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Lung cancer is one of the major causes of cancer-related deaths due to its aggressive nature and delayed detections at advanced stages. Early detection of lung cancer is very important for the survival of an individual, and is a significant challenging problem. Generally, chest radiographs (X-ray) and computed tomography (CT) scans are used initially for the diagnosis of the malignant nodules; however, the possible existence of benign nodules leads to erroneous decisions. At early stages, the benign and the malignant nodules show very close resemblance to each other. In this paper, a novel deep learning-based model with multiple strategies is proposed for the precise diagnosis of the malignant nodules. Due to the recent achievements of deep convolutional neural networks (CNN) in image analysis, we have used two deep three-dimensional (3D) customized mixed link network (CMixNet) architectures for lung nodule detection and classification, respectively. Nodule detections were performed through faster R-CNN on efficiently-learned features from CMixNet and U-Net like encoder–decoder architecture. Classification of the nodules was performed through a gradient boosting machine (GBM) on the learned features from the designed 3D CMixNet structure. To reduce false positives and misdiagnosis results due to different types of errors, the final decision was performed in connection with physiological symptoms and clinical biomarkers. With the advent of the internet of things (IoT) and electro-medical technology, wireless body area networks (WBANs) provide continuous monitoring of patients, which helps in diagnosis of chronic diseases—especially metastatic cancers. The deep learning model for nodules’ detection and classification, combined with clinical factors, helps in the reduction of misdiagnosis and false positive (FP) results in early-stage lung cancer diagnosis. The proposed system was evaluated on LIDC-IDRI datasets in the form of sensitivity (94%) and specificity (91%), and better results were obatined compared to the existing methods.

PurposeThis study explores the adoption of Industry 4.0 in developing countries' export industries, focusing on factors influencing this adoption, the moderating role of market pressure and prioritizing key factors for sustainable growth.Design/methodology/approachBased on the “TOE theory” this study has proposed a research framework to identify the factors influencing the adoption and sustainable implementation of Industry 4.0 in the export industry. This study has collected valid datasets from 387 export-oriented industries and applied SEM-ANN dual-stage hybrid model to capture linear and nonlinear interaction between variables.FindingsResults revealed that Technical Capabilities, System Flexibility, Software Infrastructure, Human Resource Competency and Market pressure significantly influence the Adoption of Industry 4.0. Higher market pressure as a moderator also improves the Industry 4.0 adoption process. Results also pointed out that system flexibility is a gray area in Industry 4.0 adoption, which can be enhanced in the export industry to maintain a sustainable adoption and implementation of Industry 4.0.Originality/valueMinute information is available on the factors influencing the adoption of Industry 4.0 in export-oriented industries. This study has empirically explored the role of influential factors in Industry 4.0 and ranked them based on their normalized importance.

Nature, a vast reservoir of pharmacologically active molecules, has been most promising source of drug leads for the cure of various pathological conditions. Formononetin is one of the bioactive isoflavones isolated from different plants mainly from Trifolium pratense, Glycine max, Sophora flavescens, Pycnanthus angolensis, and Astragalus membranaceus. Formononetin has been well-documented for its anti-inflammatory, anticancer, and antioxidant properties. Recently anticancer activity of formononetin is widely studied. This review aims to highlight the pharmacological potential of formononetin, thus providing an insight of its status in cancer therapeutics. Formononetin fights progression of cancer via inducing apoptosis, arresting cell cycle, and halting metastasis via targeting various pathways which are generally modulated in several cancers. Although reported data acclaims various biological properties of formononetin, further experimentation on mechanism of its action, medicinal chemistry studies, and preclinical investigations are surely needed to figure out full array of its pharmacological and biological potential.

One of the deadliest diseases, heart disease, claims millions of lives every year worldwide. The biomedical data collected by health service providers (HSPs) contain private information about the patient and are subject to general privacy concerns, and the sharing of the data is restricted under global privacy laws. Furthermore, the sharing and collection of biomedical data have a significant network communication cost and lead to delayed heart disease prediction. To address the training latency, communication cost, and single point of failure, we propose a hybrid framework at the client end of HSP consisting of modified artificial bee colony optimization with support vector machine (MABC-SVM) for optimal feature selection and classification of heart disease. For the HSP server, we proposed federated matched averaging to overcome privacy issues in this paper. We tested and evaluated our proposed technique and compared it with the standard federated learning techniques on the combined cardiovascular disease dataset. Our experimental results show that the proposed hybrid technique improves the prediction accuracy by 1.5%, achieves 1.6% lesser classification error, and utilizes 17.7% lesser rounds to reach the maximum accuracy.

Online Question and answer (Q&A) communities are the common and famous platforms to learn and share knowledge and are very useful for every knowledge seeker. Less knowledge contribution is a critical issue for the sustainability and future of these platforms. The motivation of inactive users to participate in Q&A communities is a real challenge. Based on the social cognitive and social exchange theory, we have studied the knowledge contribution patterns of active and consistent StackOverflow users over the last eleven years. We have used a difference generalized method of moments estimator to estimate the proposed model. Results revealed that reciprocation of knowledge and social interaction positively, whereas knowledge seeking of active and consistent users negatively influences knowledge contribution. Peer recognition and repudiation have partially positive and negative effects on users’ knowledge contribution. This research offers theoretical and practical suggestions to encourage people to contribute their knowledge to online Q&A communities.

In the field of ophthalmology, diabetic retinopathy (DR) is a major cause of blindness. DR is based on retinal lesions including exudate. Exudates have been found to be one of the signs and serious DR anomalies, so the proper detection of these lesions and the treatment should be done immediately to prevent loss of vision. In this paper, pretrained convolutional neural network- (CNN-) based framework has been proposed for the detection of exudate. Recently, deep CNNs were individually applied to solve the specific problems. But, pretrained CNN models with transfer learning can utilize the previous knowledge to solve the other related problems. In the proposed approach, initially data preprocessing is performed for standardization of exudate patches. Furthermore, region of interest (ROI) localization is used to localize the features of exudates, and then transfer learning is performed for feature extraction using pretrained CNN models (Inception-v3, Residual Network-50, and Visual Geometry Group Network-19). Moreover, the fused features from fully connected (FC) layers are fed into the softmax classifier for exudate classification. The performance of proposed framework has been analyzed using two well-known publicly available databases such as e-Ophtha and DIARETDB1. The experimental results demonstrate that the proposed pretrained CNN-based framework outperforms the existing techniques for the detection of exudates.

In order to operate a solar photovoltaic (PV) system at its maximum power point (MPP) under numerous weather conditions, it is necessary to achieve uninterrupted optimal power production and to minimize energy losses, energy generation cost, and payback time. Under partial shading conditions (PSC), the formation of multiple peaks in the power voltage characteristic curve of a PV cell puzzles conventional MPP tracking (MPPT) algorithms trying to identify the global MPP (GMPP). Meanwhile, soft-computing MPPT algorithms can identify the GMPP even under PSC. Drawbacks such as structural complexity, computational complexity, huge memory requirements, and difficult implementation all affect the viability of soft-computing algorithms. However, those drawbacks have been successfully overcome with a novel ten check algorithm (TCA). To improve the performance of the TCA in terms of MPPT speed and efficiency, a novel concept of data arrangement is introduced in this paper. The proposed structure is referred to as Optimized TCA (OTCA). A comparison of the proposed OTCA and classic TCA algorithms was conducted for standard benchmarks. The results proved the superiority of the OTCA algorithm compared to both TCA and flower pollination (FPA) algorithms. The major advantage of OTCA in MPPT stems from its speed as compared to TCA and FPA, with almost 86% and 90% improvement, respectively.

Optimal path planning on non-convex maps is challenging: sampling-based algorithms (such as RRT) do not provide optimal solution in finite time; approaches based on visibility graphs are computationally expensive, while reduced visibility graphs (e.g., tangent graph) fail on such maps. We leverage a well-established, and surprisingly less utilized in path planning, geometrical property of convex decompositions i.e. a concave shape can be decomposed into multiple convex shapes. We propose a novel local tangent based approach, inspired by such convex decompositions, to path planning in non-convex maps. Although our local tangent approach is inspired by geometric convex decompositions, it does not require complex decomposition process. Our second contribution is an efficient corner detection method which reasons on binary pixel occupancy maps. Combined with our novel local tangent approach, which intelligently selects nodes from these corners, we modify the standard A* algorithm by feeding these nodes to its open list. With our local tangent approach, only small number of selected corners are fed to A* open list which keeps its size small even for larger maps, resulting in lower convergence time. We formally prove the optimality of our solution. Simulation on our own maps and public dataset (MAPF http://mapf.info/) as well as real-world experiments show that our proposed LTA* algorithm gives better convergence time and shorter path length in environments with both convex and concave obstacles.

This study aims to develop an efficient and accurate breast cancer classification model using meta-learning approaches and multiple convolutional neural networks. This Breast Ultrasound Images (BUSI) dataset contains various types of breast lesions. The goal is to classify these lesions as benign or malignant, which is crucial for the early detection and treatment of breast cancer. The problem is that traditional machine learning and deep learning approaches often fail to accurately classify these images due to their complex and diverse nature. In this research, to address this problem, the proposed model used several advanced techniques, including meta-learning ensemble technique, transfer learning, and data augmentation. Meta-learning will optimize the model’s learning process, allowing it to adapt to new and unseen datasets quickly. Transfer learning will leverage the pre-trained models such as Inception, ResNet50, and DenseNet121 to enhance the model’s feature extraction ability. Data augmentation techniques will be applied to artificially generate new training images, increasing the size and diversity of the dataset. Meta ensemble learning techniques will combine the outputs of multiple CNNs, improving the model’s classification accuracy. The proposed work will be investigated by pre-processing the BUSI dataset first, then training and evaluating multiple CNNs using different architectures and pre-trained models. Then, a meta-learning algorithm will be applied to optimize the learning process, and ensemble learning will be used to combine the outputs of multiple CNN. Additionally, the evaluation results indicate that the model is highly effective with high accuracy. Finally, the proposed model’s performance will be compared with state-of-the-art approaches in other existing systems’ accuracy, precision, recall, and F1 score.

The world’s attention has turned towards renewable energy due to escalating energy demands, declining fossil fuel reservoirs, greenhouse gas emissions, and the unreliability of conventional energy systems. The sun is the only renewable energy source that is available every day for a specific period of time. Solar photovoltaic (PV) technology is known for its direct conversion of sunlight into electricity using the photoelectric effect. However, due to the non-linear electrical characteristics, the power output of solar PV cells is bound to a lower value and can not produce the power of which it is capable. To extract the maximum possible power, the PV cell needs to be operated at its maximum power point (MPP) uninterruptedly under numerous weather conditions. Therefore, an electronic circuit driven by a set of rules known as an algorithm is utilized. To date, the flower pollination algorithm (FPA) is one of the most renowned maximum power point tracking (MPPT) algorithms due to its effective tracking ability at the local and global positions. After an in-depth analysis of the design, strengths, weaknesses, and opportunities of the FPA algorithm, we have proposed an additional filtration and distribution process named “Random walk” along with the ordering of solutions, to improve its efficiency and tracking time. The proposed structure named “Ordered FPA” has outperformed the renowned FPA algorithm under various weather conditions at all the standard benchmarks. Simulations are performed in MATLAB/Simulink.