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Lately, with deep learning outpacing the other machine learning techniques in classifying images, we have witnessed a growing interest of the remote sensing community in employing these techniques for the land use and land cover classification based on multispectral and hyperspectral images; the number of related publications almost doubling each year since 2015 is an attest to that. The advances in remote sensing technologies, hence the fast-growing volume of timely data available at the global scale, offer new opportunities for a variety of applications. Deep learning being significantly successful in dealing with Big Data, seems to be a great candidate for exploiting the potentials of such complex massive data. However, there are some challenges related to the ground-truth, resolution, and the nature of data that strongly impact the performance of classification. In this paper, we review the use of deep learning in land use and land cover classification based on multispectral and hyperspectral images and we introduce the available data sources and datasets used by literature studies; we provide the readers with a framework to interpret the-state-of-the-art of deep learning in this context and offer a platform to approach methodologies, data, and challenges of the field.

Despite increasing improvement in extracorporeal membrane oxygenation (ECMO) technology and knowledge, thrombocytopenia and impaired platelet function are usual findings in ECMO patients and the underlying mechanisms are only partially elucidated. The purpose of this meta-analysis and systematic review was to thoroughly summarize and discuss the existing knowledge of platelet profile in adult ECMO population. All studies meeting the inclusion criteria (detailed data about platelet count and function) were selected, after screening literature from July 1975 to August 2019. Twenty-one studies from 1.742 abstracts were selected. The pooled prevalence of thrombocytopenia in ECMO patients was 21% (95% CI 12.9–29.0; 14 studies). Thrombocytopenia prevalence was 25.4% (95% CI 10.6–61.4; 4 studies) in veno-venous ECMO, whereas it was 23.2% (95% CI 11.8–34.5; 6 studies) in veno-arterial ECMO. Heparin-induced thrombocytopenia prevalence was 3.7% (95% CI 1.8–5.5; 12 studies). Meta-regression revealed no significant association between ECMO duration and thrombocytopenia. Platelet function impairment was described in 7 studies. Impaired aggregation was shown in 5 studies, whereas loss of platelet receptors was found in one trial, and platelet activation was described in 2 studies. Platelet transfusions were needed in up to 50% of the patients. Red blood cell transfusions were administered from 46 to 100% of the ECMO patients. Bleeding events varied from 16.6 to 50.7%, although the cause and type of haemorrhage was not consistently reported. Thrombocytopenia and platelet dysfunction are common in ECMO patients, regardless the type of ECMO mode. The underlying mechanisms are multifactorial, and understanding and management are still limited. Further research to design appropriate strategies and protocols for its monitoring, management, or prevention should be matter of thorough investigations.

The demand for higher data rates and energy efficiency in wireless communication systems drives power amplifiers (PAs) into nonlinear operation, causing signal distortions that hinder performance. Digital Pre-Distortion (DPD) addresses these distortions, but existing systems face challenges with complexity, adaptability, and resource limitations. This paper introduces DRL-DPD, a Deep Reinforcement Learning-based solution for DPD that aims to reduce computational burden, improve adaptation to dynamic environments, and minimize resource consumption. To ensure safety and regulatory compliance, we integrate an ad-hoc Safe Reinforcement Learning algorithm, CRE-DDPG (Cautious-Recoverable-Exploration Deep Deterministic Policy Gradient), which prevents ACLR measurements from falling below safety thresholds. Simulations and hardware experiments demonstrate the potential of DRL-DPD with CRE-DDPG to surpass current DPD limitations in both local and remote configurations, paving the way for more efficient communication systems, especially in the context of 5G and beyond.

Speckle filtering is an unavoidable step when dealing with applications that involve amplitude or intensity images acquired by coherent systems, such as Synthetic Aperture Radar (SAR). Speckle is a target-dependent phenomenon; thus, its estimation and reduction require the individuation of specific properties of the image features. Speckle filtering is one of the most prominent topics in the SAR image processing research community, who has first tackled this issue using handcrafted feature-based filters. Even if classical algorithms have slowly and progressively achieved better and better performance, the more recent Convolutional-Neural-Networks (CNNs) have proven to be a promising alternative, in the light of the outstanding capabilities in efficiently learning task-specific filters. Currently, only simplistic CNN architectures have been exploited for the speckle filtering task. While these architectures outperform classical algorithms, they still show some weakness in the texture preservation. In this work, a deep encoder–decoder CNN architecture, focused in the specific context of SAR images, is proposed in order to enhance speckle filtering capabilities alongside texture preservation. This objective has been addressed through the adaptation of the U-Net CNN, which has been modified and optimized accordingly. This architecture allows for the extraction of features at different scales, and it is capable of producing detailed reconstructions through its system of skip connections. In this work, a two-phase learning strategy is adopted, by first pre-training the model on a synthetic dataset and by adapting the learned network to the real SAR image domain through a fast fine-tuning procedure. During the fine-tuning phase, a modified version of the total variation (TV) regularization was introduced to improve the network performance when dealing with real SAR data. Finally, experiments were carried out on simulated and real data to compare the performance of the proposed method with respect to the state-of-the-art methodologies.

Hyperspectral imaging holds significant promise in remote sensing applications, particularly for land cover and land-use classification, thanks to its ability to capture rich spectral information. However, leveraging hyperspectral data for accurate segmentation poses critical challenges, including the curse of dimensionality and the scarcity of ground truth data, that hinder the accuracy and efficiency of machine learning approaches. This paper presents a holistic approach for adaptive optimized hyperspectral-based land cover and land-use segmentation using automated machine learning (AutoML). We address the challenges of high-dimensional hyperspectral data through a revamped machine learning pipeline, thus emphasizing feature engineering tailored to hyperspectral classification tasks. We propose a framework that dissects feature engineering into distinct steps, thus allowing for comprehensive model generation and optimization. This framework incorporates AutoML techniques to streamline model selection, hyperparameter tuning, and data versioning, thus ensuring robust and reliable segmentation results. Our empirical investigation demonstrates the efficacy of our approach in automating feature engineering and optimizing model performance, even without extensive ground truth data. By integrating automatic optimization strategies into the segmentation workflow, our approach offers a systematic, efficient, and scalable solution for hyperspectral-based land cover and land-use classification.

Dysgraphia is a learning disability that causes handwritten production below expectations. Its diagnosis is delayed until the completion of handwriting development. To allow a preventive training program, abilities not directly related to handwriting should be evaluated, and one of them is visual perception. To investigate the role of visual perception in handwriting skills, we gamified standard clinical visual perception tests to be played while wearing an eye tracker at three difficulty levels. Then, we identified children at risk of dysgraphia through the means of a handwriting speed test. Five machine learning models were constructed to predict if the child was at risk, using the CatBoost algorithm with Nested Cross-Validation, with combinations of game performance, eye-tracking, and drawing data as predictors. A total of 53 children participated in the study. The machine learning models obtained good results, particularly with game performances as predictors (F1 score: 0.77 train, 0.71 test). SHAP explainer was used to identify the most impactful features. The game reached an excellent usability score (89.4 ± 9.6). These results are promising to suggest a new tool for dysgraphia early screening based on visual perception skills.

Detecting buildings in the surroundings of an urban vehicle and matching them to building models available on map services is an emerging trend in robotics localization for urban vehicles. In this paper, we present a novel technique, which improves a previous work by detecting building façade, their positions, and finding the correspondences with their 3D models, available in OpenStreetMap. The proposed technique uses segmented point clouds produced using stereo images, processed by a convolutional neural network. The point clouds of the façades are then matched against a reference point cloud, produced extruding the buildings’ outlines, which are available on OpenStreetMap (OSM). In order to produce a lane-level localization of the vehicle, the resulting information is then fed into our probabilistic framework, called Road Layout Estimation (RLE). We prove the effectiveness of this proposal, testing it on sequences from the well-known KITTI dataset and comparing the results concerning a basic RLE version without the proposed pipeline.

Background Histone Mark Modifications (HMs) are crucial actors in gene regulation, as they actively remodel chromatin to modulate transcriptional activity: aberrant combinatorial patterns of HMs have been connected with several diseases, including cancer. HMs are, however, reversible modifications: understanding their role in disease would allow the design of ‘epigenetic drugs’ for specific, non-invasive treatments. Standard statistical techniques were not entirely successful in extracting representative features from raw HM signals over gene locations. On the other hand, deep learning approaches allow for effective automatic feature extraction, but at the expense of model interpretation. Results Here, we propose ShallowChrome, a novel computational pipeline to model transcriptional regulation via HMs in both an accurate and interpretable way. We attain state-of-the-art results on the binary classification of gene transcriptional states over 56 cell-types from the REMC database, largely outperforming recent deep learning approaches. We interpret our models by extracting insightful gene-specific regulative patterns, and we analyse them for the specific case of the PAX5 gene over three differentiated blood cell lines. Finally, we compare the patterns we obtained with the characteristic emission patterns of ChromHMM, and show that ShallowChrome is able to coherently rank groups of chromatin states w.r.t. their transcriptional activity. Conclusions In this work we demonstrate that it is possible to model HM-modulated gene expression regulation in a highly accurate, yet interpretable way. Our feature extraction algorithm leverages on data downstream the identification of enriched regions to retrieve gene-wise, statistically significant and dynamically located features for each HM. These features are highly predictive of gene transcriptional state, and allow for accurate modeling by computationally efficient logistic regression models. These models allow a direct inspection and a rigorous interpretation, helping to formulate quantifiable hypotheses.

Handwriting learning delays should be addressed early to prevent their exacerbation and long-lasting consequences on whole children’s lives. Ideally, proper training should start even before learning how to write. This work presents a novel method to disclose potential handwriting problems, from a pre-literacy stage, based on drawings instead of words production analysis. Two hundred forty-one kindergartners drew on a tablet, and we computed features known to be distinctive of poor handwriting from symbols drawings. We verified that abnormal features patterns reflected abnormal drawings, and found correspondence in experts’ evaluation of the potential risk of developing a learning delay in the graphical sphere. A machine learning model was able to discriminate with 0.75 sensitivity and 0.76 specificity children at risk. Finally, we explained why children were considered at risk by the algorithms to inform teachers on the specific weaknesses that need training. Thanks to this system, early intervention to train specific learning delays will be finally possible.

Background and Objectives: Lymph node management in cutaneous melanoma has undergone a paradigm shift, transitioning from routine complete lymph node dissection (CLND) to a more selective, individualized approach. This narrative review explores the historical evolution, current evidence and clinical guidelines surrounding lymphadenectomy for a patient with Stage III of melanoma. Materials and Methods: A comprehensive literature search was conducted across PubMed, Scopus and Web of Science, focusing on randomized controlled trials, meta-analyses and updated international guidelines published in the past 15 years. Results: Traditional surgical approaches favored radical lymphadenectomy for regional disease control. However, pivotal trials such as the Multicenter Selective Lymphadenectomy Trial II (MSLT-II) and German Dermatologic Cooperative Oncology Group Selective Lymphadenectomy Trial (DeCOG-SLT) demonstrated no survival advantage from immediate CLND following a positive sentinel lymph node biopsy (SLNB), underscoring increased surgical morbidity. Consequently, guidelines from Associazione Italiana di Oncologia Medica (AIOM), the European Society for Medical Oncology (ESMO), and the National Comprehensive Cancer Network (NCCN) now endorse SLNB as the standard for nodal staging, reserving CLND for select high-risk cases. Conclusions: The role of lymphadenectomy in melanoma is increasingly becoming selective, shaped by tumor burden, nodal involvement and response to systemic therapy. SLNB remains central to staging and treatment planning, while CLND is no longer routine. Continued clinical trials and integration with immunotherapy will further refine surgical strategies in melanoma care.