type mtDNA, derived from one of the patients or a maternally related asymptomatic individual. A striking protective effect against the mutation was exerted in the transformants by levels of residual wild-type mtDNA above 6%. The MELAS mutation occurs within the mtDNA binding site for a protein factor (mTERF) that promotes termination of transcription at the 16S rRNA/tRNALeu
UURgene boundary. A marked decrease in affinity of purified mTERF for the mutant target sequence was observed in in vitro assays. By contrast, RNA transfer hybridization experiments failed to show any significant change in the steady-state amounts of the two rRNA species, encoded upstream of the termination site, and of the mRNAs encoded downstream, in the transformants carrying the MELAS mutation.
Journal Article
Quo Vadis Responsible Fashion? Contingencies and Trends Influencing Sustainable Business Models in the Wearing Apparel Sector
Currently, the wearing apparel sector is relatively under-investigated in terms of sustainable business models. At the same time, the sector has been increasingly scrutinised regarding its effects on the natural environment and quality of jobs issues related to its operations, manufacturing processes, and its global supply chains. Based on data generated in two European research projects, our paper systematically identifies the environmental and quality of jobs issues most affected by the sector, relates them to current and future levels of CSR, and embeds them into the context of important sectoral macro-trends. By doing so, our paper offers insights and orientation for companies in regards to those environmental and quality of jobs issues, which may provide a genuine opportunity for creating more sustainable business models. Understanding these concerns and upcoming trends could give them a unique position for differentiating their business models.
Journal Article