Explore the vast range of titles available.

We report on the deceleration of a beam of SrF molecules from 290 to 120~m/s. Following supersonic expansion, the molecules in the \\(X^2\\Sigma\\) (\\(v=0\\), \\(N=1\\)) low-field seeking states are trapped by the moving potential wells of a traveling-wave Stark decelerator. With a deceleration strength of 9.6 km/s\\(^2\\) we have demonstrated the removal of 85 % of the initial kinetic energy in a 4 meter long modular decelerator. The absolute amount of kinetic energy removed is a factor 1.5 higher compared to previous Stark deceleration experiments. The demonstrated decelerator provides a novel tool for the creation of highly collimated and slow beams of heavy diatomic molecules, which serve as a good starting point for high-precision tests of fundamental physics.

A radioactive beam of 20Na is stopped in a gas cell filled with Ne gas. The stopped particles are polarized by optical pumping. The degree of polarization that can be achieved is studied. A maximum polarization of 50% was found. The dynamic processes in the cell are described with a phenomenological model.

We report on the production, deceleration and detection of a SrF molecular beam. The molecules are captured from a supersonic expansion and are decelerated in the X\\(^2\\Sigma^+ (v=0, N=1)\\) state. We demonstrate the removal of up to 40% of the kinetic energy with a 2 meter long modular traveling-wave decelerator. Our results demonstrate a crucial step towards the preparation of ultracold gases of heavy diatomic molecules for precision spectroscopy.

We search for a dependence of the lifetime of \\(^{20}\\text{Na}\\) nuclei on the nuclear spin direction. Such a directional dependence would be evidence for Lorentz-invariance violation in weak interactions. A difference in lifetime between nuclei that are polarized in the east and west direction is searched for. This difference is maximally sensitive to the rotation of the Earth, while the sidereal dependence is free from most systematic errors. The experiment sets a limit of \\(2\\times 10^{-4}\\) at 90 % C.L. on the amplitude of the sidereal variation of the relative lifetime differences, an improvement by a factor 15 compared to an earlier result.

Although up to one in five cases of hepatocellular carcinoma (HCC) occurs in patients without cirrhosis, there is scarce literature characterizing non-cirrhotic HCC (NCHCC). Existing NCHCC research is primarily limited to surgical case series and there is a lack of data on unresectable NCHCC. The purpose of this retrospective review was to compare the characteristics of unresectable NCHCC and cirrhotic hepatocellular carcinoma (CHCC). A retrospective chart review of adult patients with unresectable HCC treated from 2007 to 2017 was performed at the University of Florida Shands Hospital. The data set was stratified into two cohorts: NCHCC and CHCC. Continuous variables were compared using Wilcoxon-Mann-Whitney tests and Kruskal-Wallis rank-sum tests. Categorical variables were compared using Pearson's Chi-squared tests and Fisher's exact tests. Overall survival was explored utilizing the Kaplan-Meier and log-rank method. There were 1494 adult patients included in the final analysis, including 264 patients (17.7%) with NCHCC and 1230 patients (82.3%) with CHCC. Median age was 61.0 years old and median follow-up time was 30.2 months. NCHCC patients were older than CHCC patients (66.3 years vs 61.9 years; p < 0.0001). NHCC tumors were larger than CHCC tumors (7.92 ± 4.85 vs 4.38 ± 3.12 cm; p < 0.0001) and more likely to be associated with distant metastases (23.35% vs 15.91%; p = 0.0055). There was no difference in overall survival, with a median of 23.5 months in NCHCC and 22.4 months in CHCC (p = 0.9196). Our findings suggest that unresectable NCHCC and CHCC have unique characteristics but similar overall survival. To the best of our knowledge, this is the largest comparison of CHCC and NCHCC.

In recent years, driving accidents have been increasing gradually, with most of them due to drowsiness. To tackle this problem, various methods and systems were developed to alert the driver behind the wheels, and to prevent accidents. A few approaches include heartbeat monitoring, pulse rate check, blink, and yawn detector. This paper discusses a driver mechanism, which is capable of detecting fatigue in real-time, using the Eye Aspect Ratio – EAR – parameter, and also provides a database with an interface for managers to track drivers. When the driver is tired, an email will also be sent to the manager. On the drivers’ side, there will be a buzzer noise to wake the driver up and nearby resting locations will be shown to the driver. Further, mapping to the nearby resting location of the driver’s choice is shown, if the driver feels too drowsy and feels the need for rest. It is essential to fabricate and construct this complete system via IoT and OpenCV methods to address this issue.

Age-related osteoporosis poses a significant challenge in musculoskeletal health; a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms. Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss. Our study uses the prematurely aged Polg (PolgA) mouse model to scrutinize age- and sex-related alterations in musculoskeletal health parameters (frailty, grip strength, gait data), bone and particularly the osteocyte lacuno-canalicular network (LCN). Moreover, a new quantitative in silico image analysis pipeline is used to evaluate the alterations in the osteocyte network with aging. Our findings underscore the pronounced degenerative changes in the musculoskeletal health parameters, bone, and osteocyte LCN in PolgA mice as early as 40 weeks, with more prominent alterations evident in aged males. Our findings suggest that the PolgA mouse model serves as a valuable model for studying the cellular mechanisms underlying age-related bone loss, given the comparable aging signs and age-related degeneration of the bone and the osteocyte network observed in naturally aging mice and elderly humans.

Zebrafish, a popular organism for studying embryonic development and for modeling human diseases, has so far lacked a systematic functional annotation program akin to those in other animal models. To address this, we formed the international DANIO-CODE consortium and created a central repository to store and process zebrafish developmental functional genomic data. Our data coordination center ( https://danio-code.zfin.org ) combines a total of 1,802 sets of unpublished and re-analyzed published genomic data, which we used to improve existing annotations and show its utility in experimental design. We identified over 140,000 cis -regulatory elements throughout development, including classes with distinct features dependent on their activity in time and space. We delineated the distinct distance topology and chromatin features between regulatory elements active during zygotic genome activation and those active during organogenesis. Finally, we matched regulatory elements and epigenomic landscapes between zebrafish and mouse and predicted functional relationships between them beyond sequence similarity, thus extending the utility of zebrafish developmental genomics to mammals. The DANIO-CODE consortium leverages a large-scale multiomic dataset to improve zebrafish genome annotation. They identify ~140,000 cis -regulatory elements throughout development and perform a comparison with the mouse regulatory landscape.

Due to increasingly stringent rules, eliminating pollutants (NOx) emitted by diesel engines in the automobile sector remains an intriguing scientific and technological problem. To meet the strict NOx emission restrictions, a catalytic system with a high level of complexity, unit size, and quantity, as well as higher fuel consumption, is required. As a result, for a reduction in individual exhaust gas emissions, an after-treatment system for a diesel vehicle must employ integrated catalyst technology. For selective catalytic reduction of NOx without any external reductant, a highly effective catalyst “spinel nickel cobaltite” (NiCo2O4) was produced using a polymeric precursor technique. In this work, an exhaust gas treatment system without external reductants using nano-NiCo2O4 as catalyst was designed and fabricated, for NOx control in diesel and petrol engines at low temperature. In order to determine the NOx conversion efficiency in the selective catalytic reduction system, tests were carried out at different engine loads. The system was supposed to be cost-effective due to the nano-NiCo2O4 catalyst’s ability to work at low temperatures. The findings proved the developed SCR system’s potential to reduce NOx emissions. At a high load, the nitric oxide (NO) emissions were reduced by 54 and 96 percent, respectively, without increasing HC, CO, and CO2 emissions or compromising efficiency.

Glucocorticoid (GC) and hypoxic transcriptional responses play a central role in tissue homeostasis and regulate the cellular response to stress and inflammation, highlighting the potential for cross-talk between these two signaling pathways. We present results from an unbiased in vivo chemical screen in zebrafish that identifies GCs as activators of hypoxia-inducible factors (HIFs) in the liver. GCs activated consensus hypoxia response element (HRE) reporters in a glucocorticoid receptor (GR)-dependent manner. Importantly, GCs activated HIF transcriptional responses in a zebrafish mutant line harboring a point mutation in the GR DNA-binding domain, suggesting a nontranscriptional route for GR to activate HIF signaling. We noted that GCs increase the transcription of several key regulators of glucose metabolism that contain HREs, suggesting a role for GC/HIF cross-talk in regulating glucose homeostasis. Importantly, we show that GCs stabilize HIF protein in intact human liver tissue and isolated hepatocytes. We find that GCs limit the expression of Von Hippel Lindau protein (pVHL), a negative regulator of HIF, and that treatment with the c-src inhibitor PP2 rescued this effect, suggesting a role for GCs in promoting c-src–mediated proteosomal degradation of pVHL. Our data support a model for GCs to stabilize HIF through activation of c-src and subsequent destabilization of pVHL.