Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
47
result(s) for
"Mattison, Paul"
Sort by:
Understanding Deleuze, understanding modernism
This title explores the multi-faceted and formative impact of Gilles Deleuze on the development and our understanding of modernist thought in its philosophical, literary, and more broadly cultural manifestations.
Book
MUltiple Sclerosis and Extract of Cannabis: results of the MUSEC trial
Objective Multiple sclerosis (MS) is associated with chronic symptoms, including muscle stiffness, spasms, pain and insomnia. Here we report the results of the Multiple Sclerosis and Extract of Cannabis (MUSEC) study that aimed to substantiate the patient based findings of previous studies. Patients and methods Patients with stable MS at 22 UK centres were randomised to oral cannabis extract (CE) (N=144) or placebo (N=135), stratified by centre, walking ability and use of antispastic medication. This double blind, placebo controlled, phase III study had a screening period, a 2 week dose titration phase from 5 mg to a maximum of 25 mg of tetrahydrocannabinol daily and a 10 week maintenance phase. The primary outcome measure was a category rating scale (CRS) measuring patient reported change in muscle stiffness from baseline. Further CRSs assessed body pain, spasms and sleep quality. Three validated MS specific patient reported outcome measures assessed aspects of spasticity, physical and psychological impact, and walking ability. Results The rate of relief from muscle stiffness after 12 weeks was almost twice as high with CE than with placebo (29.4% vs 15.7%; OR 2.26; 95% CI 1.24 to 4.13; p=0.004, one sided). Similar results were found after 4 weeks and 8 weeks, and also for all further CRSs. Results from the MS scales supported these findings. Conclusion The study met its primary objective to demonstrate the superiority of CE over placebo in the treatment of muscle stiffness in MS. This was supported by results for secondary efficacy variables. Adverse events in participants treated with CE were consistent with the known side effects of cannabinoids. No new safety concerns were observed. Trial registration number NCT00552604.
Journal Article
Web-based physiotherapy for people moderately affected with Multiple Sclerosis; quantitative and qualitative data from a randomized, controlled pilot study
Objective:
To explore the effectiveness and participant experience of web-based physiotherapy for people moderately affected with Multiple Sclerosis (MS) and to provide data to establish the sample size required for a fully powered, definitive randomized controlled study.
Design:
A randomized controlled pilot study.
Setting:
Rehabilitation centre and participants’ homes.
Subjects:
Thirty community dwelling adults moderately affected by MS (Expanded Disability Status Scale 5-6.5).
Interventions:
Twelve weeks of individualised web-based physiotherapy completed twice per week or usual care (control). Online exercise diaries were monitored; participants were telephoned weekly by the physiotherapist and exercise programmes altered remotely by the physiotherapist as required.
Main measures:
The following outcomes were completed at baseline and after 12 weeks; 25 Foot Walk, Berg Balance Scale, Timed Up and Go, Multiple Sclerosis Impact Scale, Leeds MS Quality of Life Scale, MS-Related Symptom Checklist and Hospital Anxiety and Depression Scale. The intervention group also completed a website evaluation questionnaire and interviews.
Results:
Participants reported that website was easy to use, convenient, and motivating and would be happy to use in the future. There was no statistically significant difference in the primary outcome measure, the timed 25ft walk in the intervention group (P=0.170), or other secondary outcome measures, except the Multiple Sclerosis Impact Scale (P=0.048). Effect sizes were generally small to moderate.
Conclusion:
People with MS were very positive about web-based physiotherapy. The results suggested that 80 participants, 40 in each group, would be sufficient for a fully powered, definitive randomized controlled trial.
Journal Article
Understanding Bergson, Understanding Modernism
Henri Bergson is frequently cited amongst the holy trinity of major influences on Modernism-literary and otherwise-alongside Sigmund Freud and William James. Gilles Deleuze's Bergsonism has re-popularized Bergson for the twenty-first century, so much so that, perhaps, our Bergson is Deleuze's Bergson. Despite renewed interest in Bergson, his influence remains understudied and consequently undervalued. While books examining the impact of Freud and James on Modernism abound, Bergson's impact, though widely acknowledged, has been closely examined much more rarely. Understanding Bergson, Understanding Modernism remedies this deficiency in three ways. First, it offers close readings and critiques of six pivotal texts. Second, it reassesses Bergson's impact on Modernism while also tracing his continuing importance to literature, media, and philosophy throughout the twentieth and into the twenty-first century. In its final section it provides an extended glossary of Bergsonian terms, complete with extensive examples and citations of their use across his texts. The glossary also maps the influence of Bergson's work by including entries on related writers, all of whom Bergson either corresponded with or critiqued.
eBook
A comparison of the initial orthotic effects of functional electrical stimulation and ankle-foot orthoses on the speed and oxygen cost of gait in multiple sclerosis
Background
Foot drop affects walking in people with multiple sclerosis (pwMS). This study compares the initial orthotic effects of two treatments for foot drop: ankle-foot orthoses (AFO) and functional electrical stimulation (FES), on the speed and oxygen cost of walking in MS.
Method and materials
Seventy-eight pwMS were randomised to receive AFO or FES (ODFS PACE (OML, Salisbury, UK)). Participants completed the 25-ft walk test (25ftWT) and 5-min self-selected walk test (5minSSWT), from which oxygen cost was determined, with and without their device. Between-, within- and sub-group analyses (based on baseline walking speed of <0.8 m/s (slow) or ≥0.8 m/s (fast)) were undertaken.
Results
No significant differences between baseline measures were observed. The AFO group walked significantly slower than the FES group (5minSSWT, p = 0.037, 0.11 m/s). The AFO group walked significantly slower with than without AFO (25ftWT, p = 0.037), particularly in the fast-walking group ( p = 0.011). The slow-walking FES group walked significantly faster with FES than without (25ftWT; p = 0.029, 5minSSWT; p = 0.037). There were no differences in the fast-walking FES group or in the oxygen cost for either device.
Conclusion
AFO reduced walking speed, particularly in fast walkers. FES increased walking speed in slow, but not fast walkers.
Journal Article
YOUR VIEW: Take no pride
IT is true that Scots played a large role in the creation of the British Empire, but is it something we should be...
Newspaper Article
Regulation of mitogen -activated protein kinase signaling by the protein tyrosine phosphatases, Ptp2 and Ptp3, in the yeast Saccharomyces cerevisiae
Mitogen-activated protein kinase (MAPK) pathways regulate growth, development, and response to stress. Proper regulation of these pathways is essential as their constitutive activation can cause cell transformation, growth defects, or lethality. Protein tyrosine phosphatase-(PTP)-mediated dephosphorylation of phosphotyrosine in the activation loop of MAPK is a conserved inactivation mechanism among eukaryotes. In Saccharomyces cerevisiae two PTPs, Ptp2 and Ptp3, inactivate the Hog1 and Fus3 MAPKs with different efficacies. Ptp2 more effectively regulates Hog1, while Ptp3 more potently regulates Fus3. To further characterize the substrate specificity of these two phosphatases, their ability to inactivate the cell wall integrity MAPK, Mpk1, was examined. In vivo and in vitro data indicate that Ptp2 is a potent negative regulator of Mpk1, while Ptp3 only weakly inactivates Mpk1. Ptp2 and Ptp3 substrate specificities may be explained by differences in their subcellular localization and ability to bind Mpk1. Fusions of PtP2 and Ptp3 to green fluorescent protein indicate that Ptp2 is predominantly nuclear while Ptp3 is mainly cytoplasmic. In yeast lysates, Ptp2 binds to Mpk1 more efficiently than Ptp3. Therefore, Ptp2 and Ptp3 regulate at least three different MAPKs with differing specificity. The function of the Ptp2 amino-terminal noncatalytic domain (Ptp2-ND) is unknown. PTP2 deletion analysis indicates the ∼350 residue Ptp2-ND is essential for inactivating Hog1 in vivo. It is required to properly localize Ptp2 to the nucleus via a complex nuclear localization sequence (NLS), and it binds Hog1, suggesting it mediates Ptp2 specificity. Deletion of the Ptp2-ND increases phosphatase activity in vitro, suggesting this domain negatively regulates catalytic activity. Additional regulation of Ptp2 occurs through a novel signal-induced manner, as osmotic stress increased Ptp2 catalytic activity in a phosphorylation-dependent manner. Hog1 is known to transiently accumulate in the nucleus upon activation by osmotic stress. I show that Ptp2 and Ptp3 act as subcellular tethers to modulate Hog1 localization by binding Hog1. In strains lacking or overexpressing either PTP2 or PTP3, Hog1 subcellular localization is altered suggesting that Ptp2 acts as a nuclear tether for Hog1 while Ptp3 acts as a cytoplasmic anchor. Therefore, PTPs regulate MAPKs via both dephosphorylation and modulation of subcellular localization.
Dissertation
Sex as a risk factor regarding presbyopia in the rhesus monkey
To determine the effect of sex as a risk factor regarding presbyopia.
Maximum accommodation was pharmacologically induced (40% cabachol corneal iontophoresis) in 97 rhesus monkeys (49 males and 48 females) ranging in age from 8 to 36 years old. Accommodation was measured by Hartinger coincidence refractometry.
Accommodative amplitude measured refractometrically decreased with age, and the rate of change was not different between males and females (p = 0.827).
Presbyopia is essentially sex neutral, and no one is spared. There may be modest variations between different populations for various reasons, but essentially it is monotonously predictable. At present there is no biological therapeutic.
Journal Article