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The complex interplay between the gut microbiota, the intestinal barrier, the immune system and the liver is strongly influenced by environmental and genetic factors that can disrupt the homeostasis leading to disease. Among the modulable factors, diet has been identified as a key regulator of microbiota composition in patients with metabolic syndrome and related diseases, including the metabolic dysfunction-associated fatty liver disease (MAFLD). The altered microbiota disrupts the intestinal barrier at different levels inducing functional and structural changes at the mucus lining, the intercellular junctions on the epithelial layer, or at the recently characterized vascular barrier. Barrier disruption leads to an increased gut permeability to bacteria and derived products which challenge the immune system and promote inflammation. All these alterations contribute to the pathogenesis of MAFLD, and thus, therapeutic approaches targeting the gut-liver-axis are increasingly being explored. In addition, the specific changes induced in the intestinal flora may allow to characterize distinctive microbial signatures for non-invasive diagnosis, severity stratification and disease monitoring.

Landslides in reservoir contexts are a well-recognised hazard that may lead to dangerous situations regarding infrastructures and people’s safety. Satellite-based radar interferometry is proving to be a reliable method to monitor the activity of landslides in such contexts. Here, we present a DInSAR (Differential Interferometric Synthetic Aperture Radar) analysis of Sentinel-1 images that exemplifies the usefulness of the technique to recognize and monitor landslides in the Rules Reservoir (Southern Spain). The integration of DInSAR results with a comprehensive geomorphological study allowed us to understand the typology, evolution and triggering factors of three active landslides: Lorenzo-1, Rules Viaduct and El Arrecife. We could distinguish between rotational and translational landslides and, thus, we evaluated the potential hazards related to these typologies, i.e., retrogression (Lorenzo-1 and Rules Viaduct landslides) or catastrophic slope failure (El Arrecife Landslide), respectively. We also observed how changes in the water level of the reservoir influence the landslide’s behaviour. Additionally, we were able to monitor the stability of the Rules Dam as well as detect the deformation of a highway viaduct that crosses a branch of the reservoir. Overall, we consider that other techniques must be applied to continue monitoring the movements, especially in the El Arrecife Landslide, in order to avoid future structural damages and fatalities.

This work is focused on deformation activity mapping and monitoring using Sentinel-1 (S-1) data and the DInSAR (Differential Interferometric Synthetic Aperture Radar) technique. The main goal is to present a procedure to periodically update and assess the geohazard activity (volcanic activity, landslides and ground-subsidence) of a given area by exploiting the wide area coverage and the high coherence and temporal sampling (revisit time up to six days) provided by the S-1 satellites. The main products of the procedure are two updatable maps: the deformation activity map and the active deformation areas map. These maps present two different levels of information aimed at different levels of geohazard risk management, from a very simplified level of information to the classical deformation map based on SAR interferometry. The methodology has been successfully applied to La Gomera, Tenerife and Gran Canaria Islands (Canary Island archipelago). The main obtained results are discussed.

Rockfalls are frequent and harmful phenomena occurring in mountain ranges, coastal cliffs, and slope cuts. Although several natural processes occur in their formation and triggering, rainfall is one of the most common causes. The prediction of rock failures is of social significance for civil protection purposes and can rely on the statistical analysis of past rainfall conditions that caused the failures. The paper describes the analysis of information on rainfall-induced rockfalls in Gran Canaria and Tenerife, Canary Islands (Spain). An analysis of the monthly rainfall versus the monthly distribution of rockfalls reveals that they are correlated for most of the year, except in summer, when other triggers act to induce collapses. National and regional catalogs with hourly and daily rainfall measurements are used to reconstruct the cumulated amount (E) and the duration (D) of the rainfall responsible for the rock failures. Adopting a consolidated statistical approach, new ED rainfall thresholds for possible rockfall occurrence and the associated uncertainties are calculated for the two test sites. As far as is known, this is the first attempt to predict this type of failure using the threshold approach. Using the rainfall information, a map of the mean annual rainfall is obtained for Gran Canaria and Tenerife, and it is used to assess the differences between the thresholds. The results of this study are expected to improve the ability to forecast rockfalls in the Canary Islands in view of implementing an early-warning system to mitigate the rockfall hazard and reduce the associated risk.

The term gut–liver axis is used to highlight the close anatomical and functional relationship between the intestine and the liver. The intestine has a highly specialized epithelial membrane which regulates transport across the mucosa. Due to dysbiosis, impairment of the intestinal barrier and altered immunity status, bacterial products can reach the liver through the portal vein, where they are recognized by specific receptors, activate the immune system and lead to a proinflammatory response. Gut microbiota and bacterial translocation play an important role in the pathogenesis of chronic liver diseases, including alcoholic and non-alcoholic fatty liver disease, cirrhosis, and its complications, such as portal hypertension, spontaneous bacterial peritonitis and hepatic encephalopaty. The gut microbiota also plays a critical role as a modulator of bile acid metabolism which can also influence intestinal permeability and portal hypertension through the farnesoid-X receptor. On the other hand, cirrhosis and portal hypertension affect the microbiota and increase translocation, leading to a “chicken and egg” situation, where translocation increases portal pressure, and vice versa. A myriad of therapies targeting gut microbiota have been evaluated specifically in patients with chronic liver disease. Further studies targeting intestinal microbiota and its possible hemodynamic and metabolic effects are needed. This review summarizes the current knowledge about the role of gut microbiota in the pathogenesis of chronic liver diseases and portal hypertension.

Oxidative stress and inflammation have been postulated as underlying mechanisms for the development of obesity-related insulin resistance. This association however, remains elusive especially in childhood. We sought to investigate this relation by measuring oxidative stress and antioxidant response biomarkers, before and during an oral glucose tolerance test (OGTT), in different biological samples from obese children. 24 children were recruited for the study, (18 obese and 6 controls). After OGTT, the obese group was subdivided in two, according to whether or not carbohydrate metabolic impairment (Ob.IR+, Ob.IR-; respectively) was found. Different biomarkers were analyzed after fasting (T = 0) and during an OGTT (T = 60 and 120 min). Lipoperoxides were measured in plasma, erythrocytes, and urine; while advanced glycation end products were determined in plasma, and redox status (GSH/GSSG ratio) in erythrocytes. We found marked differences in the characterization of the oxidative status in urine and erythrocytes, and in the dynamics of the antioxidant response during OGTT. Specifically, Ob.IR+ children show increased oxidative stress, deficient antioxidant response and a significant imbalance in redox status, in comparison to controls and Ob.IR- children. Obese children with insulin resistance show increased levels of oxidative stress biomarkers, and a stunted antioxidant response to an OGTT leading to increased oxidative stress after a single glucose load, as detected in erythrocytes, but not in plasma. We propose erythrocytes as sensors of early and acute changes in oxidative stress associated with insulin resistance in childhood obesity. This is a pilot study, performed with a limited sample size, so data should be interpreted with caution until reproduced.

Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years. Childhood obesity is intimately related to the development of several comorbidities such as nonalcoholic fatty liver disease, dyslipidemia, type 2 diabetes mellitus, non-congenital cardiovascular disease, chronic inflammation and anemia, among others. Within this tangled interplay between these comorbidities and associated pathological conditions, obesity has been closely linked to important perturbations in iron metabolism. Iron is the second most abundant metal on Earth, but its bioavailability is hampered by its ability to form highly insoluble oxides, with iron deficiency being the most common nutritional disorder. Although every living organism requires iron, it may also cause toxic oxygen damage by generating oxygen free radicals through the Fenton reaction. Thus, iron homeostasis and metabolism must be tightly regulated in humans at every level (i.e., absorption, storage, transport, recycling). Dysregulation of any step involved in iron metabolism may lead to iron deficiencies and, eventually, to the anemic state related to obesity. In this review article, we summarize the existent evidence on the role of the most recently described components of iron metabolism and their alterations in obesity.

In this paper a methodology is proposed to elaborate landslide activity maps through the use of PS (Persistent Scatterer) data. This is illustrated through the case study of Tramuntana Range in the island of Majorca (Spain), where ALOS (Advanced Land Observing Satellite) images have been processed through a Persistent Scatterer Interferometry (PSI) technique during the period of 2007–2010. The landslide activity map provides, for every monitored landslide, an assessment of the PS visibility according to the relief, land use, and satellite acquisition parameters. Landslide displacement measurements are projected along the steepest slope, in order to compare landslide velocities with different slope orientations. Additionally, a ground motion activity map is also generated, based on active PS clusters not included within any known landslide phenomenon, but even moving, potentially referred to unmapped landslides or triggered by other kinds of geomorphological processes. In the Tramuntana range, 42 landslides were identified as active, four as being potential to produce moderate damage, intersecting the road Ma-10, which represents the most important road of the island and, thus, the main element at risk. In order to attest the reliability of measured displacements to represent landslide dynamics, a confidence degree evaluation is proposed. In this test site, seven landslides exhibit a high confidence degree, medium for 93 of them, and low for 51. A low confidence degree was also attributed to 615 detected active clusters with a potential to cause moderate damage, as their mechanism of the triggering cause is unknown. From this total amount, 18 of them intersect the Ma-10, representing further potentially hazardous areas. The outcomes of this work reveal the usefulness of landslide activity maps for environmental planning activities, being exportable to other radar data and different geomorphological settings.

In recent years, there was an increasing number of studies focusing on rockfalls due to their impacts on social and sustainable development. This work carries out a three-dimensional (3D) simulation of rockfalls at a cultural heritage site nearby the village of Cortes de Pallás (Valencian Community, East Spain). The simulation is based on data collected previously, during an emergency declaration due to the occurrence of a considerable rockfall (7980 m3) on the southern bank of the Cortes de Pallás reservoir, on 6 April 2015. The hydroelectric power plant was damaged, and the main access road to the village of Cortes de Pallás was blocked for eight months. The predominant discontinuities of the rock mass were analyzed by means of the application of structure from motion (SfM) photogrammetry techniques to the set of images taken by remotely piloted aircraft systems (RPAS). The average size of the block was determined as 3.2 m in diameter and 17.6 m3 in volume. Additionally, a digital elevation model (DEM) was generated from an aerial laser scanning (ALS)-derived point cloud using a 1 × 1 grid. These data were implemented in RocPro3D software, obtaining the distances traveled by the blocks detached from different source areas at a cultural heritage site located near the rockfall event, which presents the same geological context. The simulation presented herein shows aggravating circumstances that endanger the cultural heritage area, with higher rockfall hazards than previous official studies (1991) displayed.

Pregnancy-related disorders, including preeclampsia and gestational diabetes, are characterized by the presence of an adverse intrauterine milieu that may ultimately result in oxidative and nitrosative stress. This scenario may trigger uncontrolled production of reactive oxygen species (ROS) such as superoxide anion (OBLACK CIRCLE-) and reactive nitrogen species (RNS) such as nitric oxide (NO), along with an inactivation of antioxidant systems, which are associated with the occurrence of relevant changes in placental function through recognized redox post-translational modifications in key proteins. The general objective of this study was to assess the impact of a maternal obesogenic enviroment on the regulation of the placental nitroso-redox balance at the end of pregnancy. We measured oxidative damage markers-thiobarbituric acid-reacting substances (TBARS) and carbonyl groups (C=O) levels; nitrosative stress markers-inducible nitric oxide synthase, nitrosothiol groups, and nitrotyrosine residues levels; and the antioxidant biomarkers-catalase and superoxide dismutase (SOD) activity and expression, and total antioxidant capacity (TAC), in full-term placental villous from both pre-pregnancy normal weight and obese women, and with absence of metabolic complications throughout gestation. The results showed a decrease in C=O and TBARS levels in obese pregnancies. Although total SOD and catalase concentrations were shown to be increased, both activities were significantly downregulated in obese pregnancies, along with total antioxidant capacity. Inducible nitric oxide sintase levels were increased in the obese group compared to the lean group, accompanied by an increase in nitrotyrosine residues levels and lower levels of nitrosothiol groups in proteins such as ERK1/2. These findings reveal a reduction in oxidative damage, accompanied by a decline in antioxidant response, and an increase via NO-mediated nitrative stress in placental tissue from metabolically healthy pregnancies with obesity. All this plausibly points to a placental adaptation of the affected antioxidant response towards a NO-induced alternative pathway, through changes in the ROS/RNS balance, in order to reduce oxidative damage and preserve placental function in pregnancy.