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Who's buried where in London
London's many cemeteries, churches and graveyards are the last resting places of a multitude of important people from many different walks of life. Politicians, writers and military heroes rub shoulders with engineers, courtesans, artists and musicians, along with quite a few eccentric characters. Arranged geographically, this comprehensive guide describes famous graves in all the major cemeteries and churches in Greater London, including Highgate, Kensal Green, Westminster Abbey, and St Paul's Cathedral, as well as the City churches and many suburban parish churches. The book gives biographical details, information on the monuments, and is richly illustrated. As well as being an historical guide, it also serves as an indispensable reference guide for any budding tombstone tourist.
Book
Gating and modulation of a hetero-octameric AMPA glutamate receptor
AMPA receptors (AMPARs) mediate the majority of excitatory transmission in the brain and enable the synaptic plasticity that underlies learning
1
. A diverse array of AMPAR signalling complexes are established by receptor auxiliary subunits, which associate with the AMPAR in various combinations to modulate trafficking, gating and synaptic strength
2
. However, their mechanisms of action are poorly understood. Here we determine cryo-electron microscopy structures of the heteromeric GluA1–GluA2 receptor assembled with both TARP-γ8 and CNIH2, the predominant AMPAR complex in the forebrain, in both resting and active states. Two TARP-γ8 and two CNIH2 subunits insert at distinct sites beneath the ligand-binding domains of the receptor, with site-specific lipids shaping each interaction and affecting the gating regulation of the AMPARs. Activation of the receptor leads to asymmetry between GluA1 and GluA2 along the ion conduction path and an outward expansion of the channel triggers counter-rotations of both auxiliary subunit pairs, promoting the active-state conformation. In addition, both TARP-γ8 and CNIH2 pivot towards the pore exit upon activation, extending their reach for cytoplasmic receptor elements. CNIH2 achieves this through its uniquely extended M2 helix, which has transformed this endoplasmic reticulum-export factor into a powerful AMPAR modulator that is capable of providing hippocampal pyramidal neurons with their integrative synaptic properties.
Analyses of AMPA receptor–auxiliary subunit complexes provide insights into the gating and modulation of the AMPA receptor by TARP-γ8 and CNIH2.
Journal Article
Literary evidence for taro in the ancient Mediterranean: A chronology of names and uses in a multilingual world
Taro, Colocasia esculenta (L.) Schott, is a vegetable and starchy root crop cultivated in Asia, Oceania, the Americas, Africa, and the Mediterranean. Very little is known about its early history in the Mediterranean, which previous authors have sought to trace through Classical (Greek and Latin) texts that record the name colocasia (including cognates) from the 3rd century BC onwards. In ancient literature, however, this name also refers to the sacred lotus, Nelumbo nucifera Gaertn. and its edible rhizome. Like taro, lotus is an alien introduction to the Mediterranean, and there has been considerable confusion regarding the true identity of plants referred to as colocasia in ancient literature. Another early name used to indicate taro was arum, a name already attested from the 4th century BC. Today, this name refers to Arum, an aroid genus native to West Asia, Europe, and the Mediterranean. Our aim is to explore historical references to taro in order to clarify when and through which routes this plant reached the Mediterranean. To investigate Greek and Latin texts, we performed a search using the Thesaurus Linguae Graecae (TLG) and the Thesaurus Linguae Latinae (TLL), plus commentaries and English and French translations of original texts. Results show that while in the early Greek and Latin literature the name kolokasia (Greek κολοκάσια) and its Latin equivalent colocasia refer to Nelumbo nucifera Gaertn., after the 4th century AD a poorly understood linguistic shift occurs, and colocasia becomes the name for taro. We also found that aron (Greek ἄρον) and its Latin equivalent arum are names used to indicate taro from the 3rd century BC and possibly earlier.
Journal Article
What Graeco-Roman grammar was about
This book explains how the grammarians of the Graeco-Romance world perceived the nature and structure of the languages they taught. The volume focuses primarily on the early centuries AD, a time when the Roman Empire was at its peak; in this period, a grammarian not only had a secure place in the ancient system of education, but could take for granted an established technical understanding of language. By delineating what that ancient model of grammar was, P. H. Matthews highlights both those aspects that have persisted to this day and seem reassuringly familiar, such as 'parts of speech', as well as those aspects that are wholly dissimilar to our present understanding of grammar and language. The volume is written to be accessible to students of linguistics from undergraduate level upwards, and assumes no knowledge of Latin or Ancient Greek.
BOOK
Sex Distribution of Paper Mulberry (Broussonetia papyrifera) in the Pacific
Paper mulberry (Broussonetia papyrifera (L.) L'Hér. ex Vent) is a dioecious tree native to East Asia and mainland Southeast-Asia, introduced prehistorically to Polynesia as a source of bark fiber by Austronesian-speaking voyagers. In Oceania, trees are coppiced and harvested for production of bark-cloth, so flowering is generally unknown. A survey of botanical records of paper mulberry revealed a distributional disjunction: the tree is apparently absent in Borneo and the Philippines. A subsequent study of chloroplast haplotypes linked paper mulberry of Remote Oceania directly to a population in southern Taiwan, distinct from known populations in mainland Southeast-Asia.
We describe the optimization and use of a DNA marker designed to identify sex in paper mulberry. We used this marker to determine the sex distribution in selected localities across Asia, Near and Remote Oceania. We also characterized all samples using the ribosomal internal transcribed spacer sequence (ITS) in order to relate results to a previous survey of ITS diversity.
In Near and Remote Oceania, contemporary paper mulberry plants are all female with the exception of Hawaii, where plants of both sexes are found. In its natural range in Asia, male and female plants are found, as expected. Male plants in Hawaii display an East Asian ITS genotype, consistent with modern introduction, while females in Remote Oceania share a distinctive variant.
Most paper mulberry plants now present in the Pacific appear to be descended from female clones introduced prehistorically. In Hawaii, the presence of male and female plants is thought to reflect a dual origin, one a prehistoric female introduction and the other a modern male introduction by Japanese/Chinese immigrants. If only female clones were dispersed from a source-region in Taiwan, this may explain the absence of botanical records and breeding populations in the Philippines and Borneo, and Remote Oceania.
Journal Article
Evolutionary origins of taro (Colocasia esculenta) in Southeast Asia
As an ancient clonal root and leaf crop, taro (Colocasia esculenta, Araceae) is highly polymorphic with uncertain genetic and geographic origins. We explored chloroplast DNA diversity in cultivated and wild taros, and closely related wild taxa, and found cultivated taro to be polyphyletic, with tropical and temperate clades that appear to originate in Southeast Asia sensu lato. A third clade was found exclusively in wild populations from Southeast Asia to Australia and Papua New Guinea. Our findings do not support the hypothesis of taro domestication in Papua New Guinea, despite archaeological evidence for early use or cultivation there, and the presence of apparently natural wild populations in the region (Australia and Papua New Guinea). As an ancient clonal root and leaf crop, taro (Colocasia esculenta, Araceae) is highly polymorphic with uncertain genetic and geographic origins. We explored chloroplast DNA variation in wild and cultivated taros and other Colocasia species and found cultivated taro to be polyphyletic, with tropical and temperate clades originating in Southeast Asia. A third clade was found exclusively in wild populations from Southeast Asia to Australia and Papua New Guinea.
Journal Article
The distribution of income is worse than you think: Including pollution impacts into measures of income inequality
This paper calculates the distribution of an adjusted measure of income that deducts damages due to exposure to air pollution from reported market income in the United States from 2011 to 2014. The Gini coefficient for this measure of adjusted income is 0.682 in 2011, as compared to 0.482 for market income. By 2014, we estimate that the Gini for adjusted income fell to 0.646, while the market income Gini did not appreciably change. The inclusion of air pollution damage acts like a regressive tax: with air pollution, the bottom 20% of households lose roughly 10% of the share of income, while the top 20% of households gain 10%. We find that, unlike the case for market income, New England is not the most unequal division with respect to adjusted income. Further, the difference between adjusted income for white and Hispanics is smaller than expected. However, the gap in augmented income between whites and African-Americans is widening.
Journal Article