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Outdoor air pollution and especially particulate matter pollution is a major environmental health issue that raises concerns of scientists and policy makers. This study focuses on air quality perception in relation to particulate matter in order to find potential patterns. Field questionnaire-based surveys were conducted among pedestrians on two central sites in the city of Athens, Greece, during the winter period while particulate matter of 10 μm or less in diameter (PM10) were concurrently measured on-site at 1-min resolution. The participants were asked to evaluate the dust and the overall pollution-related air quality based on 5-point bipolar scales. Air quality perception patterns were explored considering PM10 concentration, meteorological and thermal conditions, and subjective variables including gender, age, smoking status, and health status. An effect of PM10 on dust perception was identified, suggesting that dusty air quality conditions are reported more frequently when particulate concentration increases. Health status, exposure time, smoking status, and gender were found to affect air quality perception. Participants experiencing health symptoms, exposed to outdoor conditions for more than 30 min, smokers, and females were more likely to report unfavorable air quality conditions. The comparison with the results of a previous study obtained using air pollution station data confirmed the dependence of air quality perception on participants’ characteristics and particularly on their health status. Ordinal logistic regression models showed that for pedestrians who were neither smokers nor experiencing health symptoms and were exposed to outdoor conditions for more than 30 min, a PM10 concentration around 64 μg·m−3 could be a threshold, to perceive dusty air quality conditions.

In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by acting on mitochondrial function, thereby heralding a life-saving path forward for patients suffering from neuroinflammatory diseases. Disorders of myelin in the nervous system damage the transmission of signals, resulting in loss of vision, motion, sensation, and other functions depending on the affected nerves, currently with no effective treatment. genes and their single-pass transmembrane Klotho proteins are powerful governors of the threads of life and death, true to the origin of their name, Fates, in Greek mythology. Among its many important functions, Klotho is an obligatory co-receptor that binds, activates, and/or potentiates critical fibroblast growth factor activity. Since the discovery of a little over two decades ago, it has become ever more apparent that when Klotho pathways go awry, oxidative stress and mitochondrial dysfunction take over, and age-related chronic disorders are likely to follow. The physiological consequences can be wide ranging, potentially wreaking havoc on the brain, eye, kidney, muscle, and more. Central nervous system disorders, neurodegenerative in nature, and especially those affecting the myelin sheath, represent worthy targets for advancing therapies that act upon Klotho pathways. Current drugs for these diseases, even therapeutics that are disease modifying rather than treating only the symptoms, leave much room for improvement. It is thus no wonder that this topic has caught the attention of biomedical researchers around the world.

Dispersed urbanization has expanded into rural land worldwide. The present work focused on the Athens’ metropolitan area, the capital of Greece, discussing the potential role of a typical rural Mediterranean landscape dominated by olive groves, in urban containment and peri-urban conservation of biodiversity and local traditions. Having a great cultural, culinary and aesthetic importance, olive groves characterize Mediterranean peri-urban landscapes in a distinctive way. This study identifies processes of urban dispersion and changes in the ‘olive landscape’ in the study area, proposing new ideas for a sustainable land management in metropolitan contexts that have recently undergone processes of territorial transformation toward urban sprawl, under the effect of socioeconomic disturbances, including economic crisis.

The incidence of Candida peritonitis is increasing and the mortality rate remains high. Candida albicans is the most common yeast causing Candida peritonitis, but a shift to more drug-resistant non- albicans strains has been observed. Major risk factors for developing Candida peritonitis include hollow viscus perforation, abdominal and thoracic surgery, surgical drains in situ, intravenous and urinary catheters, total parenteral nutrition, severe sepsis, antibiotic therapy (≥48 h before peritonitis), immunosuppression, diabetes mellitus, and extensive Candida colonization. Polymicrobial peritoneal infections with Candida spp. and enteric bacteria (such as E. coli and B. fragilis ) have been associated with higher mortality. Laboratory detection of Candida is still based on histopathological diagnosis and culture-based methods. Isolated Candida spp. must be treated as a pathogen contributing to peritonitis. Prompt diagnosis, effective antifungal therapy, and skilled surgical management are essential components of treatment. Treatment includes removal of all foreign bodies, such as intravenous and urinary catheters and drains, whereas abscesses usually require surgical or radiological drainage. Antifungal therapy should be chosen based on sensitivity profiles. Fluconazole is still appropriate for most severe community-acquired or nosocomial infections. Echinocandins are used as first-line in critically ill patients, those with prior azole exposure, and those with fluconazole-resistant candidiasis. Peritoneal lavage can be used in combination with other antifungal agents to treat refractory infections. Risk factors must be weighed to decide on prophylaxis (usually with fluconazole) to limit antifungal resistance.

The present work investigates the increase of confirmed cases of West Nile virus and the relationship between weather-related patterns and the geographical expansion of West Nile virus in Greece, with a special focus on West Attica, Central Greece, a semi-arid, ecologically fragile Mediterranean area. Using data from the European Environment Agency, European Drought Observatory of Joint Research Centre, the pairwise relationship between surface air temperature anomalies, precipitation anomalies, soil moisture index anomalies, and the fraction of absorbed photosynthetically active radiation anomalies (fAPAR) was evaluated during summer time of 2018, a particularly intense virus outbreak. The empirical results of this study indicate that total precipitation during 2018 was extremely high, nearly 500% above the average. These conditions contributed to the increase of soil moisture index anomaly and fAPAR, creating an ideal microenvironment (wet soils and green pastures) for mosquito breeding. This phenomenon was directly associated with a drastic outbreak of West Nile virus cases in the area, compared with earlier years. Our results indicate how unusually high values of summer precipitation may have contributed (both through direct and indirect ecological channels) to the rapid spread of the West Nile virus in West Attica, causing a significant number of confirmed cases and fatalities. Climate change may bring forth other issues aside from natural disasters, including—but not limited to—virus expansion.

To review data on epidemiology, differential diagnosis, clinical, laboratory, and imaging findings, natural history, and management of incidentally discovered pituitary lesions (pituitary incidentalomas). A nonsystematic review was conducted, including articles indexed in Index Medicus that contained reference to incidentally discovered pituitary masses (pituitary incidentalomas). Both autopsy and sensitive neuroimaging studies (including magnetic resonance imaging) suggest that pituitary incidentalomas are common, affecting approximately 10% of the general population. Although typically small (less than 10 mm in greatest diameter) and clinically silent, some pituitary incidentalomas may be hormonally active or cause mass effects by compressing neighboring structures. In addition, a minority of these lesions may grow over time; hence, long-term follow-up is necessary. Therapeutic interventions, including dopamine agonist therapy (in the case of prolactin-secreting adenomas) or transsphenoidal resection, are indicated in the case of pituitary lesions that are hormonally active, cause mass effects, or increase in size. Pituitary incidentalomas are common and constitute a heterogeneous group with regard to pathologic features, clinical, laboratory, and imaging characteristics, natural history, and growth potential. Currently available evidence suggests that many hormonally nonfunctioning pituitary incidentalomas causing no mass effects can be safely managed by follow-up surveillance. Nonetheless, more data are needed for further elucidation of the natural history of these lesions and for improvement in accurate and noninvasive diagnosis and in prediction of growth potential of pituitary incidentalomas. Improved understanding of the pathogenesis of this heterogeneous group of lesions may also lead to the development of novel, noninvasive therapeutic agents, rationally designed to interact with well-characterized molecular targets.

Shifts in government priorities in response to the 2007 global recession have affected wildfire management and natural disaster funding arrangements, leading to a reduced effectiveness of fire suppression actions and increasing fire vulnerability. Our study investigates the role of local socioeconomic contexts on fire suppression effectiveness under economic expansion and recession in a Mediterranean region (Attica, Greece) strongly affected by 2007 crisis and displaying a persistently high density of peri-urban wildfires. Basic characteristics of wildfires (spatial distribution, intensity, and land use preferences) were investigated in the study area over two consecutive 8-year time intervals characterized by economic expansion (2000–2007) and recession (2008–2015). An integrated approach based on multivariate statistics and artificial neural networks was implemented to evaluate latent relationships between fire suppression time, wildfire characteristics, and socioeconomic dynamics. Controlling for wildfires’ characteristics over the two time intervals, fire time length increased under crisis—mainly for small and medium-sized fires—possibly as an indirect response to reduced effectiveness of forest land management. Local contexts and political decisions influenced by economic downturns are relevant factors shaping wildfires’ severity in the Mediterranean region. With recession, local contexts vulnerable to wildfires require more effective fire prevention measures, sustainable forest management, and regional planning.

Heatwaves—excessively hot ambient conditions that are considered a serious threat to human health—are often associated with poor air quality. The aim of this study was to examine the impact of an early heatwave episode in an industrialized plain in the eastern Mediterranean region (Thriasio, Greece) on human thermal discomfort and urban air quality. The heatwave occurred in mid (15–20) May 2020, shortly after some of the restrictions that were improsed to halt the spread of coronavirus disease 2019 (COVID-19) in Greece were lifted (on 4 May). The discomfort index (DI) and the daily air quality index (DAQI) were calculated on an hourly basis throughout spring 2020 (March, April, May) using data from two stations that measure meteorological parameters and air pollutant concentrations in the Thriasio Plain. The analysis showed that the air temperature increased during 7–17 May to levels that were more than 10 °C above the monthly average value (25.8 °C). The maximum measured air temperature was 38 °C (on 17 May). The results showed a high level of thermal discomfort. The DI exceeded the threshold of 24 °C for several hours during 13–20 May. Increased air pollution levels were also identified. The average DAQI was estimated as 0.83 ± 0.1 and 1.14 ± 0.2 at two monitoring stations in the region of interest during the heatwave. Particulate matter (diameter < 10 μm) appeared to contribute significantly to the poor air quality. Significant correlations between the air temperature, DI, and AQSI were also identified.

Biological disasters endanger the lives of teachers and students, causing serious disturbances to schools, and forcing them to shut down for a short or long period of time. Over the last few decades, the Greater Athens area and Attica Prefecture in Greece have experienced several natural disasters. These events have highlighted problems and weaknesses in emergency planning for school communities at both local and regional level, and have shown the need for new precautionary measures and effective risk management for modern society and school communities. The present study reports an investigation of the perception of the risk posed by biological hazards to teacher safety. The investigation utilized a questionnaire survey of teachers working in the secondary education directorate in Western Attica, which was carried out between May and December 2019. The teachers’ perceptions of the extent to which their safety was affected by biohazards (i.e., infectious diseases and weather-related diseases) were investigated using a 5-point scale ranging from affected a lot (− 2) to not affected at all (+ 2). A multivariate statistical technique—principal component analysis—was used to explore the results of the survey. The results showed that the teachers’ feelings of safety were affected a lot (− 2) or affected enough (− 1) by biohazards. 61.5% ( n  = 72) of the participants reported that their feelings of safety were affected a lot or enough by infectious diseases, and 55.6% ( n  = 65) of the participants noted that their feelings of safety were affected a lot or enough by weather-related diseases. Compared to other natural, technological, or social hazards, biological hazards seem to have a greater impact on teachers’ feelings of safety. These results could have implications for the design of risk management plans for school communities.

This study investigates soil erosion in a rapidly expanding industrial region of Eastern Mediterranean basin (Thriasio plain, Greece), controlling how geomorphology, topography, soil drainage and vegetation cover shape the local erosivity rate. Our results show that Thriasio plain is characterized by medium–low classes of soil vulnerability in the actual environmental conditions. However, in an ‘extreme conditions’ scenario, areas with sharp slope, a branched hydrographical network and low vegetation cover are classified at high vulnerability to soil erosion. A field study has been implemented considering extreme natural conditions (January 2004) driven by rapid snow melting determining an exceptionally high volume of water flooding down to the sea through a seasonal stream. This episode was considered a ‘natural experiment’ when assessing extreme soil erosion conditions. Based on theoretical calculations and field measurements, our results confirm the estimated value of soil erosion under the ‘extreme conditions’ scenario illustrated above.