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A bstract The physical phenomena seen by an observer are defined for a local inertial system that is subjective to the observer. Such a coordinate system is called a “moving frame” because it changes from time to time. However, unlike the Thomas precession, the Unruh-DeWitt detector has been discussed for a fixed frame. We discuss the Unruh-DeWitt detector by defining the vacuum for the moving frame, showing that the problem of the Stokes phenomenon can be solved by using the vierbeins and the exact WKB, to find factor 2 discrepancy from the standard result. Differential geometry is constructed in such a way that local calculations can be performed rigorously. If one expects Markov property, the calculation is expected to be local. The final piece that was missing was a local non-perturbative calculation, which is now complemented by the exact WKB. Our analysis defines a serious problem regarding the relationship between entanglement of the Unruh effect and differential geometry.

A bstract The Bogoliubov transformation in cosmological particle production can be explained by the Stokes phenomena of the corresponding ordinary differential equation. The calculation becomes very simple as far as the solution is described by a special function. Otherwise, the calculation requires more tactics, where the Exact WKB (EWKB) may be a powerful tool. Using the EWKB, we discuss cosmological particle production focusing on the effect of more general interaction and classical scattering. The classical scattering appears when the corresponding scattering problem of the Schrödinger equation develops classical turning points on the trajectory. The higher process of fermionic preheating is also discussed using the Landau-Zener model.

Cancer has become a leading cause of death in China, with an increasing burden of cancer incidence and mortality observed over the past half century. Population-based cancer registries have been operating in China for about 60 years, and, in 2018, their role has expanded to include the formulation and evaluation of national cancer control programmes and the care of patients with cancer. The purpose of this Review is to provide an overview of the key milestones in the development of cancer registration in China, the current status of registry coverage and quality, and a description of the changing cancer profile in China from 1973 to 2015. This Review is a comprehensive and updated review on the development of population-based cancer registries in China over a 60-year time span. We highlight some aspects of cancer control plans that illustrate how cancer registration data have become central to the identification of health priorities for China and provide a means to track progress in cancer control for the country.

Background: Unlike many North American and European countries, Japan has observed a continuous increase in cancer incidence over the last few decades. We examined the most recent trends in population-based cancer incidence and mortality in Japan. Methods: National cancer mortality data between 1958 and 2018 were obtained from published vital statistics. Cancer incidence data between 1985 and 2015 were obtained from high-quality population-based cancer registries maintained by three prefectures (Yamagata, Fukui, and Nagasaki). Trends in age-standardized rates (ASR) were examined using Joinpoint regression analysis. Results: For males, all-cancer incidence increased between 1985 and 1996 (annual percent change [APC] +1.1%; 95% confidence interval [CI], 0.7–1.5%), increased again in 2000–2010 (+1.3%; 95% CI, 0.9–1.8%), and then decreased until 2015 (−1.4%; 95% CI, −2.5 to −0.3%). For females, all-cancer incidence increased until 2010 (+0.8%; 95% CI, 0.6–0.9% in 1985–2004 and +2.4%; 95% CI, 1.3–3.4% in 2004–2010), and stabilized thereafter until 2015. The post-2000 increase was mainly attributable to prostate in males and breast in females, which slowed or levelled during the first decade of the 2000s. After a sustained increase, all-cancer mortality for males decreased in 1996–2013 (−1.6%; 95% CI, −1.6 to −1.5%) and accelerated thereafter until 2018 (−2.5%; 95% CI, −2.9 to −2.0%). All-cancer mortality for females decreased intermittently throughout the observation period, with the most recent APC of −1.0% (95% CI, −1.1 to −0.9%) in 2003–2018. The recent decreases in mortality in both sexes, and in incidence in males, were mainly attributable to stomach, liver, and male lung cancers. Conclusion: The ASR of all-cancer incidence began decreasing significantly in males and levelled off in females in 2010.

A bstract The physical observables of quantum theory can be described by perturbation theory, which is often given by diverging power series. This divergence is connected to the existence of non-perturbative phenomena, where resurgence allows us to study this connection. Applying this idea to the WKB expansion, the exact WKB analysis gives a clear connection to non-perturbative phenomena. In this paper, we apply the exact WKB analysis to the Unruh effect and Hawking radiation. The mechanism we found in this paper is similar to the Schwinger effect of a constant electric field, where the background is static but the Stokes phenomenon appears in the temporal part. Comparing this with a sonic black hole, our calculations show a clear discrepancy between them. Then, we briefly explain how quantum backreactions can be included in the exact WKB formalism.

A bstract Cosmological particle production by a time-dependent scalar field is common in cosmology. We focus on the mechanism of asymmetry production when interaction explicitly violates symmetry and its motion is rapid enough to create particles by itself. Combining the exact WKB analysis and the Landau-Zener transition, we point out that perturbation before the non-perturbative analysis may drastically change the structure of the Stokes lines of the theory. The Exact WKB can play an important role in avoiding such discrepancies.

A bstract Using the exact WKB analysis of the higher-order differential equations, we analyze the asymmetry in dynamical particle production of a complex scalar field. The solution requires the Stokes phenomena of the fourth-order differential equation. We found that the interference of different types of the Stokes phenomena causes matter-antimatter asymmetry. We also showed a specific example where asymmetry is forbidden in the exact calculation, but a false asymmetry appears in the perturbative expansion.

Rare cancers collectively account for a significant proportion of the overall cancer burden in Japan. We aimed to describe and examine the incidence of each rare cancer and the temporal changes using the internationally agreed rare cancer classification. Cancer cases registered in regional population‐based cancer registries from 2011 to 2015 and the National Cancer Registry (NCR) from 2016 to 2018 were classified into 18 families, 68 Tier‐1 cancer groupings, and 216 single cancer entities based on the RARECAREnet list. Crude incidence rates and age‐standardized incidence rates (ASR) were calculated for Tier‐1 and Tier‐2 cancers. The annual percent change and the 95% and 99% confidence limits for annual ASR for each of the 68 Tier‐1 cancers were estimated using the log‐linear regression of the weighted least squares method. The differences in ASRs between 2011 and 2018 were evaluated as an absolute change. A total of 5,640,879 cases were classified into Tier‐1 and Tier‐2 cancers. The ASRs of 18 out of 52 Tier‐1 cancers in the rare cancer families increased, whereas the ASR for epithelial tumors of gallbladder decreased. The ASRs of 6 out of the 16 Tier‐1 cancers in the common cancer families increased, whereas those of epithelial tumors of stomach and liver decreased. There was no significant change in the incidence of the other 40 Tier‐1 cancers. The incidence of several cancers increased due to the dissemination of diagnostic concepts, improved diagnostic techniques, changes in coding practice, and the initiation of the NCR. Time trend of age‐standardized incidence rates of rare cancer families and common cancer families in Japan from 2011 to 2018.

The present study aimed to compare cancer incidence and trends in survival for children diagnosed in Japan and England, using population‐based cancer registry data. The analysis was based on 5192 children with cancer (age 0‐14 years) from 6 prefectural cancer registries in Japan and 21 295 children diagnosed in England during 1993‐2010. Differences in incidence rates between the 2 countries were measured with Poisson regression models. Overall survival was estimated using the Kaplan–Meier method. Incidence rates for Hodgkin lymphoma, renal tumors and Ewing sarcomas in England were more than twice as high as those in Japan. Incidence of germ cell tumors, hepatic tumors, neuroblastoma and acute myeloid leukemia (AML) was higher in Japan than in England. Incidence of all cancers combined decreased in Japan throughout the period 1993 to 2010, which was mainly explained by a decrease in registration of neuroblastoma in infants. For many cancers, 5‐year survival improved in both countries. The improvement in survival in chronic myeloid leukemia (CML) was particularly dramatic in both countries. However, 5‐year survival remained less than 80% in 2005‐2008 in both countries for AML, brain tumors, soft tissue sarcomas, malignant bone tumors and neuroblastoma (age 1‐14 years). There were significant differences in incidence of several cancers between countries, suggesting variation in genetic susceptibility and possibly environmental factors. The decrease in incidence for all cancers combined in Japan was related to the cessation of the national screening program for neuroblastoma. The large improvement in survival in CML coincided with the introduction of effective therapy (imatinib). For many of childhood cancers, 5‐year survival improved in Japan and England. The improvement in survival in chronic myeloid leukaemia (CML) was particularly dramatic in both countries.

Characterizing trends in mortality rates with consideration of trends in incidence rates at the population level could help identify unmet needs in public health and provide essential indicators of cancer control. In the late 20th century, the arrival of the first molecular targeted agent, rituximab, for non‐Hodgkin lymphoma (NHL) led to a paradigm shift in NHL treatment. However, the public health impact of this arrival has not been fully clarified. Here, we evaluated trends in the mortality and incidence rates of NHL in Japan and the United States. Age‐standardized rates of mortality reversed after the introduction of rituximab, around 2000, beginning to decline significantly with annual percent changes (95% confidence interval) of −2.6% (−3.6% to −1.6%) in Japan and − 3.9% (−4.2% to −3.5%) in the United States. Despite an increase in incidence, the mortality in all age groups weakened the upward trends or decreased in both countries. From a long‐term perspective, the trends in mortality rates differed between the countries. In the United States, the mortality rate has declined continuously since the introduction of rituximab, with a declining incidence rate. In contrast, in Japan, the mortality rate stopped declining and the incidence rate increased remarkably. The introduction of rituximab has had a substantial impact at the population level across a wide range of individuals. To reduce the disease burden in terms of mortality, elucidating risk factors that lead to a decreasing incidence rate is warranted for NHL, as well as further development of novel treatments.