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"May, Thomas"
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Aero : beginning to now
\"'Aero: beginning to now' celebrates 20 years of the famed Aero design studio with an intimate look at its founder Thomas O'Brien's design philosophy. From O'Brien's vivid reminiscences about his early days in art school in Manhattan to the opening and development of his paired studio and store, 'Aero' covers the history and aesthetic of this Soho, New York, landmark.\"--Book jacket.
Book
On the Justifiability of ACMG Recommendations for Reporting of Incidental Findings in Clinical Exome and Genome Sequencing
In spring 2013 the American College of Medical Genetics and Genomics (ACMG) Working Group on Incidental Findings in Clinical Exome and Genome Sequencing (hereafter “Working Group”) released a report of “Recommendations for Reporting of Incidental Findings in Clinical Exome and Genome Sequencing,” the culmination of a three-year long consensus project. The Working Group recommended that a number of incidental findings, which they define as “the results of a deliberate search for pathogenic or likely pathogenic alterations in genes that are not apparently relevant to a diagnostic indication for which the sequencing test was ordered,” be returned to clinicians (and patients) independent of patient preferences. The Working Group recognized that their recommendations may violate existing ethical norms, but believe this is justified by a fiduciary duty on the part of clinicians and laboratory personnel to prevent harm by warning patients about certain findings, a duty they claim “supersedes concerns about autonomy.”
Journal Article
Icon animorum, or, The mirror of minds
\"In this essay from 1614 the Neo-Latin poet, translator, and commentator John Barclay describes the manners and mores of his European contemporaries. He derives the sources of an individual's peculiarities of behavior and temperament from the 'genius' - the individual character created by each person's upbringing, time of life, and profession. Barclay likewise describes each nation's genius, its national character, and provides some of the geographical and historical background from which he claims this genius arose. The essay is a valuable study, not only for the illustration it offers of a pre-Romantic view of Europe, but for a glimpse into the continuities that mark European civilization. The introduction describes the Classical and Renaissance background to Barclay's work, with a detailed biography of the author. The Latin text reproduces Barclay's first edition, with the necessary corrections. The English translation (1631) is that of Thomas May, a skillful translator of Vergil, Lucan, and other classical authors\"-- Publisher description.
Book
Health scores for farmed animals: Screening pig health with register data from public and private databases
There are growing demands to ensure animal health and, from a broader perspective, animal welfare, especially for farmed animals. In addition to the newly developed welfare assessment protocols, which provide a harmonised method to measure animal health during farm visits, the question has been raised whether data from existing data collections can be used for an assessment without a prior farm visit. Here, we explore the possibilities of developing animal health scores for fattening pig herds using a) official meat inspection results, b) data on antibiotic usage and c) data from the QS (QS Qualität und Sicherheit GmbH) Salmonella monitoring programme in Germany. The objective is to aggregate and combine these register-like data into animal health scores that allow the comparison and benchmark of participating pig farms according to their health status. As the data combined in the scores have different units of measure and are collected in different abattoirs with possibly varying recording practices, we chose a relative scoring approach using z-transformations of different entrance variables. The final results are aggregated scores in which indicators are combined and weighted based on expert opinion according to their biological significance for animal health. Six scores have been developed to describe different focus areas, such as \"Respiratory Health\", \"External Injuries/ Alterations\", \"Animal Management\", \"Antibiotic Usage\", \"Salmonella Status\" and \"Mortality\". These \"focus\" area scores are finally combined into an \"Overall Score\". To test the scoring method, existing routine data from 1,747 pig farm units in Germany are used; these farm units are members of the QS Qualität und Sicherheit GmbH (QS) quality system. In addition, the scores are directly validated for 38 farm units. For these farm units, the farmers and their veterinarians provided their perceptions concerning the actual health status and existing health problems. This process allowed a comparison of the scoring results with actual health information using kappa coefficients as a measure of similarity. The score testing of the focus area scores using real information resulted in normalised data. The results of the validation showed satisfactory agreement between the calculated scores for the project farm units and the actual health information provided by the related farmers and veterinarians. In conclusion, the developed scoring method could become a viable benchmark and risk assessment instrument for animal health on a larger scale under the conditions of the German system.
Journal Article
A history of continental philosophy
Beginning with Kant and the earliest responses to his critical philosophy and ending with the latest developments in continental thinking across a range of disciplines, these volumes present the first coherent and comprehensive history of the continental tradition of philosophy. Divided, chronologically and thematically, into eight volumes, the \"History of Continental Philosophy\" is an indispensable resource for anyone conducting research or teaching in philosophy and related fields inthe humanities and social sciences where the influence of continental theory has been widespread. Alan Schrift has brought together an internationally renowned team of volume editors and contributors to provide an unrivalled analysis of the complex and interconnected history of continental philosophy that will become a reference point for all future work in the field.
Book
Antibiotic drug usage in pigs in Germany—Are the class profiles changing?
The development of antimicrobial resistance is triggered by the use of antibiotic drugs. Therefore, the consumption of antibiotics in livestock is monitored, and different measures may be applied if the usage of antibiotic drugs seems inappropriate. Unfortunately, the surveillance of antibiotic consumption is not standardised, and surveillance systems differ. In Germany, the food quality assurance system QS Qualität und Sicherheit GmbH (QS) began the documentation of antibiotic drug usage in pigs in 2012 in a private economic based database, and for its members, documentation has been mandatory in all pig age groups since 2014. In this investigation, we calculated the distribution of the antibiotics use per pig age group and half-year, and the percentage of the active substances used from overall treatments within German pig holdings from 1 July, 2013 to 30 June, 2015. In fattening pigs, the median of the treatment frequency is 4.3 in 2013-2 and exhibits a decreasing trend in this time period up to 2.1 in 2015-1. In weaners the median ranged between 11.3 in 2014-2 and 5.8 in 2013-2. The median of sucklers varies between 21.6 and 25.0. In sucklers and weaners, a clear temporal trend is not seen to date. The share of the active substances differs between the age groups. In fattening pigs, mostly tetracyclines and penicillines were used, occurring in approximately 60% of the total treatments. In weaners, amoxicillin and colistin have the highest shares of the treatment frequency, at approximately 60%. The treatment frequencies of macrolides and penicillines have the highest share in sucklers.
Journal Article
Sociogenetic Risks — Ancestry DNA Testing, Third-Party Identity, and Protection of Privacy
The capture of the suspected Golden State Killer illustrated that DNA information may derive from testing that an implicated person doesn’t know has occurred. Realizing DNA testing’s great potential as a public health tool will require managing its potential for misuse.
Journal Article
Factors influencing trustworthiness and perceived biases of medical information and genetic testing for Black and White Americans
Ensuring diversity in genomic research is crucial to address disparities in healthcare benefits experienced by Black Americans and other minority groups. Despite progress in promoting diversity, Black Americans remain underrepresented in most genetic studies, resulting in unequal access to the benefits of genetic medicine. This study investigates trusted sources of medical and genetic testing information among Black and White Americans, identifying key factors that influence trust and participation in genetic research. Using an online survey of 1,018 participants (Black Americans n = 500, White Americans n = 518), we analyzed trust and bias ratings across various sources, including medical providers, genetic counselors, and social media. Medical providers emerged as the most trusted source for both medical and genetic information across racial groups. In terms of bias, social media was viewed as most biased and medical providers as least biased across both groups. However, Black Americans reported significantly lower trust in medical providers and scientific literature compared to White Americans. Furthermore, Black Americans expressed a stronger preference for receiving medical information from individuals of the same race or ethnicity. These findings highlight the importance of tailoring communication outlets and strategies to address the specific trust concerns of underrepresented populations. Efforts to engage Black Americans in genetic research may benefit from increased involvement of medical providers and genetic counselors, improved transparency, and culturally relevant communication. By addressing these factors, the research community can work towards reducing disparities and promoting equitable access to the benefits of genetic medicine.
Journal Article