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The COVID-19 pandemic has disproportionately affected persons in long-term care, who often experience health disparities. To delineate the COVID-19 disease burden among persons with intellectual disabilities, we prospectively collected data from 36 care facilities for 3 pandemic waves during March 2020-May 2021. We included outcomes for 2,586 clients with PCR-confirmed SARS-CoV-2 infection, among whom 161 had severe illness and 99 died. During the first 2 pandemic waves, infection among persons with intellectual disabilities reflected patterns observed in the general population, but case-fatality rates for persons with intellectual disabilities were 3.5 times higher and were elevated among those >40 years of age. Severe outcomes were associated with older age, having Down syndrome, and having >1 concurrent condition. Our study highlights the disproportionate COVID-19 disease burden among persons with intellectual disabilities and the need for disability-inclusive research and policymaking to inform disease surveillance and public health policies for this population.

Light elements were produced in the first few minutes of the Universe through a sequence of nuclear reactions known as Big Bang nucleosynthesis (BBN) 1 , 2 . Among the light elements produced during BBN 1 , 2 , deuterium is an excellent indicator of cosmological parameters because its abundance is highly sensitive to the primordial baryon density and also depends on the number of neutrino species permeating the early Universe. Although astronomical observations of primordial deuterium abundance have reached percent accuracy 3 , theoretical predictions 4 – 6 based on BBN are hampered by large uncertainties on the cross-section of the deuterium burning D( p , γ ) 3 He reaction. Here we show that our improved cross-sections of this reaction lead to BBN estimates of the baryon density at the 1.6 percent level, in excellent agreement with a recent analysis of the cosmic microwave background 7 . Improved cross-section data were obtained by exploiting the negligible cosmic-ray background deep underground at the Laboratory for Underground Nuclear Astrophysics (LUNA) of the Laboratori Nazionali del Gran Sasso (Italy) 8 , 9 . We bombarded a high-purity deuterium gas target 10 with an intense proton beam from the LUNA 400-kilovolt accelerator 11 and detected the γ-rays from the nuclear reaction under study with a high-purity germanium detector. Our experimental results settle the most uncertain nuclear physics input to BBN calculations and substantially improve the reliability of using primordial abundances to probe the physics of the early Universe. High-precision cross-sections of the nuclear reaction that burns deuterium to create helium-3 are used to produce theoretical estimates of the primordial baryon density that are in agreement with recent astronomical observations.

Studies from Asia, Europe and the USA indicate that widely available haematological parameters could be used to determine the clinical severity of Coronavirus disease 2019 (COVID-19) and predict management outcome. There is limited data from Africa on their usefulness in patients admitted to Intensive Care Units (ICUs). We performed an evaluation of baseline haematological parameters as prognostic biomarkers in ICU COVID-19 patients. Demographic, clinical and laboratory data were collected prospectively on patients with confirmed COVID-19, admitted to the adult ICU in a tertiary hospital in Cape Town, South Africa, between March 2020 and February 2021. Robust Poisson regression methods and receiver operating characteristic (ROC) curves were used to explore the association of haematological parameters with COVID-19 severity and mortality. A total of 490 patients (median age 54.1 years) were included, of whom 237 (48%) were female. The median duration of ICU stay was 6 days and 309/490 (63%) patients died. Raised neutrophil count and neutrophil/lymphocyte ratio (NLR) were associated with worse outcome. Independent risk factors associated with mortality were age (ARR 1.01, 95%CI 1.0-1.02; p = 0.002); female sex (ARR 1.23, 95%CI 1.05-1.42; p = 0.008) and D-dimer levels (ARR 1.01, 95%CI 1.002-1.03; p = 0.016). Our study showed that raised neutrophil count, NLR and D-dimer at the time of ICU admission were associated with higher mortality. Contrary to what has previously been reported, our study revealed females admitted to the ICU had a higher risk of mortality.

The neon-sodium cycle of hydrogen burning occurs in several astrophysical sites, such as asymptotic giant branch stars and novae, affecting the production of neon and sodium isotopes. To enhance the accuracy of predicted nucleosynthesis yields, there is a pressing need for new experimental investigations of the cross sections of the reactions involved in this cycle at energies relevant to astrophysics. The 400 kV accelerator at the Laboratory for Underground Nuclear Astrophysics (LUNA) provides a unique advantage relative to above-ground laboratories thanks to its deep underground location within the Gran Sasso National Laboratory (INFN-LNGS) in Italy. We performed experiments at LUNA on two of the reactions of the NeNa cycle: 20 Ne(p, γ ) 21 Na and 21 Ne(p, γ ) 22 Na using a high-purity gas target system for isotopically enriched gases coupled with two high-resolution germanium detectors, surrounded by copper and lead shielding to further reduce the natural background at LUNA. We describe the detailed characterization of the experimental setup performed through Monte Carlo simulations, and the method for the precise determination of resonance energies, giving improved values of E r = 127.3 ± 0.5 keV, 271.4 ± 0.4 keV, 272.3 ± 0.4 keV, 291.5 ± 0.5 keV and 352.6 ± 0.4 keV. Additionally, decay branching ratios for the E x = 7016.4 keV excited state in 22 Na, and three new transitions ( R → 4770  keV, R → 3059.4  keV and R → 583.05  keV) in the E r = 291.5  keV resonance, are also reported.

The Istituto Nazionale di Fisica Nucleare—Laboratori Nazionali del Gran Sasso (LNGS) is one of the largest underground physics laboratory, a very peculiar environment suited for experiments in Astroparticle Physics, Nuclear Physics and Fundamental Symmetries. The newly established Bellotti Ion Beam facility represents a major advance in the possibilities of studying nuclear processes in an underground environment. A workshop was organized at LNGS in the framework of the Nuclear Physics Mid Term Plan in Italy, an initiative of the Nuclear Physics Division of the Instituto Nazionale di Fisica Nucleare to discuss the opportunities that will be possible to study in the near future by employing state-of-the-art detection systems. In this report, a detailed discussion of the outcome of the workshop is presented.